DRSC/TRiP Functional Genomics Resources

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Protein Alignment trol and PAPLN

DIOPT Version :10

Sequence 1:NP_001401049.1 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4489 Species:Drosophila melanogaster
Sequence 2:XP_047287828.1 Gene:PAPLN / 89932 HGNCID:19262 Length:1305 Species:Homo sapiens


Alignment Length:1699 Identity:335/1699 - (19%)
Similarity:507/1699 - (29%) Gaps:696/1699 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly  1870 GLGSASLVEKCQCPPGYVGDSCESCASGY-VRQPGGP-----------WLGHCVPFI-------P 1915
            |:||              ||:...|.|.: |.|..||           .||...|.:       .
Human    38 GVGS--------------GDTLSPCCSHWRVPQKLGPAESPRTGAGTLGLGQVFPVLWSRRRDGG 88

  Fly  1916 DSCPSGTYGDPRRGVPCKECPCPLTGSNNFASGCQQSPDGDVVCRCNEGYTGRRCEQCA----AG 1976
            .||    .|..|....|:...|| .|:.:|                       |.||||    |.
Human    89 SSC----VGPARSHRSCRTESCP-DGARDF-----------------------RAEQCAEFDGAE 125

  Fly  1977 YQGNP------LAAGGICRRIPDTSCNVDGT--YSVHSNGTCQCKDSVI-GEQCDTCKSKSFHLN 2032
            :||..      .:|...|    :.:|...|.  |..|       :::|: |..|:..|...    
Human   126 FQGRRYRWLPYYSAPNKC----ELNCIPKGENFYYKH-------REAVVDGTPCEPGKRDV---- 175

  Fly  2033 SFTYTGCIECFCSGVGLD--------------C--DSSTWYRDQVTSTFGRSRVDHGF--VLVTN 2079
                  |::..|..||.|              |  |.:|.|  .|..||..:.:..|:  :|:  
Human   176 ------CVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCY--PVAGTFDANDLSRGYNQILI-- 230

  Fly  2080 YMQPTPDTVPVSMAAEPNALSFIGSADQSGNTL-------------YWSLPAAFLGNKLSSYGGK 2131
                    ||:...:     ..|..|..|.|.|             :|::.||   ..|.:....
Human   231 --------VPMGATS-----ILIDEAAASRNFLAVKNVRGEYYLNGHWTIEAA---RALPAASTI 279

  Fly  2132 LTYTLSYSP--LPNGIMSRNSAPDVVIKSGEDLRLIHYRKSQVVPSVANTYSVEIKES----AWQ 2190
            |.|......  .|..:.:|....:.::     :.||....:   |.|...|.:.::..    :|.
Human   280 LHYERGAEGDLAPERLHARGPTSEPLV-----IELISQEPN---PGVHYEYHLPLRRPSPGFSWS 336

  Fly  2191 RGDEVVANREHVLMALSDITAIYIKATYTTSTKEASLRQVTLD-VATPTNL--GTPRAVEVEQCR 2252
            .|            :.||.:|      ......::.|...|:| .|.|.::  ..||..:...|.
Human   337 HG------------SWSDCSA------ECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCN 383

  Fly  2253 ---CPEGYLGLSCEQCAPGYARDPEGGIYLGLCRPC--ECNGHSK----YCNSDTG-------DC 2301
               |||              .:..:.|.:    .||  .|.|.|:    ||.|..|       :.
Human   384 LHPCPE--------------TKRWKAGPW----APCSASCGGGSQSRSVYCISSDGAGIQEAVEE 430

  Fly  2302 EECSDNTEGP----SC--ERCAAG----------YVGDATRGTIYDCQPDEGYPIPSPPAPGNQT 2350
            .||:.....|    :|  :||||.          ..|...|.....|:.:.|            :
Human   431 AECAGLPGKPPAIQACNLQRCAAWSPEPWGECSVSCGVGVRKRSVTCRGERG------------S 483

  Fly  2351 LECTAYCQIEG----IYDCRGNECLCKRNVIGDQCDQCRPGTYGLSAQNQDGCKECYCSGLASQC 2411
            |..||.|.:|.    ...|...:|    .::.||.  ...||:||            ||   ..|
Human   484 LLHTAACSLEDRPPLTEPCVHEDC----PLLSDQA--WHVGTWGL------------CS---KSC 527

