DRSC/TRiP Functional Genomics Resources

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Protein Alignment trol and Lrp1

DIOPT Version :10

Sequence 1:NP_001401049.1 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4489 Species:Drosophila melanogaster
Sequence 2:XP_008763615.1 Gene:Lrp1 / 299858 RGDID:1307535 Length:4562 Species:Rattus norvegicus


Alignment Length:2161 Identity:478/2161 - (22%)
Similarity:649/2161 - (30%) Gaps:961/2161 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   530 NECQA-NEFRCNNGDCIDARKRCNNVSDCSEGEDENEECPAACSGME-----YQCRDGTRCISVS 588
            :.|:| :||.|.||:||.....|:.||.|   :|:::|.|:.|:...     .||.:| ||:|..
  Rat  2540 SSCRAQDEFECANGECISFSLTCDGVSHC---KDKSDEKPSYCNSRRCKKTFRQCNNG-RCVSNM 2600

  Fly   589 QQCDGHSDCSDGDDEEHCDGSGYDSEECRFDEFHCGTGECIPMRQVCDNIYDCNDYSDEVNCVEG 653
            ..|:|..||.||.||..|:.:.     |...||.|..|.||.....|:...||.|.|||:||   
  Rat  2601 LWCNGVDDCGDGSDEIPCNKTA-----CGVGEFRCRDGSCIGNSSRCNQFVDCEDASDEMNC--- 2657

  Fly   654 EEEDRVGIPIGHQPWRPASKHDDWLHEMDTSEY-------QVYQPSNVYEKANSQNPCASNQFRC 711
                                     ...|.|.|       .::||                   |
  Rat  2658 -------------------------SATDCSSYFRLGVKGVLFQP-------------------C 2678

  Fly   712 TTSNVCIPLHLRCDGFYHCNDMSDEKSCEQYQRHTTTRRPLTLATPTSRITTQGPGLLERRNTTT 776
            ..:::|......|||...|.|.|||:.|                          ||:...|    
  Rat  2679 ERTSLCYAPSWVCDGANDCGDYSDERDC--------------------------PGVKRPR---- 2713

  Fly   777 ATEASRWPWATKTTTIATTTSNPITTVGVANSPPQTCLENIEFACHNRDCISIESVCDGIPDCGR 841
                                                |..|. |||.:..||.:...||...||..
  Rat  2714 ------------------------------------CPLNY-FACPSGRCIPMSWTCDKEDDCEN 2741

  Fly   842 NEDEDDALCKCSGDKYKCQRGGGCIPKSQVCDGKPQCHDRSDESACHLHGRLNKTRLGVKCLESQ 906
            .|||......||..:::|| ...||.|..:|||...|.|.|||:| |..|:        .|..|.
  Rat  2742 GEDETHCNKFCSEAQFECQ-NHRCISKQWLCDGSDDCGDGSDEAA-HCEGK--------TCGPSS 2796

  Fly   907 YQC-GDGSCISGYKRCNGIHDCADASDE---YNCIYDYEDTYDTDPNNNPLNECDILEFECDYSQ 967
            :.| |...|:.....|:|..||||.:||   ..|:|:              :.||..||.|....
  Rat  2797 FSCPGTHVCVPERWLCDGDKDCADGADESISAGCLYN--------------STCDDREFMCQNRL 2847

  Fly   968 CLPLEKKCDGYADCEDMSDEL-ECQSYTDHCLESEFEC-DSYCL-PRDQLCNGIPNCQDGSDER- 1028
            |:|....||...||.|.|||. ||:..|  |..:||.| :..|| .|...|:|..:|.|.|||. 
  Rat  2848 CIPKHFVCDHDRDCADGSDESPECEYPT--CGPNEFRCANGRCLSSRQWECDGENDCHDHSDEAP 2910

  Fly  1029 ---NCTF----CREDA-YLCNTGECVADNQRCNGIADCADGSDERHCARIYCPPNKLA-CNGTCV 1084
               :||.    |...: :||::|.|||:...|||..||.||||||.|....|...||: |:..|.
  Rat  2911 KNPHCTSPEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDGSDERGCHVNECLSRKLSGCSQDCE 2975

