DRSC/TRiP Functional Genomics Resources

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Protein Alignment trol and Cntn1

DIOPT Version :10

Sequence 1:NP_001401049.1 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4489 Species:Drosophila melanogaster
Sequence 2:NP_031753.1 Gene:Cntn1 / 12805 MGIID:105980 Length:1020 Species:Mus musculus


Alignment Length:1187 Identity:236/1187 - (19%)
Similarity:384/1187 - (32%) Gaps:405/1187 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  2801 FEEYVNNEII------------CEVLGNPAPRVTWARVDGHADAQSTR--TYDNRLIFDSP-RKS 2850
            |||...|.|.            |....:|.|...|...:|..|..:.|  .....|:.::| ::.
Mouse    43 FEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTNDRYSMVGGNLVINNPDKQK 107

  Fly  2851 DEGRYRCQAEND----QNRDEKYVIVYVQSNPPQPPPQQDRLYITPEEINGLAGESFQLNCQ--F 2909
            |.|.|.|.|.|:    ::.:......|:...||:..|          |:....|:...|.|.  :
Mouse   108 DAGVYYCLASNNYGMVRSTEATLSFGYLDPFPPEERP----------EVKVKEGKGMVLLCDPPY 162

  Fly  2910 TSVASLRYDWSHNGRS--LSSSPARNVEIRGNTLEVRDASESDSGVYTC-VAYDVRTRRNFTE-S 2970
            .....|.|.|..|...  ::....|.|......|.:.:...||.|.|:| |:....|:..|:: .
Mouse   163 HFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVESSDRGNYSCFVSSPSITKSVFSKFI 227

  Fly  2971 ARVNIDRREEQPFGNKPIIESLEQNILIIQGEDYSITCEASGSPYPSIKWAKVHDFMPENVHI-- 3033
            ..:.|..|..:|:....:::.  ::|..:.|::.::.|.|.|:|.|.|:|.||.:.||....|  
Mouse   228 PLIPIPERTTKPYPADIVVQF--KDIYTMMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEIST 290

  Fly  3034 SGNVLTIYGARFENRGVYSCVAENDHGSDLSSTSIDIEPRERPSVKIVSAP-----LQTFSVGAP 3093
            ||.||.|:..:.|:.|:|.|.|||..|.|          :.:..:.:.:.|     :....|...
Mouse   291 SGAVLKIFNIQLEDEGLYECEAENIRGKD----------KHQARIYVQAFPEWVEHINDTEVDIG 345

  Fly  3094 ASLY--CTVEGIPDPTVEWVRVDGQPLSPRHKIQSPGYMVIDDIQLEDSGDYECRAKNIVGE--A 3154
            :.||  |...|.|.||:.|:: :|...   ||    |.:.:.|:..|::|.|:|.|:|..|.  |
Mouse   346 SDLYWPCIATGKPIPTIRWLK-NGYSY---HK----GELRLYDVTFENAGMYQCIAENAYGSIYA 402

  Fly  3155 TGVATITVQEPTLVQIIPDNRDLRLTEGDELSLTCVGSGVPNPEVEW-------VNEMALKRDLY 3212
            .....|....||. ::.|..:.:...:|..:.:.|.....|.|:..|       ||...:.  ::
Mouse   403 NAELKILALAPTF-EMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRIL--IW 464

  Fly  3213 SPPSNTAILKIYRVTKADAGIYTCHGKNEAG-SDEAHVRVEVQERRGDIGGVDDDSDRDPINYNP 3276
            ...|    |:|..:|:.|.|||||..:|..| ::.....|.....|..:.         |||.: 
Mouse   465 EDGS----LEINNITRNDGGIYTCFAENNRGKANSTGTLVITNPTRIILA---------PINAD- 515

  Fly  3277 PQQQNPGIHQPGSNQLLATDIGDNVTLTC-DMFQP---LNTRWERVDGAPLPRNAYTIKNRLEIV 3337
                              ..:|:|.|:.| ..|.|   |...|.        .|.|.|....||.
Mouse   516 ------------------ITVGENATMQCAASFDPALDLTFVWS--------FNGYVIDFNKEIT 554

