| Sequence 1: | NP_001401049.1 | Gene: | trol / 45320 | FlyBaseID: | FBgn0284408 | Length: | 4489 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_077334.2 | Gene: | Notch2 / 29492 | RGDID: | 3188 | Length: | 2471 | Species: | Rattus norvegicus |
| Alignment Length: | 3228 | Identity: | 599/3228 - (18%) |
|---|---|---|---|
| Similarity: | 911/3228 - (28%) | Gaps: | 1390/3228 - (43%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 391 PQEEVEGSGSDDSSCRGDATFTCPRSGKTICDEMRCDREIQCPDGEDEEYCNYPNVCTEDQFKCD 455
Fly 456 DKCLELKKRCDGSIDCLDQT--DEAGCINAPEPEPEPEPEPEPEPESEPEAEPEPEPEPEPESEP 518
Fly 519 EQEPEPQVPEANECQANEFRCNNG-----------DC---------------IDARKRCNNVSDC 557
Fly 558 SEGEDE-NEECPAACSGMEY-----------QCRDGTRCISV--SQQCDGHSDCSDGDDEEHCDG 608
Fly 609 SGYDSEECRFDEFHCGTGECI---PMRQVCDNIYDCNDYSDEVNCVEGEEEDRVGIPIGHQPWRP 670
Fly 671 ASKHDDWLHEMDTSEYQVYQPSNVYEKANSQ---NPCASNQFRCTTSNVCIPLHLRCDGF--YHC 730
Fly 731 NDMSDEKSCEQYQRHTTTRRPLTLATPTSRITTQGPGLLERRNTTTATEASRWPWATKTTTIATT 795
Fly 796 TSNPITTVGVANSPPQTCLENIE------------FACHNRD----CISIESVCDGIPDCGRNED 844
Fly 845 EDDALCKCSGDKYKCQRGGGCIPK----SQVC-DGKP--QCH--DRSDESACHLHGRLNKTRLGV 900
Fly 901 KC----LESQYQCGDGSCISGYKRCNGIHDCADASDEYNCIYDYEDTYDTDPNNNP---LNECDI 958
Fly 959 LE--FECDYSQCLPLEKKCDGYAD--CEDMSDELECQSYTDHCLESEFECDSYCLPRDQLCNGIP 1019
Fly 1020 NCQDGSDERNCTFCREDAYLCNTGECVADNQRCNGIADCADGSDERHCARIYCPPNKLACNGTCV 1084
Fly 1085 SRRIKCDGIRDCLDGYDEMYCPETNNHYPTQNVNVIRPKLGPNPIPKSCRPHEWQCAN-LECID- 1147
Fly 1148 -SSLQCNEIKDCSDG-----SDEELSVCFGTATTRLKPSDCSPEQFYCDESCYNRSVRCN-GHVD 1205
Fly 1206 --CSDGSDEVGC-SLPCPQHQCPSGRC--YTESERCDRHRHCEDGSDEANC------CYANQFRC 1259
Fly 1260 NNGDCVSGSAPCNGYS-ECSDHSDELNCGGTQECLPNQFRCN--SGQCVSSSVRCNGRTDCQDSS 1321
Fly 1322 DEQNCAADSNDRRPNQLNLKTYPDSQIIKESREVIFRCR-DEGPARAKVKWSRPGGRPLPPGFTD 1385
Fly 1386 RNGRLEIPNIRVEDAGTYVCEAVGYASYIPGQQVTVNLNVERYNDVGSRP---ESACTE----YQ 1443
Fly 1444 ATCMNG----ECIDKSSICDGNP-----DCSDASDEQSCS-----LGLKCQPNQFMCSNSKCVDR 1494
Fly 1495 TWRCDGEND--CGDNSDETS----CDPEPSGAPCRYNEFQCRSGHCIPK--------SFQCDNVP 1545
Fly 1546 -----DCTDGTDEVGCMAPLPIRPPPQSVSLLEYEVLELTCVATGTPTPTIVWRLNWGHVPDKCE 1605
Fly 1606 SK---------SYGGTGTLRCPDMRPQDSGAYSCEIINTRGTHFVNPDTIVTVRPVRTDVCEAGF 1661
Fly 1662 FNM-LARKAEECVQCFCFGVAKACDSANLFTYAIHP-----PILSHRVVSVELSPLRQIVINEAA 1720
