DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trol and hspg2

DIOPT Version :10

Sequence 1:NP_001401049.1 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4489 Species:Drosophila melanogaster
Sequence 2:XP_031762624.1 Gene:hspg2 / 100494785 XenbaseID:XB-GENE-6465357 Length:4576 Species:Xenopus tropicalis


Alignment Length:4522 Identity:1084/4522 - (23%)
Similarity:1619/4522 - (35%) Gaps:1534/4522 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  1292 CLPNQFRCNSGQCVSSSVRCNGRTDCQDSSDEQNCAADSNDRRPNQLNLKTYPDSQIIKESREVI 1356
            |..::|.|.||.||.:..||:.|.||:|.|||..|..:.....|.:..:.|              
 Frog   252 CRDDEFTCTSGDCVPAEYRCDHRHDCRDMSDELECEYEVVVTVPQEPRITT-------------- 302

  Fly  1357 FRCRDEGPARAKVKWSRPGGRPLPPGFTDRNGRLEIPNIRVEDAGTYVCEAVGYASYIPGQQVTV 1421
                 .||....|..:||...| |..||.       |.:            :....|.|      
 Frog   303 -----PGPNLGPVSTARPATTP-PRPFTR-------PPV------------IATTPYKP------ 336

  Fly  1422 NLNVERYNDVGSRPESACTEYQATCMNGECIDKSSICDGNPDCSDASDEQSCSLGLKCQPNQFMC 1486
             ...:...|:.:|   .|...:|.|.||:||.:..:|||..||.|.|||..|.....|:||:|.|
 Frog   337 -FTHKPPPDLETR---QCRRDEARCPNGQCIPRDYLCDGEKDCKDGSDEMHCGTPSPCEPNEFKC 397

  Fly  1487 SNSKCVDRTWRCDGENDCGDNSDETSCDPEPSGAPCRYNEFQC-RSGHCIPKSFQCDNVPDCTDG 1550
            .|.:|..:.|||||:|||||.|||.:|..:.....|..::|.| ::..|||.|:|||:..||.|.
 Frog   398 KNGRCALKLWRCDGDNDCGDGSDELNCPTKGPSDTCAPDQFVCVQARTCIPASYQCDDEADCPDR 462

  Fly  1551 TDEVGCMAPLPIRPPPQSVSLLEYEVLELTCVATGTPTPTIVWRLNWGHVP--DKCESKSYGGTG 1613
            :|||||..|..|.||.:|:.....:.:..||||.|.|||.|.|||||||:|  .:....|..|.|
 Frog   463 SDEVGCNPPQVITPPEESIMASRGDTVRFTCVAIGVPTPIITWRLNWGHIPTSSRVSMTSENGHG 527

  Fly  1614 TLRCPDMRPQDSGAYSCEIINTRGTHFVNPDTIVTVRPVRTDVCEAGFFNMLARKAEECVQCFCF 1678
            ||...|::..|.|||:||.||.:|..|..||.::.::|.|....|..|:   ...:..|:.||||
 Frog   528 TLIIRDVKEADQGAYTCEAINAKGMVFGIPDGVLILKPHRGPCPEGSFY---VENSARCIPCFCF 589

  Fly  1679 GVAKACDSANL-------------------FTYAIH---PPILSHRVVSVELSPLRQIVINEAAP 1721
            ||.|.|.....                   ||...|   ||:.|:           |:.|:.:..
 Frog   590 GVTKVCQQTGRYRNQIRLRFDVPEDFKGVNFTVPSHVGIPPLSSN-----------QLQIDTSVE 643

  Fly  1722 GQDLLTLLHGVQFRATNVHFSGRETPYLALPADYMGNQLKSYGGNLRYEVNY---RGSGRPVNGP 1783
            ...|:.|..  :|.:.:        .:..||..::||::.||||:|.::|.|   ||...||..|
 Frog   644 EFQLVDLSR--RFLSID--------SFWTLPGQFLGNKVDSYGGSLSFKVRYGLTRGQSEPVRKP 698

  Fly  1784 DVIITGNRFTLTYRVR--TQPGQNNRVSIPFVPGGWQKPDGRKASREEIMMILANVDNILIRLGY 1846
            |||:.||...|.|||:  |||...|:..|.|....||...|...:||:::|.|.|::.|:|:..|
 Frog   699 DVILVGNGRKLIYRVQTSTQPSIVNQRKIQFTEENWQHESGASVTREDLLMTLQNLEAIMIQTVY 763

  Fly  1847 LDSTAREVDLINIALDSAGTADKGLGSASLVEKCQCPPGYVGDSCESCASGYVRQPGGPWLGHCV 1911
             |:....|.:.:|.:|:.......||.|..||:|:||.||.|.|||.||:.:.|.||||:||.|.
 Frog   764 -DNKMASVGISDIVMDTTSVEYTQLGPAVGVEECRCPGGYAGPSCEVCAAQFERVPGGPFLGTCS 827

  Fly  1912 ---------------------------PFIPDSCPSGTYGDPRRGV--PCKECPCPLTG-SNNFA 1946
                                       |.. :.|.:|.:|||.|||  .|:.||||.|. ...|:
 Frog   828 GCNCNGHASSCDPVSGYCLNCQHNTEGPQC-NKCKAGFFGDPTRGVSDACRPCPCPHTDPRRRFS 891

