DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trol and Egflam

DIOPT Version :9

Sequence 1:NP_001027038.3 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4479 Species:Drosophila melanogaster
Sequence 2:XP_006232075.1 Gene:Egflam / 365691 RGDID:1306592 Length:1013 Species:Rattus norvegicus


Alignment Length:1198 Identity:277/1198 - (23%)
Similarity:454/1198 - (37%) Gaps:268/1198 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  3348 VKTYFVKELVL---MPLPRIRFYPNIPLTVEAGQNLDVHCQVENVRPEDVHWSTDNNRPLPSSVR 3409
            :.|:.:..|:|   :|...:.....:..:.:.|..||:.....|.....:.|.|    |..|...
  Rat     4 ISTFLLHFLLLACSLPPGAVSLRTALRKSGKVGPPLDIKLGALNCTAFSIQWKT----PKRSGSS 64

  Fly  3410 IVGSVLRFVS----------------------ITQAAAG------EYRCS--AFNQYG-NRSQIA 3443
            |||..: |.|                      ||:...|      |||.|  |::|.| .|....
  Rat    65 IVGYTV-FYSELGSDKSLREQSHNVPVGQDTLITEEVIGDLKPGTEYRVSIAAYSQTGKGRLSFP 128

  Fly  3444 RVAVKKPADFHQVPQSQLQRHREGENIQLQCTVTDQYGVRAQDNVEFNWFRDDRRPLPNNARTDS 3508
            |.......|....|::..|.|        ...|:|       ..|..:|     ||..|......
  Rat   129 RHVTTLSQDSCLPPEAPHQPH--------VLVVSD-------SEVALSW-----RPGENEGSAPI 173

  Fly  3509 QILVLTNLRPEDAGRYICNSYDVDRGQQL--PEVSIDLQVLRAPQYPYNRFKGGVSLKDTPCMVL 3571
            |...:..:||           |.|:...:  ..:.:|..|::... |...::..|.     .|..
  Rat   174 QSYSVEFIRP-----------DFDKSWTIIQERLQMDSMVIKGLD-PDTNYQFAVR-----AMNA 221

  Fly  3572 YICAAATPPPNSPIYLPPQLPAKSR-------DYSLKLDDQSSNLRAGESTDVECYSSDDTYTDV 3629
            |..:..:.|.|:...|.|......|       |..:..||.:              |.|:...||
  Rat   222 YGFSLRSQPSNTIRTLGPGEAGSGRYGPGYITDTGVSEDDDA--------------SEDELDLDV 272

  Fly  3630 VWERSDGAPLSNNVRQVGN-RLVISNVSPSDAGNYVCKCKTDEGDLYTTSYKLEVEDQPHELKSS 3693
            .:|.....|.:    :||| :...::||.|:..:.:  .:.....|..|:..:.......:.|:|
  Rat   273 SFEEVKPLPAT----KVGNKKSKKTSVSNSEMDSRL--AQPTSASLPETTVAVPPTPAQRKGKNS 331

  Fly  3694 KIVYAKVGANADLQCGADESRQPTYRWSRQYGQLQAGRSLMNEKLSLDSVQANDA--GTYICTAQ 3756
            ..|.:::   .|:.|  ||:                       ..|.||...||.  |...|...
  Rat   332 VAVMSRL---FDMSC--DET-----------------------LCSADSFCVNDYAWGGSRCHCN 368

  Fly  3757 YADGETADFPNILVVTGAIPQFRQEPRSYMSFPTLPNSSFKFNFELTFRPENGDGLLLFNGQT-R 3820
            ...|..|...:|.:   ..|||  ...||::|..|.||...|...|.||.|..|||||:.|:: .
  Rat   369 LGKGGEACSEDIFI---QYPQF--FGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGESEH 428

  Fly  3821 GSGDYIALSLKDRYAEFRFDFGGKPMLVRAEEPLALNEWHTVRVSRFKRDGYIQVDEQHPVAFPT 3885
            |.||:::|:|..|...|||:.|....::.:|..:.|..||:|.:.|...:|.:|::...||...:
  Rat   429 GRGDFMSLALIRRSLHFRFNCGTGMAIIISETKIKLGAWHSVTLYRDGLNGLLQLNNGTPVTGQS 493

  Fly  3886 LQQIPQLDLIEDLYIGGVPN--WELLPADAVSQQVGFVGCISRLTLQGRTVEL----IREAKYKE 3944
            ..|..::.....||:||.|:  | |:.|...::  ||.||:..|.:.|:.:::    :.:|....
  Rat   494 QGQYSKITFRTPLYLGGAPSAYW-LVRATGTNR--GFQGCVQSLAVNGKKIDMRPWPLGKALNGA 555

  Fly  3945 GITDCRP--CAQGPCQNKGVCLESQTEQAYTCICQPGWTGRDCAIEGTQCTPGVCGAGRCENTEN 4007
            .:.:|..  |.:..|.|.|.|...:.: :|.|:|..|:.||.|....|...|             
  Rat   556 DVGECSSGICDEASCINGGTCAAIKAD-SYICLCPLGFRGRHCEDAFTLTIP------------- 606

  Fly  4008 DMECLCPLNRSGDRCQYNEILNEHSLNFKGNSFAAYGTP-------KVTKVNITLSVRPASLEDS 4065
                           |:.|.|         .|:||...|       ..|:..||.  ||.| .|.
  Rat   607 ---------------QFRESL---------RSYAATPWPLEPQHYLSFTEFEITF--RPDS-GDG 644