Fly 1721 PGQDLLTLLHGV-QFRATNVHFSGRETPYLALPADYMGNQLKSYGGNLRYEVNYRGSGRPVNGPD 1784
Fly 1785 VIITGNRFTLTYRVRTQPGQNNRVSIP-------FVPGGW-----------------QK--PDGR 1823
Fly 1824 KASREEIMMILANVDNILIRLGYLDSTAREVDLINIALD--SAGTADKGLGSASLV--EKCQCPP 1884
Fly 1885 GYVGDSCE---------SCASGYVRQPGGPWLGHCVPFIPD---SCPSGTYGDPRRGVPCKECPC 1937
Fly 1938 PLTGSNNFASGCQQSPD--GDVVCRCNEGYTGRRCE----QCAAGYQGNPLAAGG---------- 1986
Fly 1987 ---ICRR-------------IPDTSCNVDGTYSVHSN----GTCQCKDSVIGEQCDT------CK 2025
Fly 2026 --SKSFHLNSFTYTGCIECFCSGVGLDCDSSTWYRDQVTSTFGRSRVDHGFVLVTNYMQPTPDTV 2088
Fly 2089 PVSMAAEPNALSFIGSADQSGNTLYWSLPAA--FLGNKLSSYGGKLTYTLSYSPLPNGIMSRNSA 2151
Fly 2152 PDVVIKSGEDLRLIHYRKSQVVPSVANTYSVEIKESAWQRGDEVVANREHVLMALSDITAIYIKA 2216
Fly 2217 TYTTSTKEASLRQVTLDVATPTNLGTPRAVEVEQCRCPEGYLGLSCEQCAPGYARDPEGGIYLGL 2281
Fly 2282 CRPC-------ECNGHSKYCNSDTGDCEECSDNTEGPSCERCAAGYVGDATRGTIYDC---QPD- 2335
Fly 2336 --EGYPIPSPPAPGNQTL-ECTAYCQIEG------------------IYDCRGNECLC------- 2372
Fly 2373 --------KRNVIGD---------QC----DQCRPGTYGLSAQNQDGCKECYCSGLASQCRSAAL 2416
Fly 2417 YRQLIPVDFILNAPLITDESGAVQDTENLIPDISRNMYTYTHTSYLPKYWSLRGSVLGNQLFSYG 2481
Fly 2482 GRLSYSLIVESY------GNYER----GHDIV-------------LIGNGLKLIWSRPDGNE--- 2520
Fly 2521 -NQEEYNVRLHEDE-----QWTRQDRESARPASRSDFMTVLSDLQHILIRATPRV---PTQSTSI 2576
Fly 2577 GNVILESAVTTRTPGATHASDIELCQCPSGYVGTSCESCAPLHYRDASGSCSLCPCDVSNTESCD 2641
Fly 2642 LVSGGYVECRCKARWKGDRCREIDTNDPTDIGTEDPVLTQII---VSIQ-KPEITIVPVGGSMTL 2702
Fly 2703 SCSGR-------MRWSNSPVIVNWYKENSRLPENVEVQGGNLYLYDLQVSDSGVYICQAVNNETA 2760
Fly 2761 SVFKDTVSITITRYAQEMLARYEKDQLSPAEIVNLPSHVTFEEYVNNEIICEVLGNPAPRVTWAR 2825
Fly 2826 VDGHAD-----AQSTRTYDNRLIFDSPRKSDEGRYRCQAENDQNRDEKYVIVYVQSNPPQPPPQQ 2885
Fly 2886 DRLYITPEEINGLAGESFQLNCQFTSVASLRYDWSHNGRSLSSSPARNVEIRGNTLEVRDASESD 2950
Fly 2951 SGVYTCVAYDVRTRRNFTESARVNIDRREEQPFGNKPIIESLEQ-----------NILIIQGEDY 3004
Fly 3005 SITCEASG-------SP--------YPSIKWA---------KVHDFMPENV-HISGNVLTIYGAR 3044
Fly 3045 FENRGVYSCVAENDHGSDLSSTSIDIEPRERPSVKIVSAPLQTFSVGAPASLYCTVEGI----PD 3105
Fly 3106 PTVEWVRVDGQPLSPRHKIQSPGYMVIDDIQLEDSGDYECRAKNIVGEATGVATITVQEPTLVQI 3170
Fly 3171 IPDNRDLRLTEGDELSLTCVGSGVPNPEVEWVNEMALKRDLYS 3213 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| trol | NP_001401049.1 | LDLa | 447..480 | CDD:238060 | 7/34 (21%) |
| LDLa | 532..564 | CDD:238060 | 10/58 (17%) | ||
