DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trol and NetA

DIOPT Version :10

Sequence 1:NP_001401049.1 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4489 Species:Drosophila melanogaster
Sequence 2:NP_511154.3 Gene:NetA / 32398 FlyBaseID:FBgn0015773 Length:726 Species:Drosophila melanogaster


Alignment Length:824 Identity:156/824 - (18%)
Similarity:253/824 - (30%) Gaps:295/824 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1942 SNN--FASGCQQSPDGDVVCRC-NEGYTGRRC--EQCAAGYQGNPLAAGGICRRIPDTSCNVDGT 2001
            ||:  |....||:|..|   .| |:.:..|.|  :...|.|.. |:.|...|             
  Fly    22 SNDVYFKMFSQQAPPED---PCYNKAHEPRACIPDFVNAAYDA-PVVASSTC------------- 69

  Fly  2002 YSVHSNGT---CQCKDSVIGEQCDTCKS----KSFHLNSFT---YTGCIECFCSGVGLDCDSSTW 2056
               .|:|.   |:.:|.  ...|.||..    :||...|.|   .:..:.|:.|      :..|.
  Fly    70 ---GSSGAQRYCEYQDH--ERSCHTCDMTDPLRSFPARSLTDLNNSNNVTCWRS------EPVTG 123

  Fly  2057 YRDQVTSTFGRSRVDHGFVLVTNYMQPTPDTVPVSMAAEPNALSFIGSADQSGNTLYWSLPAAFL 2121
            ..|.||.|....:   .|.|....:|..|.      |..|:::....|.|..   |.|. |..|.
  Fly   124 SGDNVTLTLSLGK---KFELTYVILQLCPH------APRPDSMVIYKSTDHG---LSWQ-PFQFF 175

  Fly  2122 GNKLSSYGGK----------------------LTYTLSYSPLPNGIMSRNSAPDVVIK---SGED 2161
            .::.....|:                      |...:::|.|.....||:.....|::   :..|
  Fly   176 SSQCRRLFGRPARQSTGRHNEHEARCSDVTRPLVSRIAFSTLEGRPSSRDLDSSPVLQDWVTATD 240

  Fly  2162 LRLIHYRKSQVVPS-------------VANTYSVEIKES------AWQRGDEVVANREHVLMALS 2207
            :|::.:|..:..|.             .:..|||.:...      ....|.:|..:...:..|:|
  Fly   241 IRVVFHRLQRPDPQALLSLEAGGATDLASGKYSVPLANGPAGNNIEANLGGDVATSGSGLHYAIS 305

  Fly  2208 DITAIYIKATYTTSTKEASLRQVTLDVATPTNLGTPRAVEVEQCRCPEGYLGLSCEQCAPGYARD 2272
            |.:.    .........||  :.:.|.:...|           |.|.....|..||:|.|.:...
  Fly   306 DFSV----GGRCKCNGHAS--KCSTDASGQLN-----------CECSHNTAGRDCERCKPFHFDR 353

  Fly  2273 P-------EGGIYLGLCRPCECNGHSKYCNSDT-----------GDCEECSDNTEGPSCERCAAG 2319
            |       |.    ..|:.|.||.|::.|..:.           |.|:.|..:|.|.:|.:|..|
  Fly   354 PWARATAKEA----NECKECNCNKHARQCRFNMEIFRLSQGVSGGVCQNCRHSTTGRNCHQCKEG 414

  Fly  2320 YVGDATRGTIYD--CQPDEGYPIPSPPAPGNQTLECTAYCQIEGIYDCRGNECLCKRNVIGDQCD 2382
            :..|||:...:.  |:..:.:||.|.....|.|                ..:|.||..|.|..|:
  Fly   415 FYRDATKPLTHRKVCKACDCHPIGSSGKICNST----------------SGQCPCKDGVTGLTCN 463

  Fly  2383 QC----------------------------------------------RPGTYGLSAQNQ----D 2397
            :|                                              |.|..|::||:|    :
  Fly   464 RCARGYQQSRSHIAPCIKQPPRMINMLDTQNTAPEPDEPESSPGSGGDRNGAAGMAAQSQYYRTE 528

  Fly  2398 GCKECYCSGLASQCRSAAL---YRQLIPVDFILNAPLI---TDESGAVQDTEN--LIPDISRNMY 2454
            |.:||      .:||.:..   ..:....|:.:.|.:|   |......::.:.  :.||::    
  Fly   529 GGREC------GKCRVSTKRLNLNKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDVA---- 583

  Fly  2455 TYTHTSYLPKYWSLRGSVLGNQLFSYGGRLSYSLIVESYGNYERGHDIVLIGNGLKLIWSRPDGN 2519
            .|......|  .|.|..:.|          .|......|.|..                ..|.|:
  Fly   584 DYEMDQVQP--GSARSPITG----------VYEFQAADYPNPN----------------PNPRGS 620

