Protein Alignment trol and NetB

DIOPT Version :10

• Sequence 1: NP_001401049.1
• Gene: trol / 45320
• FlyBaseID: FBgn0284408
• Length: 4489
• Species: Drosophila melanogaster
• Sequence 2: NP_511155.1
• Gene: NetB / 32400
• FlyBaseID: FBgn0015774
• Length: 793
• Species: Drosophila melanogaster
• Alignment Length: 587
• Identity: 110/587 - (18%)
• Similarity: 182/587 - (31%)
• Gaps: 213/587 - (36%)

  Fly  1975 AGYQGNPLAAGGIC-RRIPDTSCNVDGTYSVHSNGTCQCKDSVIGEQCDTCKSKSF---HLNSFT 2035
            |.| |||:.|..:| .:.|:..|.:             .:|...|| |.:|:.:.:   .|....
  Fly    50 AAY-GNPVQASSVCGAQQPERYCEL-------------LRDGNAGE-CRSCEQQRYGPAALTDLN 99

  Fly  2036 YTGCIECFCSG-VGLDCDSSTWYRDQVTSTFGRSRVDHGFVLVTNY--MQPTPDTVPVSMAAE-- 2095
            ....:.|:.|| |.:..|..:...|.||.|....:......:..::  ..|.||::.:..:::
  Fly   100 NPSNVTCWRSGAVNVPHDPDSAPPDNVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFG 164

  Fly  2096 ----------PNALSFIGSADQSGNTLYWSLPAAFLGNKLSSYGGKLTY---TLSYSPLPNGIMS 2147
                      .....|.|..|::..:.:....|..:.::..:.|....:   ||...|..|.:.|
  Fly   165 QTWQPFQFYSSQCQKFYGRPDRAKISKFNEQEARCINSQHDTGGAAQRFAFNTLEGRPSANDLDS 229

  Fly  2148 RNSAPDVVIKSGEDLRLIHYRKSQVVPSV-----ANTYSVEI----------------------- 2184
            .....|.|  :..|:|::.:| .::.|.:     ||.:|.|:
  Fly   230 SLVLQDWV--TATDIRVVFHR-LELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEY 291

  Fly  2185 ------KESAWQRGDEVVANREHV--------LMALSDITAIY------------------IKAT 2217
                  .:||....||....::|:        |...||..::.                  :.||
  Fly   292 DYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAAT 356

  Fly  2218 Y-----------------TTSTKEASLRQVTLDVA------------------------------ 2235
            .                 :|:...|:...|||.::
  Fly   357 TPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSG 421

  Fly  2236 TPTNLG---------TPRAVEVEQ---------------CRCPEGYLGLSCEQCAPGYARDPEGG 2276
            :.|.|.         ||.|..:..               |.|.....|..||:|.|.|...|.|.
  Fly   422 SGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGR 486

  Fly  2277 IY---LGLCRPCECNGHSKYCNSDT-----------GDCEECSDNTEGPSCERCAAGYVGDATRG 2327
            ..   ...|:.|:||||::.|..:.           |.|..|..:|.|..|..|..||..|||:.
  Fly   487 ATDNDANECKMCQCNGHARRCRFNLELYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKP 551

  Fly  2328 TIY-------DCQPDEGYPIPSPPAPGNQTLECTAYCQIEGIYDCRGNECLCKRNVIGDQCDQCR 2385
            ..:       ||.|           .|:....|.   .:.|       :|.||..|.|..|::|.
  Fly   552 PNHRKVCKRCDCHP-----------VGSTGKTCN---HLSG-------QCPCKEGVTGLTCNRCA 595