| LDLa | 571..606 | CDD:238060 | 8/47 (17%) | ||
| LDLa | 616..650 | CDD:238060 | 6/36 (17%) | ||
| LDLa | 704..739 | CDD:238060 | 8/36 (22%) | ||
| LDLa | 813..847 | CDD:238060 | 10/49 (20%) | ||
| LDLa | 852..887 | CDD:238060 | 11/43 (26%) | ||
| LDLa | 902..936 | CDD:238060 | 13/37 (35%) | ||
| LDLa | 956..990 | CDD:238060 | 11/37 (30%) | ||
| LDLa | 997..1030 | CDD:238060 | 7/32 (22%) | ||
| LDLa | 1033..1067 | CDD:238060 | 6/33 (18%) | ||
| LDLa | 1072..1105 | CDD:238060 | 8/32 (25%) | ||
| LDLa | 1133..1165 | CDD:238060 | 10/39 (26%) | ||
| LDLa | 1182..1215 | CDD:238060 | 11/35 (31%) | ||
| LDLa | 1221..1251 | CDD:238060 | 6/31 (19%) | ||
| LDLa | 1252..1286 | CDD:238060 | 12/34 (35%) | ||
| LDLa | 1292..1326 | CDD:238060 | 8/35 (23%) | ||
| Ig | 1344..1405 | CDD:472250 | 12/61 (20%) | ||
| Ig strand B | 1355..1359 | CDD:409353 | 1/3 (33%) | ||
| Ig strand C | 1369..1372 | CDD:409353 | 0/2 (0%) | ||
| Ig strand E | 1388..1392 | CDD:409353 | 1/3 (33%) | ||
| LDLa | 1439..1473 | CDD:238060 | 11/46 (24%) | ||
| LDLa | 1479..1513 | CDD:238060 | 9/39 (23%) | ||
| LDLa | 1522..1556 | CDD:238060 | 9/46 (20%) | ||
| Ig_Perlecan_like | 1574..1649 | CDD:143220 | 14/83 (17%) | ||
| Ig strand B | 1577..1583 | CDD:143220 | 1/5 (20%) | ||
| Ig strand C | 1590..1595 | CDD:143220 | 0/4 (0%) | ||
| Ig strand E | 1613..1617 | CDD:143220 | 0/3 (0%) | ||
| Ig strand F | 1626..1632 | CDD:143220 | 2/5 (40%) | ||
| Ig strand G | 1641..1647 | CDD:143220 | 0/5 (0%) | ||
| Laminin_B | 1748..1878 | CDD:459652 | 24/159 (15%) | ||
| EGF_Lam | 1935..1989 | CDD:238012 | 17/72 (24%) | ||
| Laminin_B | 2113..2249 | CDD:459652 | 19/137 (14%) | ||
| EGF_Lam | <2250..2276 | CDD:238012 | 5/25 (20%) | ||
| EGF_Lam | 2284..2333 | CDD:238012 | 13/58 (22%) | ||
| Laminin_EGF | <2369..2399 | CDD:395007 | 9/57 (16%) | ||
| Laminin_B | 2465..2599 | CDD:459652 | 33/168 (20%) | ||
| Ig_3 | 2688..2756 | CDD:464046 | 10/74 (14%) | ||
| Ig_3 | 2791..2861 | CDD:464046 | 8/74 (11%) | ||
| Ig_3 | 2890..2958 | CDD:464046 | 3/67 (4%) | ||
| Ig | 2987..3071 | CDD:472250 | 17/119 (14%) | ||
| Ig strand B | 3004..3008 | CDD:409353 | 1/3 (33%) | ||
| Ig strand C | 3017..3021 | CDD:409353 | 2/3 (67%) | ||
| Ig strand E | 3036..3040 | CDD:409353 | 0/3 (0%) | ||
| Ig strand F | 3050..3055 | CDD:409353 | 1/4 (25%) | ||
