| Sequence 1: | NP_001401049.1 | Gene: | trol / 45320 | FlyBaseID: | FBgn0284408 | Length: | 4489 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001379135.1 | Gene: | lrp-1 / 172520 | WormBaseID: | WBGene00003071 | Length: | 4753 | Species: | Caenorhabditis elegans |
| Alignment Length: | 2848 | Identity: | 559/2848 - (19%) |
|---|---|---|---|
| Similarity: | 842/2848 - (29%) | Gaps: | 1194/2848 - (41%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 4 SPGSQASAIATSVGIRSGRRGQ--------AGGSLLLRLLAVTFVLAACHAPLLTNAKQISNLGD 60
Fly 61 -DQD-------FMLADDESLQGINDSEWQLMGD--------------------DIDDGLLDDVDE 97
Fly 98 TL--------KPMETKSEEEDLPT---GNW-FSQSVHRVRRSINRLFGSDDNQERGRRQQRERSQ 150
Fly 151 RNRDAINRQKEL--------------RRRQK---EDHNRWKQMRMERQLEKQRLVKRTNHVVFNR 198
Fly 199 ATDPRKRASDLYDENE---ASGYHEEDTTLYRTYFVVNEPYDN-EYR-DRESVQFQNLQKLLDDD 258
Fly 259 LRNFFHSNYEGNDDEEQEIRSTLERVEPTNDNFKIRVQLRIELPTSVNDFGSK--LQQQLNVYNR 321
Fly 322 IENLSAATDGVFSFTESSVTEESVRHLDVGFVEPHITLFHEQNTGYDDFDRKPTTETQDIEEEAI 386
Fly 387 DVTLPQEEVEGSGSDDS-SCRGDATFTCPRSGKTICDEMRCDREIQCPDGEDE--EYCNYPNVCT 448
Fly 449 EDQFKCDD-KCLELKKRCDGSIDCLDQTDEAGCINAPEPEPEPEPEPEPEPESEPEAEPEPEPEP 512
Fly 513 EPESEPEQEPEPQVPEANECQANEFRCNNGDCIDARKRCNNVSDCSEGEDENEE---CPAA---C 571
Fly 572 SGMEYQCRDGTRCISVSQQCDGHSDCSDGDDEEH--CDGSGYDSEECRFDEFHCGTGECIPMRQV 634
Fly 635 CDNIYDCNDYSDE--VNCVEGEEEDRVG--IPIGHQPWRPASKHDDWLHEMDTSEYQVYQPSNVY 695
Fly 696 EKANSQNPCASNQFRCTTSNVCIPLHLRCDGFYHCNDMSDE--------KSCEQYQRHTTTRRPL 752
Fly 753 TLATPTSRITTQGPGLLERRNTTTATEASRWPWATKTTTIATTTSNPITTVGVANSPPQTC---- 813
Fly 814 --LENIEFACHNRDCISIESVCDGIPDC--GRNEDEDDALCKCSGDKYKCQRGGGCIPKSQVCDG 874
Fly 875 KPQCHDRSDESACHLHGRLNKTRLGVKCLESQYQCGDGSCISGYKRCNGIHDCADASDE------ 933
Fly 934 ---------------------YNC---------IYD----------YE----------------- 941
Fly 942 ----DTY---------------------------------------------------------- 944
Fly 945 ---------------DTDPNNNP------------------------------------------ 952
Fly 953 ----------------------------------------------------------------- 952
Fly 953 ------------------LNECDILEFECDYSQCLPLEK-------------------------K 974
Fly 975 CD-----------------------------------------------------GY-ADCED-- 983
Fly 984 --MSDELECQSYTDHCLESEFEC---DSYCLPRDQLCNGIPNCQDGSDERNCTFCREDAYLCNTG 1043
Fly 1044 E-------CVADNQRCNGIADCADGSDERHCARIYCPP--NKLACNGTCVSRRIKCDGIRDCLDG 1099
Fly 1100 YDE--MYCPETNNHYPTQNVNVIRPKLGPNPIPKSCRPHEWQCANLECIDSSLQCNEIKDCSDGS 1162
Fly 1163 DEELSVCFGTATTRLKPSDCSPEQFYCDES--CYNRSVRCNGHVDCSDGSDEVGCSLPCPQHQCP 1225
Fly 1226 ------------SGRCYTESERCDRHRHCEDGSDE--ANC------CYANQFRCNNGDCVSGSAP 1270
Fly 1271 CNGYSECSDHSDELNCGGTQECLPNQFRCNSGQCVSSSVRCNGRTDCQDSSDEQNCAADSNDRRP 1335
