DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trol and agrn

DIOPT Version :9

Sequence 1:NP_001027038.3 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4479 Species:Drosophila melanogaster
Sequence 2:XP_017951501.1 Gene:agrn / 100492176 XenbaseID:XB-GENE-953967 Length:2109 Species:Xenopus tropicalis


Alignment Length:2716 Identity:523/2716 - (19%)
Similarity:849/2716 - (31%) Gaps:977/2716 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  2114 WSLPAAFLGNKLSSYGGKLTYTLSYSPLPNGIMSRNSAPDVVIKSGEDLRLIHYRKSQVVPSVAN 2178
            |:|.|..||             .|..|.|...:........|:.:|....:::      |..|.:
 Frog    16 WALAAVGLG-------------FSRGPCPERELELREEEANVVLTGTVEEIMN------VDPVHH 61

  Fly  2179 TYSVEIKESAWQRGDEVVANREHVLM---------------------ALSDITAIYI----KATY 2218
            |||.:::...:.:|.|:|.|  .:|:                     :..|....::    ::.:
 Frog    62 TYSCKVRVWRYLKGREIVTN--DILLDGGNKVMVGGFGDPTICDNQVSTGDTRIFFVNPAPRSMW 124

  Fly  2219 TTSTKE----ASLRQVTL------------------DVATPTNLGTPRAVEVEQCRCPEGYL--- 2258
            .|...|    :||.::||                  |...|.....|...:|  ||   |.|   
 Frog   125 PTHRNELMLNSSLMRITLRNLEEVEMCVEEHRRLSADKPGPVPNAQPTLQDV--CR---GMLCGF 184

  Fly  2259 GLSCEQCAPGYARDPEGGIYLGLCRPCECNG-HSKYCNSD----TGDCE----ECSDN------T 2308
            |..||:.    :.||.....  :|:...|.. .:..|.||    :.:||    :|:..      :
 Frog   185 GAVCEKS----STDPSQATC--ICKKTACASIVAPVCGSDYSTYSNECELERAQCNQQRRIKVIS 243

  Fly  2309 EGP-----SCERCAAGYVGDATRGTIYDCQPDEGYPIPSPPAPGNQTLECTAYCQIEGIYD---C 2365
            :||     .|...:..|.....|.|                  ..||.:|.......|:.:   |
 Frog   244 KGPCGTKDPCSTVSCSYGSTCVRST------------------DGQTAKCICPATCTGVPENVVC 290

  Fly  2366 RG------NECLCKRNVIGDQ----------CDQCRPGTYGLSAQNQDGCKECYCSGLASQCRSA 2414
            ..      |||...:....:|          ||.||     ::..||:           ..||..
 Frog   291 GSDGKDYHNECQLNKQACDNQENLYKKFDGRCDPCR-----IAMNNQN-----------KACRVN 339

  Fly  2415 ALYRQLIPVDFILNAPLITDESGAVQDTENLIPDISRNMYTYTHTSYLPKYWSL-RGSVLGNQLF 2478
            ...|||                                     ...|.|:|..: |..|..:...
 Frog   340 PRTRQL-------------------------------------EMQYRPEYCPVRRDPVCADDGV 367

  Fly  2479 SYGGRLSYSLIVESYGNYERGHDIVLIGNGLKLIWSRPDGNENQEEYNVRLHEDEQWTRQDRESA 2543
            :|...     .|.:...:.||.::..:.:|                         |...||:   
 Frog   368 TYDND-----CVMTRSGFIRGIELQKVHSG-------------------------QCQPQDK--- 399

  Fly  2544 RPASRSDFMTVLSDLQHILIRATPRVPTQSTSIGNVILESAVTTRTPG--ATHASDIE--LCQCP 2604
                      ...|.:|..:....|..|: .|...|..:|.......|  .|:|:|.|  ..:|.
 Frog   400 ----------CKEDCKHNSVCLNRRGVTR-CSCDRVTCDSTYKPVCGGDSRTYANDCERQKAECF 453

