DRSC/TRiP Functional Genomics Resources

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Protein Alignment trol and agr-1

DIOPT Version :9

Sequence 1:NP_001027038.3 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4479 Species:Drosophila melanogaster
Sequence 2:NP_001022152.3 Gene:agr-1 / 3565243 WormBaseID:WBGene00018304 Length:1473 Species:Caenorhabditis elegans


Alignment Length:1376 Identity:273/1376 - (19%)
Similarity:398/1376 - (28%) Gaps:502/1376 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   848 ALCKCSGDKYKCQRGGGCIPKSQVCDGKPQCHDRSD----------ESACHLHGR-----LNKTR 897
            |:|:.|    .|..|..|..|:.||:.|.:|...:|          .|.|||..|     .|..|
 Worm   151 AICEQS----LCPFGSKCGLKTGVCECKARCRVVTDVVCGSDHVSYSSFCHLSVRSCVLAKNGVR 211

  Fly   898 LGVKCLESQYQCGDGSCISGYKRCNGIHD--CADASDEYNCIYDYEDTYDTDPNNNPLNECDILE 960
            |.|        ...|.|    |:.|...|  |....|   |:.            |.:|  .||.
 Worm   212 LRV--------ATKGPC----KKRNPCEDLRCGPGED---CVV------------NQIN--GILL 247

  Fly   961 FECDYSQCLPLEKKCDGYADCEDMSDELECQS----YTDHCLESEFECDS----------YCLPR 1011
            .:|   .|   ..:|..|.|..:.|.  .|.|    |...|......|:|          .|.| 
 Worm   248 AKC---VC---PTQCPNYGDSVESSP--VCSSHGVDYQSSCHLRHHACESKTNITVKFFGRCDP- 303

  Fly  1012 DQLCNG--IPN---CQDGSDERNCTFCRE-----DAYLCNTGECVADNQRCNGIADCADGSD--- 1063
               |:|  .||   ||.|.|.|....|.|     .|::|.|......|:....:|.|.:..|   
 Worm   304 ---CHGHKCPNGQTCQLGVDRRPECKCSEQCTMNSAHVCGTDGKTYLNECFLKLAACKEQKDILV 365

  Fly  1064 --ERHCARIYCPPNKLACN--GTCVSRRIKCDGIRDCLDGYDEMYCPETNNHYPTQNVNVIRPKL 1124
              ..:|.....|..|:.|.  |:||   :|.|...:|              ..|.:..:|:||..
 Worm   366 WKRGNCDEAGSPCEKMECGFWGSCV---VKPDRTAEC--------------ECPNRCEDVMRPVC 413

  Fly  1125 GPN---------PIPKSCR-------PHEWQCANLEC--------------IDSSLQCNEIKDCS 1159
            ..|         ...|||.       .|:..|....|              :|...:|    .|.
 Worm   414 ATNGETFDNECEMKKKSCETKSMIKVKHQGTCGIGVCATFDSCKKPQVCVVVDGKPKC----VCP 474

  Fly  1160 DGSDEELSVCFGTATT-----RLKPSDCSPEQ-------FYCDESCYNRSVRCNGHVDCSDGSDE 1212
            ..:||...||.....|     ||:.:.|..::       ..| |:|..:..:|:.:..|..|.:|
 Worm   475 SCTDEFKEVCGSDGKTYSNECRLQNAACMAQKNIFVKYNSAC-EACKLKKEKCDFYSACVVGENE 538

  Fly  1213 -VGCSLP--CPQHQCPSGRCYTESERCDRHRHCEDGSDEANCCYANQFRCNNGDCVSGSAPCNGY 1274
             ..|..|  ||.::...|:     |.|.     .||...::.|:..:..|:....|..:..    
 Worm   539 KAECKCPDDCPSYEMEEGK-----EVCG-----TDGVTYSSECHMKKSACHQSKFVMTAFE---- 589

  Fly  1275 SECSDHSDELNCGGTQECLPNQFR----CNSGQCVSSSVRCNGRTDCQDSSDEQNCAADSNDRRP 1335
                        |...|||..|.|    |.||.||.|                .||         
 Worm   590 ------------GKCDECLHVQCRYGEECRSGVCVCS----------------YNC--------- 617

