DRSC/TRiP Functional Genomics Resources

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Protein Alignment trol and Agrn

DIOPT Version :10

Sequence 1:NP_001401049.1 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4489 Species:Drosophila melanogaster
Sequence 2:XP_017448655.1 Gene:Agrn / 25592 RGDID:2067 Length:2066 Species:Rattus norvegicus


Alignment Length:2968 Identity:575/2968 - (19%)
Similarity:861/2968 - (29%) Gaps:1249/2968 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly  1764 GGNLRYEVNYRGSGRPVNGPDVIITGNRFTLTYRVRTQPGQNNRVSIPFVPGGWQKPDGRKASRE 1828
            |||   :|...|.|.|:...:.:.||:  |..:.|...|        |::   |      .|.:.
  Rat    90 GGN---KVVIGGFGDPLICDNQVSTGD--TRIFFVNPAP--------PYM---W------PAHKN 132

  Fly  1829 EIMMILANVDNILIRLGYLDSTAREVDLINIAL-DSAG-----------TADKGL---------- 1871
            |:|:     ::.|:|:     |.|.::.:...: |..|           ...:|:          
  Rat   133 ELML-----NSSLMRI-----TLRNLEEVEFCVEDKPGIHFTPAPPTPPDVCRGMLCGFGAVCEP 187

  Fly  1872 -----GSASLVEKCQCPPGYVGDSCESCASGY-------------------VRQPGGPWLGHCVP 1912
                 |.||.|.|....|..|...|.|.||.|                   :||  || .|...|
  Rat   188 SVEDPGRASCVCKKNACPATVAPVCGSDASTYSNECELQRAQCNQQRRIRLLRQ--GP-CGSRDP 249

  Fly  1913 FIPDSCPSGTYGDPRRGVPCKECPCPLTGSNNFASGCQQSPDGDV-----------------VCR 1960
            ....:|..|:...|........|.||.|        |..:|||.|                 .|.
  Rat   250 CANVTCSFGSTCVPSADGQTASCLCPTT--------CFGAPDGTVCGSDGVDYPSECQLLSHACA 306

  Fly  1961 CNE----GYTGRRCEQCAAGYQGNPLAAGGICRRIPDTS------------------CNVDG-TY 2002
            ..|    .:.| .|:.|    ||:......|||..|.|.                  |..|| ||
  Rat   307 SQEHIFKKFNG-PCDPC----QGSMSDLNHICRVNPRTRHPEMLLRPENCPAQHTPICGDDGVTY 366

  Fly  2003 S---VHS--------------NGTCQCKDSVIGEQC-DTCKSKSFHLNSFTYTGCIECFCSGVGL 2049
            .   |.|              :|.||.:|     || :||:..|..|:.   .|...|.|..|  
  Rat   367 ENDCVMSRIGATRGLLLQKVRSGQCQTRD-----QCPETCQFNSVCLSR---RGRPHCSCDRV-- 421

  Fly  2050 DCDSSTWYRDQVTSTFGRSRVDHGFVLVTNYMQPTPDTVPVSMAAEPNALSFIGSADQSGNTL-- 2112
            .||.|  ||                              ||              ..|.|:|.  
  Rat   422 TCDGS--YR------------------------------PV--------------CAQDGHTYNN 440

  Fly  2113 -YW----------SLPAAFLGNKLSSYGGKLTYTLSYSPLP-NGIMSRNSAPDVVIKSG----ED 2161
             .|          ::|....|            ....:|.| :|:.....|. ..:|:|    |.
  Rat   441 DCWRQQAECRQQRAIPPKHQG------------PCDQTPSPCHGVQCAFGAV-CTVKNGKAECEC 492

  Fly  2162 LRLIHYRKSQVVPSVANTYS--VEIKESAWQRGDEV-VANREHVLMALSDITAIYIKATYTTSTK 2223
            .|:.......|..|...||.  .|::..|...|.|: ||                          
  Rat   493 QRVCSGIYDPVCGSDGVTYGSVCELESMACTLGREIQVA-------------------------- 531

