DRSC/TRiP Functional Genomics Resources

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Protein Alignment trol and Lamc2

DIOPT Version :9

Sequence 1:NP_001027038.3 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4479 Species:Drosophila melanogaster
Sequence 2:NP_032511.3 Gene:Lamc2 / 16782 MGIID:99913 Length:1193 Species:Mus musculus


Alignment Length:1401 Identity:312/1401 - (22%)
Similarity:471/1401 - (33%) Gaps:460/1401 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  1879 KC-QCPPGYVGDSCESCASGYVRQPGGPWLGHCVPFIPDSCPSGTYGDPRRGVPCKECPCPLTGS 1942
            :| .|.....|..||.|..|:.|                      :.|..|.:||.   |...||
Mouse    52 RCLNCNDNTAGVHCERCREGFYR----------------------HRDRDRCLPCN---CHSKGS 91

  Fly  1943 NNFASGCQQSPDGDVVCRCNEGYTGRRCEQCAAGYQGNPLAAGGICRRIP---DTSCNVD--GTY 2002
              .::||..|..    |||..|.||:||::|..|:  :.|...| |.|..   |:.|:.|  |..
Mouse    92 --LSAGCDNSGQ----CRCKPGVTGQRCDRCQPGF--HMLTDAG-CTRDQGQLDSKCDCDPAGIS 147

  Fly  2003 SVHSNGTCQCKDSVIGEQCDTCKSKSFHLNSFTYTGCIECFCSGVGLDCDSSTWYR-DQVTSTFG 2066
            ....:|.|.||.:|.||:||.|:...:||:.....||.:|||.|....|.:|..:. .::||||.
Mouse   148 GPCDSGRCVCKPAVTGERCDRCRPGYYHLDRANPEGCTQCFCYGHSASCHASADFSVHKITSTFS 212

  Fly  2067 RSRVDHGFVLVTNYMQPTPDTVPVSMAAEPNALSFIGSADQSGNTLYWSLPAAFLGNKLSSYGGK 2131
            :.        |..:.....:..|..:...........||.:| :.:|:..||.||||:..|||..
Mouse   213 QD--------VDGWKAVQRNGAPAKLHWSQRHRDVFSSARRS-DPVYFVAPAKFLGNQQVSYGQS 268

  Fly  2132 LTYTLSYSPLPNGIMSRNSAPDVVIK-SGEDLRLIHYRKSQVVP-SVANTYSVEIKE---SAWQR 2191
            |::  .|.....|  .:.||.||::: :|..:|.......:.:| .:..||:..:.|   |.|..
Mouse   269 LSF--DYRVDRGG--RQPSAYDVILEGAGLQIRAPLMAPGKTLPCGITKTYTFRLNEHPSSHWSP 329

  Fly  2192 GDEVVANREHVLMALSDITAIYIKATY-TTSTKEASLRQVTLDVATPTNLGTPRAVEVEQCRCPE 2255
            .......|.    .|.::||:.|:||| ..||  ..:..|||..|.|.: |.| |..||:|.||.
Mouse   330 QLSYFEYRR----LLRNLTALLIRATYGEYST--GYIDNVTLVSARPVS-GAP-APWVERCVCPA 386

  Fly  2256 GYLGLSCEQCAPGYARDPEGGIYLGLCRPCECNGHSKYCNSDTGDCE--------ECSD------ 2306
            ||.|..|::||.||.||.......|.|.||.|.|... |:.|||||.        ||:|      
Mouse   387 GYKGQFCQECASGYKRDSARLGPFGACVPCNCQGGGA-CDPDTGDCYSGDENPDIECADCPIGFY 450

  Fly  2307 ------------------------NTE------------GPSCERCAAGYVGD--ATRGTIYDCQ 2333
                                    .||            |..||.||.|:.||  ..||.:..||
Mouse   451 NDPHDPRSCKPCPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCADGFFGDPFGERGPVRPCQ 515

  Fly  2334 PDEGYPIPSPPAPGNQTLECTAYCQIEGIYDCRGNECL-CKRNVIGDQCDQCRPGTYG--LSAQN 2395
            ..:......|.|.||    |.   |:.|       .|| |..|..|..||||:.|.:|  |:...
Mouse   516 RCQCNNNVDPNASGN----CD---QLTG-------RCLKCIYNTAGVYCDQCKAGYFGDPLAPNP 566