  Fly  3338 RVEQQNLGQYRCNGIGRDGNVKTYFVKELVLMPLPRIRFYPNIPLTVEAGQNLDVHCQVENVRPE 3402
            .:..|.......||             ||::.                       :.|:::    
Mouse   555 HIHYQRNFMLDANG-------------ELLIR-----------------------NAQLKH---- 579

  Fly  3403 DVHWSTDNNRPLPSSVRIVGSVLRFVSITQAAAGEYRCSAFNQYGNRSQIARVAVKKPADFHQVP 3467
                                            ||.|.|:|.....|.|..|.:.|:.|..    |
Mouse   580 --------------------------------AGRYTCTAQTIVDNSSASADLVVRGPPG----P 608

  Fly  3468 QSQLQRHREGENIQLQCTVTDQYGVRAQD----NVEFNWFR--DDRRPLP--------------N 3512
            ..                     |:|.:|    :|...|.|  |:..|:.              .
Mouse   609 PG---------------------GLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWK 652

  Fly  3513 NARTDSQILVLTNLRPEDAGRYICNSYDVDRGQQLPEVSIDLQVLRA-------PQYPYNRFKGG 3570
            :|:||..|:        :.......:.|:     :|.:..:.:|:..       |..|.||.|  
Mouse   653 DAKTDPPII--------EGNMESAKAVDL-----IPWMEYEFRVVATNTLGTGEPSIPSNRIK-- 702

  Fly  3571 VSLKDTPCMVLYICAAATPPPNSPIYLPPQLPAKSRDYSLKLDDQSSNLRAGESTDVECYSSDDT 3635
                          .....|..:|                      |::..|..|:.|       
Mouse   703 --------------TDGAAPNVAP----------------------SDVGGGGGTNRE------- 724

  Fly  3636 YTDVVWERSDGAPLS------NNVRQV-------GNRLVISNVSPSDAGNYVCKCKTDEGDLYTT 3687
             ..:.|     ||||      ||...:       |.......|:..|.|.||.|   ||....:|
Mouse   725 -LTITW-----APLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHK---DETMTPST 780

  Fly  3688 SYKLEV--------------------EDQPHE---------LKSSKI------VYAKV------- 3710
            :::::|                    :|.|.|         |.||:|      |..|:       
Mouse   781 AFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWKHVLEKIVESYQIR 845

  Fly  3711 -GANADLQCGADESRQPTYRWSRQYGQLQAGRSLMNEKLSLDSVQANDAGTYICTAQYADGETAD 3774
             .|..|.:..|...:..:..:|.:...|     |.:.:..::....|.||   |      |.::|
Mouse   846 YWAGHDKEAAAHRVQVTSQEYSARLENL-----LPDTQYFIEVGACNSAG---C------GPSSD 896

  Fly  3775 FPNILVVTGAIPQFRQEPRSYMSFPT-------------LPNSSFKFNFELTFRPENGDGLLLFN 3826
            .  |...|...|. .|.||...|..:             |.|.|....:::.:||:......||:
Mouse   897 V--IETFTRKAPP-SQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKILYRPDGQHDGKLFS 958

