DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trol and CNTN1

DIOPT Version :10

Sequence 1:NP_001401049.1 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4489 Species:Drosophila melanogaster
Sequence 2:NP_001834.2 Gene:CNTN1 / 1272 HGNCID:2171 Length:1018 Species:Homo sapiens


Alignment Length:1065 Identity:222/1065 - (20%)
Similarity:362/1065 - (33%) Gaps:297/1065 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  2801 FEEYVNNEII------------CEVLGNPAPRVTWARVDGHADAQSTR--TYDNRLIFDSP-RKS 2850
            |||...|.|.            |....:|.|...|...:|..|..|.|  .....|:.::| ::.
Human    43 FEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQK 107

  Fly  2851 DEGRYRCQAEND----QNRDEKYVIVYVQSNPPQPPPQQDRLYITPEEINGLAGESFQLNCQ--F 2909
            |.|.|.|.|.|:    ::.:......|:...||:..|          |:....|:...|.|.  :
Human   108 DAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERP----------EVRVKEGKGMVLLCDPPY 162

  Fly  2910 TSVASLRYDWSHNGRS--LSSSPARNVEIRGNTLEVRDASESDSGVYTC-VAYDVRTRRNFTE-S 2970
            .....|.|.|..|...  ::....|.|......|.:.:...||.|.|:| |:....|:..|:: .
Human   163 HFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFI 227

  Fly  2971 ARVNIDRREEQPFGNKPIIESLEQNILIIQGEDYSITCEASGSPYPSIKWAKVHDFMPENVHI-- 3033
            ..:.|..|..:|:....:::.  :::..:.|::.::.|.|.|:|.|.|:|.||.:.||....|  
Human   228 PLIPIPERTTKPYPADIVVQF--KDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEIST 290

  Fly  3034 SGNVLTIYGARFENRGVYSCVAENDHGSDLSSTSIDIEPRERPSVKIVSAP-----LQTFSVGAP 3093
            ||.||.|:..:.|:.|:|.|.|||..|.|          :.:..:.:.:.|     :....|...
Human   291 SGAVLKIFNIQLEDEGIYECEAENIRGKD----------KHQARIYVQAFPEWVEHINDTEVDIG 345

  Fly  3094 ASLY--CTVEGIPDPTVEWVRVDGQPLSPRHKIQSPGYMVIDDIQLEDSGDYECRAKNIVGE--A 3154
            :.||  |...|.|.||:.|:: :|...   ||    |.:.:.|:..|::|.|:|.|:|..|.  |
Human   346 SDLYWPCVATGKPIPTIRWLK-NGYAY---HK----GELRLYDVTFENAGMYQCIAENTYGAIYA 402

  Fly  3155 TGVATITVQEPTLVQIIPDNRDLRLTEGDELSLTCVGSGVPNPEVEW-------VNEMALKRDLY 3212
            .....|....||. ::.|..:.:...:|..:.:.|.....|.|:..|       ||...:.  ::
Human   403 NAELKILALAPTF-EMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRIL--IW 464

  Fly  3213 SPPSNTAILKIYRVTKADAGIYTCHGKNEAGSDEA--------HVRVEVQERRGDI--------- 3260
            ...|    |:|..:|:.|.|||||..:|..|...:        ..|:.:.....||         
Human   465 EDGS----LEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQ 525

  Fly  3261 -----------------GGVDDDSDRDPINYNPPQQ------------QNPGIHQPGSNQLLATD 3296
                             .|...|.:::.|:|   |:            :|..:...|.....|..
Human   526 CAASFDPALDLTFVWSFNGYVIDFNKENIHY---QRNFMLDSNGELLIRNAQLKHAGRYTCTAQT 587

  Fly  3297 IGDNVTLTCDMF------QPLNTR------------WERVDGAPLPRNAYTIKNRLEIVRVEQQN 3343
            |.||.:.:.|:.      .|...|            |.|......|.:.|||:.:    .:...:
Human   588 IVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTK----TILSDD 648

  Fly  3344 LGQYRCNGIGRDGNVKTYFVKELVLMPLPRIRF-----------YPNIPLTVEAGQNLDVHCQVE 3397
            ....:.:....:||::.  .:.:.|:|.....|           .|:||     ...:.......
Human   649 WKDAKTDPPIIEGNMEA--ARAVDLIPWMEYEFRVVATNTLGRGEPSIP-----SNRIKTDGAAP 706

  Fly  3398 NVRPEDVHWSTDNNRPL-----PSSVRI-----VGSVLRF----------VSITQAAAGEY---- 3438
            ||.|.||......||.|     |.|...     .|.::.|          |::|....|.|    
Human   707 NVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKD 771

  Fly  3439 -----------RCSAFNQYG----------NRSQIARVAVKKPADFHQVPQSQLQRHREGENIQL 3482
                       :..|||..|          |.:|.|............:..|::..|.|    .:
Human   772 ETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWE----HV 832

