DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trol and Megf8

DIOPT Version :9

Sequence 1:NP_001027038.3 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4479 Species:Drosophila melanogaster
Sequence 2:NP_609180.3 Gene:Megf8 / 34099 FlyBaseID:FBgn0031981 Length:2892 Species:Drosophila melanogaster


Alignment Length:2174 Identity:427/2174 - (19%)
Similarity:635/2174 - (29%) Gaps:831/2174 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   685 EYQVYQPSNVYEKANSQNPCASNQ-----------------FRCTTSNVCIPLHLRCDGFYHCND 732
            |..:|.|.......:|...|.||.                 ..|||:...    .||.|.  |..
  Fly   643 ENTLYNPEISCRLHSSHTACLSNPECGWCSADSSCYGRTIGANCTTNLQT----TRCPGI--CPS 701

  Fly   733 MSDEKSC----EQYQRHTTTRRPLTLATPTSRITTQGPGLLE-------------RRNTTTATEA 780
            :.|..||    .|:.:.:..:...::|:..        ||.|             ..|.....::
  Fly   702 LGDCHSCLVHGSQWGKSSGNKAAFSVASKL--------GLNECTWCVQNAKCHHRDDNYGICGDS 758

  Fly   781 SRWPWATKTTTI------ATTTSNPITT---------------VGVAN-------SPPQTC---- 813
            |.| |..|.|.|      .:|...|..|               ||:.|       |||.|.    
  Fly   759 SGW-WGDKGTEIRRPSLCTSTDRRPGLTYIKYHFPINYTMPDYVGIVNATMVDFASPPFTTYFEH 822

  Fly   814 -LENIEFA--------CHNRDCISIESVCDGIPDC------GRNEDEDDALCKCSGDKYKC---- 859
             ||....|        .|..:..:|: ||......      |.|.||...:...|.::..|    
  Fly   823 KLEGEMLARLVGFVRPQHQWNNSAIQ-VCTSYSSAVLRAGLGLNLDELVNVTTQSSNQSYCSNVQ 886

  Fly   860 ---------------QRGGGCIPKSQVCDGKPQCHDRSDESACHLH-GRLNKTRLGVKCLESQYQ 908
                           :|.||        :|....:.::.....||| |:||  ....:.||..| 
  Fly   887 LPTTEQPFTIDFQTRRRIGG--------NGIYNAYQKTKMELQHLHNGQLN--AFTFEYLEPYY- 940

  Fly   909 CGDGSCISGYKRCNGIHDCADASDEYNCIYDYEDTYDTDPNNN-----PLNECDILE------FE 962
              .|.| :.|..|  :|...|||    |.:        .|..|     .:||.::.:      |.
  Fly   941 --SGKC-TQYSNC--LHCLTDAS----CAW--------CPLTNICHLRSVNETEVCKMETLDTFH 988

  Fly   963 CDY-----SQCLPLEKKCDGYADCEDMSDELECQSYTD--HC-----LESEFECDSYCLPRDQLC 1015
            ..|     |||    ..|..|..||..:...||:.:|:  .|     ..|......:| ||.  |
  Fly   989 WSYLISQPSQC----SNCTNYVSCEACARSGECEWWTEDARCGRIGKTNSSVRAVEHC-PRS--C 1046

  Fly  1016 NGIPNCQDGSDER-NCTFCREDAY--------------LCNTGECVADNQRCNGIAD-------- 1057
            .....||:...|| .|.:|...|.              :|........:::...|||        
  Fly  1047 RERHGCQECLGERGRCVWCEASAQCFSFSVYTSEYQFGMCREWVDQVVSRQTQEIADHKPQQTPH 1111

  Fly  1058 -----CADGSDERHCARIYCPPNKLACNGTCVSRRIKCDGIRDCLDG---YDEMYCP---ETNNH 1111
                 |......|:|:...   ..|:| |.|..|....:||  |:.|   |....|.   .:::|
  Fly  1112 FLQQQCKSCEQHRNCSSCL---RTLSC-GWCFDRDNPIEGI--CMQGDFSYSAGNCSLALNSSSH 1170

  Fly  1112 YPTQNVNVIRPKLGPNPIPKSCRPHEWQCANLECIDSSLQCNEIKDCSDGSDEELSVCFGTATTR 1176
            :..                      ||..|         ||.::.:|..|    |..|.      
  Fly  1171 HDA----------------------EWAYA---------QCPDVDECGLG----LHDCH------ 1194