  Fly  3827 GQTRG-------SGDYI 3836
            .....       .|:|:
Mouse   959 THKHSIEVPIPRDGEYV 975

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trolNP_001401049.1 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060
LDLa 813..847 CDD:238060
LDLa 852..887 CDD:238060
LDLa 902..936 CDD:238060
LDLa 956..990 CDD:238060
LDLa 997..1030 CDD:238060
LDLa 1033..1067 CDD:238060
LDLa 1072..1105 CDD:238060
LDLa 1133..1165 CDD:238060
LDLa 1182..1215 CDD:238060
LDLa 1221..1251 CDD:238060
LDLa 1252..1286 CDD:238060
LDLa 1292..1326 CDD:238060
Ig 1344..1405 CDD:472250
Ig strand B 1355..1359 CDD:409353
Ig strand C 1369..1372 CDD:409353
Ig strand E 1388..1392 CDD:409353
LDLa 1439..1473 CDD:238060
LDLa 1479..1513 CDD:238060
LDLa 1522..1556 CDD:238060
Ig_Perlecan_like 1574..1649 CDD:143220
Ig strand B 1577..1583 CDD:143220
Ig strand C 1590..1595 CDD:143220
Ig strand E 1613..1617 CDD:143220
Ig strand F 1626..1632 CDD:143220
Ig strand G 1641..1647 CDD:143220
Laminin_B 1748..1878 CDD:459652
EGF_Lam 1935..1989 CDD:238012
Laminin_B 2113..2249 CDD:459652
EGF_Lam <2250..2276 CDD:238012
EGF_Lam 2284..2333 CDD:238012
Laminin_EGF <2369..2399 CDD:395007
Laminin_B 2465..2599 CDD:459652
Ig_3 2688..2756 CDD:464046
Ig_3 2791..2861 CDD:464046 19/74 (26%)
Ig_3 2890..2958 CDD:464046 16/72 (22%)
Ig 2987..3071 CDD:472250 28/85 (33%)
Ig strand B 3004..3008 CDD:409353 0/3 (0%)
Ig strand C 3017..3021 CDD:409353 1/3 (33%)
Ig strand E 3036..3040 CDD:409353 2/3 (67%)
Ig strand F 3050..3055 CDD:409353 2/4 (50%)
Ig strand G 3063..3066 CDD:409353 0/2 (0%)
I-set 3089..3162 CDD:400151 23/76 (30%)
Ig strand B 3094..3098 CDD:409353 2/5 (40%)
Ig strand C 3107..3111 CDD:409353 1/3 (33%)
Ig strand E 3128..3132 CDD:409353 1/3 (33%)
Ig strand F 3142..3147 CDD:409353 2/4 (50%)
Ig strand G 3155..3158 CDD:409353 0/2 (0%)
Ig 3165..3253 CDD:472250 23/95 (24%)
Ig strand B 3185..3189 CDD:409353 0/3 (0%)
Ig strand C 3198..3202 CDD:409353 1/10 (10%)
Ig strand E 3219..3223 CDD:409353 1/3 (33%)
Ig strand F 3233..3238 CDD:409353 4/4 (100%)
Ig strand G 3246..3249 CDD:409353 0/2 (0%)
Ig 3298..3355 CDD:472250 16/60 (27%)
Ig strand B 3301..3305 CDD:409353 1/3 (33%)
Ig strand C 3313..3316 CDD:409353 0/2 (0%)
Ig strand E 3333..3336 CDD:409353 0/2 (0%)
IG_like 3381..3457 CDD:214653 9/75 (12%)
Ig strand B 3390..3394 CDD:409353 0/3 (0%)
Ig strand C 3403..3407 CDD:409353 0/3 (0%)
Ig strand F 3437..3442 CDD:409353 2/4 (50%)
IG_like 3475..>3536 CDD:214653 12/80 (15%)
Ig strand B 3480..3484 CDD:409353 0/3 (0%)
Ig strand C 3491..3503 CDD:409353 4/15 (27%)
Ig strand E 3519..3523 CDD:409353 1/3 (33%)
Ig 3613..3675 CDD:472250 16/74 (22%)
Ig strand B 3625..3629 CDD:409353 1/3 (33%)
Ig strand C 3637..3642 CDD:409353 0/4 (0%)
Ig strand E 3658..3662 CDD:409353 0/3 (0%)
IG_like 3706..3772 CDD:214653 13/73 (18%)
Ig strand B 3714..3718 CDD:409353 1/3 (33%)
Ig strand C 3727..3731 CDD:409353 0/3 (0%)