  Fly  4066 VILYTAESTLPSGDYLALVLRGGHAELLINTAARLDPVVVRSAEPLPLNRWTRIEIRRRLGEGIL 4130
            |:||:.:::  |.|:|::::..||.|...:..:...  |:||.:.|.|.:|..:.:.|....|||
  Rat   645 VLLYSYDTS--SKDFLSIIMAAGHVEFRFDCGSGTG--VLRSEDTLTLGQWHDLRVSRTAKNGIL 705

  Fly  4131 RVGDGPERKAKAPGSDRILSLKTHLYVGG---YDRSTVKVNRDVNITKGFDGCISRLYNFQKPVN 4192
            :|......:..|.|....:...|.:::||   ||    .|.::..|...|.|.|.::....:.::
  Rat   706 QVDKQKVVEGMAEGGFTQIKCNTDIFIGGVPNYD----DVKKNSGILHPFSGSIQKIILNDRTIH 766

  Fly  4193 LLADIKDAANIQSCGETNMIGGDEDSDNEPPVPPPTPDVHENELQPYAMAPCASDPCENGGSCSE 4257
            :..|.....|:::                                  |..||...||.:||||..
  Rat   767 VRHDFTSGVNVEN----------------------------------AAHPCVGAPCAHGGSCRP 797

  Fly  4258 QEDVAVCSCPFGFSGKHCQ------------EHLQLGFNASFRGDGYVELNRSHFQPALEQSYTS 4310
            :::...|.||.||.|.:||            |.:::   ..|.|..|:..:..:....:..|.::
  Rat   798 RKEGYECDCPLGFEGLNCQKECGNYCLNTITEAIEI---PQFIGRSYLTYDNPNILKRVSGSRSN 859

  Fly  4311 MGIVFTTNKPNGLLFWWGQEAGEEYTGQDFIAAAVVDGYVEYSMRL-DGEEAVIRNSDIRVDNGE 4374
            ..:.|.|...:|||.|.|.....  ...|||:..:.||.:.:|..| .|..:::.|...  .:|.
  Rat   860 AFMRFKTTAKDGLLLWRGDSPMR--PNSDFISLGLRDGALVFSYNLGSGVASIMVNGSF--SDGR 920

  Fly  4375 RHIVIAKRDENTAILEVDRM-LHSGETRPTSKKSMKLPGNVFVGGAPDLEVFTGFRYKHNLNGCI 4438
            .|.|.|.||..:..:.||.. ..:|:: |...:.:.:.|.::|||..::.:.|..:|...|.|||
  Rat   921 WHRVKAVRDGQSGKITVDDYGARTGKS-PGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCI 984

  Fly  4439 VVVEGETVGQINLSSAAVNGVNANVCPA 4466
            ......|...|:|...||:|.|.|.|.|
  Rat   985 SHFTLSTDYHISLVEDAVDGKNINTCGA 1012

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trolNP_001027038.3 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060
LDLa 813..847 CDD:238060
LDLa 852..887 CDD:238060
LDLa 902..936 CDD:238060
LDLa 956..990 CDD:238060
LDLa 997..1030 CDD:238060
LDLa 1033..1067 CDD:238060
LDLa 1072..1105 CDD:238060
LDLa 1133..1165 CDD:238060
LDLa 1182..1215 CDD:238060
LDLa 1221..1251 CDD:238060
LDLa 1252..1286 CDD:238060
LDLa 1292..1326 CDD:238060
IG 1344..1421 CDD:214652
Ig 1344..1405 CDD:299845
LDLa 1439..1473 CDD:238060
LDLa 1479..1513 CDD:238060
LDLa 1522..1556 CDD:238060
IG_like 1566..1649 CDD:214653
Ig_Perlecan_D2_like 1574..1649 CDD:143220
Laminin_B 1748..1864 CDD:278481
EGF_Lam 1935..1989 CDD:238012
Laminin_B 2113..2238 CDD:278481
EGF_Lam <2250..2276 CDD:238012
EGF_Lam 2284..2333 CDD:238012
Laminin_EGF <2369..2399 CDD:278482
Laminin_B 2465..2587 CDD:278481
I-set 2686..2772 CDD:254352
Ig_2 2689..2771 CDD:290606
Ig 2779..2865 CDD:299845
IG_like 2798..2864 CDD:214653
Ig 2882..2965 CDD:299845
IG_like 2882..2950 CDD:214653
Ig 2977..3061 CDD:299845
IG_like 2984..3058 CDD:214653
IG_like 3074..3152 CDD:214653
Ig 3086..3153 CDD:299845
I-set 3155..3243 CDD:254352
IGc2 3171..3233 CDD:197706
IG 3371..3447 CDD:214652 25/106 (24%)
IGc2 3377..3437 CDD:197706 22/89 (25%)
Ig 3456..3534 CDD:299845 15/77 (19%)
IG 3465..>3526 CDD:214652 10/60 (17%)
Ig 3603..3665 CDD:299845 14/62 (23%)
IG 3610..3683 CDD:214652 14/73 (19%)
IG 3696..3762 CDD:214652 13/67 (19%)
Ig 3704..3771 CDD:299845 14/68 (21%)
LamG 3784..3929 CDD:238058 51/147 (35%)
EGF 3952..3984 CDD:278437 10/31 (32%)
LamG 4032..4185 CDD:238058 43/162 (27%)
Laminin_G_2 4315..4444 CDD:280389 36/130 (28%)
EgflamXP_006232075.1 FN3 36..133 CDD:238020 25/101 (25%)
FN3 142..236 CDD:238020 23/130 (18%)
LamG 387..537 CDD:238058 52/154 (34%)
EGF_CA 556..598 CDD:238011 12/42 (29%)
Laminin_G_2 637..763 CDD:280389 36/136 (26%)
EGF_CA 786..816 CDD:238011 12/29 (41%)
Laminin_G_2 864..989 CDD:280389 36/129 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D17288at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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