DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trol and eys

DIOPT Version :10

Sequence 1:NP_001401049.1 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4489 Species:Drosophila melanogaster
Sequence 2:NP_001027571.3 Gene:eys / 3771890 FlyBaseID:FBgn0031414 Length:2176 Species:Drosophila melanogaster


Alignment Length:2552 Identity:516/2552 - (20%)
Similarity:793/2552 - (31%) Gaps:904/2552 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  2251 CRCPEGYLGLSCE----QCAP------GYARDPEGGIYLGLCRPCECNGHSK----YCNSDTG-D 2300
            |.||||:.|.:||    :|..      |..||...| |:..|:|.....|.:    .|.:.|| .
  Fly   206 CTCPEGFSGSNCEENVDECMSNPCQNGGLCRDRTNG-YICTCQPGYLGSHCELDVAVCETGTGAR 269

  Fly  2301 CEECSDNTEGPSCE---RCAAGYVGDATRGTIYDCQPDEGYPIPSPPAPGNQTLECTAYCQIEGI 2362
            |:...:..|||..|   .|.||:.|...:..|.:|        .|.|            ||..|:
  Fly   270 CQHGGECIEGPGLEFTCDCPAGWHGRICQEEINEC--------ASSP------------CQNGGV 314

  Fly  2363 YDC----RGNECLCKRNVIGDQCDQ---------CRPGTYGLSAQNQDGCKECYCSGLASQCRSA 2414
              |    ....|.|.....|..|::         |:.....|.   ::|...|||          
  Fly   315 --CVDKLAAYACACPMGYTGINCEEEILICADNPCQNNALCLM---EEGVPTCYC---------- 364

  Fly  2415 ALYRQLIPVDFILNAPLITDESGAVQDTENLIPDI--SRNMYTYTHTSYLPKYWSLRGSVL--GN 2475
                                           :||.  .:..:.|......|:  .:.|.|.  |.
  Fly   365 -------------------------------VPDYHGEKCEFQYDECQLGPR--CMNGGVCIDGV 396

  Fly  2476 QLFSYG------GRLSYSLIVESYGNYERGHDIVLIGNGLKLIWSRPDGNENQEEYNVRLHEDEQ 2534
            ..||..      |.|...|:|                           |.|:.         |..
  Fly   397 DTFSCSCPPLLTGMLCECLMV---------------------------GEESL---------DCN 425

  Fly  2535 WTRQDRESARPASRSDFMTVLSDLQHILIR-ATPRVPTQSTSIGNVILE-SAVTTRTPGATHASD 2597
            :|....:|  |..|:   |..|.:....:| .||...|.|.|..:..:| ..|||..|.....|.
  Fly   426 YTAPATQS--PPRRT---TTTSTMAPPTVRPVTPPETTVSPSRASEEVEIIVVTTSAPAEVVTSV 485

  Fly  2598 IE-LCQCPSGYVGTSCESCAPLHYRDASGSCSLCPCDVSNTESCDLVSG-----GYVECRCKARW 2656
            :. .....|...|.|.|...|......|||.|:      :.|....|..     ...|...|...
  Fly   486 LSPSSSSSSSEEGVSVEIKTPTVAPPESGSHSI------SVEQTTAVPAQPEPESEQEPESKPHP 544

  Fly  2657 KGDRCREIDTNDPTDI--GT--EDPVLTQIIVSIQKPEI--TIVPVGGSMTLSCSGRMRWSNSPV 2715
            :.:...|.:|....:|  ||  ..|.......|.:.|.|  |:.|:.|....|.|..   |:..|
  Fly   545 ESESASESETETEEEIIPGTTARPPTSRSSSSSEESPSIFTTLPPLPGKPQTSASSE---SSGEV 606

  Fly  2716 IVNWYKENSRLPENVEVQGGNLYLYDLQVSDSGVYICQAVNNETASVFKDTV--SITITRYAQEM 2778
            :.:  :|.:.:| :.||.|..        |:||        :|..:..:.|.  ||||:      
  Fly   607 VTS--EEYTTVP-HFEVSGSK--------SESG--------SEEVTTVRPTAAPSITIS------ 646

  Fly  2779 LARYEKDQLSPAEIVNLPSHVTFEEYVNNEIICEVLGNPAP----RVTWARVDGHADAQSTRTYD 2839
                       .:|.:..|..:..|.|      ||...|||    |||              |.:
  Fly   647 -----------VDITSSGSSSSSSESV------EVFTTPAPVFVQRVT--------------TIE 680