  Fly  2224 EASLRQVTLDVATPTNLGTPRAVEVEQCRCPEGYLGLSC-EQCAPGYARDPEGGIYLGLCRPCEC 2287
                |:...|.......|:...||..:|.||.     .| |...|....|  |..|..     ||
  Rat   532 ----RRGPCDPCGQCRFGSLCEVETGRCVCPS-----ECVESAQPVCGSD--GHTYAS-----EC 580

  Fly  2288 NGHSKYCN-------SDTGDCEECSDNTEGPSCERCAAGYVGDATRGTIYDCQPDEGYPIPSPPA 2345
            ..|...|.       :..|.|:.|.:..       |..|.|..|.:.....|:    :|   ||.
  Rat   581 ELHVHACTHQISLYVASAGHCQTCGEKV-------CTFGAVCSAGQCVCPRCE----HP---PPG 631

  Fly  2346 PGNQTLECTAYCQIEGI---YDCRGNECLCKRNVIGDQ-----CDQCRPGTYGLSAQNQDGCKEC 2402
            |         .|..:|:   ..|...|..|::.|..::     |:....|:.|..:...|.|::.
  Rat   632 P---------VCGSDGVTYLSACELREAACQQQVQIEEAHAGPCEPAECGSGGSGSGEDDECEQE 687

  Fly  2403 YCSGLASQCRSAALYRQLIPVDFILNAPLITDESGAVQDTEN----LIPDISRNMYTYTHTSYLP 2463
            .|.                             :.|.:.|.::    .:.|.|        ...:|
  Rat   688 LCR-----------------------------QRGGIWDEDSEDGPCVCDFS--------CQSVP 715

  Fly  2464 KYWSLRGSVLGNQLFSYGGRLSYSLIVESYGNYERGHDIVLIGNGLKLIWSRPDGNENQEEYNVR 2528
                 |..|.|:...:||.....                            :....|:|:|..| 
  Rat   716 -----RSPVCGSDGVTYGTECDL----------------------------KKARCESQQELYV- 746

  Fly  2529 LHEDEQWTRQDRESARPASRSDFMTVLSDLQHILIRATPRVPTQS--TSIGNVILESAVTT--RT 2589
                         :|:.|.|...:..|..:.......||....|.  |:...|.|....:|  ..
  Rat   747 -------------AAQGACRGPTLAPLLPVAFPHCAQTPYGCCQDNFTAAQGVGLAGCPSTCHCN 798

  Fly  2590 PGATHASDIE----LCQCPSGYVGTSCESCAP--LHYR----DASGSCSLCPCDVSNT--ESCDL 2642
            |..:::...:    .|.|..|..|..|:.|.|  .::|    |....|:.|.||....  :.|:.
  Rat   799 PHGSYSGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGHSGCTPCSCDPRGAVRDDCEQ 863

  Fly  2643 VSGGYVECRCKARWKGDRCREI-DTNDPTDIGTE-DPVLTQIIVSIQKPEITIVPVGGSMTLSCS 2705
            ::|   .|.|:....|.:|.:. |......:|.| ||:          ..:|.|.:......|| 
  Rat   864 MTG---LCSCRPGVAGPKCGQCPDGQVLGHLGCEADPM----------TPVTCVEIHCEFGASC- 914

  Fly  2706 GRMRWSNSPVIVNWYKENSRLPENVEVQGGNLYLYDLQVSDSGVYICQAVNNETASVFKDTVSIT 2770
                                    ||..|                                    
  Rat   915 ------------------------VEKAG------------------------------------ 919

  Fly  2771 ITRYAQEMLARYEKDQLSPAEIVNLPSHVTFEEYVNNEIICEVLGNPAPRVTWARVDGHADAQST 2835
               :||                                .||..|..|             :|.||
  Rat   920 ---FAQ--------------------------------CICPTLTCP-------------EANST 936

  Fly  2836 RTYDNRLIFDSPRKSDEGRYRCQAENDQNRDEKYVIVYVQSNPPQPPPQQDRLYITPEEINGLAG 2900
            :                                                          :.|..|
  Rat   937 K----------------------------------------------------------VCGSDG 943

  Fly  2901 ESFQLNCQFTSVASLRYDWSHNGRSLSSSPARNVEIRGNTLEVRDASESDSGVYTCVAYDVRTRR 2965
            .::...||..::|..:                                                 
  Rat   944 VTYGNECQLKAIACRQ------------------------------------------------- 959

