DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trol and si:ch211-159i8.4

DIOPT Version :10

Sequence 1:NP_001401049.1 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4489 Species:Drosophila melanogaster
Sequence 2:XP_021336818.2 Gene:si:ch211-159i8.4 / 792773 ZFINID:ZDB-GENE-141215-7 Length:2252 Species:Danio rerio


Alignment Length:2609 Identity:490/2609 - (18%)
Similarity:794/2609 - (30%) Gaps:933/2609 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1460 GNPDCSDASDEQSCSLGLKCQPNQFMCSNSKCVDRTWRCDGENDCGDNSDETSCDPEPSGAPCRY 1524
            |||...|      |.|       .::...:|..|...:|..:.|.||                  
Zfish   217 GNPWACD------CHL-------HWLLEWNKNHDGVIKCKKDRDTGD------------------ 250

  Fly  1525 NEFQCRSGHCIPKSFQCDNVPDCTDGTDEVGCMAPLPIRPPPQSVSLLEYEVLELTCVATGTPTP 1589
                  :|:|                   ..|.:|||:    .:..:|:....:|||......:|
Zfish   251 ------AGNC-------------------AACASPLPL----NNSQILQLSTNQLTCDQPSLQSP 286

  Fly  1590 TIVWRLNWG--HVPDK---------------CESKSYGGTGTLRCPDMRPQDSGAYSCEIINTRG 1637
            ..:...:.|  ..||.               ..|.|:|....:.|...||.:.            
Zfish   287 LKIGESSMGEDQEPDTPYIKDLEHPLGHLTFILSDSHGNRAHVACNVTRPVEG------------ 339

  Fly  1638 THFVNPDTIVTVRPVR-TDVCEAGFFNMLARKAEEC------VQCFCFGVAKACDSANLFTYAIH 1695
                   |.:...||| ||....   |:..|...||      :|          :...|..|...
Zfish   340 -------TTIVWEPVRKTDEIAV---NVTLRTLLECEIDRDALQ----------NLWRLIAYYYE 384

  Fly  1696 PPILSHRVVSVELSPLRQIVINEAAPGQDLLTLLHGVQFRATNVHFSGRETPYLALPADYMGNQL 1760
            .|.:..|..|:..|.......::|                      :..|:||.        .:|
Zfish   385 SPAILERGTSLGNSSKVTFQYSQA----------------------TSEESPYF--------TEL 419

  Fly  1761 KSYGGNLRYEVNYRGSGRPVNGPDVIITGNRFTLTYRVRTQPGQNNRVSIPFVPGGWQKPDGRKA 1825
            |   |:|..|..:             :...|.||         |.||               ||.
Zfish   420 K---GHLMAEPAW-------------LLQPRVTL---------QLNR---------------RKT 444

  Fly  1826 SREEIMMILANVDNILIRLGYLDSTAREVDLINIALDSAGTADKGLGSASLVEKCQCPPGYVGD- 1889
            :.:::::..:.                   .|:..|...|..:....|.:::::  ..||.:.. 
Zfish   445 TTKKLVLNFST-------------------FISKQLIGRGDEEDVTSSWAMIQR--GAPGRIQSV 488

  Fly  1890 --------SCESCASGYVRQPGGPWLGHCVPF-IPDSCPSGTYGDPRRGVPCKECPCPLTGSNNF 1945
                    .|...:||:          |.|.: :||.                 .|...|.|:|.
Zfish   489 LEHSEVSLDCSVLSSGH----------HPVEWMLPDL-----------------TPIDQTDSHNL 526

  Fly  1946 ASGCQQSPDGDVVCRCNEGYTGRRCEQCAAGYQGNPLAAGGICRRIPDTSCNVD-GTYSV----- 2004
                                   |.|......:...:|..|:......|..||| .:|.:     
Zfish   527 -----------------------RLENHRLVIKNTSIADSGLYHCFVRTDTNVDIVSYRLTVRMR 568

  Fly  2005 -----HSNGTCQCKDSVIGEQCDT----CKSKSFH------------------------------ 2030
                 ..||.   |.||  |:.||    |...|.|                              
Zfish   569 LLSPSDLNGK---KISV--EKGDTLNLPCLVTSPHPIETKWYLPNNQILKASERKGNVQVSQNNT 628

  Fly  2031 --LNSFTYTGCIECFCSGVGLDCDSSTWYRDQVTSTFGRSRVDHGFVLVTNYMQPTPDTVPVSMA 2093
              :.:.|:....|..|....|               :|...:.| .::||...:.|...|.||..
Zfish   629 LIIKTVTHEDAGEYSCLAANL---------------YGADMLSH-LIVVTAEKEETQRGVLVSKG 677