  Fly  2396 QDGCKECYCSGLASQ--------------------CRSAAL------YRQL-IPVDFILNAPLIT 2433
            .|.|:.|.||.:.|:                    |..|||      |.|: |.:|         
Mouse   567 ADKCRACNCSPMGSEPGECRGDGSCVCKPGFGGLNCDHAALTSCPACYNQVKIQMD--------- 622

  Fly  2434 DESGAVQDTENLIPDISRNMYTYTHTSYLPKYWSLRGSVLGNQLFSYGGRLSYSLIVESYGNYER 2498
                  |.|:.|                    .||...|...|....||.:              
Mouse   623 ------QFTQQL--------------------QSLEALVSKAQGGGGGGTV-------------- 647

  Fly  2499 GHDIVLIGNGLKLIWSRPDGNENQEEYNVRLHEDEQWTR------QDRESARPA----------S 2547
                             |.|     |...|:.:.||..|      |..|.|..|          .
Mouse   648 -----------------PSG-----ELEGRMQQAEQALRDILREAQISEGAMRALGFRLAKARSQ 690

  Fly  2548 RSDFMTVLSDLQHIL--IRA-----TPRVPTQSTSIGNVILESAVTTRTPGATHASDIELCQCPS 2605
            .:|:.|.|.||:...  |||     ..||...|..|..:.|..|.:..:...|:....|....|:
Mouse   691 ENDYKTRLDDLKMTAERIRALGSQHQNRVQDTSRLISQMRLSLAGSEASLQNTNIHSSEHYVGPN 755

  Fly  2606 GYVGTSCES--CAPLHYRDASGSCSLCPCDVSNTESCDLVSGGYVECRCKARWKGDRCREIDTND 2668
            |:...:.|:  .|..|...|:....|                               .||     
Mouse   756 GFKSLAQEATRLADSHAESANAMKQL-------------------------------ARE----- 784

  Fly  2669 PTDIGTEDPVLTQIIVSIQKPEITIVPVGGSMTLSCS------GRMRWSNSPVIVNWYKENSRLP 2727
                 |||  .::..:|:.:..::  ..|||..|..|      |::..:.|     ..::.||..
Mouse   785 -----TED--YSKQALSLARKALS--GGGGSGVLDSSVVQGLMGKLEKTKS-----LSQQLSREG 835

  Fly  2728 ENVEVQGGNLYLYDLQVSDSGVYICQAVNNETASVFKDTVSITITKKDQLSPAEIVNLPSHVT-- 2790
            ...:::....|.:.|::.||...: |.|::.:..|....:.   .|.|.||     ||.:..|  
Mouse   836 TQADIEADRSYQHSLRLLDSASQL-QGVSDLSFQVEAKRIR---QKADSLS-----NLVTRQTDA 891

  Fly  2791 FEEYVNNEIICEVLGNPAPRVTWARVDGHADAQSTRTYDNRLIFDSPRKSDEGRYRCQAENDQNR 2855
            |....||      |||      |.:                          |.|...|...|:.:
Mouse   892 FTRVRNN------LGN------WEK--------------------------ETRQLLQTGKDRRQ 918

  Fly  2856 DEKYVIVYVQSNPPQPPPQQDRLYITPEEINGLAGESFQL-NCQFTSVASL-----RYDWSHNGR 2914
                              ..|:|..........|.|:..: |..|..|.::     .:|.....|
Mouse   919 ------------------TSDQLLSRANLAKNRAQEALSMGNATFYEVENILKNLREFDLQVEDR 965

  Fly  2915 SLSSSPARNVEIRGNTLEVRDASESDSGVYTCVAYDVRTRRNFTESARVNIDRREEQPFGNKPII 2979
            ...:..|.. .:...:.:|.|||:......|.:.......:....:||..::           |.
Mouse   966 KAEAEEAMK-RLSSISQKVADASDKTQQAETALGSATADTQRAKNAAREALE-----------IS 1018

  Fly  2980 ESLEQNILIIQGEDYSITCEASGSPYPSIKWAKVHDFMPENVHISGNVLTIYGARFENRGVYSCV 3044
            ..:||.|               ||                 :::..|| |..||....:|:.:..
Mouse  1019 SEIEQEI---------------GS-----------------LNLEANV-TADGALAMEKGLATLK 1050