| Ig strand G | 3063..3066 | CDD:409353 | 2/2 (100%) | ||
| I-set | 3089..3162 | CDD:400151 | 14/76 (18%) | ||
| Ig strand B | 3094..3098 | CDD:409353 | 1/3 (33%) | ||
| Ig strand C | 3107..3111 | CDD:409353 | 0/3 (0%) | ||
| Ig strand E | 3128..3132 | CDD:409353 | 0/3 (0%) | ||
| Ig strand F | 3142..3147 | CDD:409353 | 0/4 (0%) | ||
| Ig strand G | 3155..3158 | CDD:409353 | 1/2 (50%) | ||
| Ig | 3165..3253 | CDD:472250 | 13/49 (27%) | ||
| Ig strand B | 3185..3189 | CDD:409353 | 2/3 (67%) | ||
| Ig strand C | 3198..3202 | CDD:409353 | 0/3 (0%) | ||
| Ig strand E | 3219..3223 | CDD:409353 | |||
| Ig strand F | 3233..3238 | CDD:409353 | |||
| Ig strand G | 3246..3249 | CDD:409353 | |||
| Ig | 3298..3355 | CDD:472250 | |||
| Ig strand B | 3301..3305 | CDD:409353 | |||
| Ig strand C | 3313..3316 | CDD:409353 | |||
| Ig strand E | 3333..3336 | CDD:409353 | |||
| IG_like | 3381..3457 | CDD:214653 | |||
| Ig strand B | 3390..3394 | CDD:409353 | |||
| Ig strand C | 3403..3407 | CDD:409353 | |||
| Ig strand F | 3437..3442 | CDD:409353 | |||
| IG_like | 3475..>3536 | CDD:214653 | |||
| Ig strand B | 3480..3484 | CDD:409353 | |||
| Ig strand C | 3491..3503 | CDD:409353 | |||
| Ig strand E | 3519..3523 | CDD:409353 | |||
| Ig | 3613..3675 | CDD:472250 | |||
| Ig strand B | 3625..3629 | CDD:409353 | |||
| Ig strand C | 3637..3642 | CDD:409353 | |||
| Ig strand E | 3658..3662 | CDD:409353 | |||
| IG_like | 3706..3772 | CDD:214653 | |||
| Ig strand B | 3714..3718 | CDD:409353 | |||
| Ig strand C | 3727..3731 | CDD:409353 | |||
| Ig strand E | 3746..3750 | CDD:409353 | |||
| Ig strand F | 3760..3765 | CDD:409353 | |||
| Ig strand G | 3774..3777 | CDD:409353 | |||
| LamG | 3794..3939 | CDD:238058 | |||
| EGF | 3962..3994 | CDD:394967 | |||
| LamG | 4042..4195 | CDD:238058 | |||
| EGF_CA | 4254..4286 | CDD:238011 | |||
| LamG | 4295..4448 | CDD:238058 | |||
| Notch2 | NP_077334.2 | EGF_CA | 109..143 | CDD:238011 | 5/34 (15%) |
| EGF_CA | 182..218 | CDD:238011 | 7/39 (18%) | ||
| EGF_CA | 260..296 | CDD:238011 | 12/115 (10%) | ||
| EGF_CA | 298..335 | CDD:238011 | 4/38 (11%) | ||
| EGF_CA | 415..454 | CDD:238011 | 14/58 (24%) | ||
| EGF_CA | 456..492 | CDD:238011 | 12/44 (27%) | ||
| EGF_CA | 495..530 | CDD:238011 | 11/49 (22%) | ||
| EGF_CA | 532..567 | CDD:238011 | 13/80 (16%) | ||