  Fly  1947 SGCQQSPDGDVVC-RCNEGYTGRRCEQCAAGYQGNPLAAGGICRRIPDTSCNVDGTYSVHSNGTC 2010
            ..|....||...| .|..||||||||:||.||.|.|:..||.|..:.:. |:|.|..|. .:|:|
 Frog   892 DTCFMDVDGQPTCDSCAPGYTGRRCERCAEGYDGRPMQPGGRCEPVGNV-CDVKGALST-GDGSC 954

  Fly  2011 QCKDSVIGEQCDTCKSKSFHLNSFTYTGCIECFCSGVGLDCDSSTWYRDQVTSTFGRSRVDHGFV 2075
            .||..|.|..|:.|||.:|:|:.....||::|||.|:...|.||.|.||||:||:          
 Frog   955 VCKSHVEGNFCNECKSGTFYLSEKNPDGCLKCFCMGITRQCSSSFWNRDQVSSTY---------- 1009

  Fly  2076 LVTNYMQPTPDTVP--VSMAAEPNALS------------FIGSADQSGNTLYWSLPAAFLGNKLS 2126
                   .:.|.||  :|.|.....||            |....:...:..:|.||..|.|:|::
 Frog  1010 -------DSQDRVPFTISNAGSTRTLSESIRVTGQSELTFSNFLNVPQDVYFWVLPDRFKGDKVT 1067

  Fly  2127 SYGGKLTYTLSYSPLPNGIMSRNSAPDVVIKSGEDLRLIHYRKSQVVPSVANTYSVEIKESAWQR 2191
            ||||:|.||:::. .|.|.......||||:: |..:.|.|...::..|....|.:|..:|.||:|
 Frog  1068 SYGGELRYTITFE-APAGSQPLFGQPDVVLQ-GNGIFLEHSANTRTAPGFPITITVPFRERAWRR 1130

  Fly  2192 GDEVVANREHVLMALSDITAIYIKATYTTSTKEASLRQVTLDVATPTNLGTPRAVEVEQCRCPEG 2256
            .|...|.|||:||||:||..:.|:|:|.....|..:..:.:|||.|......||||||.|.||.|
 Frog  1131 ADGQDATREHLLMALADIDLLMIRASYAERMVETRISNIHMDVAVPYPTDRQRAVEVEHCVCPPG 1195

  Fly  2257 YLGLSCEQCAPGYARDPEGGIYLGLCRPCECNGHSKYCNSDTGDCEECSDNTEGPSCERCAAGYV 2321
            |.|.||:.|..||.|. ..|:|||.|..|:|.|||..|:.:||:|..|..||||..||:|.||..
 Frog  1196 YSGPSCQDCDTGYTRS-TSGLYLGTCERCQCGGHSSECDRETGECLNCQHNTEGTKCEKCKAGSY 1259

  Fly  2322 GDATRGTIYDCQP-----------------DEGYP-IPSPPA--PGNQTLECT-AY--------- 2356
            .|..||...:|||                 .:|:| ..|.|.  .|.|...|. .|         
 Frog  1260 RDPNRGAAAECQPCPCQGTSAQYFGTCFLDRDGHPTCDSCPVGYAGRQCERCAPGYRGDPARGQP 1324

  Fly  2357 CQIEGIYDC----RGN---------ECLCKRNVIGDQCDQCRPGTYGLSAQNQDGCKECYCSGLA 2408
            |..:|...|    ||:         :|.||.||.|..|..|||..:.||.:|.|||..|:|.|:.
 Frog  1325 CTADGGSSCPCDLRGSVSDRCDSRRQCECKPNVEGASCGTCRPHHFYLSTENPDGCLPCFCMGVT 1389

  Fly  2409 SQCRSAALYRQLIPVDFI---------------------------LNAPLITDES---------- 2436
            .||.|:..:|:||...|:                           .:.|.:|..|          
 Frog  1390 QQCTSSTYHRELISTPFLPGNFQNFALVNRQRSSRITSGFTVEMSRHGPQLTHSSFDQLGQESYY 1454

  Fly  2437 ----------------------------------------------------------------- 2436
                                                                             
 Frog  1455 WQLPEGYQGDKREMYFARMRRAHKNDTSLSEEELRKKVASGQMEEAPPTRARSRRQAKMDEKQKQ 1519

  Fly  2437 ----------------------------------------------GA----------------- 2438
                                                          ||                 
 Frog  1520 IDSEIWNLLSGGSSSASLPKAPPPSAAHNKSQGTPIPPPSSYVGPPGARSEFPHPIREGPVAQSR 1584

  Fly  2439 ----------------------------------VQDTENLI-PDISRN------MYTYTHTSYL 2462
                                              .||:.||: |..:|.      ...|...|.|
 Frog  1585 AHPRSSPEPGPPGHNREHRASQEAPSGDSPPRSRAQDSTNLLFPQTTRPRGSEKFSLVYKGFSLL 1649

  Fly  2463 PK---YWSLRGSVLGNQLFSYGGRLSYSLIVESYGNYERGH-----DIVLIGNGLKLIWSRPDGN 2519
            |:   ||.|..:.||:::.||||:|.|:|   :|....||.     |:.:.||.:.|:..:.|..
 Frog  1650 PEGVFYWQLPKAFLGDKVASYGGKLRYTL---TYNAGIRGSALPDADVQITGNDITLVAYQHDLR 1711

  Fly  2520 ENQEEYNVRLHEDEQWTRQDRESARPASRSDFMTVLSDLQHILIRATPRVPTQSTSIGNVILESA 2584
            ..:.:....:..:..|.|.|   .:||:|...|..|:||..||:||:......|:||..|.:|:|
 Frog  1712 PRESKSFEIVFRESSWKRPD---GQPATREHLMMALADLDEILVRASYSTDMLSSSITGVSMETA 1773