Fly 1336 NQLNLKTYPDSQIIKESREVIFRCRDEGPARAKVKWSRPGGRPLPPGFTDRNGRLEIPNIRVEDA 1400
Fly 1401 GTYVCEAVGYASYIPGQQVTVNLNVERYNDVGSRPESACTEYQATCMNGECIDKSSICDGNPDCS 1465
Fly 1466 DASDEQSCSL-GLKCQPN-QFMCSNSK-CVDRTWRCDGENDCGDN--SDE--TSCDPEPSGAPCR 1523
Fly 1524 YNEFQCRSGHCIPKSFQCDNVPDCTDGTDEVGCMAPLPIRPPPQSVSLLEYEVLELTCVATGTPT 1588
Fly 1589 PTIVWRLNWGHVPDKCESKSYGGTGTLR--CPDMR--------------PQD----------SGA 1627
Fly 1628 YSCE--IINTRGTHFV----NPDTIVTVRPVRTDVCEA--GFFNMLARKAEECVQCFCFG----- 1679
Fly 1680 --VAKACDSANLFTYAIHPPILSHRVVSVELSPLRQIVI-----------------NEAAPGQDL 1725
Fly 1726 LTLLHGVQFRATNVHFSGRETPYLALPADY-MGNQ-LKSYGGNLRYEVNYRGSGRPVNGPDVIIT 1788
Fly 1789 GNRFTLTYRVRTQPGQNNRVSIPFVPGGWQKPDGRKASR-------EEIMMI------------- 1833
Fly 1834 -------LANVD----NILI------------------RLGYLDSTAREVDLINIALDSAGTADK 1869
Fly 1870 GLGSASLVEKCQCPPGYVGDSCES--------CASGYVRQPGGPWL----------GHCVPFIPD 1916
Fly 1917 SCPSGTYG-DPRRGVP-CKECPCPLTGSNNFASGCQQSPDGDVVCRCNEGYTGRRCEQCAAGYQG 1979
Fly 1980 NPLAAGGICRRIPDTSCNVDGTYSVHSNGTCQCKDSVIGEQCDTCKSKSFHL------NSFTYTG 2038
Fly 2039 CIECFCSGVGL--DCDSSTWYRDQVTSTFGRSRVDHGFVLVTNYMQPTPDTVPVSMAAEPNALSF 2101
Fly 2102 IGSADQSGNTLYWSLPAAFLGNKLSSYGGKL-------------TYTLSYSPLPNGIMS----RN 2149
Fly 2150 SAPDVVIKSGEDLRLIHYRKSQVVPSVANTYSVEIKESAWQRGDEVVANREHV 2202 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| trol | NP_001401049.1 | LDLa | 447..480 | CDD:238060 | 12/33 (36%) |
| LDLa | 532..564 | CDD:238060 | 11/31 (35%) | ||
| LDLa | 571..606 | CDD:238060 | 13/36 (36%) | ||
| LDLa | 616..650 | CDD:238060 | 13/35 (37%) | ||
| LDLa | 704..739 | CDD:238060 | 10/42 (24%) | ||
| LDLa | 813..847 | CDD:238060 | 14/41 (34%) | ||
| LDLa | 852..887 | CDD:238060 | 14/34 (41%) | ||
| LDLa | 902..936 | CDD:238060 | 16/60 (27%) | ||
| LDLa | 956..990 | CDD:238060 | 10/116 (9%) | ||
| LDLa | 997..1030 | CDD:238060 | 16/35 (46%) | ||
| LDLa | 1033..1067 | CDD:238060 | 14/40 (35%) | ||
| LDLa | 1072..1105 | CDD:238060 | 16/36 (44%) | ||
| LDLa | 1133..1165 | CDD:238060 | 13/31 (42%) | ||
| LDLa | 1182..1215 | CDD:238060 | 13/34 (38%) | ||
| LDLa | 1221..1251 | CDD:238060 | 13/43 (30%) | ||
| LDLa | 1252..1286 | CDD:238060 | 16/33 (48%) | ||
| LDLa | 1292..1326 | CDD:238060 | 11/33 (33%) | ||
| Ig | 1344..1405 | CDD:472250 | 0/60 (0%) | ||
| Ig strand B | 1355..1359 | CDD:409353 | 0/3 (0%) | ||
| Ig strand C | 1369..1372 | CDD:409353 | 0/2 (0%) | ||
| Ig strand E | 1388..1392 | CDD:409353 | 0/3 (0%) | ||
| LDLa | 1439..1473 | CDD:238060 | 14/33 (42%) | ||
| LDLa | 1479..1513 | CDD:238060 | 16/39 (41%) | ||
| LDLa | 1522..1556 | CDD:238060 | 12/33 (36%) | ||
| Ig_Perlecan_like | 1574..1649 | CDD:143220 | 17/106 (16%) | ||
| Ig strand B | 1577..1583 | CDD:143220 | 0/5 (0%) | ||