  Fly  3483 QCTVTDQYGVRAQDNVEFNWFRDDRRPLPNNARTDSQ--ILVLTNLRPEDAGRYI----CNSYDV 3541
            ...:.:.|.:|       .|...|:....|..:..||  ...|.||.| |...:|    |||   
Human   833 LEKIVESYQIR-------YWAAHDKEEAANRVQVTSQEYSARLENLLP-DTQYFIEVGACNS--- 886

  Fly  3542 DRGQQLPEVSIDLQVLRAPQYPYNRFKGGVSLKDTPCMVLYICAAATPPPNSPIYLPPQLPAKSR 3606
             .|...|...|:....:|                              ||:.|..:...:.:.||
Human   887 -AGCGPPSDMIEAFTKKA------------------------------PPSQPPRIISSVRSGSR 920

  Fly  3607 -----DYSLKLDDQSS------NLRAGESTDVECYSS-----------DDTYTDVVWERSDGAPL 3649
                 |:.:.|.::|:      ..|.....|.:.||:           |..|...|...|||.. 
Human   921 YIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPRDGEYVVEVRAHSDGGD- 984

  Fly  3650 SNNVRQVGNRLVIS---NVSPSDAG 3671
                 .|.:::.||   .:|||..|
Human   985 -----GVVSQVKISGAPTLSPSLLG 1004