  Fly  2840 NRLIFDSPRKSDEGRYRCQAENDQNRDEKYVIVYVQSNPPQPPPQQDRLYITPEEINGLAGESFQ 2904
            ..:..|                           ||   .|.|.|:.....:.|......|.|. .
  Fly   681 TSISID---------------------------YV---TPTPLPETTTPRVVPVPRPTFAPEP-P 714

  Fly  2905 LNCQFTSVASLRYDWSHNGRS----LSSSPARNVEIRGNTLEVRDASESDSGVYTCVAYDVR-TR 2964
            |:...|: ||..:.|:....:    .:..||   |:...|      ..:.:|.:|.|..... |.
  Fly   715 LDVVETT-ASTHHLWTEVPTTAAPFFTEYPA---EVLITT------HRTSAGRFTTVQPPAGVTT 769

  Fly  2965 RNFTESARVNIDRREEQPFGNKP--IIESLEQNILIIQGEDYSITCEASGSPYPSIKWAKVHDFM 3027
            .:.||.:.|      |.|..:.|  ::..|:.|.:|    ...||  .:|||       ..|...
  Fly   770 TSPTEDSSV------ELPTPHTPQIVVTILDSNEVI----PSLIT--TTGSP-------TTHHHH 815

  Fly  3028 PENVHISGNVLTIYGARFENRGVYSCVAENDHGSDLSSTSIDIEPRERPSVKIVSA-PLQTFSVG 3091
            ..:.|......|:.....:..       .:.|..|..:|.   :|     |:|.:. ||||..  
  Fly   816 HHHPHHEAEGTTLQPLEEDEH-------HHHHHHDEFTTP---QP-----VEITTGHPLQTED-- 863

  Fly  3092 APASLYCTVEGIPDPTVEWVRVDGQPLSPRHKIQSPGYMVIDDIQLEDSGDYECRAKNIVGEATG 3156
                    :.|:.:|.|....   .|.:|......|   |:....:..           :|.|..
  Fly   864 --------LIGVQEPAVVTTE---SPFAPAETTVVP---VVVPATIAP-----------LGTAAP 903

  Fly  3157 VAT-----------------ITVQEPTLVQIIPDNRDLRLTEGDELSLTCVGSGVPNPEVEWVNE 3204
            .||                 :..:.|||...:|             .:|......|.|.:.    
  Fly   904 PATPAPVPPATTTPPPSPPSLATETPTLPPTLP-------------PVTLPPVTQPPPTIP---- 951

  Fly  3205 MALKRDLYSPPSNTAILKIYRVTKADAGIYTC-HGKNEAGSDEAHVRVEVQERRG---------D 3259
                   .:|||..:...:...|.| ..:||. .|...|...:..|....:|..|         .
  Fly   952 -------PTPPSTQSAQTLPPPTSA-INVYTTPDGPPTASQTKPSVTESSEEVEGTNTVSTGGRG 1008

  Fly  3260 IGGVDDD--SDRDPINYNPPQQQNPGIHQPGSNQLLATDIGDNVTLTCDMFQPLNTRWERVDGAP 3322
            .|||.::  .|.|.|..        |.:..|:  .:.|..|.......|...||         ..
  Fly  1009 SGGVPEEKAGDVDCIKL--------GCYNGGT--CVTTSEGSRCVCRFDRQGPL---------CE 1054

  Fly  3323 LP---RNAYTIKNRLEIVRVEQQNLGQYRCNGIGRDGNVKTYFVKELVLMPLPRIRFYPNIPLTV 3384
            ||   |||                       ....|..|..              |.|.:|....
  Fly  1055 LPIIIRNA-----------------------AFSGDSYVSH--------------RIYKDIGGHE 1082

  Fly  3385 EAGQNLDVHCQVENVRPEDVHWSTDNNRPLPSSVRIVGSVLRFVSITQAAAGEYRCSAFNQYGNR 3449
            .....|.:|.|::      |.....|.             |..::..|...|.:..:.|.|.|..
  Fly  1083 SLDAVLPMHIQLK------VRTRATNG-------------LIMLAAAQGTKGGHYMALFLQKGLM 1128

  Fly  3450 SQIARVAVKKPADFHQVPQSQLQRHREGENIQLQCTVTDQYGVRAQDNVEFNWFRDDRRPLPNNA 3514
                                         ..|..|.:                            
  Fly  1129 -----------------------------QFQFSCGL---------------------------- 1136