  Fly  1085 SRRI--KC----------DGIRDCLDGYDE--------MYCPETNNHYPTQNVNVIRPKLGPNPI 1129
            ..:|  ||          || |.|.| .||        ..|..|:..|....|....|:.|.   
  Rat  2976 DLKIGFKCRCRPGFRLKDDG-RTCAD-VDECSTTFPCSQLCINTHGSYKCLCVEGYAPRGGD--- 3035

  Fly  1130 PKSC------------------------------------------------------------- 1133
            |.||                                                             
  Rat  3036 PHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYRGQMIYWTDVTTQGSM 3100

  Fly  1134 --RPH----------------------EWQCANLECIDSSLQCNEIKDCS--------------- 1159
              |.|                      :|...||...|......|:...:               
  Rat  3101 IRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREP 3165

  Fly  1160 ----------------------------------------------------------------- 1159
                                                                             
  Rat  3166 RALVVDVQNGYLYWTDWGDHSLIGRIGMDGSGRSIIVDTKITWPNGLTVDYVTERIYWADAREDY 3230

  Fly  1160 ------DGSD---------------------------EELSVCFGTATT---------------- 1175
                  |||:                           |..|:.....||                
  Rat  3231 IEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGANKTLLISTLHRPMD 3295

  Fly  1176 ----------------------------RLKP----------------------SDCSPEQFYC- 1189
                                        .|.|                      |:|:..||.| 
  Rat  3296 LHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGGDGRTCVSNCTASQFVCK 3360

  Fly  1190 DESCYNRSVRCNGHVDCSDGSDEVGCSLP--CP-------QHQCPSGRCYTESERCDRHRHCEDG 1245
            ::.|.....:|:...||.|.|||     |  ||       |.||.:|.|...:..||....|:|.
  Rat  3361 NDKCIPFWWKCDTEDDCGDHSDE-----PPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDN 3420

  Fly  1246 SDEANC----CYANQFRCNNGD-CVSGSAPCNGYSECSDHSDELNCGGTQECLPNQFRCN-SGQC 1304
            ||||||    |..:||:|.|.: |:.|...|||...|.|..||.:|... .|.||||:|: :.:|
  Rat  3421 SDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEV-TCAPNQFQCSITKRC 3484

  Fly  1305 VSSSVRCNGRTDCQDSSDE------QNCAADSNDRRPNQLNLKTYPDSQIIKESREVIFRCRDEG 1363
            :.....|:...||.|.|||      ..|..|.                          |||:|.|
  Rat  3485 IPRVWVCDRDNDCVDGSDEPANCTQMTCGVDE--------------------------FRCKDSG 3523

  Fly  1364 ---PARAKVKWSRPGGRPLPPGFTDRNGRLEIPNIRVEDAGTYVCEAVGYASYIPGQQVTVNLNV 1425
               |||    |...|                     .:|.|                        
  Rat  3524 RCIPAR----WKCDG---------------------EDDCG------------------------ 3539

  Fly  1426 ERYNDVGSRPESACTE-----YQATCMNGECIDKSSICDGNPDCSDASDEQSCSLGLKCQPNQFM 1485
                |....|:..|.|     ||..|.|..|:.....||.:.||.|.|||:||: ...|..::|.
  Rat  3540 ----DGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCT-PRPCSESEFS 3599

  Fly  1486 CSNSKCVDRTWRCDGENDCGDNSDETSCDPEPSGAPCRYNEFQCRSGHCIPKSFQCDNVPDCTDG 1550
            |:|.:|:...|:|||::||.|.|||..|.|.     |..::|||:||||||..::||...||.||
  Rat  3600 CANGRCIAGRWKCDGDHDCADGSDEKDCTPR-----CDMDQFQCKSGHCIPLRWRCDADADCMDG 3659

  Fly  1551 TDEVGCMAPLPIRPPPQSVSLLEYEVLELTCVATGTPTPTIVWRL--------NWGHVPDKCESK 1607
            :||..|...:...|      |.|::.....|       ..:.|:.        |....|::|.  
  Rat  3660 SDEEACGTGVRTCP------LDEFQCNNTLC-------KPLAWKCDGEDDCGDNSDENPEECT-- 3709

