| Sequence 1: | NP_001401049.1 | Gene: | trol / 45320 | FlyBaseID: | FBgn0284408 | Length: | 4489 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_077719.2 | Gene: | NOTCH2 / 4853 | HGNCID: | 7882 | Length: | 2471 | Species: | Homo sapiens |
| Alignment Length: | 3319 | Identity: | 620/3319 - (18%) |
|---|---|---|---|
| Similarity: | 962/3319 - (28%) | Gaps: | 1438/3319 - (43%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 431 QCPDGEDEEYCNYPNVCTEDQFKCDDKCLELKKRCDGSIDCLDQT--DEAGCINAPEPEPEPEPE 493
Fly 494 PEPEPESEPEAEPEPEPEPEPESEPEQEPEPQVPEANECQANEFRCNNGDCIDARKRCNNVSDCS 558
Fly 559 EGEDENEECPAACSGMEYQCRDGTRCISVS-------------QQCDGHSDCSDGDDEEHCDGSG 610
Fly 611 Y-----DSEECRFDEFHCGTGECIPMRQVCDNIY---------------DCNDYSDEVNCVEGEE 655
Fly 656 EDRVGIPIGHQPWRPASKHDDWLHEMDTSEYQVYQPSNVYEKANSQNPCASNQFRCTTSNVCIPL 720
Fly 721 HLRCDGF--YHCNDMSDEKSCEQYQRHTTTRRPLTLATPTSRITTQGPGLLERRNTTTATEASRW 783
Fly 784 PWATKTTTIATTTSNPITTVGVANSPPQTCLENIE------------FACHNRD----CISIESV 832
Fly 833 CDGIPDCGRNEDEDDALCKCSGDKYKCQRGGGCIPK----SQVC-DGKP--QCH--DRSDESACH 888
Fly 889 LHGRLNKTRLGVKC----LESQYQCGDGSCISGYKRCNGIHDCADASDEYNCIYDYEDTYDTDPN 949
Fly 950 NNP---LNECDILE--FECDYSQCLPLEKKCDGYAD--CEDMSDELECQSYTDHCLESEFECDSY 1007
Fly 1008 CLPRDQLCNGIPNCQDGSDERNCTFCREDAYLCNTGECVADNQRCNGIADCADGSDERHCARIYC 1072
Fly 1073 PPNKLA---------CNGTCVSRRIKC----DGIR-DCLDGYDEMYCPETNNHYPTQNVNVIRPK 1123
Fly 1124 LGPNPIPKSCRPHEWQCANLECIDS-SLQCN-----EIKDCSDGSDEELSVCFGTATTRLKPSDC 1182
Fly 1183 SPEQFYCDESCYNRSVRC----NGH-VDCSDGSDEVGCSL--------PCPQHQCPSG------- 1227
Fly 1228 --------RCYTE-----SERCDRHRHCEDGSDEANC----------CYANQFRCNNGDCVSGSA 1269
Fly 1270 P--CNGYS-ECSDHSDELNCG-GTQECLPNQFRCNSGQC--VSSSVRCNGRT-----DCQDSSDE 1323
Fly 1324 QNCAADSNDRRPNQLNLKTYPDSQIIKESREVIFRCRDEGPARAKVKWSRPGGRP----LPPGFT 1384
Fly 1385 DRNGRLEI----PNIRVEDAGTYVC-EAVGYASYI-------PGQQVTVNLN--VER-------- 1427
Fly 1428 YNDVGSRPESACTEYQATCMNG----ECIDKSSICDGNP-----DCSDASDEQSC-----SLGLK 1478
Fly 1479 CQPNQFMCSNSKCVDRTWRCDGENDCGD--NSDETSCDPEPSGAPCRYNEFQCRSGHCIPKSFQC 1541
Fly 1542 DNVPDCTDGTDEVGCMAPLPIRPPPQSVSLLEYEVLELT---CVATGTPTPTIVWRLNWGHVPDK 1603
Fly 1604 CESKSYGGTGTLRCPDMRPQDSGAYSCEIINTRGTHFVNPDTIVTV---RPVRT-DVCEAGFFNM 1664