  Fly  2412 RSAALYRQLI----------------PVDFILNAPLITDESGAVQDTENLIPDISRNMYTYTHTS 2460
            .|....||:|                |||.   .|..|......|:..::     ::::|.....
Human   528 SSGTRRRQVICAIGPPSHCGSLQHSKPVDV---EPCNTQPCHLPQEVPSM-----QDVHTPASNP 584

  Fly  2461 YLPKYWSLRGSVLGNQLFSYGGRLSYSLIVESYGNYERGHDIVLIGNGLKLIWSRPDGNENQEEY 2525
            ::|         ||.|              ||..:..||.            |            
Human   585 WMP---------LGPQ--------------ESPASDSRGQ------------W------------ 602

  Fly  2526 NVRLHEDEQWTRQDRESARPASRSDFMTVLSDLQHILIRATPRVPTQSTSIGNVILESAVTTRTP 2590
                     |..|:..|||...|.:             |..|| ..|.|.:.  .|..|.:.:.|
Human   603 ---------WAAQEHPSARGDHRGE-------------RGDPR-GDQGTHLS--ALGPAPSLQQP 642

  Fly  2591 ----GATHASDIELCQ------CPSGY---VGTSCESCAPLHYRDASGSCSLCPCDVSNTESCDL 2642
                .....|....|:      ||.|:   :|...:.|.....:.:...|  ||..||       
Human   643 PYQQPLRSGSGPHDCRHSPHGCCPDGHTASLGPQWQGCPGAPCQQSRYGC--CPDRVS------- 698

  Fly  2643 VSGGYVECRCKARWKGD------RCREI------------DTNDPTDI-GTE-----DPVLTQII 2683
            |:.|.....|...:.||      |.|.:            ..|:|::. |::     |.|.|   
Human   699 VAEGPHHAGCTKSYGGDSTGGMPRSRAVASTVHNTHQPQAQQNEPSECRGSQFGCCYDNVAT--- 760

  Fly  2684 VSIQKPEITIVPVGGSMTLSCSGR------------------MRWSNSPVIVNWYKENSRLPENV 2730
                        ..|.:...|.|:                  ..|:     ..||...|      
Human   761 ------------AAGPLGEGCVGQPSHAYPVRCLLPSAHGSCADWA-----ARWYFVAS------ 802

  Fly  2731 EVQGGNLYLYDLQVSDSGVYICQAVNNETASVFKDTVSITITRYAQEMLARYEKDQLSPAEIVNL 2795
             |...|.:.|      .|   |....|..||             .||.::..:.....|.     
Human   803 -VGQCNRFWY------GG---CHGNANNFAS-------------EQECMSSCQGSLHGPR----- 839

  Fly  2796 PSHVTFEEYVNNEIICEVLGNPAPRVTWARVDGHADAQSTRTYDNRLIFDSPRKSDEGRYRCQAE 2860
                                .|.|         .|..:||.|       |....|..|    :.|
Human   840 --------------------RPQP---------GASGRSTHT-------DGGGSSPAG----EQE 864

  Fly  2861 NDQNRDEKYVI--------VYVQSNPPQP---------------------------------PPQ 2884
            ..|:|....|.        ::.|...|.|                                 ||.
Human   865 PSQHRTGAAVQRKPWPSGGLWRQDQQPGPGEAPHTQAFGEWPWGQELGSRAPGLGGDAGSPAPPF 929

  Fly  2885 QDRLY------ITPEEINGLAGESFQLNCQFTSVASLRYDWSHNGRSLSSSPARNVEIRGNTLEV 2943
            ....|      :.|..:....|:..:|:|...:....:..|..:|:.:||...| ::..| :|.:
Human   930 HSSSYRISLAGVEPSLVQAALGQLVRLSCSDDTAPESQAAWQKDGQPISSDRHR-LQFDG-SLII 992

  Fly  2944 RDASESDSGVYTCVAYDVRTRRNFTESARVNIDRREEQPFGNKPIIESLEQNILIIQGEDYSITC 3008
            ......|:|.|:|            .|.|...|.::.|               |.|.|.|.::..
Human   993 HPLQAEDAGTYSC------------GSTRPGRDSQKIQ---------------LRIIGGDMAVLS 1030