  Fly  1336 NQLNLKTYPDSQIIKESREVIFRCRDEGPARAKVKWSRPGGRPLPPGFTDRNGRLEIPNIRVEDA 1400
                                                  |...||.......||.| .|::     
 Worm   618 --------------------------------------PANPPLSARICGENGVL-YPSL----- 638

  Fly  1401 GTYVCEAVGYASYIPGQQVTVNLNVERYNDVGSRPESAC----TEYQATCMNGECIDKSSICDGN 1461
                |. :..||...|..::            ..|.|.|    |.:..:|...........||..
 Worm   639 ----CH-LQLASCQKGAPIS------------EMPPSHCHSSKTSFPDSCQCNRVGSFGHTCDET 686

  Fly  1462 PDCSDASDEQSCSLGLKCQPNQFMCSNSKCVDRTW----------RCDGENDCGDNSDETS-CDP 1515
            ..|             ||:|.........|:...|          .|   ..||.::..:| .|.
 Worm   687 GQC-------------KCRPGVAGIKCDHCLPSFWGIHLIAQGALSC---RPCGCSAFGSSRSDC 735

  Fly  1516 EPSGAPCRYNEFQCRSGHCIPKSFQCDNVPDCTDGTDEVGCMAPLPIRPPPQSVSLLEYEVLELT 1580
            |.:...|     :|::|....|...|.|....|.|    ||::|...:.|....||..:...:  
 Worm   736 EQTTGKC-----ECKNGALGDKCDLCPNGSMMTAG----GCVSPAVYKTPRDCHSLRCFHGAK-- 789

  Fly  1581 CVATGTPTPTIVWRLNWGHVPDKCESKSYGGTGTLR-CPDMRPQDSGAYS--CEIINTRGTHFVN 1642
            ||.:.:..|..:       .|..|.....|....:. |    ..|...||  ||:......|.::
 Worm   790 CVPSPSSFPDCI-------CPQSCNMNHLGIVANMTVC----GSDGTTYSNLCELKMFACKHQID 843

  Fly  1643 PDTIVTVRPVRTDVCEAGFFNMLAR-----------------KAEEC----VQC----------- 1675
                  |.||...:|:...|.:|.|                 :.|||    .||           
 Worm   844 ------VVPVSMGICDDENFEVLDRLQREKNSNEKRLGSPCTRHEECEKLSAQCITRPGRKSVCD 902

  Fly  1676 ----------FCFGVAK--ACDSANLFT------------------YAIHPPI------LSHRVV 1704
                      .|..::|  ..|...|.|                  .::|..:      :..|:|
 Worm   903 CDDGWKSHLGICIEISKKRKSDQLELTTDINSDWYFSRKDINRFSKLSMHIHLKEKREGILIRMV 967

  Fly  1705 SVELSPL------RQIVINEAAPGQD-LLTLLHGV----QFRATNVHF----------------S 1742
            :.:...|      |:|||.......| |.|:.:.|    :::...|||                |
 Worm   968 TEDKKDLQISHENRRIVIKVGKARVDSLQTIAYNVSLELKWKRNEVHFKLNGEVQKYTFEDVLDS 1032

  Fly  1743 GRETPYLALPADYMGNQLKSYGGNLRYEVNYRGSGRPVN---------GPDVIIT----GNRFTL 1794
            ..:..|:.....:..|:|.|..|.|..:      ..||.         .|::..|    .|.|..
 Worm  1033 SVKRIYVGTDGKWPRNRLNSIVGYLEID------DEPVRIDEIKPFYMAPEISRTLKFKENGFVQ 1091

  Fly  1795 TYRVRTQPGQNNRVSIPFVP---GG----WQKPDGRKASREEIMMILANVDNILIRLG------- 1845
            ...::....:..||.|.|.|   .|    |..|...........||.|. .:.:..||       
 Worm  1092 FENLQIDVRERTRVEIVFKPYRTNGILFYWSVPSDPHTDFIAFAMIDAK-PHFVYELGSGLSYIR 1155

  Fly  1846 ------------YLDSTAREVDL-INIALDSAGTADKGLGSASLVEKCQCPPGYVGDSCESCASG 1897
                        .::..|::|.: :|..|....|:........:.:|...   |||...|...|.
 Worm  1156 GEPIPLNSWHTVRIERLAKDVSMFVNETLVKKHTSQSKNAHLDISKKDAL---YVGFVPEGIISH 1217

