DRSC/TRiP Functional Genomics Resources

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Protein Alignment trol and LanB1

DIOPT Version :9

Sequence 1:NP_001027038.3 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4479 Species:Drosophila melanogaster
Sequence 2:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster


Alignment Length:2143 Identity:405/2143 - (18%)
Similarity:664/2143 - (30%) Gaps:818/2143 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly  1092 GIRDCLDGYDEMYCPET-NNHYPTQNVNVIRPKLGPN-----PIPKSCRPHEWQCANL------- 1143
            |:...|:...::.|... :|..|::|..||...|.||     |..:..: ::.:..||       
  Fly   194 GVPTVLENITDVMCTSRYSNVEPSRNGEVIFRVLPPNINVTDPYAEHVQ-NQLKMTNLRIQMTKL 257

  Fly  1144 -----ECIDSSLQCNEIK------------DCSDGSDEELSVCFGTATTRLKPSDCSPEQFYCDE 1191
                 ..:||.|: ||.|            .||         |:|.|:..| |.|  |.....| 
  Fly   258 HKLGDNLLDSRLE-NEEKYYYGISNMVVRGSCS---------CYGHASQCL-PLD--PAFSQAD- 308

  Fly  1192 SCYNRSVRCNGHVDCSDGSDEVGCSLPCPQHQCPS-----------GRCYTESERCDRHRHCEDG 1245
               |.....:|..:|:..:..:.|      .:|..           |:.....::|:    |   
  Fly   309 ---NEDGMVHGRCECTHNTKGMNC------EECEDFFNDLPWKPAFGKKTNACKKCE----C--- 357

  Fly  1246 SDEANCCYANQFRCNNGDCVSGSAPCNGYSECSDHSDELNCGGTQECLPNQFRCNSGQCVSSSVR 1310
            :|.|..|:.::........|||.. |:   .|..::...:|   :||:|..:| :..|.::|...
  Fly   358 NDHAVSCHFDEAVFTASGFVSGGV-CD---NCLHNTRGQHC---EECMPYFYR-DPEQDITSERV 414

  Fly  1311 CNGRTDC--QDSSDEQNCAADSNDRRPNQLNLKTYPDSQIIKESREVIFRCRDEGPARAKVKWSR 1373
            |. ..||  |.|||:..|  ||    .|:|                      :||..        
  Fly   415 CQ-PCDCDPQGSSDDGIC--DS----LNEL----------------------EEGAV-------- 442

  Fly  1374 PGGRPLPPGFTDRNGRLEIPNIRVEDAGTYVCEAVGYASYIPGQQVTV----NLNVERYNDVGSR 1434
                                      ||...|:|     ::.|::...    ..|::..|..|..
  Fly   443 --------------------------AGACHCKA-----FVTGRRCNQCKDGYWNLQSDNPEGCE 476

  Fly  1435 PESACT-EYQATCMNGECIDKSSICDGNPDCSDASDEQSCSLGLKCQPNQFMCSNSKCVDRTWRC 1498
            |   || ....|..|..|:.::..|    .|......:.|:   :|.|..:..|.|........|
  Fly   477 P---CTCNPLGTLNNSGCVMRTGEC----KCKKYVTGKDCN---QCMPETYGLSESPEGCSLCNC 531

  Fly  1499 DG----ENDCGDNSDETSCDPEPSGAPC---RYNEFQCRSGHCIPKSFQCDNVPDCTDGTDEVGC 1556
            |.    :|.|...|.:..|.|..:|..|   :.|.|                             
  Fly   532 DAGGSYDNYCDVISGQCRCRPHMTGRSCSQPKQNYF----------------------------- 567

  Fly  1557 MAPLPIRPPPQSVSLLEYEVLELTCVATG-TPTPTIVWRLNWGHVPDKCESKSYGGTGTLRCPDM 1620
               :|:.|     .:.|.||:: .|::.| ....::|     ...||    .|:.|.|..|.|: 
  Fly   568 ---IPLLP-----EVHEAEVVD-ECISYGANGNCSLV-----AETPD----GSFTGIGFTRVPE- 613

  Fly  1621 RPQDSGAYSCEIINTRG--THFVNPDTIVTVRPVRTDVCEAGFFNMLARKAEECVQCFCFGVAKA 1683
                    :.|::.|.|  ...:..|.::..:.......|..|.. |.|..:...:..|..:|.|
  Fly   614 --------NSELVFTVGDIPRSMPYDAVIRYQSTSRGDWENAFIT-LVRPDQVDPEGGCGELAAA 669