  Fly  2966 NFTESARVNIDRREEQPFGNKPIIESLEQNILIIQGEDYSITCEASGSPYPSIKWAKVHDFMPEN 3030
                  |::|..:...|                         |:.|.:|                
  Rat   960 ------RLDISTQSLGP-------------------------CQESVTP---------------- 977

  Fly  3031 VHISGNVLTIYGARFENRGVYSCVAENDHGSDLSSTSIDIEPRERPSVKIVSAPLQTFSVGAPAS 3095
                                         |:..:|.|: ..||.     |:|..|.......|.|
  Rat   978 -----------------------------GASPTSASM-TTPRH-----ILSKTLPFPHNSLPLS 1007

  Fly  3096 LYCTVEGIPDPTVEWVRVDGQPLSPRHKIQSPGYMVIDDIQLEDSGDYECRAKNIVGEATGVATI 3160
            ...|....|.|.         |:||...:..|                         .:|....:
  Rat  1008 PGSTTHDWPTPL---------PISPHTTVSIP-------------------------RSTAWPVL 1038

  Fly  3161 TVQEPTLVQIIPDNRDLRLTEGDELSLTCVGSGVPNPEVEWVNEMALKRDLYSPPSNTAILKIYR 3225
            ||                                                   ||:..|    ..
  Rat  1039 TV---------------------------------------------------PPTAAA----SD 1048

  Fly  3226 VTKADAGIYTCHGKNEAGSDEAHVRVEVQERRGDIGGVDDDSDRDPINYNPPQQQNPGIHQPGSN 3290
            ||.....|::..|......|| .:..:.:...|..||::.......:.:.||.::....:.|   
  Rat  1049 VTSLATSIFSESGSANGSGDE-ELSGDEEASGGGSGGLEPPVGSIVVTHGPPIERASCYNSP--- 1109

  Fly  3291 QLLATDIG---DNVTLTCDMFQPLNTRWERVDGAPLPRNAYTIKNRLEIVRVEQQNLGQYRCNGI 3352
                  :|   |..|.:.|.           :|:..|... ..:..||:..||.|.|        
  Rat  1110 ------LGCCSDGKTPSLDS-----------EGSNCPATK-AFQGVLELEGVEGQEL-------- 1148

  Fly  3353 GRDGNVKTYFVKELVLMPLPRIRFYPNIPLTVEAGQNLDVHCQVENVRPEDV---HWSTDNNRPL 3414
                    ::..|   |..|:...:.....::|:  .||     :..|..||   .||.......
  Rat  1149 --------FYTPE---MADPKSELFGETARSIES--TLD-----DLFRNSDVKKDFWSVRLRELG 1195

  Fly  3415 PSS-VRIVGSVLRFVSITQAAAGEYRCSAFNQYGNRSQIAR---VAVKKPADFHQVPQSQLQRHR 3475
            |.. ||.:..| .|...|...|.:...:...|.    |::|   :||::|          ||.| 
  Rat  1196 PGKLVRAIVDV-HFDPTTAFQASDVGQALLRQI----QVSRPWALAVRRP----------LQEH- 1244

  Fly  3476 EGENIQLQCTVTDQYGVRAQDNVEFNWFRDDRRPLP---NNARTDSQILVLTNLRPEDAGRYICN 3537
                            ||..|   |:||       |   ..|.|.:...:.|           ..
  Rat  1245 ----------------VRFLD---FDWF-------PTFFTGAATGTTAAMAT-----------AR 1272

  Fly  3538 SYDVDRGQQLPEVSIDLQVLRAPQYP--YNRFKGGVSLKDTPCMVLYICAAATPP--------PN 3592
            :..|.|   ||..|:..:|     ||  .:|..|..:...|         ...||        |.
  Rat  1273 ATTVSR---LPASSVTPRV-----YPSHTSRPVGRTTAPPT---------TRRPPTTATNMDRPR 1320