  Fly  2605 SGYVGTSCESCAPLHYRDASGSCSLCPCDVSNTESC----------DLVSGGYVECRCKARWKGD 2659
            .       ::..|:.::.        |||:.:...|          .:|......|.|:     .
 Frog   454 Q-------KATIPVKHKG--------PCDLHSPSPCLNTTCSFGAACVVKNKKAVCECQ-----Q 498

  Fly  2660 RCREIDTNDPTDIGTE-----DPVLTQIIVSIQKPEITIVPVG----------GSMTLSCSGRMR 2709
            .|:.:  .||. .|::     :|...|......|.||||:..|          |::..:.:||..
 Frog   499 VCQAV--YDPV-CGSDKRTYGNPCELQSTACTLKKEITILHKGPCDRCGKCQFGAICEAETGRCV 560

  Fly  2710 W------SNSPVI---VNWYKENSRLPENVEVQGGNLYLYDLQVSDSG----------VYICQAV 2755
            .      |..||.   .|.|:....|......|..|     |||:..|          .:..:.|
 Frog   561 CPTECVPSAQPVCGTDGNTYESECELHVRACTQQIN-----LQVAAQGDCKTCGNTLCTFGAKCV 620

  Fly  2756 NNETASVFKDTVSITITKKDQLSPAEIVNLPSHVTFEEYVNNEIICEVLGNPAPRVTWARV---- 2816
            ||:       .|.:|..::..|.    |...:.||::..      ||:......::....|    
 Frog   621 NNQ-------CVCLTCERQPYLP----VCGSNGVTYDNQ------CELKAASCKQMKLIEVSRAG 668

  Fly  2817 -----------------DGHADAQSTRTY---------DNRLIFDSPRK---------SDEGRYR 2846
                             |...:....|.|         |:|.:.|....         ||...|.
 Frog   669 SCEDECGSGTDGSGSGEDSECEQDRCRRYGGSWDEDAEDDRCVCDFTCHAVLRILVCGSDGITYS 733

  Fly  2847 CQAENDQNRDEKYVIVYV----------QSNPPQPPPQQDRLY-ITPEEIN-----GLAGESFQL 2895
            .:.|..:.|.||...:||          .|:||..|.....:| ..|:.|.     ||||.....
 Frog   734 NECELKKTRCEKRQDLYVAGQGACRAATTSSPPLVPHCSHTVYGCCPDNITAALGVGLAGCPSSC 798

  Fly  2896 NC-QFTS-----------------VASLRYD------WSHNG----RSLSSSPARNVEIRGNTLE 2932
            .| |:.|                 |..|:.|      |:..|    :....:|. |.:..|   .
 Frog   799 QCHQYGSYGGTCDPTTGQCSCKPGVGGLKCDRCEPGFWNFRGIVTDKKSGCTPC-NCDPVG---A 859

  Fly  2933 VRDASESDSGVYTCVAYDVRTRRNFTESARVNID--RREEQPFGNKPIIESLEQNILIIQGED-- 2993
            |||..|..:|:.:|               :..|.  :..:.|.|.||.:...|::....:..|  
 Frog   860 VRDDCEQMTGLCSC---------------KTGISGLKCSQCPDGRKPGLTGCEKDPSAPKSCDAI 909

  Fly  2994 ---YSITCEASGSPYPSIKWAKVHDFMPENVHISGNVLTIYGARFENRGVYSCVAENDHGSDLSS 3055
               :..||...|        ...|...|..:....|:..:.|:           .:..:|.....
 Frog   910 KCQFGATCVVIG--------GFAHCECPSPLCAEANLTKVCGS-----------DDVTYGDWCQL 955

  Fly  3056 TSIDIEPRERPSVK--------IVSAPLQTFSVGAPASLYCTVEGIPDPTVEWVRVDGQPLSPRH 3112
            .:|........:||        :..|.|||.|   |.       |.|.|.:  ||.         
 Frog   956 KTIACRQGRTITVKHTGPCQETVTHANLQTLS---PT-------GTPSPPI--VRT--------- 999