| Ig strand C | 1590..1595 | CDD:143220 | 0/4 (0%) | ||
| Ig strand E | 1613..1617 | CDD:143220 | 1/5 (20%) | ||
| Ig strand F | 1626..1632 | CDD:143220 | 2/7 (29%) | ||
| Ig strand G | 1641..1647 | CDD:143220 | 0/9 (0%) | ||
| Laminin_B | 1748..1878 | CDD:459652 | 29/180 (16%) | ||
| EGF_Lam | 1935..1989 | CDD:238012 | 9/53 (17%) | ||
| Laminin_B | 2113..2249 | CDD:459652 | 21/107 (20%) | ||
| EGF_Lam | <2250..2276 | CDD:238012 | |||
| EGF_Lam | 2284..2333 | CDD:238012 | |||
| Laminin_EGF | <2369..2399 | CDD:395007 | |||
| Laminin_B | 2465..2599 | CDD:459652 | |||
| Ig_3 | 2688..2756 | CDD:464046 | |||
| Ig_3 | 2791..2861 | CDD:464046 | |||
| Ig_3 | 2890..2958 | CDD:464046 | |||
| Ig | 2987..3071 | CDD:472250 | |||
| Ig strand B | 3004..3008 | CDD:409353 | |||
| Ig strand C | 3017..3021 | CDD:409353 | |||
| Ig strand E | 3036..3040 | CDD:409353 | |||
| Ig strand F | 3050..3055 | CDD:409353 | |||
| Ig strand G | 3063..3066 | CDD:409353 | |||
| I-set | 3089..3162 | CDD:400151 | |||
| Ig strand B | 3094..3098 | CDD:409353 | |||
| Ig strand C | 3107..3111 | CDD:409353 | |||
| Ig strand E | 3128..3132 | CDD:409353 | |||
| Ig strand F | 3142..3147 | CDD:409353 | |||
| Ig strand G | 3155..3158 | CDD:409353 | |||
| Ig | 3165..3253 | CDD:472250 | |||
| Ig strand B | 3185..3189 | CDD:409353 | |||
| Ig strand C | 3198..3202 | CDD:409353 | |||
| Ig strand E | 3219..3223 | CDD:409353 | |||
| Ig strand F | 3233..3238 | CDD:409353 | |||
| Ig strand G | 3246..3249 | CDD:409353 | |||
| Ig | 3298..3355 | CDD:472250 | |||
| Ig strand B | 3301..3305 | CDD:409353 | |||
| Ig strand C | 3313..3316 | CDD:409353 | |||
| Ig strand E | 3333..3336 | CDD:409353 | |||
| IG_like | 3381..3457 | CDD:214653 | |||
| Ig strand B | 3390..3394 | CDD:409353 | |||
| Ig strand C | 3403..3407 | CDD:409353 | |||
| Ig strand F | 3437..3442 | CDD:409353 | |||
| IG_like | 3475..>3536 | CDD:214653 | |||
| Ig strand B | 3480..3484 | CDD:409353 | |||
| Ig strand C | 3491..3503 | CDD:409353 | |||
| Ig strand E | 3519..3523 | CDD:409353 | |||
| Ig | 3613..3675 | CDD:472250 | |||
| Ig strand B | 3625..3629 | CDD:409353 | |||
| Ig strand C | 3637..3642 | CDD:409353 | |||
| Ig strand E | 3658..3662 | CDD:409353 | |||
| IG_like | 3706..3772 | CDD:214653 | |||
| Ig strand B | 3714..3718 | CDD:409353 | |||
| Ig strand C | 3727..3731 | CDD:409353 | |||
| Ig strand E | 3746..3750 | CDD:409353 | |||
| Ig strand F | 3760..3765 | CDD:409353 | |||
| Ig strand G | 3774..3777 | CDD:409353 | |||
| LamG | 3794..3939 | CDD:238058 | |||
| EGF | 3962..3994 | CDD:394967 | |||
| LamG | 4042..4195 | CDD:238058 | |||
| EGF_CA | 4254..4286 | CDD:238011 | |||
| LamG | 4295..4448 | CDD:238058 | |||