Fly 1665 LARKAEECVQCFC-FGVAKA-CDSANLFTYAIHPPILSHRVVSVELSPLRQIVINEAAPGQDLLT 1727
Fly 1728 LLHGVQFRATNVHFSGRETPYLALPADYMGN----QLKSYGGNLRYEVNYRGSGRPVNGPDVIIT 1788
Fly 1789 GNRFTLTYRVRTQPGQNNRVSIPFVPGGWQKPDGRKASREEIMMILANVDNILIRLGYLDSTARE 1853
Fly 1854 VDLINIALDSAGTADKGLGSASLVEKCQCPPGYVGDSCE---------SCASGYVRQPGGPWLGH 1909
Fly 1910 CVPFIPD---SCPSGTYGDPRRGVPCKE----C---PCPLTGSNNFASGCQQSPD--GDVVCRCN 1962
Fly 1963 EGYTGRRCE----QCAAGYQGNPLAAGG-------------ICRR-------------IPDTSCN 1997
Fly 1998 VDGTYSVHSN----GTCQCKDSVIGEQCDT------CK--SKSFHLNSFTYTGCIECFCSGVGLD 2050
Fly 2051 CDSSTWYRDQVTSTFGRSRVDHGFVLVTNYMQPTPDTVPVSMAAEPNALSFIGSADQSGNTLYWS 2115
Fly 2116 LPAA--FLGNKLSSYGGKLTYTLSYSPLPNGIMSRNSAPDVVIKSGEDLRLIHYRKSQVVPSVAN 2178
Fly 2179 TYSVEIKESAWQRGDEVVANREHVLMALSDITAIYIKATYTTSTKEASLRQVTLDVATP-TNLGT 2242
Fly 2243 PRAVEVEQCRCPEGYLGLSCEQCAPGYARDPEGGIYLGLCR--PC-----ECNGHSKYCNSDTGD 2300
Fly 2301 CEECSDN--TEGPSCERCAAGYVGDATRGTIYDC---QPD---EGYPIPSPPAPGNQTL-ECTAY 2356
Fly 2357 CQIEG------------------IYDCRGNEC-------LCKRNVIGDQCDQCRPGTYGLSAQNQ 2396
Fly 2397 DGCKE---CYCSGLASQCRSAALYRQLIPVDFILNAPLITDESGAVQDTENLIPDISRNMYTYTH 2458
Fly 2459 TSYLPKYWSLRGSVLGNQLFSYGGRLSYSL-IVESY------GNYER----GHDIV--------- 2503
Fly 2504 ----LIGNGLKLIWSRPDGNENQE---EYNVRLHEDEQ------WTRQDRESARPASRSDFMTVL 2555
Fly 2556 SDLQHILIRATPRV---PTQSTSIGNVILESAVTTRTPGATHASDIELCQCPSGYVGTSCESCAP 2617
Fly 2618 LHYRDASGSCSLCPCDVSNTESCDLVSGGYVECRCKARWKGDRCREIDTNDPTDIGTEDPVLTQI 2682
Fly 2683 I---VSIQ-KPEITIVPVGGSMTLSCSGR-------MRWSNSPVIVNWYKENSRLPENVEVQGGN 2736
Fly 2737 LYLYDLQVSDSGVYICQAVNNETASVFKDTVSITITRYAQEMLARYEKDQLSPAEIVNLPSHVTF 2801
Fly 2802 EEYVNNEIICEVLGNPAPRVTWARVDGHAD-----AQSTRTYDNRLIFDSPRKSDEGRYRCQAEN 2861
Fly 2862 DQNRDEKYVIVYVQSNPPQPPPQQDRLYITPEEINGLAGESFQLNCQFTSVASLRYDWSHNGRSL 2926
Fly 2927 SSSPARNVEIRGNTLEVRDASESDSGVYTCVAYDVRTRRNFTESARVNIDRREEQPFGNKPIIES 2991
Fly 2992 LEQ-----------NILIIQGEDYSITCEASG-------SPY----------------------P 3016
Fly 3017 SIKWAKVHDFMPENV-HISGNVLTIYGARFENRGVYSCVAENDHGSDLSSTSIDIEPRERPSVKI 3080
Fly 3081 ---VSAPLQTFSVGAPASLYCTVEGIPDPTVEWVRVDGQPLSPRHKIQSPGYMVIDDIQLEDSGD 3142
Fly 3143 YECRAKNIVGEATGVATITVQEPTLVQIIPDNRDLRLTEGDELSLTCVGSGVPNPEVEWVNEMAL 3207
Fly 3208 KRDLYSPPSNTAILKIYRVTKADAGIYTCHGKNEAGSDEAHVRVEVQERRGDIGGVDDDSDRDPI 3272