  Fly  3593 SPIYLPPQLPAKSRDYSLKLDDQSSNLRAGESTDVECYSSDDTYTDVVWERSDGAPLSNNVRQVG 3657
            :|.:   |.|:||       .|....|..|...|                               
  Rat  1321 TPGH---QQPSKS-------CDSQPCLHGGTCQD------------------------------- 1344

  Fly  3658 NRLVISNVSPSDAG-NYVCKCKTDEGDLYTTSYKLEVEDQPHELKSSKIVYAKVGANADLQCGAD 3721
                      .|:| .:.|.|                                            
  Rat  1345 ----------QDSGKGFTCSC-------------------------------------------- 1355

  Fly  3722 ESRQPTYRWSRQYGQLQAGRSLMNEKLSLDSVQANDAGTYICTAQYADGETADFPNILVVTGAIP 3786
                            .|||                 |..:|       |....|       ::|
  Rat  1356 ----------------TAGR-----------------GGSVC-------EKVQPP-------SMP 1373

  Fly  3787 QFRQEPRSYMSFPTLPNSSFKFNFELTFRPENGDGLLLFNGQTRGSGDYIALSLKDRYAEFRFDF 3851
            .|:  ..|:::|||| .:.......|.||....:||||:||..||. |::||:|.|...:||||.
  Rat  1374 AFK--GHSFLAFPTL-RAYHTLRLALEFRALETEGLLLYNGNARGK-DFLALALLDGRVQFRFDT 1434

  Fly  3852 GGKPMLVRAEEPLALNEWHTVRVSRFKRDGYIQVDEQHPVAFPTLQQIPQLDLIEDLYIGGVPNW 3916
            |..|.::.:..|:....||.:.:||..|.|.:.||.:.||...:......|:|..:||:||:|..
  Rat  1435 GSGPAVLTSLVPVEPGRWHRLELSRHWRQGTLSVDGETPVVGESPSGTDGLNLDTNLYVGGIPEE 1499

  Fly  3917 EL-LPADAVSQQVGFVGCISRLTLQGRTVELI---REAKYKEGITDC--RPCAQGPCQNKGVCLE 3975
            :: :..|..|..||..|||..|.:..:.:||.   |.|....|:.:|  .||...||....:|  
  Rat  1500 QVAMVLDRTSVGVGLKGCIRMLDINNQQLELSDWQRAAVQSSGVGECGDHPCLPNPCHGGALC-- 1562

  Fly  3976 SQTEQA--YTCICQPGWTGRDCAIEGTQCTPGVC-GAGRCE-NTENDMECLCPLNRSGDRCQ--- 4033
             |..:|  :.|.|.||..|..||.|.:.|.|..| ||..|. .:....:|.|||.|||..||   
  Rat  1563 -QALEAGMFLCQCPPGRFGPTCADEKSPCQPNPCHGAAPCRVLSSGGAKCECPLGRSGTFCQTVL 1626

  Fly  4034 -------YNEILNEHS-LNFKG-NSFAAYGTPKVTKVNITLSVRPASLEDSVILYTAESTLPSGD 4089
                   :....|..| |..|| ::|......|:....:.|:..|:.|    :||..:.|...||
  Rat  1627 ETAGSRPFLADFNGFSYLELKGLHTFERDLGEKMALEMVFLARGPSGL----LLYNGQKTDGKGD 1687

  Fly  4090 YLALVLRGGHAELLINTAARLDPVVVRSAEPLPLNRWTRIEIRRRLGEGILRVGDGPERKAKAPG 4154
            :::|.|...|.|...:...  ...|:||.||:.|..|.|:.:.|...:|.|:|||||....::|.
  Rat  1688 FVSLALHNRHLEFCYDLGK--GAAVIRSKEPIALGTWVRVFLERNGRKGALQVGDGPRVLGESPK 1750

  Fly  4155 SDRI----LSLKTHLYVGGY-DRSTVKVNRDVNITKGFDGCIS----RLYNFQKPVNLLADIKDA 4210
            |.::    |:||..||:||. |.|  |:.|...::.||:|.|.    |.:......::|..:   
  Rat  1751 SRKVPHTMLNLKEPLYIGGAPDFS--KLARGAAVSSGFNGVIQLVSLRGHQLLTQEHVLRAV--- 1810