  Fly  2094 AEPNALSFIGSADQSGNTLYWSL--PAAFLGNKLSSYGGKLTYTLSYSPLPNGIMSRNSAPDVVI 2156
            ..|     :..::.|..:.|..:  |.|           |||..........||:.:|:....| 
Zfish   678 EVP-----LFESEGSEGSGYEEIKRPTA-----------KLTPQKIDGKHRGGIIRQNTKGKKV- 725

  Fly  2157 KSGEDLRLIHYRKSQVVPSVANTYSVEIKESAWQRGDEVVANREHVLMALSDITAIYIKATYTTS 2221
            |.|       .||       .|....|:..|.|   :::||.....|..:..:| |:::...||:
Zfish   726 KEG-------VRK-------PNNSVKELDPSRW---EQIVAKANAKLSTVLPVT-IHLENVITTT 772

  Fly  2222 TKEASLRQVTLDVATPTNLGTPRAVE---VEQCRCPEGYLGLSCEQCAPGYARDPEGGIYLGLCR 2283
            |...|..|.|....|.:...|..:::   |:|.            :.||                
Zfish   773 TISLSAIQTTKTDVTASGASTTSSLQRFNVKQL------------ETAP---------------- 809

  Fly  2284 PCECNGHSKYCNSDTGDCEECSDNTEG----------PSCERCAAGYVGDATRGTIYD------- 2331
                  ||::...:|...||.....:|          |..|   ...|....|.||.:       
Zfish   810 ------HSEHVKQETTHGEESKQKIDGYNNSDLTTAVPEHE---TQLVKQVDRHTIEEKIRANNN 865

  Fly  2332 --------CQPDEGYPIPSPPAPGNQTLECTAYCQIEGIYDCRGNECLCKRNVIGDQCDQCRPGT 2388
                    ....:..|:|..|.|.......|....: .:.....|......|            :
Zfish   866 SIWNQRRRLPHRQRRPLPRRPLPKRPNFTATPTTTV-SLTQSPVNNIAMTTN------------S 917

  Fly  2389 YGLSAQNQDGCKECYCSGLASQCRSAALYRQLIPVDFILNAPLITDESGA-VQDTENLIPDISRN 2452
            |. .||::|                             |.||:..:.:.| ...||:|:..::.:
Zfish   918 YS-PAQDKD-----------------------------LTAPVTLEVTPAHYPVTESLVVAVTES 952

  Fly  2453 MYTYTHTSYLPKYWSLRGSVLGNQLFSYGGRLSYSLIVESYGNYERGHDIVLIGNGLKLIWSRPD 2517
                  |..:||.....|.:  |:..|....:::...:.:....|.  .::.:.:..:|| :|.:
Zfish   953 ------TLKVPKTTRTDGKL--NEFESKTKHIAWVQHISTTSVQET--KVIPVTHAPRLI-NRHE 1006

  Fly  2518 GNENQE---EYNVRLHEDEQWTRQDRESARP----------------ASRSDFMTVLSDLQHI-- 2561
             :||:|   ..|.:.::|:  .||...:|.|                .::...:|.: |.|.:  
Zfish  1007 -HENREFIMRINSQTNDDK--IRQISATATPNLQISNINPPETKKAHTTKKPTLTYV-DQQRVYN 1067

  Fly  2562 --------------LIRATPRVPTQSTSIG-NVILESAVTTRTPGATHASDIELCQCPSGYVG-- 2609
                          :.:.|||..|||:|:. |..:....|.::....|:.|.......:|..|  
Zfish  1068 WGLHPEGVPIHPWLIQKNTPRSFTQSSSLAKNNGIPFWPTVQSSRHHHSQDKSWYFLQTGGRGAG 1132

  Fly  2610 ------TSCESCAPLHYRDASGSCSLCPCDVSNTESCDLVSGGYVECRCKARWKGDRCREIDTND 2668
                  .|.::..|..|...|.:.|. |..::...|...|....:..|.:.|:   |..::|...
Zfish  1133 VTNQPQVSAQTVKPTVYISGSATASF-PKTIAPHVSSSRVRDQLLFNRLRNRY---RQTQLDAYR 1193