  Fly  3113 KIQSPGYMVI-------DDIQLEDSGDYECRAKNIVGEATGVA--TITVQEPTLVQIIPDNRDLR 3168
             :.:||...|       |..||             |.|||.::  :.|...|             
 Frog  1000 -LPTPGTTKITKTKKKTDSFQL-------------VLEATSLSPFSSTTMRP------------- 1037

  Fly  3169 LTEGDELSLTCVGSGVPNPEVEWVNEMALKRDLYSPPSNTAILKIYRVTKADAGIYTCHGKNEAG 3233
            :|:......:.|...:..|.|                 :..:|:||               :|:|
 Frog  1038 VTQTHRAHTSTVRPAITIPTV-----------------HPTVLQIY---------------DESG 1070

  Fly  3234 SDEAHVRVEVQERRGDIGGVDDDSDRDPINYNPPQQQNPGIHQPGSNQLLATDIGD-----NVTL 3293
            |......:|....: |:.||:   .::|.:....|::    ........:||.:.:     |..|
 Frog  1071 SGSGDEELEASGDQ-DLSGVE---PKEPFDVENEQKE----EAEEKRDFVATTVIERASCYNTPL 1127

  Fly  3294 TC--DMFQPLNTRWERVDGAPLPRNAYTIKNRLEIVRVEQQ------NLGQYRCNGIGRDGNVKT 3350
            .|  |...|.|.    .:|...|:.. ..:..|.|..:|.|      .:..|:....|.......
 Frog  1128 GCCSDGKTPAND----AEGTNCPKTK-IFQGVLIIEELEGQEVFYTPEMSDYKSELFGETARSIE 1187

  Fly  3351 YFVKELVLMPLPRIRFYPNIPLTVEAGQNLDVHCQVENVRPEDVHWSTDNNRPLPSSVRIVGSVL 3415
            ..:..|:                    :|.|:....:::|..|:..|        :|:|.:... 
 Frog  1188 NALDNLL--------------------RNSDIKRDFKSIRVRDLGPS--------NSIRAIVEA- 1223

  Fly  3416 RFVSITQAAAGEYRCSAFNQYGNRSQIARVAVKKP-------ADFHQVPQSQLQRHREGENIQLQ 3473
            .|...|..:|.:.:.:...|..:..:.| :.:|||       .||.::|          :.:.|.
 Frog  1224 HFDPATTMSAMDVQRALLRQLKSSKKRA-ITIKKPIQENVKFLDFGEIP----------DWVPLM 1277

  Fly  3474 CTVTDQYGVRAQDNVEFNWFRDDRRPLPNNARTDSQILVLTNLRPEDAGRYICNSYDVDRGQQLP 3538
            .|.|                       ...|.|.|.: ..|.:.|......:..:..|.| ..||
 Frog  1278 VTTT-----------------------TTTAATTSMV-ATTAVAPTTTTPVVATTTTVAR-TPLP 1317

  Fly  3539 E---------VSIDLQVLRAPQYPYNRFKGGVSLKDTPCMVLYICAAATPPPNSPIYLPPQLPAK 3594
            .         |:|..|.:..|:....|   .|:.| .|...:.......||....:...|..|.:
 Frog  1318 RRIVAVKTTPVTITQQPVTTPRMTTRR---PVTTK-RPMTTIPATTRRKPPRIQAVTKKPPRPCE 1378

  Fly  3595 SRDYSLKLDDQSSNLRAGESTDVECYSSDDTYTDVVWERSDGAPLSNNVRQVGNRLVISNVSPSD 3659
            |...          |..|...|                                          :
 Frog  1379 SHPC----------LHGGTCED------------------------------------------N 1391