  Fly  2585 VTTRTPGATHASDIELCQCPSGYVGTSCESCAP-------------------------------- 2617
            ..:.| ....|.::|.|:||.||.|.||:.|||                                
 Frog  1774 GPSYT-NLPQALEVEECRCPPGYQGLSCQDCAPGYTRTGGGLYLGHCEPCYCNGHSESCHPETGA 1837

  Fly  2618 ----LH--------------YRDASG----SCSLCPCDVSN-----TESCDLV-SGGYVECRCKA 2654
                ||              |.|||.    .|..|.|.::|     :::|::: :.||....|:.
 Frog  1838 CSNCLHNTVGESCDQCAPGFYGDASAGTPEDCQPCACPLTNPDNQFSKTCEILGTSGYRCTACQP 1902

  Fly  2655 RWKG---DRCREIDTNDPTDIGTE---DPVLTQIIVSIQKPEITIVPVGGSMTLSC--SGRMRWS 2711
            .:.|   :||....|.:|...|.:   :...:::||.|...:.|:.| ||.:||.|  ||     
 Frog  1903 GYTGQYCERCAPGYTGNPNIPGQKCVPEDSRSKLIVRIHPQKATLSP-GGEVTLRCHVSG----- 1961

  Fly  2712 NSPVIVNWYKENSR-LPENVEV--QGGNLYLYDLQVSDSGVYIC-----QAVNNETASV------ 2762
            |.|....|.:|:.| :|.:.:.  :|.||:...:|.:|||||||     ::||...|.:      
 Frog  1962 NPPYYFYWTREDGRPIPPSAKAVGEGENLHFSRVQPTDSGVYICTCRSPESVNTSKAEIVVSAAP 2026

  Fly  2763 ----------------------------------------------------------------- 2762
                                                                             
 Frog  2027 SKPITVTVEEQRVQTVRPGSDVTFICTAKSKSPAYTLVWTRQHNRKLPDRAMDFNGILTIRRVQP 2091

  Fly  2763 ----------------------------------------------------------------- 2762
                                                                             
 Frog  2092 EDAGIYVCTGSNMYDMDEGNATLYVQDSSQTQMFYGPYETMEGHRPSGTATSPNAAAEPRQLTVQ 2156

  Fly  2763 ------FK--------------------------------------------------------- 2764
                  |:                                                         
 Frog  2157 RGQTAEFRCTATGTPTPAVEWTGPNGGLSPRAVVQGGVLRFHSVEPSDEGQYTCRVHNSAGQHFA 2221

  Fly  2765 --------------------------DTVSI---------------------------------- 2769
                                      |||.:                                  
 Frog  2222 RVDLRVHSGSLPEVQVSPERTEVREGDTVRLYCRAGGTPAATISWRKEGGSLPPQALSTFGFLHF 2286

  Fly  2770 ------TITRYAQEMLARYEKDQLSPAEIVNL--------------------------------- 2795
                  .|.|.|||:.||.|:..:|...|.::                                 
 Frog  2287 RSSSWEAIKRRAQELQARTERTDISTLVIPSISAADGGTYLCVGTSSAGSAQARIEVIVIGAPIH 2351

  Fly  2796 -------PSHVTFEEYVNNEIICEVLGNPAPRVTWARVDGHADAQSTRTYDNRLIFDSPRKSDEG 2853
                   ||..|..|....|:.| |..||...|||.|..|...:.:.:.|.::|.......:|.|
 Frog  2352 GPTLRIEPSSDTVIEGQLVELNC-VSANPYATVTWHRGGGRPLSPNHQAYGSKLRILQASTADSG 2415

  Fly  2854 RYRCQAENDQNRDEKYVIVYV--QSNPPQPPPQQDRLYITPEEINGLAGESFQLNCQFTSVASLR 2916
            .|.|:..|.....:..:|:.:  .|.|.||......|.|.|.....:.|::.:|||.|.|..:..
 Frog  2416 EYICRVTNGAATQQASIIITITRSSGPQQPSGNVPALRIEPSSDTLVEGQTLELNCLFPSYPNAV 2480

  Fly  2917 YDWSHNGRSLS-----------------------------------------------------S 2928
            ..|..:|:.||                                                     :
 Frog  2481 VTWHRSGQPLSPNHQVSGPRLRILQASVADSGEYICRVTTGPVTQKASILVTITRASGPSIPLGN 2545

  Fly  2929 SPARNVE------IRGNTLE----------------------------------VRDASESDSGV 2953
            .||..:|      :.|.|||                                  :..||.:|||.
 Frog  2546 GPAVRIETSSGSVVEGQTLELNCVVAGQPDAVVTWHRAGRLLSPNHQVLGSRLRITQASVADSGE 2610

  Fly  2954 YTCVAYDVRTRR------NFTESA----------RVNIDR------------------------- 2977
            |.|......|.|      ..|.|.          .:||:.                         
 Frog  2611 YICRTTTGTTTRQGSIMVTITHSTSSGHSSLITPTINIESAPDSVAEGQTVVLNCVIEGRPHQEV 2675

  Fly  2978 ---REEQPFG---------------------------------------------------NKPI 2988
               |.:||..                                                   ..||
 Frog  2676 TWYRPDQPLAPNHQVSGSRLRITHASPRDSGEYICRIQSGAGVQMASIMVSIEGSSLNTGLGSPI 2740