  Fly  1608 SYGGTGTLRCPDMRP----------------------------QD-------------------- 1624
                  ..:||..||                            :|                    
  Rat  3710 ------RFQCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAQNPHCKDKKEFLCR 3768

  Fly  1625 -----SGAYSCEIINTRGTHFVNPDTIV----------------TVRPVRTD-----VCEAGFFN 1663
                 |.:..|.:.:..|......|..:                ..|.|||:     .|..||..
  Rat  3769 NQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASMCGDEARCVRTEKAAYCACRPGFHT 3833

  Fly  1664 MLARK-AEECVQCFCFGVAK----------ACDSANLFTYAIHPPILSHRVVSVELSPLRQIVIN 1717
            :..:. .::..:|..||...          .|..|..|       :.:|.....|.|..:.:.| 
  Rat  3834 VPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNF-------MKTHNTCKAEGSEYQVLYI- 3890

  Fly  1718 EAAPGQDLLTLLHGVQFRATNVHFSGRETPYLALPADYMGNQLKSYGGNLRYEVNYRGSGRPVNG 1782
              |...::.:|..|....|....|.|.|    ::..|.|...:|:  |.: |..|:.        
  Rat  3891 --ADDNEIRSLFPGHPHSAYEQAFQGDE----SVRIDAMDVHVKA--GRV-YWTNWH-------- 3938

  Fly  1783 PDVIITGNRFTLTYR---VRTQPGQNNR----------------------VSIPFVPGG--W--- 1817
                 ||   |::||   ....|..:||                      ::|.:|.|.  |   
  Rat  3939 -----TG---TISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDS 3995

  Fly  1818 ---------QKPDGRKASREEIMMILANVD---------------------NILIRLGYLDSTAR 1852
                     .|.:.||.      :|...:|                     :..|....:|.|.|
  Rat  3996 GRDVIEVAQMKGENRKT------LISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLR 4054

  Fly  1853 E--------------VDLIN------------------------IALDS-AGTADK--------- 1869
            |              ||..|                        :|:|| .|.:..         
  Rat  4055 ETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAVDSKRGLSHPFSIDVFEDY 4119

  Fly  1870 ---------------------------GLGSASLV-----------------EKCQ--CPPGYVG 1888
                                       ||..||.|                 :||:  |.....|
  Rat  4120 IYGVTYINNRVFKIHKFGHSPLINLTGGLSHASDVVLYHQHKQPEVTNPCDRKKCEWLCLLSPSG 4184

  Fly  1889 DSCESCASGYVRQPGGPWL--GHCVPF-----IPDSCPSGT-----------YGDPRRGVPCKEC 1935
            ..| :|       |.|..|  |.|||.     .||:...||           :.:.||...|: |
  Rat  4185 PVC-TC-------PNGKRLDNGTCVPVPSPTPPPDAPRPGTCTLQCFNGGSCFLNARRQPKCR-C 4240

  Fly  1936 PCPLTGSN----------NFASGCQQSPDGDVVCRCNEGYTGRRC-EQCAAGY----------QG 1979
            ....||..          :....|..||.|...|||..|:||.|| :|..|||          ||
  Rat  4241 QPRYTGDKCELDQCWEYCHNGGTCAASPSGMPTCRCPTGFTGPRCTQQVCAGYCANNSTCTVNQG 4305

  Fly  1980 N-------PLAAGGICR-RIPDTSCNVDGTYSVHSNGTCQCKDSVIGE-------QCDTCKSKSF 2029
            |       |...|..|: |.....|...||..:.::|:.||:.:|..|       :|..|...:.
  Rat  4306 NQPQCRCLPGFLGDRCQYRQCSGFCENFGTCQMAADGSRQCRCTVYFEGTRCEVNKCSRCLQGAC 4370