| EGF_CA | 570..604 | CDD:238011 | 8/43 (19%) | ||
| EGF_CA | 608..643 | CDD:238011 | 13/44 (30%) | ||
| EGF_CA | 645..679 | CDD:238011 | 14/51 (27%) | ||
| EGF_CA | 682..717 | CDD:238011 | 15/82 (18%) | ||
| EGF_CA | 757..793 | CDD:238011 | 8/36 (22%) | ||
| EGF_CA | 795..831 | CDD:238011 | 7/35 (20%) | ||
| EGF_CA | 873..909 | CDD:238011 | 7/35 (20%) | ||
| EGF_CA | 911..947 | CDD:238011 | 10/54 (19%) | ||
| EGF_CA | 949..985 | CDD:238011 | 11/68 (16%) | ||
| EGF_CA | 987..1022 | CDD:238011 | 9/35 (26%) | ||
| EGF_CA | 1025..1061 | CDD:238011 | 10/90 (11%) | ||
| EGF_CA | 1117..1147 | CDD:238011 | 6/29 (21%) | ||
| EGF_CA | 1151..1185 | CDD:238011 | 8/33 (24%) | ||
| EGF_CA | 1188..1223 | CDD:238011 | 11/49 (22%) | ||
| EGF_CA | 1225..1262 | CDD:238011 | 11/37 (30%) | ||
| EGF_CA | 1264..1302 | CDD:238011 | 6/41 (15%) | ||
| EGF_CA | <1312..1343 | CDD:238011 | 9/30 (30%) | ||
| Notch | 1423..1456 | CDD:459658 | 6/82 (7%) | ||
| Negative regulatory region (NRR). /evidence=ECO:0000250 | 1425..1677 | 58/365 (16%) | |||
| Notch | 1463..1497 | CDD:459658 | 9/50 (18%) | ||
| Notch | 1501..1534 | CDD:459658 | 8/39 (21%) | ||
| NOD | 1539..1594 | CDD:462014 | 8/54 (15%) | ||
| NODP | 1618..1673 | CDD:462229 | 17/83 (20%) | ||
| JMTM_Notch2 | 1659..1740 | CDD:411986 | 16/90 (18%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1751..1788 | 7/36 (19%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1794..1813 | 8/36 (22%) | |||
| ANK repeat | 1827..1874 | CDD:293786 | 12/80 (15%) | ||
| ANK 1 | 1827..1871 | 11/77 (14%) | |||
| ANKYR | <1851..2066 | CDD:440430 | 47/365 (13%) | ||
| ANK 2 | 1876..1905 | 6/33 (18%) | |||
| ANK repeat | 1877..1907 | CDD:293786 | 6/29 (21%) | ||
| ANK 3 | 1909..1939 | 3/29 (10%) | |||
| ANK repeat | 1943..1974 | CDD:293786 | 10/69 (14%) | ||
| ANK 4 | 1943..1972 | 10/67 (15%) | |||
| ANK repeat | 1976..2007 | CDD:293786 | 7/51 (14%) | ||
| ANK 5 | 1976..2005 | 7/49 (14%) | |||
| ANK repeat | 2009..2040 | CDD:293786 | 11/111 (10%) | ||
| ANK 6 | 2009..2038 | 10/109 (9%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2097..2116 | 2/18 (11%) | |||
| Atrophin-1 | 2105..>2422 | CDD:460830 | 40/199 (20%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2380..2471 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||