  Fly  1177 LKPSDCSPEQ----------------FYCDESCYN--RSVRCNGHVD----CSDGSDEVGCSLPC 1219
             |.:.|:..|                |.|..:||.  ::..|:|..|    |:.|.....|.|.|
  Fly  1195 -KEAKCTNTQGSYNCHCRRGYIGDGKFSCVRTCYELCQNGNCSGPPDYTCRCALGWTGADCGLSC 1258

  Fly  1220 PQHQCPS-GRCYTESERCDRHRHCEDGSDEANCCYANQFRCNNGDCVSGSAPCNGYSECSDHSDE 1283
               .|.: ..|.....:||:   |:|.|:...|....|....|.....|..||    ||:.|   
  Fly  1259 ---GCNNHSTCNERLGKCDQ---CQDWSEGEKCERCRQGSYGNATAPHGCLPC----ECNGH--- 1310

  Fly  1284 LNCGGTQECLPNQFRCNSGQCVSSSVRCNGRTDCQDSSDEQNCAADSNDRRPNQLNLKTYPDSQI 1348
                |.|:.         |.|..|    ||...|:|::...||...:    |..     |.|   
  Fly  1311 ----GNQDL---------GVCNVS----NGECYCKDNTQGLNCELCA----PGY-----YGD--- 1346

  Fly  1349 IKESREVIFRCRDEGPARAKVKWSRPGGRPLPPGFTDRNGRLEIPNIRVEDAGTYVCEAVGYASY 1413
                                   .|.||:..                       |.||:.|    
  Fly  1347 -----------------------PRGGGKCY-----------------------YQCESRG---- 1361

  Fly  1414 IPGQQVTVNLNVERYNDVGSRPESACTEYQ-------ATCMNGECI----------DKSSI---- 1457
                 :..|:.           :||...||       |:....||:          :||.:    
  Fly  1362 -----ILTNIG-----------KSAIGSYQSYRSPWGASLEVKECLWILQPKTLQAEKSLLQLEF 1410

  Fly  1458 --------CDGN--------PDCSDASDEQSCSLGLKCQP---NQFMCSNSKCVDRTWRCDGEND 1503
                    ||.|        ||.:.|: :|:..|.:.|.|   .:.:.:.|..|...::...|. 
  Fly  1411 QWQSLAMDCDENAVYIYDSLPDLTGAT-QQNQLLAVVCAPYSSPRIIEARSSHVTVHYKQGSER- 1473

  Fly  1504 CGDNSDETSCDPEPSGAPCRYNEFQCRSGHCIPKSFQCDNVPDCTDGTDEVGCMAPLPIRPP--- 1565
                        ...|....|:...|.:|.||.... ||....|......||....:.|.|.   
  Fly  1474 ------------RHFGFNALYSVMNCVAGSCISPHI-CDAQQRCVCPAGYVGASCEIEICPSNCN 1525

  Fly  1566 ---PQSVSLLEYEVLELTCVATGTPTPTIVWRLNWGHVPDKCESKSYGGT--GTLRCPDMRPQDS 1625
               .|.....||.    .|:                     |.:.:|.|.  |||      .|.:
  Fly  1526 AKRMQGFCDTEYG----RCI---------------------CSNANYAGADCGTL------VQRN 1559

  Fly  1626 GAYSCEIINT---------------RGTHFVNPD------------------------------- 1644
            .....|:.||               |..|.||.|                               
  Fly  1560 HLVMTELFNTQLLSESLEHLRKTIPRFGHSVNADRRGSLWMFGGYSPNHGPLNDFRQFDTKNSTW 1624

  Fly  1645 ---TIVTVRPVRTDVCEAG-FFNMLARKAEECVQCFCFGVAKACDSANLF--------------- 1690
               |:.:..|  .|....| :|:......::.:.....|:.......|.|               
  Fly  1625 LQVTVESSTP--EDRMPLGRYFHASEIYVKKQIIYIYGGIGANSQLLNDFWMFSIQNQRWSQIKV 1687

  Fly  1691 -------TYAIH--PPILSHRVVSVELSPLRQIV------INEAAP------------GQDL--- 1725
                   .|.:.  ||:..|.:..:.......::      :|::.|            .|.|   
  Fly  1688 EVEPPEADYEVDVPPPLAGHTLTHIRYQEHESLILLGGLSLNKSRPLELWEFNLDTGRWQQLAAV 1752

  Fly  1726 ---LTLLHGVQFRATNVHFSGRETPYLALPADYMGNQLKSYGG-------NLRYEVNYR------ 1774
               :.:|:|    .|:|:.....:.||             :||       || |.::.:      
  Fly  1753 GARMPVLYG----HTSVYHQETNSVYL-------------FGGYSTEPQSNL-YALDLQKLSWTE 1799