Ig strand E 3746..3750 CDD:409353 0/3 (0%)
Ig strand F 3760..3765 CDD:409353 1/4 (25%)
Ig strand G 3774..3777 CDD:409353 1/2 (50%)
LamG 3794..3939 CDD:238058 10/63 (16%)
EGF 3962..3994 CDD:394967
LamG 4042..4195 CDD:238058
EGF_CA 4254..4286 CDD:238011
LamG 4295..4448 CDD:238058
Cntn1NP_031753.1 IgI_1_Contactin-1 40..134 CDD:409436 20/90 (22%)
Ig strand A 42..46 CDD:409436 2/2 (100%)
Ig strand A' 49..54 CDD:409436 2/4 (50%)
Ig strand B 60..68 CDD:409436 1/7 (14%)
Ig strand C 73..79 CDD:409436 2/5 (40%)
Ig strand C' 81..84 CDD:409436 1/2 (50%)
Ig strand D 90..94 CDD:409436 1/3 (33%)
Ig strand E 96..102 CDD:409436 1/5 (20%)
Ig strand F 109..118 CDD:409436 4/8 (50%)
Ig strand G 121..134 CDD:409436 0/12 (0%)
Ig2_Contactin-2-like 142..230 CDD:409392 20/97 (21%)
Ig strand A 144..149 CDD:409392 2/14 (14%)
Ig strand B 153..159 CDD:409392 1/5 (20%)
Ig strand C 168..174 CDD:409392 3/5 (60%)
Ig strand C' 179..181 CDD:409392 0/1 (0%)
Ig strand D 186..191 CDD:409392 2/4 (50%)
Ig strand E 194..198 CDD:409392 1/3 (33%)
Ig strand F 208..216 CDD:409392 3/7 (43%)
Ig strand G 218..230 CDD:409392 2/11 (18%)
IgI_3_Contactin-1 241..328 CDD:143259 28/98 (29%)
Ig strand A 241..246 CDD:143259 0/4 (0%)
Ig strand A' 249..254 CDD:143259 1/4 (25%)
Ig strand B 257..266 CDD:143259 1/8 (13%)
Ig strand C 272..276 CDD:143259 1/3 (33%)
Ig strand C' 279..281 CDD:143259 0/1 (0%)
Ig strand D 289..292 CDD:143259 0/2 (0%)
Ig strand E 293..298 CDD:143259 2/4 (50%)
Ig strand F 306..314 CDD:143259 4/7 (57%)
Ig strand G 317..328 CDD:143259 2/20 (10%)
Ig 332..408 CDD:472250 22/83 (27%)
Ig strand B 348..352 CDD:143205 2/3 (67%)
Ig strand C 361..365 CDD:143205 1/3 (33%)
Ig strand E 374..378 CDD:143205 1/3 (33%)
Ig strand F 388..393 CDD:143205 2/4 (50%)
Ig strand G 401..404 CDD:143205 1/2 (50%)
Ig5_Contactin-1 413..501 CDD:409438 22/94 (23%)
Ig strand A 413..418 CDD:409438 2/5 (40%)
Ig strand A' 421..426 CDD:409438 0/4 (0%)
Ig strand B 430..437 CDD:409438 0/6 (0%)
Ig strand C 445..449 CDD:409438 0/3 (0%)
Ig strand D 463..466 CDD:409438 0/2 (0%)
Ig strand E 467..472 CDD:409438 2/8 (25%)
Ig strand F 480..488 CDD:409438 5/7 (71%)
Ig strand G 494..501 CDD:409438 0/6 (0%)
Ig6_Contactin 503..603 CDD:409359 31/207 (15%)
Ig strand A 503..509 CDD:409359 1/5 (20%)
Ig strand A' 512..517 CDD:409359 2/23 (9%)
Ig strand B 520..528 CDD:409359 3/7 (43%)
Ig strand C 537..541 CDD:409359 0/3 (0%)
Ig strand D 564..567 CDD:409359 0/2 (0%)
Ig strand E 568..572 CDD:409359 3/16 (19%)
Ig strand F 581..588 CDD:409359 3/6 (50%)
Ig strand G 595..599 CDD:409359 1/3 (33%)
FN3 612..699 CDD:238020 16/99 (16%)
FN3 650..>947 CDD:442628 67/380 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 695..719 7/61 (11%)
fn3 813..895 CDD:394996 17/95 (18%)
FN3 907..991 CDD:238020 13/70 (19%)
Blue background indicates that the domain is not in the aligned region.

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