  Fly  3660 AGNYVCKCKTDEGDLYTTSYKLEVEDQPHELKSSKIVYAKVGANADLQCGADESRQPTYRWSRQY 3724
            ..::.|.|                                                         
 Frog  1392 GKDFTCSC--------------------------------------------------------- 1399

  Fly  3725 GQLQAGRSLMNEKLSLDSVQANDAGTYICTAQYADGETADFPNILVVTGAIPQFRQEPRSYMSFP 3789
               .|||                 |..:|...              :...||.|  ..:||::|.
 Frog  1400 ---PAGR-----------------GGAVCEKS--------------IKYFIPGF--GGKSYLAFK 1428

  Fly  3790 TLPNSSFKFNFELTFRPENGDGLLLFNGQTRGSGDYIALSLKDRYAEFRFDFGGKPMLVRAEEPL 3854
            .: .:.......:.||....:||||:|||:.|. |:|:|::.:.:.|.||:.|....::.::.|:
 Frog  1429 MM-KAYHTVRIAMEFRSSEQNGLLLYNGQSLGK-DFISLAVNNGFVELRFNTGSGTGIITSKVPI 1491

  Fly  3855 ALNEWHTVRVSRFKRDGYIQVDEQHPVAFPTLQQIPQLDLIEDLYIGGVPNWEL-LPADAVSQQV 3918
            ...:||.:.|:|.:|.|.:.||.:..|...:......|:|..||:|||.|..:: :.::..|..|
 Frog  1492 EPGKWHQLVVNRNRRSGMLSVDGESHVNGESPSGTDGLNLDTDLFIGGAPEDQMAVVSERTSLSV 1556

  Fly  3919 GFVGCISRLTLQGRTVELIR---EAKYKEGITDC--RPCAQGPCQNKGVCLESQTEQAYTCICQP 3978
            |..|||.:|.:..:...|..   :..|..|:.:|  .||...||.|...|...:.|. :.|.|..
 Frog  1557 GLKGCIRQLDVNNQLYNLQEGGADVLYGSGVGECGNNPCQPNPCHNGAACQVKEAEM-FHCQCLS 1620

  Fly  3979 GWTGRDCAIEGTQCTPGVC-----------GAGRCENTENDMECLCPLNRSGDRCQ--YNEILNE 4030
            |:||..||.|...|.|..|           |..:||         ||:.|.|:.|:  .|:.||.
 Frog  1621 GYTGPTCADERNPCDPNPCHVSATCLVLPEGGAKCE---------CPMGREGEFCEKVSNQDLNL 1676

  Fly  4031 HSL-NFKGNSF------AAYGTPKVTKVNITLSVRPASLEDSVILYTAESTLPSGDYLALVLRGG 4088
            ..| .|.|.|:      ..:.|....|:.:.: |..||..:.:|.|..:.|...||:::|.|..|
 Frog  1677 PFLPQFNGYSYLEMKGLQTFATDLQDKLAMEV-VFLASNPNGLIFYNGQKTDGKGDFVSLSLHDG 1740

  Fly  4089 HAELLINTAARLD----PVVVRSAEPLPLNRWTRIEIRRRLGEGILRV-------GDGPERKAKA 4142
            :.|.      |.|    ..|::|.|.:|||.|..:.:.|...:|::|:       |:.|:.: ||
 Frog  1741 NLEY------RYDLGKGAAVIKSKEKIPLNTWLSVSLERSGRKGLMRINNMEQVTGESPKSR-KA 1798

  Fly  4143 PGSDRILSLKTHLYVGGY-DRSTVKVNRDVNITKGFDGCISRLYNFQKPVNLLADIKDAANIQSC 4206
            |.:  .|:||..|:|||. |.|  |:.|....:..|:|.|.::.....||....:|:.|.     
 Frog  1799 PHT--ALNLKEPLFVGGAPDFS--KLARAAAASTSFEGAIQKISIKGLPVLREENIRSAI----- 1854