  Fly  2669 PTDIGTEDPVLTQII-VSIQKPEI---TIVPVGGSMTLSCSGRMRWSNSPVIVNWYKE------- 2722
                      |.|:. ::..||.|   |..|               :.:|.:.|.||:       
Zfish  1194 ----------LAQLAKLATSKPRIYHPTPQP---------------NQAPNVPNIYKKVTPPSIL 1233

  Fly  2723 --NSRLPENVEVQGGNLYLYDLQVSDSGVYICQAVNNETASVFKDTVSITITRYAQEMLARYEKD 2785
              .::.|....:..|:.:.|    |..|     |....||..|.:.:.                .
Zfish  1234 AYTNKPPPTASIPHGDRWHY----SHFG-----AKKLSTAIPFPNLMG----------------S 1273

  Fly  2786 QLSPAEIVNLPSHVTFEEYVNNEII--CEVLGNPAPRVTWARVDGHADAQSTRTYDNR------- 2841
            .:.|.  :..|...|.......:::  |...|:|.|.|:|.:|...|..||...:..|       
Zfish  1274 GVKPR--ITAPESATVSALAEGDVLLSCRSSGDPKPVVSWTKVSTGATIQSNTKFGQRFEVLSNG 1336

  Fly  2842 -LIFDSPRKSDEGRYRCQAENDQNRDEKYVIVYVQSNPPQPPPQQDRLYITPEEINGLAGESFQL 2905
             .:..:.:..|.|:|.|.|:|....|...|.:.||:.||                          
Zfish  1337 TFVIKNVQLQDRGQYLCTAQNKFGSDRMVVTLVVQTQPP-------------------------- 1375

  Fly  2906 NCQFTSVASLRYDWSHNGRSLSSSPARNVEIRGNTLEVRDASESDSGVYTCVAYDVRTRRNFTES 2970
                              :.:|:.|             ||.|                       
Zfish  1376 ------------------KIMSARP-------------RDVS----------------------- 1386

  Fly  2971 ARVNIDRREEQPFGNKPIIESLEQNILIIQGEDYSITCEASGSPYPSIKWAKVHDFMPENVHI-- 3033
                                       :..|...::.|.|.|.|...|.|     .:|:...:  
Zfish  1387 ---------------------------VFLGNPVNLDCIAVGKPEAQISW-----ILPDRTFVRD 1419

  Fly  3034 -----------SGNVLTIYGARFENRGVYSCVAENDHGSDLSSTSIDIEPRERPSVKIVSAPLQT 3087
                       ....|:|:.|.|.|:|.|.|:|.|..|:|..:..|.:.... |.:..||.....
Zfish  1420 IGTFDRKVSLFPNGTLSIHSANFSNKGDYKCIASNAAGADTLTYHIRVSALP-PIIAEVSYETIF 1483

  Fly  3088 FSVGAPASLYCTVEGIPDPTVEWVRVDGQPLSPRHKIQS------PGYMVIDDIQLEDSGDYECR 3146
            .:||....:.||.:|.|.|..:||..||..:.|...|.|      .|.:.|.::...|||.|||.
Zfish  1484 MNVGRNVYMDCTAKGEPLPLNKWVLPDGSEMKPTQFIGSRIFIFPNGTLYIKNVIPNDSGKYECS 1548

  Fly  3147 AKNIVGEATGVATITVQE--PTLVQIIPDNRDLRLTEGDELSLTCVGS-GVPNPEVEWVNEMALK 3208
            |.|.:|.|.....:.|::  |...:.:..:..:..|.|..:.|.|..| |.....|..:....:.
Zfish  1549 ATNPIGFAKRTVQMDVRQEAPGPWKGLYQHHSVTATYGSTVFLYCPESIGSQRGTVWRLPSKTIL 1613

  Fly  3209 RDLYSP-------PSNTAILKIYRVTKADAGIYTCHGKNEAGSDEAHVRVEVQERRGDIGGVDDD 3266
            ...|||       |:.|  |:|.|:|:.|.|.|.|..:...|.|....:|||..|          
Zfish  1614 EHQYSPHRHITAFPNGT--LRILRLTEKDGGNYLCMYQRPNGEDMELFQVEVLMR---------- 1666

  Fly  3267 SDRDPINYNPPQQQNPGI-HQPGSNQLLATDIGDNVTLTC---DMFQPLNTRWERVDGAPLPRNA 3327
                     ||:.:|.|. |:..:|       |||..:.|   .:..|. ..|...||..: .||
Zfish  1667 ---------PPKIENAGAQHKRVAN-------GDNFLVDCIASGLPDPA-VSWSLPDGTMI-NNA 1713