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trolNP_001401049.1 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060
LDLa 813..847 CDD:238060
LDLa 852..887 CDD:238060
LDLa 902..936 CDD:238060
LDLa 956..990 CDD:238060
LDLa 997..1030 CDD:238060
LDLa 1033..1067 CDD:238060
LDLa 1072..1105 CDD:238060
LDLa 1133..1165 CDD:238060
LDLa 1182..1215 CDD:238060
LDLa 1221..1251 CDD:238060
LDLa 1252..1286 CDD:238060
LDLa 1292..1326 CDD:238060
Ig 1344..1405 CDD:472250
Ig strand B 1355..1359 CDD:409353
Ig strand C 1369..1372 CDD:409353
Ig strand E 1388..1392 CDD:409353
LDLa 1439..1473 CDD:238060
LDLa 1479..1513 CDD:238060
LDLa 1522..1556 CDD:238060
Ig_Perlecan_like 1574..1649 CDD:143220
Ig strand B 1577..1583 CDD:143220
Ig strand C 1590..1595 CDD:143220
Ig strand E 1613..1617 CDD:143220
Ig strand F 1626..1632 CDD:143220
Ig strand G 1641..1647 CDD:143220
Laminin_B 1748..1878 CDD:459652
EGF_Lam 1935..1989 CDD:238012
Laminin_B 2113..2249 CDD:459652
EGF_Lam <2250..2276 CDD:238012
EGF_Lam 2284..2333 CDD:238012
Laminin_EGF <2369..2399 CDD:395007
Laminin_B 2465..2599 CDD:459652
Ig_3 2688..2756 CDD:464046
Ig_3 2791..2861 CDD:464046 20/74 (27%)
Ig_3 2890..2958 CDD:464046 16/72 (22%)
Ig 2987..3071 CDD:472250 27/85 (32%)
Ig strand B 3004..3008 CDD:409353 0/3 (0%)
Ig strand C 3017..3021 CDD:409353 1/3 (33%)
Ig strand E 3036..3040 CDD:409353 2/3 (67%)
Ig strand F 3050..3055 CDD:409353 2/4 (50%)
Ig strand G 3063..3066 CDD:409353 0/2 (0%)
I-set 3089..3162 CDD:400151 23/76 (30%)
Ig strand B 3094..3098 CDD:409353 2/5 (40%)
Ig strand C 3107..3111 CDD:409353 1/3 (33%)
Ig strand E 3128..3132 CDD:409353 1/3 (33%)
Ig strand F 3142..3147 CDD:409353 2/4 (50%)
Ig strand G 3155..3158 CDD:409353 0/2 (0%)
Ig 3165..3253 CDD:472250 23/102 (23%)
Ig strand B 3185..3189 CDD:409353 0/3 (0%)
Ig strand C 3198..3202 CDD:409353 1/10 (10%)
Ig strand E 3219..3223 CDD:409353 1/3 (33%)
Ig strand F 3233..3238 CDD:409353 4/4 (100%)
Ig strand G 3246..3249 CDD:409353 0/10 (0%)
Ig 3298..3355 CDD:472250 11/74 (15%)
Ig strand B 3301..3305 CDD:409353 0/3 (0%)
Ig strand C 3313..3316 CDD:409353 1/14 (7%)
Ig strand E 3333..3336 CDD:409353 0/2 (0%)
IG_like 3381..3457 CDD:214653 24/120 (20%)
Ig strand B 3390..3394 CDD:409353 0/3 (0%)
Ig strand C 3403..3407 CDD:409353 2/3 (67%)
Ig strand F 3437..3442 CDD:409353 1/19 (5%)
IG_like 3475..>3536 CDD:214653 14/66 (21%)
Ig strand B 3480..3484 CDD:409353 0/3 (0%)
Ig strand C 3491..3503 CDD:409353 1/11 (9%)
Ig strand E 3519..3523 CDD:409353 1/5 (20%)
Ig 3613..3675 CDD:472250 18/79 (23%)
Ig strand B 3625..3629 CDD:409353 1/3 (33%)
Ig strand C 3637..3642 CDD:409353 1/4 (25%)
Ig strand E 3658..3662 CDD:409353 0/3 (0%)
IG_like 3706..3772 CDD:214653
Ig strand B 3714..3718 CDD:409353
Ig strand C 3727..3731 CDD:409353
Ig strand E 3746..3750 CDD:409353
Ig strand F 3760..3765 CDD:409353
Ig strand G 3774..3777 CDD:409353
LamG 3794..3939 CDD:238058
EGF 3962..3994 CDD:394967
LamG 4042..4195 CDD:238058
EGF_CA 4254..4286 CDD:238011
LamG 4295..4448 CDD:238058
CNTN1NP_001834.2 IgI_1_Contactin-1 40..134 CDD:409436 21/90 (23%)
Ig strand A 42..46 CDD:409436 2/2 (100%)
Ig strand A' 49..54 CDD:409436 2/4 (50%)
Ig strand B 60..68 CDD:409436 1/7 (14%)
Ig strand C 73..79 CDD:409436 2/5 (40%)
Ig strand C' 81..84 CDD:409436 1/2 (50%)
Ig strand D 90..94 CDD:409436 1/3 (33%)
Ig strand E 96..102 CDD:409436 1/5 (20%)
Ig strand F 109..118 CDD:409436 4/8 (50%)
Ig strand G 121..134 CDD:409436 0/12 (0%)
Ig2_Contactin-2-like 142..230 CDD:409392 20/97 (21%)
Ig strand A 144..149 CDD:409392 2/14 (14%)
Ig strand B 153..159 CDD:409392 1/5 (20%)
Ig strand C 168..174 CDD:409392 3/5 (60%)
Ig strand C' 179..181 CDD:409392 0/1 (0%)
Ig strand D 186..191 CDD:409392 2/4 (50%)
Ig strand E 194..198 CDD:409392 1/3 (33%)
Ig strand F 208..216 CDD:409392 3/7 (43%)
Ig strand G 218..230 CDD:409392 2/11 (18%)
IgI_3_Contactin-1 241..328 CDD:143259 27/98 (28%)
Ig strand A 241..246 CDD:143259 0/4 (0%)
Ig strand A' 249..254 CDD:143259 0/4 (0%)
Ig strand B 257..266 CDD:143259 1/8 (13%)
Ig strand C 272..276 CDD:143259 1/3 (33%)
Ig strand C' 279..281 CDD:143259 0/1 (0%)
Ig strand D 289..292 CDD:143259 0/2 (0%)
Ig strand E 293..298 CDD:143259 2/4 (50%)
Ig strand F 306..314 CDD:143259 4/7 (57%)
Ig strand G 317..328 CDD:143259 2/20 (10%)
Ig 332..408 CDD:472250 22/83 (27%)
Ig strand B 348..352 CDD:143205 2/3 (67%)
Ig strand C 361..365 CDD:143205 1/3 (33%)
Ig strand E 374..378 CDD:143205 1/3 (33%)
Ig strand F 388..393 CDD:143205 2/4 (50%)
Ig strand G 401..404 CDD:143205 1/2 (50%)
Ig5_Contactin-1 413..501 CDD:409438 22/94 (23%)
Ig strand A 413..418 CDD:409438 2/5 (40%)
Ig strand A' 421..426 CDD:409438 0/4 (0%)
Ig strand B 430..437 CDD:409438 0/6 (0%)
Ig strand C 445..449 CDD:409438 0/3 (0%)
Ig strand D 463..466 CDD:409438 0/2 (0%)
Ig strand E 467..472 CDD:409438 2/8 (25%)
Ig strand F 480..488 CDD:409438 5/7 (71%)
Ig strand G 494..501 CDD:409438 0/6 (0%)
Ig6_Contactin 503..601 CDD:409359 15/100 (15%)
Ig strand A 503..509 CDD:409359 1/5 (20%)
Ig strand A' 512..517 CDD:409359 1/4 (25%)
Ig strand B 520..528 CDD:409359 0/7 (0%)
Ig strand C 537..541 CDD:409359 0/3 (0%)
Ig strand D 562..565 CDD:409359 0/2 (0%)
Ig strand E 566..570 CDD:409359 0/3 (0%)
Ig strand F 579..586 CDD:409359 1/6 (17%)
Ig strand G 593..597 CDD:409359 0/3 (0%)
FN3 610..697 CDD:238020 15/97 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 693..717 7/28 (25%)
FN3 <745..>945 CDD:442628 43/245 (18%)
fn3 811..893 CDD:394996 20/97 (21%)
FN3 905..989 CDD:238020 18/89 (20%)
Blue background indicates that the domain is not in the aligned region.

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