  Fly  2989 -IESLEQNILIIQGEDYSITCEASGSPYPSIKWAKVHDF-MPENVHISGNVLTIYGARFENRGVY 3051
             |||..:.:.:  |:...:.|.|.|.|...:.|.:.... :|.|..:||:.:.|..|...:.|:|
 Frog  2741 RIESSSETVEL--GQTIELNCLAEGHPGAVVTWHRSGGLPLPSNHQVSGSRMRILQASPADSGIY 2803

  Fly  3052 SCVAENDHGSDLSSTSIDIE-----PRERPSVKIVSAPLQTFSVGAPASLYCTVEGIPDPTVEWV 3111
            .|...:..||..:|.:|::.     |.:.|...::.....|.|.|....|.|.|.|.|...|.|.
 Frog  2804 ICRVSSASGSQEASVTINVHSSAQVPNQFPYPILIEKSADTVSEGQTLDLNCVVVGQPQAPVSWH 2868

  Fly  3112 RVDGQPLSPRHKI-----------------------------------------------QSP-- 3127
            | .|...|..|:|                                               |||  
 Frog  2869 R-PGASFSSNHQISGSRLRIVQASTADSGQYVCRHDTGAGIQQASISVSILSGAASSYRLQSPVI 2932

  Fly  3128 -----------------------GYMVI-------------DDIQL--------------EDSGD 3142
                                   |...|             |::.:              ::.|.
 Frog  2933 SIDPHSATVQRGQNATFKCRIHDGAQPIRVTWQMRHNQPMEDNVHISPNGSIITIVGATHKNQGS 2997

  Fly  3143 YECRAKNIVGEATGVATITVQEPTLVQIIPDNRDLRLTEGDELSLTCVGSGVPNPEVEWVNEMA- 3206
            |.|.|.|..|.......:.||....|.:||..: :|:.||:.:::.|:|.|.|.|.|.|....| 
 Frog  2998 YRCMASNAYGMVHSSVNLVVQGRPSVSVIPHGK-IRVKEGEPINVECMGIGDPRPIVSWRRTGAR 3061

  Fly  3207 --LKRDLYSPPSNTAILKIYRVTKADAGIYTCHGKNEAGSDEAHVRVEVQERRGDIGGVDDDSDR 3269
              ||:...:|...||:|:|.....||:|.|||...|..||.:.||.|.|:..             
 Frog  3062 ENLKQHRLAPLDGTAVLQIPSAKPADSGSYTCVAHNPHGSTQVHVEVHVEGH------------- 3113

  Fly  3270 DPINYNPPQQQNPGIHQPGSNQLLATD------IGDNVTLTCDMF-QPLNT-RWERVDGAPLPRN 3326
                          :..||:..:||..      .|...||:|... .|..| .|.:: .||||..
 Frog  3114 --------------VISPGAPLVLADKPVHVVVTGGQATLSCSASGNPTPTITWSKL-RAPLPWQ 3163

  Fly  3327 AYTIKNRLEIVRVEQQNLGQYRCNGIGRDGNVKTYFVKELVLMPLPRIRFYPNIP--LTVEAGQN 3389
            ...:.|.|.|..|.||:.|||.||....||:.:.|     |.:.:....:...:|  .:|..|:.
 Frog  3164 HQVVNNTLIIPNVAQQDSGQYICNASNADGHAEVY-----VTLDVETPAYATTLPHEASVSPGEP 3223

  Fly  3390 LDVHCQVENVRPEDVHWSTDNNRPLPSSVRIVGSVLRFVSITQAAAGEYRCSAFNQYGNRSQIAR 3454
            :.:.|......|....||..:. .||....|...||.....:.:.:|.|||.|.|:.|:....|:
 Frog  3224 IQIQCLAHGTPPIKFQWSRVDG-TLPGQASIQDGVLHIDQASASDSGTYRCVASNKVGSSEAFAQ 3287

  Fly  3455 VAVK---------------------------------------------------------KPAD 3462
            |.|.                                                         .|.|
 Frog  3288 VTVSGGGAETGRPTASIIPRGPVRVKVGSPIYLECMGQGDPRPVVSWRRTGDRQNLKPQQLVPLD 3352

  Fly  3463 FHQV------------------------PQSQLQRHRE----------------------GENIQ 3481
            .|.|                        .|.|::.|.|                      |:...
 Frog  3353 SHAVLQILSARPEDSGSYTCTAQNPSGSTQVQVEVHVEGRVITPGVPKVTAEQPLHVVVAGDRAS 3417

  Fly  3482 LQCTVTDQYGVRAQDNVEFNWFRDDRRPLPNNARTDSQILVLTNLRPEDAGRYICN--------- 3537
            |.||..      .....:..|.: .|.|||......:..|::.....:|:|:||||         
 Frog  3418 LSCTAV------GNPAPKITWSK-LRAPLPWQHEIVNDTLIIPKAALQDSGQYICNASNAEGYSE 3475

  Fly  3538 ---SYDVDR---GQQLP-EVS------IDLQVL---RAP-QYPYNRFKGGV----SLKDTPCMV- 3580
               :.||:.   ...|| |||      |.:|.|   .:| ::.:::..|.:    :::|:...: 
 Frog  3476 VFVTLDVETPPYATTLPDEVSVSVGEVIQIQCLAHGTSPLKFQWSKVNGSLPDRATVRDSTLHIN 3540

  Fly  3581 --------LYICAAATPPPNSPIY-----LPP--------------------------------- 3599
                    .|.|.......:|..:     |.|                                 
 Frog  3541 LAKAADAGTYRCVVGNKVGSSEAFAQVSVLAPFAVRVSPLIDTKAVSGTAEFTCTVVGDPRARIQ 3605

