DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trol and CADM4

DIOPT Version :10

Sequence 1:NP_001401049.1 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4489 Species:Drosophila melanogaster
Sequence 2:NP_660339.1 Gene:CADM4 / 199731 HGNCID:30825 Length:388 Species:Homo sapiens


Alignment Length:287 Identity:65/287 - (22%)
Similarity:111/287 - (38%) Gaps:43/287 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly  2798 HVTFEEYVNNEIICE---------VLGNPAPRV-----TWARVDGHADAQSTRTYDNRLIFDSPR 2848
            :||..|....||.|.         |:.|||.:.     |.|..|.....:.......|:.....|
Human    31 NVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDAR 95

  Fly  2849 KSDEGRYRCQ--AENDQNRDEKYVIVYVQSNPPQPPPQQDRLYITPEEINGLAGESFQLNC---Q 2908
            ..|||.|.||  .|:..::.....::....||.....:|           .:.|...:|:|   :
Human    96 LEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQ-----------AVEGGEVELSCLVPR 149

  Fly  2909 FTSVASLRYDWSHNGRSLS--SSPARNVEI--RGNTLEVRDASESDSGVYTCVAYDVRTRRNFTE 2969
            ....|:||  |..:.:.|.  ||...|.::  ..:|:..|...:.|.|:..|.|.:.......::
Human   150 SRPAATLR--WYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSK 212

  Fly  2970 SARVNIDRREEQPFGNKPIIESLEQNILIIQGEDYSITCEASGSPYPS-IKWAKVHDFMPENVHI 3033
            ..:..:|.:      ..|.........::.:|:...:||..:|:|.|: |:|.:.::.:||....
Human   213 QTQYVLDVQ------YSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEA 271

  Fly  3034 SGNVLTIYGARFENRGVYSCVAENDHG 3060
            .|..||:.|....:.|.|:|.|.|.||
Human   272 VGETLTLPGLVSADNGTYTCEASNKHG 298

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trolNP_001401049.1 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060
LDLa 813..847 CDD:238060
LDLa 852..887 CDD:238060
LDLa 902..936 CDD:238060
LDLa 956..990 CDD:238060
LDLa 997..1030 CDD:238060
LDLa 1033..1067 CDD:238060
LDLa 1072..1105 CDD:238060
LDLa 1133..1165 CDD:238060
LDLa 1182..1215 CDD:238060
LDLa 1221..1251 CDD:238060
LDLa 1252..1286 CDD:238060
LDLa 1292..1326 CDD:238060
Ig 1344..1405 CDD:472250
Ig strand B 1355..1359 CDD:409353
Ig strand C 1369..1372 CDD:409353
Ig strand E 1388..1392 CDD:409353
LDLa 1439..1473 CDD:238060
LDLa 1479..1513 CDD:238060
LDLa 1522..1556 CDD:238060
Ig_Perlecan_like 1574..1649 CDD:143220
Ig strand B 1577..1583 CDD:143220
Ig strand C 1590..1595 CDD:143220
Ig strand E 1613..1617 CDD:143220
Ig strand F 1626..1632 CDD:143220
Ig strand G 1641..1647 CDD:143220
Laminin_B 1748..1878 CDD:459652
EGF_Lam 1935..1989 CDD:238012
Laminin_B 2113..2249 CDD:459652
EGF_Lam <2250..2276 CDD:238012
EGF_Lam 2284..2333 CDD:238012
Laminin_EGF <2369..2399 CDD:395007
Laminin_B 2465..2599 CDD:459652
Ig_3 2688..2756 CDD:464046
Ig_3 2791..2861 CDD:464046 21/78 (27%)
Ig_3 2890..2958 CDD:464046 16/74 (22%)
Ig 2987..3071 CDD:472250 22/75 (29%)
Ig strand B 3004..3008 CDD:409353 0/3 (0%)
Ig strand C 3017..3021 CDD:409353 1/4 (25%)
Ig strand E 3036..3040 CDD:409353 1/3 (33%)
Ig strand F 3050..3055 CDD:409353 2/4 (50%)
Ig strand G 3063..3066 CDD:409353
I-set 3089..3162 CDD:400151
Ig strand B 3094..3098 CDD:409353
Ig strand C 3107..3111 CDD:409353
Ig strand E 3128..3132 CDD:409353
Ig strand F 3142..3147 CDD:409353
Ig strand G 3155..3158 CDD:409353
Ig 3165..3253 CDD:472250
Ig strand B 3185..3189 CDD:409353
Ig strand C 3198..3202 CDD:409353
Ig strand E 3219..3223 CDD:409353
Ig strand F 3233..3238 CDD:409353
Ig strand G 3246..3249 CDD:409353
Ig 3298..3355 CDD:472250
Ig strand B 3301..3305 CDD:409353
Ig strand C 3313..3316 CDD:409353
Ig strand E 3333..3336 CDD:409353
IG_like 3381..3457 CDD:214653
Ig strand B 3390..3394 CDD:409353
Ig strand C 3403..3407 CDD:409353
Ig strand F 3437..3442 CDD:409353
IG_like 3475..>3536 CDD:214653
Ig strand B 3480..3484 CDD:409353
Ig strand C 3491..3503 CDD:409353
Ig strand E 3519..3523 CDD:409353
Ig 3613..3675 CDD:472250
Ig strand B 3625..3629 CDD:409353
Ig strand C 3637..3642 CDD:409353
Ig strand E 3658..3662 CDD:409353
IG_like 3706..3772 CDD:214653
Ig strand B 3714..3718 CDD:409353
Ig strand C 3727..3731 CDD:409353
Ig strand E 3746..3750 CDD:409353
Ig strand F 3760..3765 CDD:409353
Ig strand G 3774..3777 CDD:409353
LamG 3794..3939 CDD:238058
EGF 3962..3994 CDD:394967
LamG 4042..4195 CDD:238058
EGF_CA 4254..4286 CDD:238011
LamG 4295..4448 CDD:238058
CADM4NP_660339.1 Ig 29..120 CDD:472250 22/88 (25%)
Ig strand B 40..44 CDD:409353 2/3 (67%)
Ig strand C 53..57 CDD:409353 1/3 (33%)
Ig strand E 87..91 CDD:409353 1/3 (33%)
Ig strand F 101..106 CDD:409353 2/4 (50%)
Ig strand G 113..116 CDD:409353 0/2 (0%)
IgI_2_Necl-4 121..220 CDD:409468 20/111 (18%)
Ig strand A 121..124 CDD:409468 0/2 (0%)
Ig strand A' 127..131 CDD:409468 1/3 (33%)
Ig strand B 139..149 CDD:409468 2/9 (22%)
Ig strand C 152..161 CDD:409468 4/10 (40%)
Ig strand C' 162..165 CDD:409468 0/2 (0%)
Ig strand D 167..174 CDD:409468 2/6 (33%)
Ig strand E 177..187 CDD:409468 1/9 (11%)
Ig strand F 195..203 CDD:409468 3/7 (43%)
Ig strand G 212..219 CDD:409468 0/6 (0%)
Ig_3 224..295 CDD:464046 19/70 (27%)
4.1m 344..362 CDD:128590
Blue background indicates that the domain is not in the aligned region.

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