  Fly  3009 EASGSPYPSIKWAKVHDFMPENVHISGNVLTIYGARFENRGVYSCVAENDHGSDLSSTSIDIEPR 3073
            ||..|.:|..: ....||        |..    ||    .|....: .:.|....:...:|   :
Human  1031 EAELSRFPQPR-DPAQDF--------GQA----GA----AGPLGAI-PSSHPQPANRLRLD---Q 1074

  Fly  3074 ERPSVKIVSAPLQTFSVGAPASLYCTVEGIPDPTVEWVRVDGQPL-SPRHKIQSPGYMVIDDIQL 3137
            .:|  ::|.|     |.|....:.|..||.|.|.:||.| ||||: ||||::|..|.:||..:.:
Human  1075 NQP--RVVDA-----SPGQRIRMTCRAEGFPPPAIEWQR-DGQPVSSPRHQLQPDGSLVISRVAV 1131

  Fly  3138 EDSGDYECRAKN------------IVGEATGVATITVQEPTLVQIIPDNRDLRLTEGDELSLTCV 3190
            ||.|.|.|.|.|            ::||    .||:...||:.  :|        |||...|.||
Human  1132 EDGGFYTCVAFNGQDRDQRWVQLRVLGE----LTISGLPPTVT--VP--------EGDTARLLCV 1182

  Fly  3191 GSGVPNPEVEWV-NEMALKRD---LYSPPSNTAILKIYRVTKADAGIYTC--HGKNEAGSDEAHV 3249
            .:| .:..:.|. |.:.::.|   ::..|..|  |.||.:...|.|.|||  :..::|.|....|
Human  1183 VAG-ESVNIRWSRNGLPVQADGHRVHQSPDGT--LLIYNLRARDEGSYTCSAYQGSQAVSRSTEV 1244

  Fly  3250 RVEVQERRGDIGGVDDDSDRDPINYNP-PQQQNPG---IHQP---GSNQLLATDIGDN------V 3301
            :|                    ::..| .|.::||   :.||   ..:.:|...:..|      .
Human  1245 KV--------------------VSPAPTAQPRDPGRDCVDQPELANCDLILQAQLCGNEYYSSFC 1289