  Fly  3600 ------QLPA-----------------KSRDYSLKLDD-----QSS-------------NLR--- 3620
                  ||||                 ....|:.::..     |.|             |:|   
 Frog  3606 WSKEGGQLPAGHQVQGGVLRIPNLESGNEGTYTCRVSSRFGQAQESVRLVLQALPKVRINIRTSV 3670

  Fly  3621 ----AGESTDVECYSSDDTYTDVVWERSDGAPLSNNVRQVGNRLVISNVSPSDAGNYVCKCKTDE 3681
                ||.|.:.||.:..|....|.|.:. |:.|..:....|..|.|..|..||||.|.|....|.
 Frog  3671 QTVLAGNSVEFECLALGDPRAKVTWSKV-GSRLPGDAVISGGTLRIEQVKQSDAGQYRCTAANDV 3734

  Fly  3682 GDLYTTSYKLEVEDQPHELKSSKIVYAKVGANADLQCGADESRQPTYRWSRQYGQLQAGRSLMNE 3746
            |:: .:...|.|:..|......::.....|:.|...|.|.....|...||:..|.|.:...:.|.
 Frog  3735 GEV-QSHVILHVQSVPQIAAQPEMKEITAGSTAVFPCLASGFPVPDITWSKLEGDLPSDHQIDNN 3798

  Fly  3747 KLSLDSVQANDAGTYICTAQYADGETADFPNILVVTGAIPQFRQEPRSYMSFPTLPNSSFKFNFE 3811
            .|::.||:..|||||:|||....|....|..:.|....:|.|..:|:||:|.|::.::..|...:
 Frog  3799 VLTILSVKPEDAGTYVCTAANRQGRVTAFSMLKVRERVVPYFTGQPQSYLSLPSIKDAHKKLEIK 3863

  Fly  3812 LTFRPENGD------GLLLFNGQTRGSG-DYIALSLKDRYAEFRFDFGGKPMLVRAEEPLALNEW 3869
            :||||:..|      |:|:::||.:.:| |:::..|.....|||||.|.....:|....::|.|:
 Frog  3864 ITFRPDTADALILYSGMLVYSGQKKSNGADFVSFGLVGGRPEFRFDAGSGMATIRYPTAISLGEF 3928

  Fly  3870 HTVRVSRFKRDGYIQVDEQHPVAFPTLQQIPQLDLIEDLYIGGVPNWELLPADAVSQQVGFVGCI 3934
            |||.:.|....|.:.||...||...:..:...|||.|:|::||..:::.:....::.  |||||:
 Frog  3929 HTVTLYRNLTQGSLVVDRHVPVNGTSQGKFQGLDLNEELFLGGYSHYDSISKTGLNS--GFVGCV 3991

  Fly  3935 SRLTLQGRTVELIREAKYKE------GITDCRPCAQGPCQNKGVCLESQTEQAYTCICQPGWTGR 3993
            .:|.:||      .|..:|:      |:::|..|...||:|:|.|.:|:: .:|.|:|..|:||.
 Frog  3992 RQLIIQG------EEVIFKDLDLSANGVSNCPTCRDRPCKNRGTCQDSES-SSYVCVCSAGFTGS 4049

  Fly  3994 DCA-IEGTQCTPGVCGA-GRCENTENDM--ECLCPLNRSGDRCQYNEILNEHSLNFKGNSFAAYG 4054
            :|. .:...|.|..||. ..|.|..:..  .|.|.|.:||::|....::|..|.| ..:|:.:| 
 Frog  4050 NCEHSQALHCHPEACGPDATCINRADGQGYTCRCHLGKSGEKCMDGTMVNTPSFN-GDSSYISY- 4112

  Fly  4055 TPKVTKVN----ITLSVRPASLEDSVILYTAESTLPSGDYLALVLRGGHAELLINTAARLDPVVV 4115
             |.:|.::    :.|..:|.| .|.::.::.....|..|::::.:.||:.|......:.|  .::
 Frog  4113 -PSLTNIHNELRVDLEFKPIS-PDGLLFFSGGKAAPVEDFVSIAMVGGYLEFRYELGSGL--AIL 4173

  Fly  4116 RSAEPLPLNRWTRIEIRRRLGEGILRVGDGPERKAKAPGSDRILSLKTHLYVGGYDRSTVKVNRD 4180
            ||.||:.|.:|.::...|...:|.|.|......|..|||..:.|:|||.:|:||.|.| |::...
 Frog  4174 RSLEPVTLGQWHKVSAERVNKDGTLIVDGTDPVKRSAPGKSQGLNLKTLMYLGGVDGS-VELPSA 4237

  Fly  4181 VNITKGFDGCISRLYNFQKPVNLLADIKDAANIQSCGETNMIGGDEDSDNEP--PVP-------P 4236
            .||::.|.|||..:....|.|::.....:::.|..|           .||.|  .:|       .
 Frog  4238 ANISRHFQGCIGEVSINGKKVDISYSFTESSAIGQC-----------YDNSPCDRMPCLHGGRCQ 4291

  Fly  4237 PTP-----------------DVHENELQPYAMAPCASDPCENGGSCSEQEDVAVCSCPFGFSGKH 4284
            ||.                 :.||::.|.:       :||.||.:|.:..    |.||.|:||..
 Frog  4292 PTGEYEYQCLCLDGFKGDRCETHEDQCQIH-------NPCLNGATCKDNR----CHCPSGYSGTI 4345

