DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trol and EGFLAM

DIOPT Version :10

Sequence 1:NP_001401049.1 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4489 Species:Drosophila melanogaster
Sequence 2:NP_001192230.1 Gene:EGFLAM / 133584 HGNCID:26810 Length:1017 Species:Homo sapiens


Alignment Length:1305 Identity:291/1305 - (22%)
Similarity:459/1305 - (35%) Gaps:421/1305 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  3292 LLATDIGDN-VTLTCDMFQPLNTRWERVDGAPLPRNAYTIKNRLEIVRVEQQNLGQYRCNGIGRD 3355
            |||:.:|.. |:|...:.:|...      |.||     .||            ||...|....  
Human    13 LLASSLGPGAVSLRAAIRKPGKV------GPPL-----DIK------------LGALNCTAFS-- 52

  Fly  3356 GNVKTYFVKELVLMPLPRIRFYPNIPL---TV---EAGQNLDVHCQVENVRPEDVHWSTDNNRPL 3414
                       :...:||   :|..|:   ||   |.|.:..:.        |.:| |...:|.:
Human    53 -----------IQWKMPR---HPGSPILGYTVFYSEVGADKSLQ--------EQLH-SVPLSRDI 94

  Fly  3415 PSSVRIVGSVLRFVSITQAAAGEYRCS--AFNQYG-NRSQIARVAVKKPADFHQVPQSQLQRH-- 3474
            |::..::|.:        ....|||.|  |::|.| .|....|.......|....|.:..|.|  
Human    95 PTTEEVIGDL--------KPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVI 151

  Fly  3475 ---------------REG------------------------ENIQLQCTVTD--------QYGV 3492
                           .||                        |.||:...|..        |:.|
Human   152 VVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAV 216

  Fly  3493 RAQDNVEFNWFRDDRRPLPNNARTDSQILVLTNLRPEDA--GRYICNSYDVDRGQQLPEVSIDLQ 3555
            ||.::         ..|.|.:..:|    ::..|.||:|  |||                     
Human   217 RAMNS---------HGPSPRSWPSD----IIRTLCPEEAGSGRY--------------------- 247

  Fly  3556 VLRAPQYPYNRFKGGVSLKDTPCMVLYICAAATPPPNSPIYLPPQLPAKSRDYSLKLDDQSSNLR 3620
               .|:|                                                     .:::.
Human   248 ---GPRY-----------------------------------------------------ITDMG 256

  Fly  3621 AGESTDVECYSSDDTYTDVVWERSDGAPLSNNVRQVGN--------RLVISN-------VSPSDA 3670
            |||  |.|.: .||...|:.:|.....|.:..    ||        ::.|||       :.|:.|
Human   257 AGE--DDEGF-EDDLDLDISFEEVKPLPATKG----GNKKFLVESKKMSISNPKTISRLIPPTSA 314

  Fly  3671 GNYVCKCKTDEGDLYTTSYKLEVEDQPHELKSSKIVYAKVGANA-------------DLQCGADE 3722
            ...|           ||     |..||       |...:.|.|.             :..|.||.
Human   315 SLPV-----------TT-----VAPQP-------IPIQRKGKNGVAIMSRLFDMPCDETLCSADS 356

  Fly  3723 SRQPTYRWSRQYGQLQAGRSLMNEKLSLDSVQANDAGTYICTAQYADGETADFPNILVVTGAIPQ 3787
            .....|.|.....|...|:.  .|..|.|.|           .||                  ||
Human   357 FCVNDYTWGGSRCQCTLGKG--GESCSEDIV-----------IQY------------------PQ 390

  Fly  3788 FRQEPRSYMSFPTLPNSSFKFNFELTFRPENGDGLLLFNGQT-RGSGDYIALSLKDRYAEFRFDF 3851
            |  ...||::|..|.||...|...|.||.|..|||||:.|:. .|.||:::|::..|..:|||:.
Human   391 F--FGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNC 453

  Fly  3852 GGKPMLVRAEEPLALNEWHTVRVSRFKRDGYIQVDEQHPVAFPTLQQIPQLDLIEDLYIGGVPN- 3915
            |....::.:|..:.|..||||.:.|...:|.:|::...||...:..|..::.....||:||.|: 
Human   454 GTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSA 518