  Fly  3515 RTDSQILVLTNLR-PEDAGRYICNSYDVDRGQQLPEVSIDLQV--------------------LR 3558
                |.::|:.|. |.:.|..|....::|..:.....:..|.|                    |.
  Fly  1137 ----QTMLLSELETPVNTGHEITIRAELDFSRNYTHCNASLLVNDTLAMSGDQPTWLKLLPPRLH 1197

  Fly  3559 APQYPYNRFKGGVSLKDTPCMVLYICAAATPPPNSPIYLPPQL-PAKSRD------YSLKLDDQS 3616
            .|:...|.:             |::..|    |.:||.|..:| ||:|..      ::|:::.|:
  Fly  1198 TPEAILNTW-------------LHLGGA----PQAPIGLIIELPPAQSGSGFTGCLHTLRINGQA 1245

  Fly  3617 SNLRAGESTD----VECYSSDDTYTDVVWERSDGAPLSNNVRQVGNRLVISNVSPSD-------A 3670
            ..: .|::.|    .||.|.              |.||:..|   |......:..:|       |
  Fly  1246 REI-FGDALDGFGITECGSL--------------ACLSSPCR---NGAACIKIETNDLDENGEKA 1292

  Fly  3671 GNYVCKCKTDEGDLYTTSYKLEVEDQPHELKSSKIVYAKVGANADLQCGADESRQPTYRWSRQYG 3735
            ..:.|||.|  |.:..|......||.|                    |              |||
  Fly  1293 EKWKCKCPT--GYMGPTCEISVCEDNP--------------------C--------------QYG 1321

  Fly  3736 QLQAGRSLMNEKLSLDSVQANDAGTYICT------AQYADGETADFPNILVVTGAIPQFRQEPRS 3794
            .              ..||...:| |:|.      ..|.:      .|:.|   |:|.|......
  Fly  1322 G--------------TCVQFPGSG-YLCLCPLGKHGHYCE------HNLEV---ALPSFSGSVNG 1362

  Fly  3795 YMSFP--TLPNSSFKFNFELTFR--PENGD--GLLLFNGQTRGSG------DYIALSLKDRYAEF 3847
            ..||.  |:| ...:::.||:|:  |:...  .||.|.||   ||      |::|:|....|...
  Fly  1363 LSSFVAYTVP-IPLEYSLELSFKILPQTMSQISLLAFFGQ---SGYHDEKSDHLAVSFIQGYIML 1423

  Fly  3848 RFDFGGKPMLVRAEEPL-----ALNEWHTVRVSRFKRDGYIQVDEQHPVAFPTLQQIPQLDLIED 3907
            .::.|..|..:..::|:     |....:.::|.|..|..::.||.:..:...:.....::|::..
  Fly  1424 TWNLGAGPRRIFTQKPIDFRLDAPRVPYEIKVGRIGRQAWLSVDGKFNITGRSPGSGSRMDVLPI 1488

  Fly  3908 LYIGG--VPNWELLPADAVSQQVGFVGCISRLTLQ-GRTVELIREAK--YKEGITDC--RPCAQG 3965
            ||:||  :.|:..||.| :....||.|||..:.|: |:....::|.:  ...|:..|  |.|.:.
  Fly  1489 LYLGGHEIANFNTLPHD-LPLHSGFQGCIYDVQLKAGQVTVPLQETRGVRGRGVGQCGTRECHRH 1552

  Fly  3966 PCQNKGVCLESQTEQAYTCICQPGWTGRDCA-------------IEGTQCTPGVCGAGRCENTEN 4017
            .||:.|.||  |....:|||||.||.|..||             .|...|.|.|          |
  Fly  1553 ACQHDGACL--QHGATFTCICQEGWYGPLCAQPTNPCDSFNNKCYEDATCVPLV----------N 1605

  Fly  4018 DMECLCPLNRSGDRCQYNEILNEHS------------------------LNFKGNSFAAY----- 4053
            ..||.||:.|:|..|:  |::...|                        |..|.:...:|     
  Fly  1606 GYECDCPVGRTGKNCE--EVIRSLSDVSLTGRRSYLAVRWPYLYDGGDKLGAKRSQMVSYRNFTK 1668

  Fly  4054 --------GTP---------------------------------KVTKVNITLSVRPASLEDSVI 4077
                    .||                                 :|....|...:||.| |..::
  Fly  1669 KLMPPKPITTPSSHFVMKLLNEVEKQRSFSPVPLMGSKSFEEHHRVQFFFIEFQLRPLS-ERGLL 1732

