Protein Alignment trol and LOC1275280

DIOPT Version :10

• Sequence 1: NP_001401049.1
• Gene: trol / 45320
• FlyBaseID: FBgn0284408
• Length: 4489
• Species: Drosophila melanogaster
• Sequence 2: XP_314518.4
• Gene: LOC1275280 / 1275280
• VectorBaseID: AGAMI1_006197
• Length: 385
• Species: Anopheles gambiae
• Alignment Length: 412
• Identity: 104/412 - (25%)
• Similarity: 159/412 - (38%)
• Gaps: 115/412 - (27%)

  Fly  1546 DCTDGTDEVGCMAPLPIR---PPPQSVSLLEYEVLELTCVATGTPTPTIV------WRL---NWG 1598
            ||......||.:.||.|.   ...:.|| ||||.         |||..:|      .:|   ::|
Mosquito     4 DCVKLLAVVGLLFPLCILVNCNDSEDVS-LEYET---------TPTFDVVIAEGKKLKLKVHDYG 58

  Fly  1599 HVPDKC------------ESKSYGGTGTLRCPDMRPQDSGAY-----------SCEII---NTRG 1637
            |.| .|            :|:.....|.|.||.::.:|:|.|           ...:|   |.:.
Mosquito    59 HRP-LCNPVWYFNGRPVSKSRCIPSYGELVCPSVKREDAGRYDLWGGDGSRHSQARLIFSANVQV 122

  Fly  1638 THFVNPDTIVTVRPVRTDVCEAGFFNMLARKAEECVQCFCFGVAKACDSANLFTYAIHPPILSHR 1702
            |..|..| :...|..:.......||.   ||......|||.||.:.|..|
Mosquito   123 TRAVERD-LPKERIAKVQDEPPPFFE---RKNRVENDCFCSGVTERCRMA--------------- 168

  Fly  1703 VVSVELSPLRQIVINEAAPGQDLLTLLHGVQFRATNVHFSGRET--PYLALPAD-YMGNQLKSYG 1764
               ::|..:|:.        .||..|        |.|...|..:  .|:.:|.. .:||.:.:||
Mosquito   169 ---LDLYRMRKT--------YDLSNL--------TAVRLGGESSGAKYIRIPLSVLLGNLITAYG 214

  Fly  1765 GNLRYEVN---YRGSGRPVNGPDVIITGNR---FTLTYRVRTQPGQNNRVSIPFVPGGWQ----- 1818
            |.:|:.|.   |....:|.    |::...|   ..:.|.:.|...| .:|.:......|:
Mosquito   215 GYMRFPVTEECYTDRSKPC----VVMVDKRNMHRAVGYFLPTSHDQ-RQVQVLLKESNWKLLPAI 274

  Fly  1819 -----KPDGRKASREEIMMILANVDNILIRLGYLDSTAREVDLINIALDSAGTADKGLGSASLVE 1878
                 :..|.:.::...|..|:|:.::.||..|  .|..|.::::|  |.|.:.|:|||:.:.||
Mosquito   275 DELSDRDSGDELTKFIFMSTLSNIHSVYIRGRY--RTRSEENILSI--DMASSYDEGLGTVTTVE 335