  Fly  4285 CQEHLQLG-------------------FNASFRGDGYVELNRSHFQPALEQSYTSMGIVFTTNKP 4330
            |:.....|                   :.:.|..|.|:.|.:..|..:..::..::.:...|:..
 Frog  4346 CEHGRTAGAEDRDWPVEGSGGNDAPGLYGSFFSDDSYIALPKHVFPRSRPEAPETIELEIRTSSS 4410

  Fly  4331 NGLLFWWG--------------QEAGEEYTGQDFIAAAVVDGYVEYSMRLDGEEAVIRNSDIRVD 4381
            .|::.|.|              ||..|:..|:|||:..:.||::.:|.:|...||.||:.| .|:
 Frog  4411 EGVILWQGMVSHSSENHLLGTNQEENEQSKGKDFISLGLKDGHLVFSYQLGSGEANIRSED-PVN 4474

  Fly  4382 NGERHIVIAKRDENTAILEVDRMLHSGETRPTSKKSMKLPGNVFVGGAPDLEVFTGFRYKHNLNG 4446
            :||.|.::|.|:.....:::|.........|.....:...|:|::||||:::..||.::...:||
 Frog  4475 DGEWHRIVAVREGKLGSIQIDGEDSVSGASPGRNIMVNTKGSVYLGGAPNVKTLTGGKFSSGING 4539