  Fly  1684 CDSANLFTYAIHPPILSHRVVSVEL-----------------------SPLRQIVINEAAPGQDL 1725
            ..|.....:::  |..|.:||::..                       ||...|::       |.
  Fly   670 TSSETRIPFSL--PDRSRQVVALNEVCLEAGKVYKFRIYFERKRHDVDSPTATILV-------DS 725

  Fly  1726 LTLLHGVQFRATNVHFSGRETPYLALPADYMGNQLKSYGGNLR---YEVNYRGSGRPVNGPDVII 1787
            |||:..:.  .|.: |.|      ::.||......:.|  |.:   |::||:...:..|..:::.
  Fly   726 LTLIPRID--VTPI-FQG------SVLADIRKKDYEKY--NCKSSLYDMNYKSDPKCQNLDNILS 779

  Fly  1788 --------------TGNRFTLTYR----VRTQPGQNNRVSIPFVPGGWQ-KPDGRKASREEIMMI 1833
                          ||:...:...    .:.:|....|......||.:. .|:|.||        
  Fly   780 VFVHDGASMCNCNPTGSLSKVCESNGGYCQCKPNVVGRQCDQCAPGTYGFGPEGCKA-------- 836

  Fly  1834 LANVDNILIRLGYLDSTAREVDLINIALDSAGTADKGLGSASLVE-KCQCPPGYVGDSCESCASG 1897
                                     ...:|.|:.||   ...|:. :|||.|...|..|..|..|
  Fly   837 -------------------------CDCNSIGSKDK---YCDLITGQCQCVPNTYGRECNQCQPG 873

  Fly  1898 Y-------VRQPGG------PWLGHCVP-------FIPDSCPSGTYGDPRRG--VPCKECPCPLT 1940
            |       |.|..|      |..|.|:.       :..|||..|.||:|..|  :.|:.|.||.|
  Fly   874 YWNFPECRVCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLFGSEIGCRPCRCPET 938

  Fly  1941 GSNNF--ASGCQ-QSPDGDVVCRCNEGYTGRRCEQCAAGYQGNPLAAGGICRRIPDTSCNVDGTY 2002
            .::..  |.||. .:.:.:::|.|.|||:|.|||.||..:.||| ..||.|.:. :.|.|||   
  Fly   939 VASGLAHADGCSLDTRNNNMLCHCQEGYSGSRCEICADNFFGNP-DNGGTCSKC-ECSNNVD--- 998

  Fly  2003 SVHSNGTC--------QCKDSVIGEQCDTCKSKSFHLNSFTYTGCIECFCSGVGLDCDSSTWYRD 2059
             ::..|.|        :|.....|:.|:.||...|  .......|.:|.|..:|           
  Fly   999 -LYDTGNCDRQTGACLKCLYQTTGDHCELCKDGFF--GDALQQNCQQCECDFLG----------- 1049

  Fly  2060 QVTSTFGRSRVDHGFVLVTNYMQPTPDTVPVSMAAEPNALSFIGSADQSGNTLYWSLPAAFLGNK 2124
                              ||                    :.|...|:            |.|  
  Fly  1050 ------------------TN--------------------NTIAHCDR------------FTG-- 1062

  Fly  2125 LSSYGGKLTYTLSYSPLPNGIMSRNSAPDVVIKSGEDLRLIHYRKSQVVPSVANTYSVEIKESAW 2189
                                                        :...:|:|......:..|:.|
  Fly  1063 --------------------------------------------QCPCLPNVQGVRCDQCAENHW 1083

  Fly  2190 QRGDEVVANREHVLMALSD-ITAIYIKATYTTSTKEASLRQVTLDVATPTNLGTPRAVEVEQCRC 2253
            :     :|:.|.......| |.|::.:....|.                            ||:|
  Fly  1084 K-----IASGEGCESCNCDPIGALHEQCNSYTG----------------------------QCQC 1115

  Fly  2254 PEGYLGLSCEQCAPGYARDPEGGIYLGLCRPCECN--GHSKY-CNSDTGDCEECSDNTEGPSCER 2315
            ..|:.|.:|.||...|..:|.     ..|:||||:  |.:.: |:.:||:| .|.:...|..|..
  Fly  1116 KPGFGGRACNQCQAHYWGNPN-----EKCQPCECDQFGAADFQCDRETGNC-VCHEGIGGYKCNE 1174