Fly 3273 NYNPP-----------QQQNPGIHQPGSNQLLATDIGDNVTLTCD--MFQPLNTRWERVDGAPLP 3324
Fly 3325 RNAY 3328 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| trol | NP_001401049.1 | LDLa | 447..480 | CDD:238060 | 7/34 (21%) |
| LDLa | 532..564 | CDD:238060 | 7/31 (23%) | ||
| LDLa | 571..606 | CDD:238060 | 8/47 (17%) | ||
| LDLa | 616..650 | CDD:238060 | 8/48 (17%) | ||
| LDLa | 704..739 | CDD:238060 | 9/36 (25%) | ||
| LDLa | 813..847 | CDD:238060 | 10/49 (20%) | ||
| LDLa | 852..887 | CDD:238060 | 11/43 (26%) | ||
| LDLa | 902..936 | CDD:238060 | 13/37 (35%) | ||
| LDLa | 956..990 | CDD:238060 | 11/37 (30%) | ||
| LDLa | 997..1030 | CDD:238060 | 7/32 (22%) | ||
| LDLa | 1033..1067 | CDD:238060 | 6/33 (18%) | ||
| LDLa | 1072..1105 | CDD:238060 | 10/46 (22%) | ||
| LDLa | 1133..1165 | CDD:238060 | 14/37 (38%) | ||
| LDLa | 1182..1215 | CDD:238060 | 11/37 (30%) | ||
| LDLa | 1221..1251 | CDD:238060 | 8/49 (16%) | ||
| LDLa | 1252..1286 | CDD:238060 | 8/36 (22%) | ||
| LDLa | 1292..1326 | CDD:238060 | 12/40 (30%) | ||
| Ig | 1344..1405 | CDD:472250 | 11/68 (16%) | ||
| Ig strand B | 1355..1359 | CDD:409353 | 0/3 (0%) | ||
| Ig strand C | 1369..1372 | CDD:409353 | 0/2 (0%) | ||
| Ig strand E | 1388..1392 | CDD:409353 | 0/3 (0%) | ||
| LDLa | 1439..1473 | CDD:238060 | 9/42 (21%) | ||
| LDLa | 1479..1513 | CDD:238060 | 8/35 (23%) | ||
| LDLa | 1522..1556 | CDD:238060 | 8/33 (24%) | ||
| Ig_Perlecan_like | 1574..1649 | CDD:143220 | 17/77 (22%) | ||
| Ig strand B | 1577..1583 | CDD:143220 | 2/8 (25%) | ||
| Ig strand C | 1590..1595 | CDD:143220 | 0/4 (0%) | ||
| Ig strand E | 1613..1617 | CDD:143220 | 2/3 (67%) | ||
| Ig strand F | 1626..1632 | CDD:143220 | 2/5 (40%) | ||
| Ig strand G | 1641..1647 | CDD:143220 | 2/5 (40%) | ||
| Laminin_B | 1748..1878 | CDD:459652 | 12/133 (9%) | ||
| EGF_Lam | 1935..1989 | CDD:238012 | 19/75 (25%) | ||
| Laminin_B | 2113..2249 | CDD:459652 | 20/138 (14%) | ||
| EGF_Lam | <2250..2276 | CDD:238012 | 3/25 (12%) | ||
| EGF_Lam | 2284..2333 | CDD:238012 | 17/58 (29%) | ||
| Laminin_EGF | <2369..2399 | CDD:395007 | 5/36 (14%) | ||
| Laminin_B | 2465..2599 | CDD:459652 | 35/169 (21%) | ||