  Fly  1879 KCQCPPGYVGDSCESCASGYVR 1900
            :|.|.|||.|.|||.|..||:|
Mosquito   336 ECDCHPGYGGLSCERCEKGYLR 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trol	NP_001401049.1	LDLa	447..480	CDD:238060
		LDLa	532..564	CDD:238060
		LDLa	571..606	CDD:238060
		LDLa	616..650	CDD:238060
		LDLa	704..739	CDD:238060
		LDLa	813..847	CDD:238060
		LDLa	852..887	CDD:238060
		LDLa	902..936	CDD:238060
		LDLa	956..990	CDD:238060
		LDLa	997..1030	CDD:238060
		LDLa	1033..1067	CDD:238060
		LDLa	1072..1105	CDD:238060
		LDLa	1133..1165	CDD:238060
		LDLa	1182..1215	CDD:238060
		LDLa	1221..1251	CDD:238060
		LDLa	1252..1286	CDD:238060
		LDLa	1292..1326	CDD:238060
		Ig	1344..1405	CDD:472250
		Ig strand B	1355..1359	CDD:409353
		Ig strand C	1369..1372	CDD:409353
		Ig strand E	1388..1392	CDD:409353
		LDLa	1439..1473	CDD:238060
		LDLa	1479..1513	CDD:238060
		LDLa	1522..1556	CDD:238060	3/9 (33%)
		Ig_Perlecan_like	1574..1649	CDD:143220	24/109 (22%)
		Ig strand B	1577..1583	CDD:143220	0/5 (0%)
		Ig strand C	1590..1595	CDD:143220	1/10 (10%)
		Ig strand E	1613..1617	CDD:143220	2/3 (67%)
		Ig strand F	1626..1632	CDD:143220	2/16 (13%)
		Ig strand G	1641..1647	CDD:143220	2/5 (40%)
		Laminin_B	1748..1878	CDD:459652	34/146 (23%)
		EGF_Lam	1935..1989	CDD:238012
		Laminin_B	2113..2249	CDD:459652
		EGF_Lam	<2250..2276	CDD:238012
		EGF_Lam	2284..2333	CDD:238012
		Laminin_EGF	<2369..2399	CDD:395007
		Laminin_B	2465..2599	CDD:459652
		Ig_3	2688..2756	CDD:464046
		Ig_3	2791..2861	CDD:464046
		Ig_3	2890..2958	CDD:464046
		Ig	2987..3071	CDD:472250
		Ig strand B	3004..3008	CDD:409353
		Ig strand C	3017..3021	CDD:409353
		Ig strand E	3036..3040	CDD:409353
		Ig strand F	3050..3055	CDD:409353
		Ig strand G	3063..3066	CDD:409353
		I-set	3089..3162	CDD:400151
		Ig strand B	3094..3098	CDD:409353
		Ig strand C	3107..3111	CDD:409353
		Ig strand E	3128..3132	CDD:409353
		Ig strand F	3142..3147	CDD:409353
		Ig strand G	3155..3158	CDD:409353
		Ig	3165..3253	CDD:472250
		Ig strand B	3185..3189	CDD:409353
		Ig strand C	3198..3202	CDD:409353
		Ig strand E	3219..3223	CDD:409353
		Ig strand F	3233..3238	CDD:409353
		Ig strand G	3246..3249	CDD:409353
		Ig	3298..3355	CDD:472250
		Ig strand B	3301..3305	CDD:409353
		Ig strand C	3313..3316	CDD:409353
		Ig strand E	3333..3336	CDD:409353
		IG_like	3381..3457	CDD:214653
		Ig strand B	3390..3394	CDD:409353
Ig strand C	3403..3407	CDD:409353
Ig strand F	3437..3442	CDD:409353
IG_like	3475..>3536	CDD:214653
Ig strand B	3480..3484	CDD:409353
Ig strand C	3491..3503	CDD:409353
Ig strand E	3519..3523	CDD:409353
Ig	3613..3675	CDD:472250
Ig strand B	3625..3629	CDD:409353
Ig strand C	3637..3642	CDD:409353
Ig strand E	3658..3662	CDD:409353
IG_like	3706..3772	CDD:214653
Ig strand B	3714..3718	CDD:409353
Ig strand C	3727..3731	CDD:409353
Ig strand E	3746..3750	CDD:409353
Ig strand F	3760..3765	CDD:409353
Ig strand G	3774..3777	CDD:409353
LamG	3794..3939	CDD:238058
EGF	3962..3994	CDD:394967
LamG	4042..4195	CDD:238058
EGF_CA	4254..4286	CDD:238011
LamG	4295..4448	CDD:238058
LOC1275280	XP_314518.4	None