  Fly  4447 CI---VVVEGETVGQ----INLSSAAVNGVNANVCPA 4476
            ||   |::......|    |:|...|..|.|...||:
 Frog  4540 CIKNLVILNARPSQQPHQPIDLKHHAEAGHNTKECPS 4576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trolNP_001401049.1 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060
LDLa 813..847 CDD:238060
LDLa 852..887 CDD:238060
LDLa 902..936 CDD:238060
LDLa 956..990 CDD:238060
LDLa 997..1030 CDD:238060
LDLa 1033..1067 CDD:238060
LDLa 1072..1105 CDD:238060
LDLa 1133..1165 CDD:238060
LDLa 1182..1215 CDD:238060
LDLa 1221..1251 CDD:238060
LDLa 1252..1286 CDD:238060
LDLa 1292..1326 CDD:238060 16/33 (48%)
Ig 1344..1405 CDD:472250 10/60 (17%)
Ig strand B 1355..1359 CDD:409353 0/3 (0%)
Ig strand C 1369..1372 CDD:409353 1/2 (50%)
Ig strand E 1388..1392 CDD:409353 0/3 (0%)
LDLa 1439..1473 CDD:238060 16/33 (48%)
LDLa 1479..1513 CDD:238060 20/33 (61%)
LDLa 1522..1556 CDD:238060 16/34 (47%)
Ig_Perlecan_like 1574..1649 CDD:143220 35/76 (46%)
Ig strand B 1577..1583 CDD:143220 2/5 (40%)
Ig strand C 1590..1595 CDD:143220 2/4 (50%)
Ig strand E 1613..1617 CDD:143220 3/3 (100%)
Ig strand F 1626..1632 CDD:143220 4/5 (80%)
Ig strand G 1641..1647 CDD:143220 2/5 (40%)
Laminin_B 1748..1878 CDD:459652 49/134 (37%)
EGF_Lam 1935..1989 CDD:238012 27/55 (49%)
Laminin_B 2113..2249 CDD:459652 52/135 (39%)
EGF_Lam <2250..2276 CDD:238012 12/25 (48%)
EGF_Lam 2284..2333 CDD:238012 22/48 (46%)
Laminin_EGF <2369..2399 CDD:395007 14/29 (48%)
Laminin_B 2465..2599 CDD:459652 42/138 (30%)
Ig_3 2688..2756 CDD:464046 26/77 (34%)
Ig_3 2791..2861 CDD:464046 21/109 (19%)
Ig_3 2890..2958 CDD:464046 26/160 (16%)
Ig 2987..3071 CDD:472250 24/85 (28%)
Ig strand B 3004..3008 CDD:409353 0/3 (0%)
Ig strand C 3017..3021 CDD:409353 0/3 (0%)
Ig strand E 3036..3040 CDD:409353 0/3 (0%)
Ig strand F 3050..3055 CDD:409353 2/4 (50%)
Ig strand G 3063..3066 CDD:409353 0/2 (0%)
I-set 3089..3162 CDD:400151 26/171 (15%)
Ig strand B 3094..3098 CDD:409353 1/3 (33%)
Ig strand C 3107..3111 CDD:409353 1/3 (33%)
Ig strand E 3128..3132 CDD:409353 1/3 (33%)
Ig strand F 3142..3147 CDD:409353 2/4 (50%)
Ig strand G 3155..3158 CDD:409353 0/2 (0%)
Ig 3165..3253 CDD:472250 33/90 (37%)
Ig strand B 3185..3189 CDD:409353 0/3 (0%)
Ig strand C 3198..3202 CDD:409353 1/3 (33%)
Ig strand E 3219..3223 CDD:409353 2/3 (67%)
Ig strand F 3233..3238 CDD:409353 3/4 (75%)
Ig strand G 3246..3249 CDD:409353 0/2 (0%)
Ig 3298..3355 CDD:472250 22/58 (38%)
Ig strand B 3301..3305 CDD:409353 2/3 (67%)
Ig strand C 3313..3316 CDD:409353 1/3 (33%)
Ig strand E 3333..3336 CDD:409353 1/2 (50%)
IG_like 3381..3457 CDD:214653 21/77 (27%)
Ig strand B 3390..3394 CDD:409353 0/3 (0%)
Ig strand C 3403..3407 CDD:409353 0/3 (0%)
Ig strand F 3437..3442 CDD:409353 3/4 (75%)
IG_like 3475..>3536 CDD:214653 14/82 (17%)
Ig strand B 3480..3484 CDD:409353 1/3 (33%)
Ig strand C 3491..3503 CDD:409353 0/11 (0%)
Ig strand E 3519..3523 CDD:409353 1/3 (33%)
Ig 3613..3675 CDD:472250 23/86 (27%)
Ig strand B 3625..3629 CDD:409353 0/3 (0%)
Ig strand C 3637..3642 CDD:409353 1/4 (25%)
Ig strand E 3658..3662 CDD:409353 1/3 (33%)
IG_like 3706..3772 CDD:214653 22/65 (34%)
Ig strand B 3714..3718 CDD:409353 1/3 (33%)
Ig strand C 3727..3731 CDD:409353 0/3 (0%)
Ig strand E 3746..3750 CDD:409353 1/3 (33%)
Ig strand F 3760..3765 CDD:409353 3/4 (75%)
Ig strand G 3774..3777 CDD:409353 1/2 (50%)
LamG 3794..3939 CDD:238058 48/151 (32%)
EGF 3962..3994 CDD:394967 13/31 (42%)
LamG 4042..4195 CDD:238058 46/156 (29%)
EGF_CA 4254..4286 CDD:238011 11/31 (35%)
LamG 4295..4448 CDD:238058 43/166 (26%)
hspg2XP_031762624.1 SEA 123..234 CDD:470595
LDLa 252..286 CDD:238060 16/33 (48%)
LDLa 350..384 CDD:238060 16/33 (48%)
LDLa 390..424 CDD:238060 20/33 (61%)
Ldl_recept_a 431..468 CDD:395011 16/36 (44%)
Ig_Perlecan_like 486..563 CDD:143220 35/76 (46%)
Ig strand B 489..495 CDD:143220 2/5 (40%)
Ig strand C 502..507 CDD:143220 2/4 (50%)
Ig strand E 527..531 CDD:143220 3/3 (100%)
Ig strand F 540..546 CDD:143220 4/5 (80%)
Ig strand G 555..561 CDD:143220 2/5 (40%)
Laminin_B 660..794 CDD:459652 49/134 (37%)
EGF_Lam 829..871 CDD:238012 6/42 (14%)
Laminin_EGF 879..934 CDD:395007 27/54 (50%)
Laminin_EGF 941..983 CDD:395007 16/42 (38%)
Laminin_B 1054..1188 CDD:459652 52/135 (39%)
EGF_Lam 1222..1271 CDD:238012 22/48 (46%)
EGF_Lam 1272..1326 CDD:238012 9/53 (17%)
Laminin_EGF 1333..1380 CDD:395007 17/46 (37%)
PHA03378 <1499..1596 CDD:223065 2/96 (2%)
Laminin_B 1655..1787 CDD:459652 42/138 (30%)
EGF_Lam 1821..1870 CDD:238012 6/48 (13%)
EGF_Lam 1872..1920 CDD:214543 11/47 (23%)
IG_like 1942..2022 CDD:214653 29/85 (34%)
Ig strand B 1953..1957 CDD:409549 2/3 (67%)
Ig strand C 1966..1971 CDD:409549 1/4 (25%)
Ig strand E 1989..1992 CDD:409549 2/2 (100%)
Ig strand F 2002..2007 CDD:409549 4/4 (100%)