| Ig_3 | 2688..2756 | CDD:464046 | 10/74 (14%) | ||
| Ig_3 | 2791..2861 | CDD:464046 | 8/74 (11%) | ||
| Ig_3 | 2890..2958 | CDD:464046 | 3/67 (4%) | ||
| Ig | 2987..3071 | CDD:472250 | 17/124 (14%) | ||
| Ig strand B | 3004..3008 | CDD:409353 | 1/3 (33%) | ||
| Ig strand C | 3017..3021 | CDD:409353 | 2/3 (67%) | ||
| Ig strand E | 3036..3040 | CDD:409353 | 0/3 (0%) | ||
| Ig strand F | 3050..3055 | CDD:409353 | 0/4 (0%) | ||
| Ig strand G | 3063..3066 | CDD:409353 | 1/2 (50%) | ||
| I-set | 3089..3162 | CDD:400151 | 11/72 (15%) | ||
| Ig strand B | 3094..3098 | CDD:409353 | 1/3 (33%) | ||
| Ig strand C | 3107..3111 | CDD:409353 | 0/3 (0%) | ||
| Ig strand E | 3128..3132 | CDD:409353 | 0/3 (0%) | ||
| Ig strand F | 3142..3147 | CDD:409353 | 0/4 (0%) | ||
| Ig strand G | 3155..3158 | CDD:409353 | 1/2 (50%) | ||
| Ig | 3165..3253 | CDD:472250 | 15/87 (17%) | ||
| Ig strand B | 3185..3189 | CDD:409353 | 2/3 (67%) | ||
| Ig strand C | 3198..3202 | CDD:409353 | 0/3 (0%) | ||
| Ig strand E | 3219..3223 | CDD:409353 | 0/3 (0%) | ||
| Ig strand F | 3233..3238 | CDD:409353 | 0/4 (0%) | ||
| Ig strand G | 3246..3249 | CDD:409353 | 0/2 (0%) | ||
| Ig | 3298..3355 | CDD:472250 | 9/33 (27%) | ||
| Ig strand B | 3301..3305 | CDD:409353 | 0/3 (0%) | ||
| Ig strand C | 3313..3316 | CDD:409353 | 1/2 (50%) | ||
| Ig strand E | 3333..3336 | CDD:409353 | |||
| IG_like | 3381..3457 | CDD:214653 | |||
| Ig strand B | 3390..3394 | CDD:409353 | |||
| Ig strand C | 3403..3407 | CDD:409353 | |||
| Ig strand F | 3437..3442 | CDD:409353 | |||
| IG_like | 3475..>3536 | CDD:214653 | |||
| Ig strand B | 3480..3484 | CDD:409353 | |||
| Ig strand C | 3491..3503 | CDD:409353 | |||
| Ig strand E | 3519..3523 | CDD:409353 | |||
| Ig | 3613..3675 | CDD:472250 | |||
| Ig strand B | 3625..3629 | CDD:409353 | |||
| Ig strand C | 3637..3642 | CDD:409353 | |||
| Ig strand E | 3658..3662 | CDD:409353 | |||
| IG_like | 3706..3772 | CDD:214653 | |||
| Ig strand B | 3714..3718 | CDD:409353 | |||
| Ig strand C | 3727..3731 | CDD:409353 | |||
| Ig strand E | 3746..3750 | CDD:409353 | |||
| Ig strand F | 3760..3765 | CDD:409353 | |||
| Ig strand G | 3774..3777 | CDD:409353 | |||
| LamG | 3794..3939 | CDD:238058 | |||