  Fly  2316 CAAGYVGDATRGTIYDCQPDEGYPIPSPPAPGNQTLECTAYCQIEGIYDCRGNECLCKRNVIGDQ 2380
            ||.||:|.              :|..||                     |  .||....::|...
  Fly  1175 CARGYIGQ--------------FPHCSP---------------------C--GECFNNWDLILSA 1202

  Fly  2381 CDQCRPGTYGLSAQ--NQDGCKECYCSGLASQCRSAALYRQLIPVDFILNAPLITDESGAVQDTE 2443
            .:.....|. |.|:  .|.|....|.|..:...:.....|.|:                  |:|.
  Fly  1203 LEDATTATI-LRAKEIKQVGATGAYTSEFSELDKKLQHIRNLL------------------QNTS 1248

  Fly  2444 NLIPDISRNMYTYTHTSYLPKYWSLRGSVLGNQLFSYGGRLS---------YSLI------VESY 2493
            ..:.||.:..|         :..|||     :||.:..||||         |:.:      :||.
  Fly  1249 VSLVDIEKLDY---------ETQSLR-----DQLQASHGRLSETEQNLDDIYNSLSLSGVELESL 1299

  Fly  2494 GNYERGHDIV------LIGNGLKLIWSRPDGNENQEEYNVRLHEDEQ----WTRQDRESARPASR 2548
            .|:.|   :|      |..||::|..|..:|     ..|:..|..|:    .|.:| |:...||.
  Fly  1300 QNHSR---LVQQLSKELKENGIQLQESNIEG-----ALNLTRHAYERVSNLSTLKD-EANELASN 1355

  Fly  2549 SDFMTVLSDLQHILIRATPRVPTQSTSI---------GNVILE------SAVTTRTPGATHASDI 2598
            :|             |...||...|..|         .|.::|      :::|::.|...:    
  Fly  1356 TD-------------RNCKRVENLSNKIQAEADDLANNNKLIEDYRAELTSLTSQIPELNN---- 1403

  Fly  2599 ELCQCPSGYVGTSCESCAPLHYRDASGSCSLCPCDVSNTESCDLVSGGYVECRCKARWKGDRCRE 2663
            ::|    |..|..|:|..      ....|..|              ||::.|...|:...:...:
  Fly  1404 QVC----GKPGDPCDSLC------GGAGCGHC--------------GGFLSCEHGAKTHSEEALK 1444

  Fly  2664 IDTNDPTDIGTEDPVLTQIIVSIQKPEITIVPVGGSMTLSCS-----GRMRWSNSPVIVNWYKEN 2723
            :..:..|.|.::.....|.|.::.:.:           |:.|     .:..:..|...:|....|
  Fly  1445 VAKDAETAITSKKDQADQTIRALTQAK-----------LNASEAYEKAKRGFEQSERYLNQTNAN 1498

  Fly  2724 SRLPENVEVQGGNLYLYDLQVSDSGVYICQAVNNETA--SVFKDTVSITITKKDQLSPAEIVNLP 2786
            .:|.||:.:...|..                 .|:||  |..|:....|:....:|.|.||    
  Fly  1499 IKLAENLFIALNNFQ-----------------ENKTASPSESKELAQKTLDLDLKLEPEEI---- 1542

  Fly  2787 SHVTFEEYVNNEIICEVLGNPAPRVTWARVDGHADAQSTRTYDNRLIFDSPRKSDEGRYRCQAEN 2851
                           |.||:..                     ||.:  |..|:.|         
  Fly  1543 ---------------ETLGDQI---------------------NRAV--SSLKNVE--------- 1560

  Fly  2852 DQNRDEKYVIVYVQSNPPQPPPQQDRLYITPEEINGLAGESFQ-----LNCQFTSVASLRYDWSH 2911
                    .|:|      :..|..||:    ..:..:|..:.:     |:...:.|.||......
  Fly  1561 --------AIIY------RTKPDLDRV----NNLQSIANATKEKADKILDSANSVVESLAAADES 1607

  Fly  2912 NGRSLSS--SPARNVEIRGNTLEVRDASESDSGVYTCVAYDVRTRRNFTESARVNIDRREEQPFG 2974
            .|::..:  ....|:|:.|..||..|                  ...::..|..|...::.:...
  Fly  1608 QGKAKDAIQQANSNIELAGQDLEKID------------------EETYSAEAPANNTAQQVEKLA 1654