  Fly  4211 ANIQSCGETNMIGGDEDSDNEPPVPPPTPDVHENELQPYAMAPCA---SDPCENGGSCSEQEDVA 4272
                                              ::.|:|..||.   .:||.|||||..:|...
  Rat  1811 ----------------------------------DVSPFADHPCTQALGNPCLNGGSCVPREATY 1841

  Fly  4273 VCSCPFGFSGKHCQEHL---QLG--FNASFRGDGYVE-LN-------------------RSHF-Q 4311
            .|.||.||||.||::.|   .:|  ...:|.|..|:| ||                   |:.| :
  Rat  1842 ECLCPGGFSGLHCEKGLVEKSVGDLETLAFDGRTYIEYLNAVIESELTNEIPAPETLDSRALFSE 1906

  Fly  4312 PALEQSYTSMGIVFTTNKPNGLLFWWGQEAGEEYTGQDFIAAAVVDGYVEYSMRLDGEEAVIRNS 4376
            .||:.::..:.:  .|....||:.|.|:.|..    .|::|.|:|||:::.|..| |.:.|:..|
  Rat  1907 KALQSNHFELSL--RTEATQGLVLWIGKAAER----ADYMALAIVDGHLQLSYDL-GSQPVVLRS 1964

  Fly  4377 DIRVDNGERHIVIAKRDENTAILEVDRMLHSGETRPTSKKSMKLPGNVFVGGAPDLEV------- 4434
            .::|:......:.|.|:.....|:|........:.|.....:...|.:::||...|.|       
  Rat  1965 TVKVNTNRWLRIRAHREHREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLQKLPVGQALPKA 2029

  Fly  4435 -FTGFRYKHNLNGCI-VVVEGETVGQINLSSAAVNGVNANVCP 4475
             .|||      .||: .||.|..  |::|...||.......||
  Rat  2030 YGTGF------VGCLRDVVVGHR--QLHLLEDAVTKPELRPCP 2064