  Fly  1898 YVRQPGGPWLGHC----VPFIPDSCPSGTYGDPRRGVPCKE------CPCPLTGSNNFASGCQQS 1952
            .||:...|:.|..    :..:|.:..||...:....|...|      ..|         .|....
 Worm  1218 KVRKLNVPFEGELQELRINELPINLISGVSKEVMDKVDVMEINEKEISKC---------DGASFD 1273

  Fly  1953 PDGDVVCRCNE 1963
            ..|.||||.:|
 Worm  1274 RKGSVVCRQHE 1284

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trolNP_001027038.3 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060
LDLa 813..847 CDD:238060
LDLa 852..887 CDD:238060 11/44 (25%)
LDLa 902..936 CDD:238060 7/35 (20%)
LDLa 956..990 CDD:238060 8/33 (24%)
LDLa 997..1030 CDD:238060 14/47 (30%)
LDLa 1033..1067 CDD:238060 9/43 (21%)
LDLa 1072..1105 CDD:238060 9/34 (26%)
LDLa 1133..1165 CDD:238060 8/52 (15%)
LDLa 1182..1215 CDD:238060 8/40 (20%)
LDLa 1221..1251 CDD:238060 5/29 (17%)
LDLa 1252..1286 CDD:238060 3/33 (9%)
LDLa 1292..1326 CDD:238060 10/37 (27%)
IG 1344..1421 CDD:214652 11/76 (14%)
Ig 1344..1405 CDD:299845 7/60 (12%)
LDLa 1439..1473 CDD:238060 6/37 (16%)
LDLa 1479..1513 CDD:238060 8/44 (18%)
LDLa 1522..1556 CDD:238060 8/33 (24%)
IG_like 1566..1649 CDD:214653 15/85 (18%)
Ig_Perlecan_D2_like 1574..1649 CDD:143220 13/77 (17%)
Laminin_B 1748..1864 CDD:278481 29/155 (19%)
EGF_Lam 1935..1989 CDD:238012 8/29 (28%)
Laminin_B 2113..2238 CDD:278481
EGF_Lam <2250..2276 CDD:238012
EGF_Lam 2284..2333 CDD:238012
Laminin_EGF <2369..2399 CDD:278482
Laminin_B 2465..2587 CDD:278481
I-set 2686..2772 CDD:254352
Ig_2 2689..2771 CDD:290606
Ig 2779..2865 CDD:299845
IG_like 2798..2864 CDD:214653
Ig 2882..2965 CDD:299845
IG_like 2882..2950 CDD:214653
Ig 2977..3061 CDD:299845
IG_like 2984..3058 CDD:214653
IG_like 3074..3152 CDD:214653
Ig 3086..3153 CDD:299845
I-set 3155..3243 CDD:254352
IGc2 3171..3233 CDD:197706
IG 3371..3447 CDD:214652
IGc2 3377..3437 CDD:197706
Ig 3456..3534 CDD:299845
IG 3465..>3526 CDD:214652
Ig 3603..3665 CDD:299845
IG 3610..3683 CDD:214652
IG 3696..3762 CDD:214652
Ig 3704..3771 CDD:299845
LamG 3784..3929 CDD:238058
EGF 3952..3984 CDD:278437
LamG 4032..4185 CDD:238058
Laminin_G_2 4315..4444 CDD:280389
agr-1NP_001022152.3 KAZAL 172..220 CDD:197624 13/55 (24%)
KAZAL 251..301 CDD:197624 11/54 (20%)
KAZAL 327..371 CDD:197624 9/43 (21%)
KAZAL 400..445 CDD:197624 9/44 (20%)
KAZAL 472..516 CDD:197624 9/43 (21%)
KAZAL 547..592 CDD:197624 11/70 (16%)
KAZAL 612..660 CDD:197624 17/133 (13%)
EGF_Lam 670..716 CDD:238012 9/58 (16%)
EGF_Lam 722..>759 CDD:238012 10/41 (24%)
KAZAL <819..852 CDD:197624 10/42 (24%)
LamG 1081..1236 CDD:238058 31/158 (20%)
LamG 1289..1450 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D17288at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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