  Fly  2975 NKPIIESLEQNILIIQGEDYSITCEASGSPYPSIKWAKVHDFMPENVHISGNVLTIYGARFEN 3037
            .|  ::.|:.||:....:...||.||......:::.....:.:......:...||...:|.||
  Fly  1655 KK--VQKLQNNIMKNDRDAKEITKEAGSVKLEAMRARGEANNLQSATSATNQTLTDRASRSEN 1715

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trolNP_001027038.3 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060
LDLa 813..847 CDD:238060
LDLa 852..887 CDD:238060
LDLa 902..936 CDD:238060
LDLa 956..990 CDD:238060
LDLa 997..1030 CDD:238060
LDLa 1033..1067 CDD:238060
LDLa 1072..1105 CDD:238060 2/12 (17%)
LDLa 1133..1165 CDD:238060 10/55 (18%)
LDLa 1182..1215 CDD:238060 5/32 (16%)
LDLa 1221..1251 CDD:238060 6/40 (15%)
LDLa 1252..1286 CDD:238060 6/33 (18%)
LDLa 1292..1326 CDD:238060 12/35 (34%)
IG 1344..1421 CDD:214652 7/76 (9%)
Ig 1344..1405 CDD:299845 4/60 (7%)
LDLa 1439..1473 CDD:238060 7/34 (21%)
LDLa 1479..1513 CDD:238060 9/37 (24%)
LDLa 1522..1556 CDD:238060 3/36 (8%)
IG_like 1566..1649 CDD:214653 17/85 (20%)
Ig_Perlecan_D2_like 1574..1649 CDD:143220 16/77 (21%)
Laminin_B 1748..1864 CDD:278481 18/137 (13%)
EGF_Lam 1935..1989 CDD:238012 23/56 (41%)
Laminin_B 2113..2238 CDD:278481 12/125 (10%)
EGF_Lam <2250..2276 CDD:238012 10/25 (40%)
EGF_Lam 2284..2333 CDD:238012 17/51 (33%)
Laminin_EGF <2369..2399 CDD:278482 7/31 (23%)
Laminin_B 2465..2587 CDD:278481 37/161 (23%)
I-set 2686..2772 CDD:254352 15/92 (16%)
Ig_2 2689..2771 CDD:290606 14/88 (16%)
Ig 2779..2865 CDD:299845 13/85 (15%)
IG_like 2798..2864 CDD:214653 9/65 (14%)
Ig 2882..2965 CDD:299845 13/89 (15%)
IG_like 2882..2950 CDD:214653 12/74 (16%)
Ig 2977..3061 CDD:299845 12/61 (20%)
IG_like 2984..3058 CDD:214653 11/54 (20%)
IG_like 3074..3152 CDD:214653
Ig 3086..3153 CDD:299845
I-set 3155..3243 CDD:254352
IGc2 3171..3233 CDD:197706
IG 3371..3447 CDD:214652
IGc2 3377..3437 CDD:197706
Ig 3456..3534 CDD:299845
IG 3465..>3526 CDD:214652
Ig 3603..3665 CDD:299845
IG 3610..3683 CDD:214652
IG 3696..3762 CDD:214652
Ig 3704..3771 CDD:299845
LamG 3784..3929 CDD:238058
EGF 3952..3984 CDD:278437
LamG 4032..4185 CDD:238058
Laminin_G_2 4315..4444 CDD:280389
LanB1NP_476618.1 Laminin_N 63..286 CDD:278484 20/93 (22%)
EGF_Lam 287..343 CDD:238012 15/77 (19%)
Laminin_EGF 355..415 CDD:278482 17/74 (23%)
Laminin_EGF 418..475 CDD:278482 20/123 (16%)
EGF_Lam 477..526 CDD:238012 13/58 (22%)
EGF_Lam 529..567 CDD:214543 10/37 (27%)
EGF_Lam 789..834 CDD:214543 7/44 (16%)
Laminin_EGF 837..885 CDD:278482 15/50 (30%)
Laminin_EGF 883..930 CDD:278482 13/46 (28%)
Laminin_EGF 933..988 CDD:278482 23/55 (42%)
Laminin_EGF 991..1043 CDD:278482 13/58 (22%)
Laminin_EGF 1043..1091 CDD:278482 15/159 (9%)
Laminin_EGF 1094..1142 CDD:278482 15/80 (19%)
Laminin_EGF 1142..1190 CDD:278482 20/85 (24%)
COG6 1212..>1398 CDD:303003 51/239 (21%)
TelA 1439..1782 CDD:226371 63/394 (16%)
ApoLp-III_like 1545..1702 CDD:304399 34/226 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45445137
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR10574
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.940

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