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trolNP_001401049.1 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060
LDLa 813..847 CDD:238060
LDLa 852..887 CDD:238060
LDLa 902..936 CDD:238060
LDLa 956..990 CDD:238060
LDLa 997..1030 CDD:238060
LDLa 1033..1067 CDD:238060
LDLa 1072..1105 CDD:238060
LDLa 1133..1165 CDD:238060
LDLa 1182..1215 CDD:238060
LDLa 1221..1251 CDD:238060
LDLa 1252..1286 CDD:238060
LDLa 1292..1326 CDD:238060
Ig 1344..1405 CDD:472250
Ig strand B 1355..1359 CDD:409353
Ig strand C 1369..1372 CDD:409353
Ig strand E 1388..1392 CDD:409353
LDLa 1439..1473 CDD:238060
LDLa 1479..1513 CDD:238060
LDLa 1522..1556 CDD:238060
Ig_Perlecan_like 1574..1649 CDD:143220
Ig strand B 1577..1583 CDD:143220
Ig strand C 1590..1595 CDD:143220
Ig strand E 1613..1617 CDD:143220
Ig strand F 1626..1632 CDD:143220
Ig strand G 1641..1647 CDD:143220
Laminin_B 1748..1878 CDD:459652 27/140 (19%)
EGF_Lam 1935..1989 CDD:238012 17/74 (23%)
Laminin_B 2113..2249 CDD:459652 26/153 (17%)
EGF_Lam <2250..2276 CDD:238012 7/26 (27%)
EGF_Lam 2284..2333 CDD:238012 11/55 (20%)
Laminin_EGF <2369..2399 CDD:395007 7/34 (21%)
Laminin_B 2465..2599 CDD:459652 21/137 (15%)
Ig_3 2688..2756 CDD:464046 7/67 (10%)
Ig_3 2791..2861 CDD:464046 7/69 (10%)
Ig_3 2890..2958 CDD:464046 5/67 (7%)
Ig 2987..3071 CDD:472250 6/83 (7%)
Ig strand B 3004..3008 CDD:409353 0/3 (0%)
Ig strand C 3017..3021 CDD:409353 0/3 (0%)
Ig strand E 3036..3040 CDD:409353 0/3 (0%)
Ig strand F 3050..3055 CDD:409353 0/4 (0%)
Ig strand G 3063..3066 CDD:409353 0/2 (0%)
I-set 3089..3162 CDD:400151 10/72 (14%)
Ig strand B 3094..3098 CDD:409353 1/3 (33%)
Ig strand C 3107..3111 CDD:409353 0/3 (0%)
Ig strand E 3128..3132 CDD:409353 0/3 (0%)
Ig strand F 3142..3147 CDD:409353 0/4 (0%)
Ig strand G 3155..3158 CDD:409353 1/2 (50%)
Ig 3165..3253 CDD:472250 9/87 (10%)
Ig strand B 3185..3189 CDD:409353 0/3 (0%)
Ig strand C 3198..3202 CDD:409353 0/3 (0%)
Ig strand E 3219..3223 CDD:409353 1/3 (33%)
Ig strand F 3233..3238 CDD:409353 1/4 (25%)
Ig strand G 3246..3249 CDD:409353 1/2 (50%)
Ig 3298..3355 CDD:472250 12/59 (20%)
Ig strand B 3301..3305 CDD:409353 1/3 (33%)
Ig strand C 3313..3316 CDD:409353 0/2 (0%)
Ig strand E 3333..3336 CDD:409353 1/2 (50%)
IG_like 3381..3457 CDD:214653 18/82 (22%)
Ig strand B 3390..3394 CDD:409353 2/3 (67%)
Ig strand C 3403..3407 CDD:409353 2/6 (33%)
Ig strand F 3437..3442 CDD:409353 0/4 (0%)
IG_like 3475..>3536 CDD:214653 10/63 (16%)
Ig strand B 3480..3484 CDD:409353 0/3 (0%)
Ig strand C 3491..3503 CDD:409353 4/11 (36%)
Ig strand E 3519..3523 CDD:409353 0/3 (0%)
Ig 3613..3675 CDD:472250 6/62 (10%)
Ig strand B 3625..3629 CDD:409353 1/3 (33%)
Ig strand C 3637..3642 CDD:409353 0/4 (0%)
Ig strand E 3658..3662 CDD:409353 0/3 (0%)
IG_like 3706..3772 CDD:214653 5/65 (8%)
Ig strand B 3714..3718 CDD:409353 0/3 (0%)
Ig strand C 3727..3731 CDD:409353 0/3 (0%)
Ig strand E 3746..3750 CDD:409353 0/3 (0%)
Ig strand F 3760..3765 CDD:409353 1/4 (25%)
Ig strand G 3774..3777 CDD:409353 0/2 (0%)
LamG 3794..3939 CDD:238058 53/145 (37%)
EGF 3962..3994 CDD:394967 11/33 (33%)
LamG 4042..4195 CDD:238058 52/163 (32%)
EGF_CA 4254..4286 CDD:238011 17/34 (50%)
LamG 4295..4448 CDD:238058 42/181 (23%)
AgrnXP_017448655.1 NtA 33..148 CDD:460825 21/89 (24%)
KAZAL 198..244 CDD:197624 13/48 (27%)
KAZAL 274..319 CDD:197624 11/53 (21%)
Kazal_1 351..391 CDD:395004 8/39 (21%)
KAZAL_FS 423..463 CDD:238052 13/97 (13%)
KAZAL 491..536 CDD:197624 13/74 (18%)
KAZAL 556..601 CDD:197624 13/56 (23%)
KAZAL 621..666 CDD:197624 11/60 (18%)
KAZAL 706..752 CDD:197624 13/100 (13%)
Laminin_EGF 795..837 CDD:395007 8/41 (20%)
Laminin_EGF 849..>885 CDD:395007 9/38 (24%)
KAZAL 924..971 CDD:197624 15/197 (8%)
SEA 1130..1254 CDD:214554 39/192 (20%)
Laminin_G_1 1398..1529 CDD:395008 47/131 (36%)
Laminin_G_1 1666..1801 CDD:395008 46/142 (32%)
EGF_CA 1823..1855 CDD:238011 16/31 (52%)
Laminin_G_1 1919..2049 CDD:395008 37/142 (26%)
Blue background indicates that the domain is not in the aligned region.

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