  Fly  3328 YT-----IKNRLEIV---------RVEQQNLGQYRC---NGIGRDGNVKTYFVKELVLMPLPRIR 3375
            ..     .:||..|:         ::.:::.|.|.|   |.:|.|. :|   |...|:...|::.
Zfish  1714 LQSDDNGSRNRRYIIFGNGTLLLQQMGKKDEGNYTCYAKNTLGEDA-MK---VSVQVMTTPPQLS 1774

  Fly  3376 FYPNIPLTVEAGQNLDVHCQVENVRPEDVHWSTDNNRPLPSS---VRIVG-SVLRFVSITQAAAG 3436
            ......:.|..||:..:.|....|.|..:.|.:..|..:.||   .:|:. ..|....:|.|..|
Zfish  1775 TKEPETMRVPFGQSTQIKCDAPGVLPHTIIWISPRNEIITSSSVKYQILNDGTLIIKKLTLADQG 1839

  Fly  3437 EYRCSAFNQYGNRSQIARVAVKKPADFHQVPQSQLQRHREGENIQ-----------LQC------ 3484
            :|.|.|.|..|......::.|       :|.:.|:.: :.|:.:.           |.|      
Zfish  1840 KYSCVAQNPAGANIGNVKLLV-------EVKEPQINK-QSGQTVSKVLAVYFQTLLLDCKAEGMP 1896

  Fly  3485 ----TVTDQYGVRAQDNVEFNWFRDDRRPLPNNARTDSQILVLTNLRPEDAGRYIC--NSYDVDR 3543
                |.|..||:..........|:..|          :..|.|..:|..|.||::|  .:|    
Zfish  1897 EPQITWTTPYGMSLPTPYLGGRFQVHR----------NGTLELRGIRKTDEGRFLCIAKNY---- 1947

  Fly  3544 GQQLPEVS--IDLQVLRAPQYPYNRFKGGVSLKDTPCMVLYICAAATPPPNSPIYLPPQLPAKSR 3606
               |.|.|  :||:|              .||.:.|...:         ||..:     ||    
Zfish  1948 ---LGEASLVVDLEV--------------ASLAEKPSFTV---------PNIEV-----LP---- 1977

  Fly  3607 DYSLKLDDQSSNLRAGESTDVECYSSDDTYTDVVWERSDGAPLSNNVR-------QVGNRLVISN 3664
               ||.|        |:...:||.::.....:::|....|..|:..::       .....|.:..
Zfish  1978 ---LKPD--------GDDIFLECRATGRPKPEILWILPSGTVLNPGMKLHRFTHYLENGTLHVMQ 2031

  Fly  3665 VSPSDAGNYVCKCKTDEGDLYTTSYKLEVEDQPHELKSSKIVYAKVGANADLQCGADESRQPTYR 3729
            ....|.|.|.|..|...|.. ...|.||:..:|....::..:....|...::.|.||...|.|..
Zfish  2032 PGVIDKGVYRCLAKNVAGQA-EKRYSLELGQKPQIRSTAATMKISFGQTLNMPCNADGYPQATIT 2095

  Fly  3730 WSRQYGQL----QA-GR--SLMNEKLSLDSVQANDAGTYICTAQYADG-ETADFP-NILVVTGAI 3785
            |:...|.:    || ||  .|.|..|.:......|.|||.|.|:...| .|..:| :|:|..   
Zfish  2096 WTLPNGLVLDKPQAIGRVVYLSNGTLQIKETSKLDRGTYTCKAKNTFGLSTLSYPVSIMVFP--- 2157