  Fly  1775 -GSGRPVNGPDVI----------ITGNRFTLTYRVRTQPGQNNRVSIPFV--PGGWQKPD----- 1821
             .|.|.:|.|..:          :|...:.:.|..||||.....|.|.:|  ...|.:..     
  Fly  1800 LPSFRELNSPASLLPRARYFHSAVTTEHYMILYGGRTQPFNGTDVLIAYVYACNQWVRLTEDVEL 1864

  Fly  1822 -GR--KASREEIMMILANVDNILIRLGYLD--STAREVDLINIALDSAGTADKGLGSASLVEKCQ 1881
             ||  .:|..|.|.|..:...|.: :|..|  ||...|..|.:..|.......|        |.|
  Fly  1865 IGRVPASSYAEDMAIDPDTGAIYV-IGGWDGSSTHSHVTKITLPDDICQLWSNG--------KYQ 1920

  Fly  1882 CPPGYVGDSCESCASGYVRQPGGPWLGHCVPFIPDSCPSGTYGDP---RRGVPCKECPCPLTGSN 1943
            | ..|:|  |..|..    |....:..||  |.....|...:...   ..|..|.:........:
  Fly  1921 C-RHYMG--CSYCTI----QNTYSYSSHC--FSHGRTPCANHNGTLVVNNGAACDDDWMASRNCS 1976

  Fly  1944 NFAS--GC--------QQSPDGDVVCRCNEGYTGRRCEQCAAGYQGNPLAAGGICRRIPDTSCNV 1998
            :||:  .|        :.:|    ||..        |:.|  |.:|..:.||..|.| ....||.
  Fly  1977 SFATCGACLAAWPTHQEVAP----VCHW--------CDDC--GIRGRCVPAGVDCGR-RSAWCNK 2026

  Fly  1999 DGTYSVHSNGTC--------QCKDSVIGEQCDTCKS---------------------KSFHLNSF 2034
            :  .||...|.|        .|:..::..||:..::                     :|..|...
  Fly  2027 E--LSVGVLGLCPLPQCYQLSCESCMLQPQCNWARNELGTVECIAKELVEKNQYRVVESCPLPCH 2089

  Fly  2035 TYTGCIECFCSGVGLDCDSSTWYRDQVTSTFGRSRVDH------------GFVLVTNYMQPTPDT 2087
            ||..|..|.......|.....|      ||.....:..            |.||..:.:|..|:.
  Fly  2090 TYENCSLCLSQTPTQDHQECKW------STMLNLCLTPSSQPLLCAGGVCGLVLEASELQRCPEP 2148

  Fly  2088 VPVSMAAEPNALSFIGSADQSGNTLY-----WSLPAAFLGNKLSSYGGKLTYTLSYSPLPNGIMS 2147
            ..|              ..|..:.|.     |.....|.|:.:.:.|. |.:...:   |:|   
  Fly  2149 CHV--------------YTQCSSCLEHAHCGWCAREGFNGDGICTEGA-LEHKQEH---PSG--- 2192

  Fly  2148 RNSAPDVVIKS-GEDLRLIHYRKSQVVPSVANTYSVEIKESAWQRGDEVVANREHVLMALSD--- 2208
              |..|::..| ..|.:|.|       ..|.:.:.|:..      .:....|..|....:|:   
  Fly  2193 --STCDLIYASWRNDSQLTH-------ADVVSWHYVQCP------AENECINGHHNCDTVSEQCI 2242

  Fly  2209 --ITAIYIKATYTTSTKEASLRQVTLDVATPTNLGTPR--AVEVEQCRCPEGYLGLSCE-QCAPG 2268
              .||:..|.......:|.  :...|.|.:.   |..|  .|..:||:|..||:|.:|. ||.  
  Fly  2243 DLDTAVGYKCVCAQGYREE--QGACLPVCSQ---GCVRGNCVSPDQCQCDFGYVGANCSIQCL-- 2300

  Fly  2269 YARDPEGGIYLGLCRPCECNGHSKYCNSDTGD-CEECSDNTEGPSCERCAAGYVGDATRGTIYDC 2332
                              |||||...:|...| |.:|.:||.|..||:|...:||:...|  :.|
  Fly  2301 ------------------CNGHSNCESSSRLDICLKCHNNTMGEQCEKCQPLFVGNPREG--HAC 2345

  Fly  2333 QPDEGYPIPSPPAPGNQTLECTAYCQIEGIYDCRGNE--------------CL-CKRNVIGDQCD 2382
            ||...|      ..|:..: |.||.....:::...:|              || |..:..||:||
  Fly  2346 QPCLDY------CHGHSDV-CVAYDADPAVFNMTRSELERILQEGPAYNATCLRCGNHTAGDRCD 2403