  Fly  3916 -WELLPADAVSQQVGFVGCISRLTLQGRTVEL----IREAKYKEGITDCRP--CAQGPCQNKGVC 3973
             | |:.|...::  ||.||:..|.:.||.:::    :.:|.....:.:|..  |.:..|.:.|.|
Human   519 YW-LVRATGTNR--GFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTC 580

  Fly  3974 LESQTEQAYTCICQPGWTGRDCAIEGTQCTPGVCGAGRCENTENDMECLCPLNRSGDRCQYNEIL 4038
            ...:.: :|.|:|..|:.||.|....|...|                            |:.|.|
Human   581 TAIKAD-SYICLCPLGFKGRHCEDAFTLTIP----------------------------QFRESL 616

  Fly  4039 NEHSLNFKGNSFAAYGTP-----KVTKVNITLSVRPASLEDSVILYTAESTLPSGDYLALVLRGG 4098
                     .|:||...|     .::.:...::.||.| .|.|:||:.::  .|.|:|::.|.||
Human   617 ---------RSYAATPWPLEPQHYLSFMEFEITFRPDS-GDGVLLYSYDT--GSKDFLSINLAGG 669

  Fly  4099 HAELLINTAARLDPVVVRSAEPLPLNRWTRIEIRRRLGEGILRVGDGPERKAKAPGSDRILSLKT 4163
            |.|...:..:...  |:||.:||.|..|..:.:.|....|||:|......:..|.|....:...|
Human   670 HVEFRFDCGSGTG--VLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNT 732

  Fly  4164 HLYVGG---YDRSTVKVNRDVNITKGFDGCISRLYNFQKPVNLLADIKDAANIQSCGETNMIGGD 4225
            .:::||   ||    .|.::..:.|.|.|.|.::....:.:::..|.....|:::          
Human   733 DIFIGGVPNYD----DVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVEN---------- 783

  Fly  4226 EDSDNEPPVPPPTPDVHENELQPYAMAPCASDPCENGGSCSEQEDVAVCSCPFGFSGKHCQ---- 4286
                                    |..||...||.:||||..:::...|.||.||.|.|||    
Human   784 ------------------------AAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKECG 824

  Fly  4287 --------EHLQLGFNASFRGDGYVELNRSHFQPALEQSYTSMGIVFTTNKPNGLLFWWGQEAGE 4343
                    |.:::   ..|.|..|:..:.......:..|.:::.:.|.|...:|||.|.|.....
Human   825 NYCLNTIIEAIEI---PQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMR 886

  Fly  4344 EYTGQDFIAAAVVDGYVEYSMRL-DGEEAVIRNSDIRVDNGERHIVIAKRDENTAILEVDRM-LH 4406
              ...|||:..:.||.:.:|..| .|..:::.|...  ::|..|.|.|.||..:..:.||.. ..
Human   887 --PNSDFISLGLRDGALVFSYNLGSGVASIMVNGSF--NDGRWHRVKAVRDGQSGKITVDDYGAR 947

  Fly  4407 SGETRPTSKKSMKLPGNVFVGGAPDLEVFTGFRYKHNLNGCIVVVEGETVGQINLSSAAVNGVNA 4471
            :|:: |...:.:.:.|.::|||..::.:.|..:|...|.|||......|...|:|...||:|.|.
Human   948 TGKS-PGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNI 1011