  Fly  4078 LYTAESTLPSGD-----YLALVLRGGHAELLINTAARLDPVVVRSAEPLPLNRWTRIEIRRRLGE 4137
            ||.  .||.:..     :::|.|:||..|..|:..:. ...||||...|.:..|.:|::.:| |.
  Fly  1733 LYF--GTLNNNQDKKIGFVSLSLQGGVVEFRISGPSN-HVTVVRSVRMLAIGEWHKIKMAQR-GR 1793

  Fly  4138 GILRVGDGPERKAKAPGSDRILSLKTHLYVGGY-DRSTVKVNRDVNITKGFDGCISRL-YNFQKP 4200
            .:....:|....|.||.::.::...:.||:||. |.|.:..|........|.||:..| .:..:.
  Fly  1794 WLTLWVEGSASSALAPSAEVLVEPDSLLYIGGLKDVSKLPHNAISGFPIPFRGCVRGLVVSGTRI 1858

  Fly  4201 VNLLADIKDAANIQSCGETNMIGGDEDSDNEPPVPPPTPDVH---ENELQPYAMAP--------- 4253
            |....:|.::.||:.|..| ..|||......          |   :.:|||:.:.|         
  Fly  1859 VLNETNIVESRNIRDCDGT-ACGGDSCESGG----------HCWLDEKLQPHCICPEYAKGDRCE 1912

  Fly  4254 ----CASDPCENGGSCSEQEDVAVCSCPFGFSGKHCQEHLQLGFNASFRGDGY-------VELNR 4307
                |...||:|.|.|...   ..||||.|:.|.:|:..:......||||:.|       :.:..
  Fly  1913 YSETCKLIPCKNNGRCLRS---GRCSCPNGWGGFYCEIAMSKPTTPSFRGNSYLILPPPRIPMKD 1974

  Fly  4308 SHFQPAL---EQSYTSMGIVFTTNKPNGLLFWWGQEAGEEYTGQDFIAAAVVDGYVEYSMRLDGE 4369
            ....|:|   .:....:.:.|:|.:|:|||.|      .|:....|:...:..|:::.:..|.|.
  Fly  1975 KRRGPSLYVRPREAIQVSLNFSTIEPDGLLLW------SEHERSKFLGLGLEAGHLKLASNLLGS 2033

  Fly  4370 EAVIRNSDIR------VDNGERHIVIAKRDENTAILEVD-------------RMLHSGETRPTS- 4414
                .|..:|      :.:|..|......|.:...|::|             |.|  |.|.|.| 
  Fly  2034 ----TNDTVRAPASGFIADGAWHWTSVLLDRSRLELQLDGEVIFTERLPEGGRSL--GSTTPRST 2092

  Fly  4415 -----KKSMKLP----GNVF-VGGAPDLEVF---TGFRYKHNLNGCIVVVE-GETVGQINLSSAA 4465
                 |.|.|.|    .:|| :||.|:.:..   |..|:.....||:..:: |.....|....:.
  Fly  2093 LAGRRKNSSKEPTISYEDVFYLGGFPNSDSVSRRTKGRFFDPFKGCLQDIQFGAEPTAIISDFST 2157