  Fly  2030 HLNSFTYTGCIECFCS 2045
            .:|.  .||.:.|.|:
  Rat  4371 VVNK--QTGDVTCNCT 4384

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trolNP_001401049.1 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060 14/32 (44%)
LDLa 571..606 CDD:238060 15/39 (38%)
LDLa 616..650 CDD:238060 14/33 (42%)
LDLa 704..739 CDD:238060 10/34 (29%)
LDLa 813..847 CDD:238060 14/33 (42%)
LDLa 852..887 CDD:238060 15/34 (44%)
LDLa 902..936 CDD:238060 13/37 (35%)
LDLa 956..990 CDD:238060 15/34 (44%)
LDLa 997..1030 CDD:238060 14/38 (37%)
LDLa 1033..1067 CDD:238060 18/34 (53%)
LDLa 1072..1105 CDD:238060 15/53 (28%)
LDLa 1133..1165 CDD:238060 11/229 (5%)
LDLa 1182..1215 CDD:238060 12/33 (36%)
LDLa 1221..1251 CDD:238060 13/29 (45%)
LDLa 1252..1286 CDD:238060 14/34 (41%)
LDLa 1292..1326 CDD:238060 14/40 (35%)
Ig 1344..1405 CDD:472250 12/63 (19%)
Ig strand B 1355..1359 CDD:409353 1/3 (33%)
Ig strand C 1369..1372 CDD:409353 0/2 (0%)
Ig strand E 1388..1392 CDD:409353 0/3 (0%)
LDLa 1439..1473 CDD:238060 15/38 (39%)
LDLa 1479..1513 CDD:238060 15/33 (45%)
LDLa 1522..1556 CDD:238060 18/33 (55%)
Ig_Perlecan_like 1574..1649 CDD:143220 14/151 (9%)
Ig strand B 1577..1583 CDD:143220 1/5 (20%)
Ig strand C 1590..1595 CDD:143220 1/4 (25%)
Ig strand E 1613..1617 CDD:143220 0/3 (0%)
Ig strand F 1626..1632 CDD:143220 1/5 (20%)
Ig strand G 1641..1647 CDD:143220 1/5 (20%)
Laminin_B 1748..1878 CDD:459652 40/281 (14%)
EGF_Lam 1935..1989 CDD:238012 24/81 (30%)
Laminin_B 2113..2249 CDD:459652
EGF_Lam <2250..2276 CDD:238012
EGF_Lam 2284..2333 CDD:238012
Laminin_EGF <2369..2399 CDD:395007
Laminin_B 2465..2599 CDD:459652
Ig_3 2688..2756 CDD:464046
Ig_3 2791..2861 CDD:464046
Ig_3 2890..2958 CDD:464046
Ig 2987..3071 CDD:472250
Ig strand B 3004..3008 CDD:409353
Ig strand C 3017..3021 CDD:409353
Ig strand E 3036..3040 CDD:409353
Ig strand F 3050..3055 CDD:409353
Ig strand G 3063..3066 CDD:409353
I-set 3089..3162 CDD:400151
Ig strand B 3094..3098 CDD:409353
Ig strand C 3107..3111 CDD:409353
Ig strand E 3128..3132 CDD:409353
Ig strand F 3142..3147 CDD:409353
Ig strand G 3155..3158 CDD:409353
Ig 3165..3253 CDD:472250
Ig strand B 3185..3189 CDD:409353
Ig strand C 3198..3202 CDD:409353
Ig strand E 3219..3223 CDD:409353
Ig strand F 3233..3238 CDD:409353
Ig strand G 3246..3249 CDD:409353
Ig 3298..3355 CDD:472250
Ig strand B 3301..3305 CDD:409353
Ig strand C 3313..3316 CDD:409353
Ig strand E 3333..3336 CDD:409353
IG_like 3381..3457 CDD:214653
Ig strand B 3390..3394 CDD:409353
Ig strand C 3403..3407 CDD:409353
Ig strand F 3437..3442 CDD:409353
IG_like 3475..>3536 CDD:214653
Ig strand B 3480..3484 CDD:409353
Ig strand C 3491..3503 CDD:409353
Ig strand E 3519..3523 CDD:409353
Ig 3613..3675 CDD:472250
Ig strand B 3625..3629 CDD:409353
Ig strand C 3637..3642 CDD:409353
Ig strand E 3658..3662 CDD:409353