  Fly  2520 ENQEEYNVRLHEDEQWTRQDRESARPASRSDFMTVLSDLQHILIRATPRVPTQSTSIGNVI-LES 2583
            | .|.::::                             :|.:..|:.   |.:|:..|||. :.:
  Fly   621 E-MERFDLQ-----------------------------IQAVFKRSR---PGESSGAGNVYGMPN 652

  Fly  2584 AVTTRTP--GATHASDIELCQCP-----SGYVGTSCESCAPLHY 2620
            ....|.|  ......|:| |:||     ..|:....:|.||..|
  Fly   653 TTLKRGPMTWIIPTKDLE-CRCPRIRVNRSYLILGRDSEAPPGY 695

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trolNP_001401049.1 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060
LDLa 813..847 CDD:238060
LDLa 852..887 CDD:238060
LDLa 902..936 CDD:238060
LDLa 956..990 CDD:238060
LDLa 997..1030 CDD:238060
LDLa 1033..1067 CDD:238060
LDLa 1072..1105 CDD:238060
LDLa 1133..1165 CDD:238060
LDLa 1182..1215 CDD:238060
LDLa 1221..1251 CDD:238060
LDLa 1252..1286 CDD:238060
LDLa 1292..1326 CDD:238060
Ig 1344..1405 CDD:472250
Ig strand B 1355..1359 CDD:409353
Ig strand C 1369..1372 CDD:409353
Ig strand E 1388..1392 CDD:409353
LDLa 1439..1473 CDD:238060
LDLa 1479..1513 CDD:238060
LDLa 1522..1556 CDD:238060
Ig_Perlecan_like 1574..1649 CDD:143220
Ig strand B 1577..1583 CDD:143220
Ig strand C 1590..1595 CDD:143220
Ig strand E 1613..1617 CDD:143220
Ig strand F 1626..1632 CDD:143220
Ig strand G 1641..1647 CDD:143220
Laminin_B 1748..1878 CDD:459652
EGF_Lam 1935..1989 CDD:238012 15/51 (29%)
Laminin_B 2113..2249 CDD:459652 26/179 (15%)
EGF_Lam <2250..2276 CDD:238012 9/32 (28%)
EGF_Lam 2284..2333 CDD:238012 16/61 (26%)
Laminin_EGF <2369..2399 CDD:395007 13/79 (16%)
Laminin_B 2465..2599 CDD:459652 20/136 (15%)
Ig_3 2688..2756 CDD:464046
Ig_3 2791..2861 CDD:464046
Ig_3 2890..2958 CDD:464046
Ig 2987..3071 CDD:472250
Ig strand B 3004..3008 CDD:409353
Ig strand C 3017..3021 CDD:409353
Ig strand E 3036..3040 CDD:409353
Ig strand F 3050..3055 CDD:409353
Ig strand G 3063..3066 CDD:409353
I-set 3089..3162 CDD:400151
Ig strand B 3094..3098 CDD:409353
Ig strand C 3107..3111 CDD:409353
Ig strand E 3128..3132 CDD:409353
Ig strand F 3142..3147 CDD:409353
Ig strand G 3155..3158 CDD:409353
Ig 3165..3253 CDD:472250
Ig strand B 3185..3189 CDD:409353
Ig strand C 3198..3202 CDD:409353
Ig strand E 3219..3223 CDD:409353
Ig strand F 3233..3238 CDD:409353
Ig strand G 3246..3249 CDD:409353
Ig 3298..3355 CDD:472250
Ig strand B 3301..3305 CDD:409353
Ig strand C 3313..3316 CDD:409353
Ig strand E 3333..3336 CDD:409353
IG_like 3381..3457 CDD:214653
Ig strand B 3390..3394 CDD:409353
Ig strand C 3403..3407 CDD:409353
Ig strand F 3437..3442 CDD:409353
IG_like 3475..>3536 CDD:214653
Ig strand B 3480..3484 CDD:409353
Ig strand C 3491..3503 CDD:409353
Ig strand E 3519..3523 CDD:409353
Ig 3613..3675 CDD:472250
Ig strand B 3625..3629 CDD:409353
Ig strand C 3637..3642 CDD:409353
Ig strand E 3658..3662 CDD:409353
IG_like 3706..3772 CDD:214653
Ig strand B 3714..3718 CDD:409353
Ig strand C 3727..3731 CDD:409353
Ig strand E 3746..3750 CDD:409353
Ig strand F 3760..3765 CDD:409353
Ig strand G 3774..3777 CDD:409353
LamG 3794..3939 CDD:238058
EGF 3962..3994 CDD:394967
LamG 4042..4195 CDD:238058
EGF_CA 4254..4286 CDD:238011
LamG 4295..4448 CDD:238058
NetANP_511154.3 LamNT 44..280 CDD:214532 51/273 (19%)
EGF_Lam 312..357 CDD:238012 12/57 (21%)
EGF_Lam 369..426 CDD:238012 16/56 (29%)
EGF_Lam 431..479 CDD:238012 12/63 (19%)
NTR_netrin-1_like 545..723 CDD:239634 37/217 (17%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.