| EGF | 3962..3994 | CDD:394967 | |||
| LamG | 4042..4195 | CDD:238058 | |||
| EGF_CA | 4254..4286 | CDD:238011 | |||
| LamG | 4295..4448 | CDD:238058 | |||
| NOTCH2 | NP_077719.2 | EGF_CA | 182..218 | CDD:238011 | 9/43 (21%) |
| EGF_CA | 260..296 | CDD:238011 | 13/128 (10%) | ||
| EGF_CA | 298..335 | CDD:238011 | 4/38 (11%) | ||
| EGF_CA | 415..454 | CDD:238011 | 14/58 (24%) | ||
| EGF_CA | 456..492 | CDD:238011 | 12/44 (27%) | ||
| EGF_CA | 495..530 | CDD:238011 | 10/44 (23%) | ||
| EGF_CA | 532..568 | CDD:238011 | 7/35 (20%) | ||
| EGF_CA | 570..604 | CDD:238011 | 13/47 (28%) | ||
| EGF_CA | 608..643 | CDD:238011 | 14/58 (24%) | ||
| EGF_CA | 645..679 | CDD:238011 | 4/33 (12%) | ||
| EGF_CA | 682..717 | CDD:238011 | 5/34 (15%) | ||
| EGF_CA | 757..793 | CDD:238011 | 9/36 (25%) | ||
| EGF_CA | 795..831 | CDD:238011 | 11/72 (15%) | ||
| EGF_CA | 873..909 | CDD:238011 | 6/43 (14%) | ||
| EGF_CA | 911..947 | CDD:238011 | 9/35 (26%) | ||
| EGF_CA | 949..985 | CDD:238011 | 8/42 (19%) | ||
| EGF_CA | 987..1022 | CDD:238011 | 10/46 (22%) | ||
| EGF_CA | 1026..1061 | CDD:238011 | 14/70 (20%) | ||
| EGF_CA | 1117..1147 | CDD:238011 | 11/42 (26%) | ||
| EGF_CA | 1151..1185 | CDD:238011 | 12/130 (9%) | ||
| EGF_CA | 1188..1223 | CDD:238011 | 11/49 (22%) | ||
| EGF_CA | 1225..1262 | CDD:238011 | 13/44 (30%) | ||
| EGF_CA | 1264..1302 | CDD:238011 | 6/41 (15%) | ||
| EGF_CA | <1312..1343 | CDD:238011 | 9/30 (30%) | ||
| Notch | 1423..1456 | CDD:459658 | 7/87 (8%) | ||
| Notch | 1463..1497 | CDD:459658 | 9/57 (16%) | ||
| Notch | 1501..1534 | CDD:459658 | 10/41 (24%) | ||
| NOD | 1539..1594 | CDD:462014 | 8/54 (15%) | ||
| NODP | 1618..1673 | CDD:462229 | 11/65 (17%) | ||
| JMTM_Notch2 | 1659..1740 | CDD:411986 | 19/91 (21%) | ||
| ANK repeat | 1827..1874 | CDD:293786 | 12/80 (15%) | ||
| ANKYR | <1851..2066 | CDD:440430 | 47/365 (13%) | ||
| ANK repeat | 1877..1907 | CDD:293786 | 6/29 (21%) | ||
| ANK repeat | 1943..1974 | CDD:293786 | 10/69 (14%) | ||
| ANK repeat | 1976..2007 | CDD:293786 | 7/51 (14%) | ||
| ANK repeat | 2009..2040 | CDD:293786 | 11/111 (10%) | ||
| DUF5585 | 2068..2422 | CDD:465521 | 67/368 (18%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||