  Fly  3786 PQFRQEPRS 3794
            ||....|.|
Zfish  2158 PQITHAPPS 2166

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trolNP_001401049.1 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060
LDLa 813..847 CDD:238060
LDLa 852..887 CDD:238060
LDLa 902..936 CDD:238060
LDLa 956..990 CDD:238060
LDLa 997..1030 CDD:238060
LDLa 1033..1067 CDD:238060
LDLa 1072..1105 CDD:238060
LDLa 1133..1165 CDD:238060
LDLa 1182..1215 CDD:238060
LDLa 1221..1251 CDD:238060
LDLa 1252..1286 CDD:238060
LDLa 1292..1326 CDD:238060
Ig 1344..1405 CDD:472250
Ig strand B 1355..1359 CDD:409353
Ig strand C 1369..1372 CDD:409353
Ig strand E 1388..1392 CDD:409353
LDLa 1439..1473 CDD:238060 4/12 (33%)
LDLa 1479..1513 CDD:238060 6/33 (18%)
LDLa 1522..1556 CDD:238060 2/33 (6%)
Ig_Perlecan_like 1574..1649 CDD:143220 14/91 (15%)
Ig strand B 1577..1583 CDD:143220 3/5 (60%)
Ig strand C 1590..1595 CDD:143220 0/4 (0%)
Ig strand E 1613..1617 CDD:143220 0/3 (0%)
Ig strand F 1626..1632 CDD:143220 0/5 (0%)
Ig strand G 1641..1647 CDD:143220 1/5 (20%)
Laminin_B 1748..1878 CDD:459652 18/129 (14%)
EGF_Lam 1935..1989 CDD:238012 8/53 (15%)
Laminin_B 2113..2249 CDD:459652 31/140 (22%)
EGF_Lam <2250..2276 CDD:238012 3/25 (12%)
EGF_Lam 2284..2333 CDD:238012 12/73 (16%)
Laminin_EGF <2369..2399 CDD:395007 5/29 (17%)
Laminin_B 2465..2599 CDD:459652 30/169 (18%)
Ig_3 2688..2756 CDD:464046 15/79 (19%)
Ig_3 2791..2861 CDD:464046 18/79 (23%)
Ig_3 2890..2958 CDD:464046 5/67 (7%)
Ig 2987..3071 CDD:472250 21/96 (22%)
Ig strand B 3004..3008 CDD:409353 0/3 (0%)
Ig strand C 3017..3021 CDD:409353 1/3 (33%)
Ig strand E 3036..3040 CDD:409353 1/3 (33%)
Ig strand F 3050..3055 CDD:409353 2/4 (50%)
Ig strand G 3063..3066 CDD:409353 0/2 (0%)
I-set 3089..3162 CDD:400151 26/78 (33%)
Ig strand B 3094..3098 CDD:409353 0/3 (0%)
Ig strand C 3107..3111 CDD:409353 0/3 (0%)
Ig strand E 3128..3132 CDD:409353 1/3 (33%)
Ig strand F 3142..3147 CDD:409353 3/4 (75%)
Ig strand G 3155..3158 CDD:409353 0/2 (0%)
Ig 3165..3253 CDD:472250 24/95 (25%)
Ig strand B 3185..3189 CDD:409353 1/3 (33%)
Ig strand C 3198..3202 CDD:409353 1/3 (33%)
Ig strand E 3219..3223 CDD:409353 1/3 (33%)
Ig strand F 3233..3238 CDD:409353 2/4 (50%)
Ig strand G 3246..3249 CDD:409353 0/2 (0%)
Ig 3298..3355 CDD:472250 18/76 (24%)
Ig strand B 3301..3305 CDD:409353 0/3 (0%)
Ig strand C 3313..3316 CDD:409353 0/2 (0%)
Ig strand E 3333..3336 CDD:409353 1/2 (50%)
IG_like 3381..3457 CDD:214653 20/79 (25%)
Ig strand B 3390..3394 CDD:409353 0/3 (0%)
Ig strand C 3403..3407 CDD:409353 0/3 (0%)
Ig strand F 3437..3442 CDD:409353 2/4 (50%)
IG_like 3475..>3536 CDD:214653 15/81 (19%)
Ig strand B 3480..3484 CDD:409353 1/14 (7%)
Ig strand C 3491..3503 CDD:409353 1/11 (9%)
Ig strand E 3519..3523 CDD:409353 1/3 (33%)
Ig 3613..3675 CDD:472250 11/68 (16%)
Ig strand B 3625..3629 CDD:409353 0/3 (0%)
Ig strand C 3637..3642 CDD:409353 0/4 (0%)
Ig strand E 3658..3662 CDD:409353 1/3 (33%)
IG_like 3706..3772 CDD:214653 22/73 (30%)
Ig strand B 3714..3718 CDD:409353 0/3 (0%)
Ig strand C 3727..3731 CDD:409353 1/3 (33%)
Ig strand E 3746..3750 CDD:409353 1/3 (33%)
Ig strand F 3760..3765 CDD:409353 3/4 (75%)
Ig strand G 3774..3777 CDD:409353 1/3 (33%)
LamG 3794..3939 CDD:238058 1/1 (100%)
EGF 3962..3994 CDD:394967
LamG 4042..4195 CDD:238058
EGF_CA 4254..4286 CDD:238011
LamG 4295..4448 CDD:238058
si:ch211-159i8.4XP_021336818.2 None
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.