Ig strand G 2015..2018 CDD:409549 0/2 (0%)
IgI_Perlecan_like 2030..2115 CDD:409412 0/84 (0%)
Ig strand A 2030..2034 CDD:409412 0/3 (0%)
Ig strand A' 2039..2042 CDD:409412 0/2 (0%)
Ig strand B 2046..2056 CDD:409412 0/9 (0%)
Ig strand C 2062..2066 CDD:409412 0/3 (0%)
Ig strand C' 2069..2071 CDD:409412 0/1 (0%)
Ig strand D 2076..2081 CDD:409412 0/4 (0%)
Ig strand E 2082..2088 CDD:409412 0/5 (0%)
Ig strand F 2095..2103 CDD:409412 0/7 (0%)
Ig strand G 2106..2115 CDD:409412 0/8 (0%)
IG_like 2150..2227 CDD:214653 1/76 (1%)
Ig strand B 2161..2165 CDD:409353 1/3 (33%)
Ig strand C 2174..2178 CDD:409353 0/3 (0%)
Ig strand E 2193..2197 CDD:409353 0/3 (0%)
Ig strand F 2207..2212 CDD:409353 0/4 (0%)
I-set 2233..2345 CDD:400151 13/111 (12%)
Ig strand B 2250..2254 CDD:409562 1/3 (33%)
Ig strand C 2263..2267 CDD:409562 0/3 (0%)
Ig strand E 2311..2315 CDD:409562 1/3 (33%)
Ig strand F 2325..2330 CDD:409562 0/4 (0%)
Ig strand G 2338..2341 CDD:409562 0/2 (0%)
Ig 2353..2436 CDD:472250 22/83 (27%)
Ig strand B 2370..2374 CDD:409562 1/3 (33%)
Ig strand C 2382..2386 CDD:409562 2/3 (67%)
Ig strand E 2402..2406 CDD:409562 1/3 (33%)
Ig strand F 2416..2421 CDD:409562 2/4 (50%)
IG_like 2456..2533 CDD:214653 11/76 (14%)
Ig strand B 2467..2471 CDD:409353 1/3 (33%)
Ig strand C 2480..2484 CDD:409353 0/3 (0%)
Ig strand F 2513..2518 CDD:409353 0/4 (0%)
Ig strand G 2527..2530 CDD:409353 0/2 (0%)
Ig 2547..2614 CDD:472250 13/66 (20%)
Ig strand B 2564..2568 CDD:409353 2/3 (67%)
Ig strand C 2577..2581 CDD:409353 0/3 (0%)
Ig strand E 2596..2600 CDD:409353 0/3 (0%)
Ig strand F 2610..2614 CDD:409353 1/3 (33%)
Ig_3 2644..2711 CDD:464046 5/66 (8%)
IG_like 2744..2822 CDD:214653 20/79 (25%)
Ig strand B 2755..2759 CDD:409562 0/3 (0%)
Ig strand C 2768..2772 CDD:409562 0/3 (0%)
Ig strand E 2788..2792 CDD:409562 0/3 (0%)
Ig strand F 2802..2807 CDD:409562 2/4 (50%)
Ig strand G 2815..2818 CDD:409562 0/2 (0%)
Ig 2844..2917 CDD:472250 15/73 (21%)
Ig strand B 2851..2855 CDD:409353 1/3 (33%)
Ig strand C 2864..2868 CDD:409353 1/3 (33%)
Ig strand E 2883..2887 CDD:409353 0/3 (0%)
Ig strand F 2897..2902 CDD:409353 0/4 (0%)
Ig strand G 2910..2913 CDD:409353 0/2 (0%)
IG_like 2936..3017 CDD:214653 9/80 (11%)
Ig strand B 2947..2951 CDD:409562 0/3 (0%)
Ig strand C 2960..2965 CDD:409562 1/4 (25%)
Ig strand E 2983..2987 CDD:409562 0/3 (0%)
Ig strand F 2997..3002 CDD:409562 2/4 (50%)
Ig strand G 3010..3013 CDD:409562 0/2 (0%)
I-set 3021..3110 CDD:400151 33/89 (37%)
Ig strand C 3052..3056 CDD:409544 1/3 (33%)
Ig strand E 3076..3080 CDD:409544 2/3 (67%)
Ig strand F 3090..3095 CDD:409544 3/4 (75%)
Ig strand G 3103..3106 CDD:409544 0/2 (0%)
IG_like 3127..3203 CDD:214653 26/81 (32%)
Ig strand B 3137..3141 CDD:409353 2/3 (67%)
Ig strand C 3150..3154 CDD:409353 1/3 (33%)
Ig strand E 3169..3173 CDD:409353 2/3 (67%)
Ig strand F 3183..3188 CDD:409353 3/4 (75%)
IG_like 3213..3290 CDD:214653 21/77 (27%)
Ig strand B 3224..3228 CDD:409390 0/3 (0%)
Ig strand C 3237..3241 CDD:409390 0/3 (0%)
Ig strand E 3256..3260 CDD:409390 2/3 (67%)
Ig strand F 3270..3275 CDD:409390 3/4 (75%)
Ig strand G 3283..3286 CDD:409390 0/2 (0%)
I-set 3300..3389 CDD:400151 6/88 (7%)
Ig strand B 3318..3322 CDD:409544 0/3 (0%)
Ig strand C 3331..3335 CDD:409544 0/3 (0%)
Ig strand E 3355..3359 CDD:409544 1/3 (33%)
Ig strand F 3369..3374 CDD:409544 0/4 (0%)
Ig strand G 3382..3385 CDD:409544 1/2 (50%)
Ig_3 3399..3469 CDD:464046 16/76 (21%)
IG_like 3492..3569 CDD:214653 13/76 (17%)
Ig strand B 3503..3507 CDD:409394 1/3 (33%)
Ig strand C 3516..3520 CDD:409394 0/3 (0%)
Ig strand E 3535..3539 CDD:409394 0/3 (0%)
Ig strand F 3549..3554 CDD:409394 2/4 (50%)
Ig 3577..3654 CDD:472250 7/76 (9%)
Ig strand B 3590..3594 CDD:409390 0/3 (0%)
Ig strand C 3603..3607 CDD:409390 0/3 (0%)
Ig strand E 3622..3626 CDD:409390 0/3 (0%)
Ig strand F 3636..3641 CDD:409390 1/4 (25%)
Ig strand G 3649..3652 CDD:409390 1/2 (50%)
Ig 3663..3745 CDD:472250 25/83 (30%)
Ig strand B 3679..3683 CDD:409394 0/3 (0%)
Ig strand C 3692..3696 CDD:409394 1/3 (33%)
Ig strand E 3711..3715 CDD:409394 1/3 (33%)
Ig strand F 3725..3730 CDD:409394 2/4 (50%)
Ig strand G 3738..3742 CDD:409394 0/3 (0%)
I-set 3749..3832 CDD:400151 24/82 (29%)
Ig strand B 3766..3770 CDD:409390 1/3 (33%)
Ig strand C 3779..3783 CDD:409390 0/3 (0%)
Ig strand E 3798..3802 CDD:409390 1/3 (33%)
Ig strand F 3812..3817 CDD:409390 3/4 (75%)
Ig strand G 3825..3828 CDD:409390 0/2 (0%)
LamG 3839..3996 CDD:238058 50/158 (32%)
EGF_CA <4023..4052 CDD:238011 12/29 (41%)
LamG 4102..4254 CDD:238058 46/158 (29%)
EGF 4279..4310 CDD:394967 3/30 (10%)
EGF_CA 4316..4347 CDD:238011 12/41 (29%)
LamG 4374..4546 CDD:238058 45/172 (26%)
Blue background indicates that the domain is not in the aligned region.

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