  Fly  3045 AE-NDHGSDLSSTSIDIEPRERPSVKIVSAPLQTFSVGAPAS------LYCTVEGIPDPTVEWVR 3102
            :| .:...:|:...::.: .::.:|::|....|.....|.::      ...|::||         
Mouse  1051 SEMREMEGELARKELEFD-TDKDTVQLVITEAQQADARATSAGVTIQDTLNTLDGI--------- 1105

  Fly  3103 VDGQPLSPRHKIQSPGYMVIDDIQLEDSGDYECRAK 3138
                    .|.|..||.:..:.:.|.:.|.::.:.:
Mouse  1106 --------LHLIDQPGSVDEEGMMLLEQGLFQAKTQ 1133

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trolNP_001027038.3 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060
LDLa 813..847 CDD:238060
LDLa 852..887 CDD:238060
LDLa 902..936 CDD:238060
LDLa 956..990 CDD:238060
LDLa 997..1030 CDD:238060
LDLa 1033..1067 CDD:238060
LDLa 1072..1105 CDD:238060
LDLa 1133..1165 CDD:238060
LDLa 1182..1215 CDD:238060
LDLa 1221..1251 CDD:238060
LDLa 1252..1286 CDD:238060
LDLa 1292..1326 CDD:238060
IG 1344..1421 CDD:214652
Ig 1344..1405 CDD:299845
LDLa 1439..1473 CDD:238060
LDLa 1479..1513 CDD:238060
LDLa 1522..1556 CDD:238060
IG_like 1566..1649 CDD:214653
Ig_Perlecan_D2_like 1574..1649 CDD:143220
Laminin_B 1748..1864 CDD:278481
EGF_Lam 1935..1989 CDD:238012 18/53 (34%)
Laminin_B 2113..2238 CDD:278481 39/130 (30%)
EGF_Lam <2250..2276 CDD:238012 13/25 (52%)
EGF_Lam 2284..2333 CDD:238012 25/100 (25%)
Laminin_EGF <2369..2399 CDD:278482 13/32 (41%)
Laminin_B 2465..2587 CDD:278481 31/144 (22%)
I-set 2686..2772 CDD:254352 16/91 (18%)
Ig_2 2689..2771 CDD:290606 16/87 (18%)
Ig 2779..2865 CDD:299845 14/87 (16%)
IG_like 2798..2864 CDD:214653 8/65 (12%)
Ig 2882..2965 CDD:299845 15/88 (17%)
IG_like 2882..2950 CDD:214653 13/73 (18%)
Ig 2977..3061 CDD:299845 14/84 (17%)
IG_like 2984..3058 CDD:214653 12/74 (16%)
IG_like 3074..3152 CDD:214653 11/71 (15%)
Ig 3086..3153 CDD:299845 9/53 (17%)
I-set 3155..3243 CDD:254352
IGc2 3171..3233 CDD:197706
IG 3371..3447 CDD:214652
IGc2 3377..3437 CDD:197706
Ig 3456..3534 CDD:299845
IG 3465..>3526 CDD:214652
Ig 3603..3665 CDD:299845
IG 3610..3683 CDD:214652
IG 3696..3762 CDD:214652
Ig 3704..3771 CDD:299845
LamG 3784..3929 CDD:238058
EGF 3952..3984 CDD:278437
LamG 4032..4185 CDD:238058
Laminin_G_2 4315..4444 CDD:280389
Lamc2NP_032511.3 Laminin_EGF 28..86 CDD:365839 12/58 (21%)
EGF_Lam 83..127 CDD:238012 19/54 (35%)
Laminin_EGF 139..184 CDD:365839 15/44 (34%)
Laminin_B 245..370 CDD:383018 40/135 (30%)
EGF_Lam 461..509 CDD:238012 10/47 (21%)
Laminin_EGF 517..564 CDD:365839 19/60 (32%)
EGF_Lam 572..>604 CDD:238012 5/31 (16%)
Cell attachment site. /evidence=ECO:0000255 586..588 0/1 (0%)
SMC_prok_B <614..1192 CDD:274008 131/769 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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