  Fly  4472 NVCPA 4476
            |.|.|
Human  1012 NTCGA 1016

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trolNP_001401049.1 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060
LDLa 813..847 CDD:238060
LDLa 852..887 CDD:238060
LDLa 902..936 CDD:238060
LDLa 956..990 CDD:238060
LDLa 997..1030 CDD:238060
LDLa 1033..1067 CDD:238060
LDLa 1072..1105 CDD:238060
LDLa 1133..1165 CDD:238060
LDLa 1182..1215 CDD:238060
LDLa 1221..1251 CDD:238060
LDLa 1252..1286 CDD:238060
LDLa 1292..1326 CDD:238060
Ig 1344..1405 CDD:472250
Ig strand B 1355..1359 CDD:409353
Ig strand C 1369..1372 CDD:409353
Ig strand E 1388..1392 CDD:409353
LDLa 1439..1473 CDD:238060
LDLa 1479..1513 CDD:238060
LDLa 1522..1556 CDD:238060
Ig_Perlecan_like 1574..1649 CDD:143220
Ig strand B 1577..1583 CDD:143220
Ig strand C 1590..1595 CDD:143220
Ig strand E 1613..1617 CDD:143220
Ig strand F 1626..1632 CDD:143220
Ig strand G 1641..1647 CDD:143220
Laminin_B 1748..1878 CDD:459652
EGF_Lam 1935..1989 CDD:238012
Laminin_B 2113..2249 CDD:459652
EGF_Lam <2250..2276 CDD:238012
EGF_Lam 2284..2333 CDD:238012
Laminin_EGF <2369..2399 CDD:395007
Laminin_B 2465..2599 CDD:459652
Ig_3 2688..2756 CDD:464046
Ig_3 2791..2861 CDD:464046
Ig_3 2890..2958 CDD:464046
Ig 2987..3071 CDD:472250
Ig strand B 3004..3008 CDD:409353
Ig strand C 3017..3021 CDD:409353
Ig strand E 3036..3040 CDD:409353
Ig strand F 3050..3055 CDD:409353
Ig strand G 3063..3066 CDD:409353
I-set 3089..3162 CDD:400151
Ig strand B 3094..3098 CDD:409353
Ig strand C 3107..3111 CDD:409353
Ig strand E 3128..3132 CDD:409353
Ig strand F 3142..3147 CDD:409353
Ig strand G 3155..3158 CDD:409353
Ig 3165..3253 CDD:472250
Ig strand B 3185..3189 CDD:409353
Ig strand C 3198..3202 CDD:409353
Ig strand E 3219..3223 CDD:409353
Ig strand F 3233..3238 CDD:409353
Ig strand G 3246..3249 CDD:409353
Ig 3298..3355 CDD:472250 12/57 (21%)
Ig strand B 3301..3305 CDD:409353 2/3 (67%)
Ig strand C 3313..3316 CDD:409353 0/2 (0%)
Ig strand E 3333..3336 CDD:409353 0/2 (0%)
IG_like 3381..3457 CDD:214653 20/84 (24%)
Ig strand B 3390..3394 CDD:409353 0/3 (0%)
Ig strand C 3403..3407 CDD:409353 1/3 (33%)
Ig strand F 3437..3442 CDD:409353 4/6 (67%)
IG_like 3475..>3536 CDD:214653 20/94 (21%)
Ig strand B 3480..3484 CDD:409353 2/3 (67%)
Ig strand C 3491..3503 CDD:409353 3/11 (27%)
Ig strand E 3519..3523 CDD:409353 0/3 (0%)
Ig 3613..3675 CDD:472250 17/76 (22%)
Ig strand B 3625..3629 CDD:409353 1/3 (33%)
Ig strand C 3637..3642 CDD:409353 1/4 (25%)
Ig strand E 3658..3662 CDD:409353 1/11 (9%)
IG_like 3706..3772 CDD:214653 15/78 (19%)
Ig strand B 3714..3718 CDD:409353 0/16 (0%)
Ig strand C 3727..3731 CDD:409353 1/3 (33%)
Ig strand E 3746..3750 CDD:409353 1/3 (33%)
Ig strand F 3760..3765 CDD:409353 0/4 (0%)
Ig strand G 3774..3777 CDD:409353 0/2 (0%)
LamG 3794..3939 CDD:238058 51/147 (35%)
EGF 3962..3994 CDD:394967 9/31 (29%)
LamG 4042..4195 CDD:238058 43/160 (27%)
EGF_CA 4254..4286 CDD:238011 14/31 (45%)
LamG 4295..4448 CDD:238058 38/154 (25%)
EGFLAMNP_001192230.1 FN3 36..133 CDD:238020 31/146 (21%)
FN3 142..234 CDD:238020 16/104 (15%)
LamG 391..541 CDD:238058 52/154 (34%)
EGF_CA 560..602 CDD:238011 11/42 (26%)
LamG 618..765 CDD:238058 43/155 (28%)
EGF_CA <792..820 CDD:238011 13/27 (48%)
Laminin_G_2 868..993 CDD:460494 36/129 (28%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.