| lrp-1 | NP_001379135.1 | LDLa | 53..87 | CDD:238060 | |
| LDLa | 92..131 | CDD:238060 | |||
| LDLa | 140..173 | CDD:238060 | |||
| LDLa | 182..216 | CDD:238060 | |||
| LDLa | 223..257 | CDD:238060 | |||
| LDLa | 262..297 | CDD:238060 | |||
| YncE | <376..564 | CDD:442618 | |||
| LY | 547..589 | CDD:214531 | |||
| LY | 883..925 | CDD:214531 | |||
| LDLa | 1057..1087 | CDD:197566 | |||
| LDLa | 1100..1133 | CDD:197566 | |||
| LDLa | 1146..1177 | CDD:197566 | |||
| LDLa | 1187..1219 | CDD:238060 | |||
| LDLa | 1228..1263 | CDD:238060 | |||
| LDLa | 1270..1302 | CDD:238060 | |||
| LDLa | 1313..1344 | CDD:238060 | |||
| FXa_inhibition | 1447..1475 | CDD:464251 | |||
| LY | 1511..1545 | CDD:214531 | |||
| LY | 1548..1585 | CDD:214531 | |||
| LY | 1590..1634 | CDD:214531 | |||
| LY | 1635..1677 | CDD:214531 | |||
| Vgb | <1921..2043 | CDD:443399 | |||
| LY | 2193..2239 | CDD:214531 | |||
| LY | 2240..2283 | CDD:214531 | |||
| LY | 2284..2325 | CDD:214531 | |||
| Ldl_recept_b | 2582..2629 | CDD:459654 | 8/46 (17%) | ||
| LY | 2613..2655 | CDD:214531 | 9/70 (13%) | ||
| LDLa | 2794..2824 | CDD:197566 | 8/30 (27%) | ||
| LDLa | 2834..2868 | CDD:238060 | 12/33 (36%) | ||
| LDLa | 2874..2907 | CDD:197566 | 11/32 (34%) | ||
| LDLa | 2961..2994 | CDD:238060 | 13/32 (41%) | ||
| LDLa | 3012..3038 | CDD:238060 | 9/56 (16%) | ||
| LDLa | 3048..3088 | CDD:197566 | 9/69 (13%) | ||
| LDLa | 3099..3131 | CDD:197566 | 12/31 (39%) | ||
| LDLa | 3140..3174 | CDD:238060 | 14/34 (41%) | ||
| LDLa | 3186..3218 | CDD:197566 | 14/31 (45%) | ||
| FXa_inhibition | 3276..3305 | CDD:464251 | 2/28 (7%) | ||
| LY | 3382..3424 | CDD:214531 | 0/41 (0%) | ||
| Ldl_recept_b | 3445..3491 | CDD:459654 | 0/45 (0%) | ||
| LY | 3476..3516 | CDD:214531 | 4/39 (10%) | ||
| FXa_inhibition | 3586..3623 | CDD:464251 | 6/36 (17%) | ||
| LDLa | 3627..3660 | CDD:197566 | 14/32 (44%) | ||
| LDLa | 3671..3705 | CDD:238060 | 13/33 (39%) | ||
| LDLa | 3792..3825 | CDD:197566 | 11/32 (34%) | ||
| LDLa | 3837..3868 | CDD:238060 | 10/30 (33%) | ||
| LDLa | 3878..3912 | CDD:238060 | 16/33 (48%) | ||
| LDLa | 3917..3951 | CDD:238060 | 11/33 (33%) | ||
| LDLa | 3958..3990 | CDD:197566 | 12/31 (39%) | ||
| LDLa | 4049..4083 | CDD:238060 | 12/33 (36%) | ||
| FXa_inhibition | 4097..>4121 | CDD:464251 | 4/23 (17%) | ||
| EGF_CA | 4132..4163 | CDD:214542 | 5/30 (17%) | ||
| NHL | 4219..>4431 | CDD:302697 | 41/258 (16%) | ||
| NHL repeat | 4219..4257 | CDD:271332 | 5/49 (10%) | ||
| NHL repeat | 4267..4330 | CDD:271332 | 17/86 (20%) | ||
| NHL repeat | 4333..4371 | CDD:271332 | 4/37 (11%) | ||
| NHL repeat | 4373..4410 | CDD:271332 | 8/45 (18%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||