IG_like 3706..3772 CDD:214653
Ig strand B 3714..3718 CDD:409353
Ig strand C 3727..3731 CDD:409353
Ig strand E 3746..3750 CDD:409353
Ig strand F 3760..3765 CDD:409353
Ig strand G 3774..3777 CDD:409353
LamG 3794..3939 CDD:238058
EGF 3962..3994 CDD:394967
LamG 4042..4195 CDD:238058
EGF_CA 4254..4286 CDD:238011
LamG 4295..4448 CDD:238058
Lrp1XP_008763615.1 LDLa 27..60 CDD:197566
LDLa 72..105 CDD:197566
FXa_inhibition 120..149 CDD:464251
FXa_inhibition 159..189 CDD:464251
LY 276..315 CDD:214531
LY 317..359 CDD:214531
LY 362..402 CDD:214531
FXa_inhibition 487..520 CDD:464251
LY 552..594 CDD:214531
LY 595..634 CDD:214531
LY 641..690 CDD:214531
LY <701..734 CDD:214531
FXa_inhibition 808..843 CDD:464251
LDLa 854..886 CDD:197566
LDLa 896..929 CDD:238060
LDLa 936..968 CDD:197566
LDLa 979..1012 CDD:238060
LDLa 1033..1066 CDD:238060
LDLa 1080..1115 CDD:238060
LDLa 1122..1158 CDD:238060
LDLa 1163..1196 CDD:238060
FXa_inhibition 1203..1239 CDD:464251
Vgb 1328..>1521 CDD:443399
LY 1354..1394 CDD:214531
LY 1398..1441 CDD:214531
LY 1631..1667 CDD:214531
LY 1668..1711 CDD:214531
LY 1715..1752 CDD:214531
LY 1752..1793 CDD:214531
FXa_inhibition 1868..1904 CDD:464251
LY 1934..1974 CDD:214531
LY 1977..2017 CDD:214531
LY 2018..2061 CDD:214531
LY 2063..2105 CDD:214531
FXa_inhibition 2177..2212 CDD:464251
LY 2293..2333 CDD:214531
Ldl_recept_b 2362..2404 CDD:459654
LY 2388..2429 CDD:214531
FXa_inhibition 2500..2532 CDD:464251
LDLa 2545..2575 CDD:238060 12/32 (38%)
LDLa 2584..2618 CDD:238060 14/34 (41%)
LDLa 2623..2657 CDD:238060 14/33 (42%)
LDLa <2684..2706 CDD:238060 9/21 (43%)
LDLa 2714..2748 CDD:238060 14/34 (41%)
LDLa 2752..2783 CDD:197566 13/31 (42%)
LDLa 2791..2824 CDD:197566 11/32 (34%)
LDLa 2835..2867 CDD:197566 13/31 (42%)
LDLa 2875..2908 CDD:197566 13/34 (38%)
LDLa 2925..2957 CDD:238060 17/31 (55%)
cEGF 2982..3003 CDD:463661 7/22 (32%)
EGF_CA 3000..>3029 CDD:214542 7/29 (24%)
LY 3067..3111 CDD:214531 2/43 (5%)
LY 3112..3154 CDD:214531 5/41 (12%)
LY 3156..3198 CDD:214531 0/41 (0%)
LY 3200..3241 CDD:214531 3/40 (8%)
LY 3242..3282 CDD:214531 4/39 (10%)
FXa_inhibition 3312..3348 CDD:464251 2/35 (6%)
LDLa 3352..3383 CDD:238060 10/30 (33%)
LDLa 3392..3426 CDD:238060 13/33 (39%)
LDLa 3431..3466 CDD:238060 14/34 (41%)
LDLa 3470..3503 CDD:197566 12/32 (38%)
LDLa 3511..3544 CDD:197566 15/111 (14%)
LDLa 3554..3588 CDD:238060 13/33 (39%)
LDLa 3593..3627 CDD:238060 15/33 (45%)
LDLa 3631..3665 CDD:238060 18/33 (55%)
LDLa 3671..3703 CDD:197566 6/44 (14%)
LDLa 3713..3749 CDD:238060 4/35 (11%)
LDLa 3764..3794 CDD:238060 3/29 (10%)
YncE 3880..4082 CDD:442618 41/233 (18%)
LY 3973..4010 CDD:214531 5/36 (14%)
Ldl_recept_b 4031..4072 CDD:459654 6/40 (15%)
LY 4055..4096 CDD:214531 4/40 (10%)
Blue background indicates that the domain is not in the aligned region.

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