  Fly  2386 PG 2387
            .|
  Fly   596 RG 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trol	NP_001401049.1	LDLa	447..480	CDD:238060
		LDLa	532..564	CDD:238060
		LDLa	571..606	CDD:238060
		LDLa	616..650	CDD:238060
		LDLa	704..739	CDD:238060
		LDLa	813..847	CDD:238060
		LDLa	852..887	CDD:238060
		LDLa	902..936	CDD:238060
		LDLa	956..990	CDD:238060
		LDLa	997..1030	CDD:238060
		LDLa	1033..1067	CDD:238060
		LDLa	1072..1105	CDD:238060
		LDLa	1133..1165	CDD:238060
		LDLa	1182..1215	CDD:238060
		LDLa	1221..1251	CDD:238060
		LDLa	1252..1286	CDD:238060
		LDLa	1292..1326	CDD:238060
		Ig	1344..1405	CDD:472250
		Ig strand B	1355..1359	CDD:409353
		Ig strand C	1369..1372	CDD:409353
		Ig strand E	1388..1392	CDD:409353
		LDLa	1439..1473	CDD:238060
		LDLa	1479..1513	CDD:238060
		LDLa	1522..1556	CDD:238060
		Ig_Perlecan_like	1574..1649	CDD:143220
		Ig strand B	1577..1583	CDD:143220
		Ig strand C	1590..1595	CDD:143220
		Ig strand E	1613..1617	CDD:143220
		Ig strand F	1626..1632	CDD:143220
		Ig strand G	1641..1647	CDD:143220
		Laminin_B	1748..1878	CDD:459652
		EGF_Lam	1935..1989	CDD:238012	7/14 (50%)
		Laminin_B	2113..2249	CDD:459652	37/254 (15%)
		EGF_Lam	<2250..2276	CDD:238012	9/40 (23%)
		EGF_Lam	2284..2333	CDD:238012	19/66 (29%)
		Laminin_EGF	<2369..2399	CDD:395007	8/19 (42%)
		Laminin_B	2465..2599	CDD:459652
		Ig_3	2688..2756	CDD:464046
		Ig_3	2791..2861	CDD:464046
		Ig_3	2890..2958	CDD:464046
		Ig	2987..3071	CDD:472250
		Ig strand B	3004..3008	CDD:409353
		Ig strand C	3017..3021	CDD:409353
		Ig strand E	3036..3040	CDD:409353
		Ig strand F	3050..3055	CDD:409353
		Ig strand G	3063..3066	CDD:409353
		I-set	3089..3162	CDD:400151
		Ig strand B	3094..3098	CDD:409353
		Ig strand C	3107..3111	CDD:409353
		Ig strand E	3128..3132	CDD:409353
		Ig strand F	3142..3147	CDD:409353
		Ig strand G	3155..3158	CDD:409353
		Ig	3165..3253	CDD:472250
		Ig strand B	3185..3189	CDD:409353
		Ig strand C	3198..3202	CDD:409353
		Ig strand E	3219..3223	CDD:409353
		Ig strand F	3233..3238	CDD:409353
		Ig strand G	3246..3249	CDD:409353
		Ig	3298..3355	CDD:472250
		Ig strand B	3301..3305	CDD:409353
		Ig strand C	3313..3316	CDD:409353
		Ig strand E	3333..3336	CDD:409353
		IG_like	3381..3457	CDD:214653
		Ig strand B	3390..3394	CDD:409353
Ig strand C	3403..3407	CDD:409353
Ig strand F	3437..3442	CDD:409353
IG_like	3475..>3536	CDD:214653
Ig strand B	3480..3484	CDD:409353
Ig strand C	3491..3503	CDD:409353
Ig strand E	3519..3523	CDD:409353
Ig	3613..3675	CDD:472250
Ig strand B	3625..3629	CDD:409353
Ig strand C	3637..3642	CDD:409353
Ig strand E	3658..3662	CDD:409353
IG_like	3706..3772	CDD:214653
Ig strand B	3714..3718	CDD:409353
Ig strand C	3727..3731	CDD:409353
Ig strand E	3746..3750	CDD:409353
Ig strand F	3760..3765	CDD:409353
Ig strand G	3774..3777	CDD:409353
LamG	3794..3939	CDD:238058
EGF	3962..3994	CDD:394967
LamG	4042..4195	CDD:238058
EGF_CA	4254..4286	CDD:238011
LamG	4295..4448	CDD:238058
NetB	NP_511155.1	LamNT	37..261	CDD:214532	43/228 (19%)
		EGF_Lam	<458..484	CDD:238012	8/25 (32%)
		EGF_Lam	498..555	CDD:238012	18/56 (32%)
		EGF_Lam	560..608	CDD:238012	14/59 (24%)
		NTR_netrin-1_like	661..791	CDD:239634