  Fly  2383 QCRPGTYGLSAQNQDGCKECYCSGLASQC 2411
            .|..|.:..|......|:.|.|.|..:.|
  Fly  2404 SCLTGYFRGSEDLHKECRPCQCHGHGNIC 2432

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trolNP_001027038.3 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060 11/51 (22%)
LDLa 813..847 CDD:238060 11/52 (21%)
LDLa 852..887 CDD:238060 6/53 (11%)
LDLa 902..936 CDD:238060 11/33 (33%)
LDLa 956..990 CDD:238060 9/44 (20%)
LDLa 997..1030 CDD:238060 10/38 (26%)
LDLa 1033..1067 CDD:238060 8/60 (13%)
LDLa 1072..1105 CDD:238060 10/35 (29%)
LDLa 1133..1165 CDD:238060 7/31 (23%)
LDLa 1182..1215 CDD:238060 11/54 (20%)
LDLa 1221..1251 CDD:238060 7/30 (23%)
LDLa 1252..1286 CDD:238060 8/33 (24%)
LDLa 1292..1326 CDD:238060 7/33 (21%)
IG 1344..1421 CDD:214652 8/76 (11%)
Ig 1344..1405 CDD:299845 5/60 (8%)
LDLa 1439..1473 CDD:238060 14/70 (20%)
LDLa 1479..1513 CDD:238060 5/36 (14%)
LDLa 1522..1556 CDD:238060 9/33 (27%)
IG_like 1566..1649 CDD:214653 20/133 (15%)
Ig_Perlecan_D2_like 1574..1649 CDD:143220 18/125 (14%)
Laminin_B 1748..1864 CDD:278481 35/151 (23%)
EGF_Lam 1935..1989 CDD:238012 12/63 (19%)
Laminin_B 2113..2238 CDD:278481 24/135 (18%)
EGF_Lam <2250..2276 CDD:238012 9/26 (35%)
EGF_Lam 2284..2333 CDD:238012 18/49 (37%)
Laminin_EGF <2369..2399 CDD:278482 11/44 (25%)
Laminin_B 2465..2587 CDD:278481
I-set 2686..2772 CDD:254352
Ig_2 2689..2771 CDD:290606
Ig 2779..2865 CDD:299845
IG_like 2798..2864 CDD:214653
Ig 2882..2965 CDD:299845
IG_like 2882..2950 CDD:214653
Ig 2977..3061 CDD:299845
IG_like 2984..3058 CDD:214653
IG_like 3074..3152 CDD:214653
Ig 3086..3153 CDD:299845
I-set 3155..3243 CDD:254352
IGc2 3171..3233 CDD:197706
IG 3371..3447 CDD:214652
IGc2 3377..3437 CDD:197706
Ig 3456..3534 CDD:299845
IG 3465..>3526 CDD:214652
Ig 3603..3665 CDD:299845
IG 3610..3683 CDD:214652
IG 3696..3762 CDD:214652
Ig 3704..3771 CDD:299845
LamG 3784..3929 CDD:238058
EGF 3952..3984 CDD:278437
LamG 4032..4185 CDD:238058
Laminin_G_2 4315..4444 CDD:280389
Megf8NP_609180.3 CUB 33..141 CDD:238001
KELCH repeat 228..268 CDD:276965
Kelch_4 369..414 CDD:290154
KELCH repeat 370..420 CDD:276965
KELCH repeat 425..476 CDD:276965
KELCH repeat 480..540 CDD:276965
EGF_3 1186..1220 CDD:289699 7/44 (16%)
EGF_Lam 1257..1302 CDD:238012 11/50 (22%)
EGF_Lam 1304..1354 CDD:238012 22/108 (20%)
CUB 1372..1484 CDD:238001 22/125 (18%)
Kelch_4 1584..1628 CDD:290154 5/43 (12%)
KELCH repeat 1585..1638 CDD:276965 8/54 (15%)
KELCH repeat 1642..1685 CDD:276965 4/42 (10%)
Kelch_3 1656..1710 CDD:290151 7/53 (13%)
KELCH repeat 1760..1813 CDD:276965 14/70 (20%)
Kelch_4 1760..1802 CDD:290154 10/59 (17%)
KELCH repeat 1817..1867 CDD:276965 10/49 (20%)
EGF_Lam 2299..2346 CDD:238012 19/68 (28%)
EGF_Lam 2422..2487 CDD:238012 4/11 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45445141
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR10574
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.030

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