  Fly  3302 TLTCDMFQP 3310
            ..:|..|||
Human  1290 CASCSRFQP 1298

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trolNP_001401049.1 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060
LDLa 813..847 CDD:238060
LDLa 852..887 CDD:238060
LDLa 902..936 CDD:238060
LDLa 956..990 CDD:238060
LDLa 997..1030 CDD:238060
LDLa 1033..1067 CDD:238060
LDLa 1072..1105 CDD:238060
LDLa 1133..1165 CDD:238060
LDLa 1182..1215 CDD:238060
LDLa 1221..1251 CDD:238060
LDLa 1252..1286 CDD:238060
LDLa 1292..1326 CDD:238060
Ig 1344..1405 CDD:472250
Ig strand B 1355..1359 CDD:409353
Ig strand C 1369..1372 CDD:409353
Ig strand E 1388..1392 CDD:409353
LDLa 1439..1473 CDD:238060
LDLa 1479..1513 CDD:238060
LDLa 1522..1556 CDD:238060
Ig_Perlecan_like 1574..1649 CDD:143220
Ig strand B 1577..1583 CDD:143220
Ig strand C 1590..1595 CDD:143220
Ig strand E 1613..1617 CDD:143220
Ig strand F 1626..1632 CDD:143220
Ig strand G 1641..1647 CDD:143220
Laminin_B 1748..1878 CDD:459652 3/7 (43%)
EGF_Lam 1935..1989 CDD:238012 13/63 (21%)
Laminin_B 2113..2249 CDD:459652 25/144 (17%)
EGF_Lam <2250..2276 CDD:238012 4/28 (14%)
EGF_Lam 2284..2333 CDD:238012 19/77 (25%)
Laminin_EGF <2369..2399 CDD:395007 7/29 (24%)
Laminin_B 2465..2599 CDD:459652 23/137 (17%)
Ig_3 2688..2756 CDD:464046 12/85 (14%)
Ig_3 2791..2861 CDD:464046 9/69 (13%)
Ig_3 2890..2958 CDD:464046 15/67 (22%)
Ig 2987..3071 CDD:472250 16/83 (19%)
Ig strand B 3004..3008 CDD:409353 0/3 (0%)
Ig strand C 3017..3021 CDD:409353 0/3 (0%)
Ig strand E 3036..3040 CDD:409353 0/3 (0%)
Ig strand F 3050..3055 CDD:409353 0/4 (0%)
Ig strand G 3063..3066 CDD:409353 0/2 (0%)
I-set 3089..3162 CDD:400151 33/85 (39%)
Ig strand B 3094..3098 CDD:409353 0/3 (0%)
Ig strand C 3107..3111 CDD:409353 1/3 (33%)
Ig strand E 3128..3132 CDD:409353 1/3 (33%)
Ig strand F 3142..3147 CDD:409353 2/4 (50%)
Ig strand G 3155..3158 CDD:409353 0/2 (0%)
Ig 3165..3253 CDD:472250 27/93 (29%)
Ig strand B 3185..3189 CDD:409353 1/3 (33%)
Ig strand C 3198..3202 CDD:409353 0/3 (0%)
Ig strand E 3219..3223 CDD:409353 1/3 (33%)
Ig strand F 3233..3238 CDD:409353 3/6 (50%)
Ig strand G 3246..3249 CDD:409353 0/2 (0%)
Ig 3298..3355 CDD:472250 5/19 (26%)
Ig strand B 3301..3305 CDD:409353 0/3 (0%)
Ig strand C 3313..3316 CDD:409353
Ig strand E 3333..3336 CDD:409353
IG_like 3381..3457 CDD:214653
Ig strand B 3390..3394 CDD:409353
Ig strand C 3403..3407 CDD:409353
Ig strand F 3437..3442 CDD:409353
IG_like 3475..>3536 CDD:214653
Ig strand B 3480..3484 CDD:409353
Ig strand C 3491..3503 CDD:409353
Ig strand E 3519..3523 CDD:409353
Ig 3613..3675 CDD:472250
Ig strand B 3625..3629 CDD:409353
Ig strand C 3637..3642 CDD:409353
Ig strand E 3658..3662 CDD:409353
IG_like 3706..3772 CDD:214653
Ig strand B 3714..3718 CDD:409353
Ig strand C 3727..3731 CDD:409353
Ig strand E 3746..3750 CDD:409353
Ig strand F 3760..3765 CDD:409353
Ig strand G 3774..3777 CDD:409353
LamG 3794..3939 CDD:238058
EGF 3962..3994 CDD:394967
LamG 4042..4195 CDD:238058
EGF_CA 4254..4286 CDD:238011
LamG 4295..4448 CDD:238058
PAPLNXP_047287828.1 ADAMTS_CR_3 112..209 CDD:437068 26/140 (19%)
ADAMTS_spacer1 211..325 CDD:461796 25/139 (18%)
TSP1_ADAMTS 335..387 CDD:465950 13/69 (19%)
TSP1_ADAMTS 393..451 CDD:465950 14/61 (23%)
TSP1_ADAMTS 454..507 CDD:465950 10/64 (16%)
TSP1_ADAMTS 515..565 CDD:465950 16/67 (24%)
Kunitz_papilin 781..831 CDD:438678 14/83 (17%)
Papilin_u7 841..932 CDD:374683 18/110 (16%)
Ig 941..>1005 CDD:472250 14/65 (22%)
Ig strand B 954..958 CDD:409353 1/3 (33%)
Ig strand C 967..971 CDD:409353 0/3 (0%)
Ig strand E 988..992 CDD:409353 2/4 (50%)
I-set 1076..1146 CDD:400151 32/77 (42%)
Ig strand B 1088..1092 CDD:409353 0/3 (0%)
Ig strand C 1101..1105 CDD:409353 1/3 (33%)
Ig strand E 1122..1126 CDD:409353 1/3 (33%)
Ig strand F 1136..1141 CDD:409353 2/4 (50%)
IG_like 1166..1246 CDD:214653 26/92 (28%)
Ig strand B 1177..1181 CDD:409353 1/3 (33%)
Ig strand C 1189..1193 CDD:409353 0/3 (0%)
Ig strand E 1212..1216 CDD:409353 2/5 (40%)
Ig strand F 1226..1231 CDD:409353 3/4 (75%)
Ig strand G 1239..1242 CDD:409353 1/2 (50%)
PLAC 1262..1294 CDD:462560 4/31 (13%)
Blue background indicates that the domain is not in the aligned region.

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