  Fly  4466 VNGVNANVCPAN-DDPL 4481
            ..|.|...|..: |:||
  Fly  2158 YQGENIGSCDLHGDEPL 2174

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trolNP_001401049.1 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060
LDLa 813..847 CDD:238060
LDLa 852..887 CDD:238060
LDLa 902..936 CDD:238060
LDLa 956..990 CDD:238060
LDLa 997..1030 CDD:238060
LDLa 1033..1067 CDD:238060
LDLa 1072..1105 CDD:238060
LDLa 1133..1165 CDD:238060
LDLa 1182..1215 CDD:238060
LDLa 1221..1251 CDD:238060
LDLa 1252..1286 CDD:238060
LDLa 1292..1326 CDD:238060
Ig 1344..1405 CDD:472250
Ig strand B 1355..1359 CDD:409353
Ig strand C 1369..1372 CDD:409353
Ig strand E 1388..1392 CDD:409353
LDLa 1439..1473 CDD:238060
LDLa 1479..1513 CDD:238060
LDLa 1522..1556 CDD:238060
Ig_Perlecan_like 1574..1649 CDD:143220
Ig strand B 1577..1583 CDD:143220
Ig strand C 1590..1595 CDD:143220
Ig strand E 1613..1617 CDD:143220
Ig strand F 1626..1632 CDD:143220
Ig strand G 1641..1647 CDD:143220
Laminin_B 1748..1878 CDD:459652
EGF_Lam 1935..1989 CDD:238012
Laminin_B 2113..2249 CDD:459652
EGF_Lam <2250..2276 CDD:238012 12/34 (35%)
EGF_Lam 2284..2333 CDD:238012 15/56 (27%)
Laminin_EGF <2369..2399 CDD:395007 6/38 (16%)
Laminin_B 2465..2599 CDD:459652 30/143 (21%)
Ig_3 2688..2756 CDD:464046 17/69 (25%)
Ig_3 2791..2861 CDD:464046 14/73 (19%)
Ig_3 2890..2958 CDD:464046 14/71 (20%)
Ig 2987..3071 CDD:472250 15/85 (18%)
Ig strand B 3004..3008 CDD:409353 1/3 (33%)
Ig strand C 3017..3021 CDD:409353 0/3 (0%)
Ig strand E 3036..3040 CDD:409353 0/3 (0%)
Ig strand F 3050..3055 CDD:409353 0/4 (0%)
Ig strand G 3063..3066 CDD:409353 0/2 (0%)
I-set 3089..3162 CDD:400151 11/89 (12%)
Ig strand B 3094..3098 CDD:409353 0/3 (0%)
Ig strand C 3107..3111 CDD:409353 1/3 (33%)
Ig strand E 3128..3132 CDD:409353 0/3 (0%)
Ig strand F 3142..3147 CDD:409353 0/4 (0%)
Ig strand G 3155..3158 CDD:409353 0/2 (0%)
Ig 3165..3253 CDD:472250 17/88 (19%)
Ig strand B 3185..3189 CDD:409353 0/3 (0%)
Ig strand C 3198..3202 CDD:409353 0/3 (0%)
Ig strand E 3219..3223 CDD:409353 0/3 (0%)
Ig strand F 3233..3238 CDD:409353 2/5 (40%)
Ig strand G 3246..3249 CDD:409353 0/2 (0%)
Ig 3298..3355 CDD:472250 9/59 (15%)
Ig strand B 3301..3305 CDD:409353 0/3 (0%)
Ig strand C 3313..3316 CDD:409353 0/2 (0%)
Ig strand E 3333..3336 CDD:409353 0/2 (0%)
IG_like 3381..3457 CDD:214653 11/75 (15%)
Ig strand B 3390..3394 CDD:409353 1/3 (33%)
Ig strand C 3403..3407 CDD:409353 1/3 (33%)
Ig strand F 3437..3442 CDD:409353 0/4 (0%)
IG_like 3475..>3536 CDD:214653 7/61 (11%)
Ig strand B 3480..3484 CDD:409353 1/3 (33%)
Ig strand C 3491..3503 CDD:409353 0/11 (0%)
Ig strand E 3519..3523 CDD:409353 1/3 (33%)
Ig 3613..3675 CDD:472250 13/72 (18%)
Ig strand B 3625..3629 CDD:409353 1/7 (14%)
Ig strand C 3637..3642 CDD:409353 0/4 (0%)
Ig strand E 3658..3662 CDD:409353 1/3 (33%)
IG_like 3706..3772 CDD:214653 10/71 (14%)
Ig strand B 3714..3718 CDD:409353 0/3 (0%)
Ig strand C 3727..3731 CDD:409353 0/3 (0%)
Ig strand E 3746..3750 CDD:409353 0/3 (0%)
Ig strand F 3760..3765 CDD:409353 2/10 (20%)
Ig strand G 3774..3777 CDD:409353 0/2 (0%)
LamG 3794..3939 CDD:238058 42/163 (26%)
EGF 3962..3994 CDD:394967 15/31 (48%)
LamG 4042..4195 CDD:238058 46/229 (20%)
EGF_CA 4254..4286 CDD:238011 12/31 (39%)
LamG 4295..4448 CDD:238058 44/195 (23%)
eysNP_001027571.3 EGF_CA 184..218 CDD:238011 6/11 (55%)
EGF_CA 220..256 CDD:238011 9/36 (25%)
EGF_CA <270..298 CDD:238011 9/27 (33%)
EGF_CA 301..336 CDD:238011 11/56 (20%)
EGF 342..371 CDD:394967 8/72 (11%)
EGF_CA 378..413 CDD:238011 8/36 (22%)
Laminin_G_2 1096..1244 CDD:460494 33/238 (14%)
EGF_CA 1314..1346 CDD:238011 13/80 (16%)
LamG 1355..1521 CDD:238058 43/170 (25%)
EGF 1549..1578 CDD:394967 14/30 (47%)
EGF_CA 1585..1621 CDD:238011 11/45 (24%)
Laminin_G_2 1723..1856 CDD:460494 38/137 (28%)
LamG 1956..2144 CDD:238058 45/199 (23%)
Blue background indicates that the domain is not in the aligned region.

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