  Fly  4207 GETNMIGGDEDSDNEPPVPPPTPDVHENELQPYAMAPCASD--PCENGGSCSEQEDVAVCSCPFG 4269
                                        |:..:...||...  ||:|||.||..:....|.|..|
 Frog  1855 ----------------------------EISTFRSHPCTKKPFPCQNGGLCSPNKGNYECVCQRG 1891

  Fly  4270 FSGKHCQE---HLQLGFN--ASFRGDGYVELNRSHFQPALEQSYTSMGIVFTTNKPN-------- 4321
            |||..|::   ....|.:  .||.|..|:|.:.:..:..|.......|.|...:.|:        
 Frog  1892 FSGSQCEKVTIEKAAGESEAVSFDGKTYLEYHIAVTKSQLTNEIPETGPVDNPDDPSEKALLVNQ 1956

  Fly  4322 -----------GLLFWWGQEAGEEYTGQDFIAAAVVDGYVEYSMRLDGEEAVIRNSDIRVDNGER 4375
                       ||:.|.|:.....|    :||.|||.||||.:..| |.:.|:..|.:.|:..|.
 Frog  1957 FELSIKTEATQGLILWSGKGTERAY----YIALAVVGGYVEMTYDL-GSKPVVLRSTVPVNTNEW 2016

  Fly  4376 HIVIAKRDENTAILEV--DRMLHSGETRPTSKKSMKLPGNVFVGGAPDLEV--------FTGFRY 4430
            ..:.|.||....||.|  :..:|.  :.|...|.:...|.:::||...|..        .|||  
 Frog  2017 IHIKAVRDNRDGILRVGNEDPVHG--SSPFGVKELDTDGALWLGGIEKLSASYKLPKAYSTGF-- 2077

  Fly  4431 KHNLNGCI--VVVEGETVGQINLSSAAVNGVNANVCPANDDPLGGTEPPVV 4479
                .||:  |:|:.:   .::|...|:|                 :||::
 Frog  2078 ----IGCMKDVLVDQQ---DLHLVEDALN-----------------KPPIL 2104

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trolNP_001027038.3 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060
LDLa 813..847 CDD:238060
LDLa 852..887 CDD:238060
LDLa 902..936 CDD:238060
LDLa 956..990 CDD:238060
LDLa 997..1030 CDD:238060
LDLa 1033..1067 CDD:238060
LDLa 1072..1105 CDD:238060
LDLa 1133..1165 CDD:238060
LDLa 1182..1215 CDD:238060
LDLa 1221..1251 CDD:238060
LDLa 1252..1286 CDD:238060
LDLa 1292..1326 CDD:238060
IG 1344..1421 CDD:214652
Ig 1344..1405 CDD:299845
LDLa 1439..1473 CDD:238060
LDLa 1479..1513 CDD:238060
LDLa 1522..1556 CDD:238060
IG_like 1566..1649 CDD:214653
Ig_Perlecan_D2_like 1574..1649 CDD:143220
Laminin_B 1748..1864 CDD:278481
EGF_Lam 1935..1989 CDD:238012
Laminin_B 2113..2238 CDD:278481 28/170 (16%)
EGF_Lam <2250..2276 CDD:238012 9/28 (32%)
EGF_Lam 2284..2333 CDD:238012 13/68 (19%)
Laminin_EGF <2369..2399 CDD:278482 9/39 (23%)
Laminin_B 2465..2587 CDD:278481 18/122 (15%)
I-set 2686..2772 CDD:254352 26/114 (23%)
Ig_2 2689..2771 CDD:290606 24/110 (22%)
Ig 2779..2865 CDD:299845 21/134 (16%)
IG_like 2798..2864 CDD:214653 16/104 (15%)
Ig 2882..2965 CDD:299845 23/115 (20%)
IG_like 2882..2950 CDD:214653 23/100 (23%)
Ig 2977..3061 CDD:299845 12/88 (14%)
IG_like 2984..3058 CDD:214653 9/78 (12%)
IG_like 3074..3152 CDD:214653 20/86 (23%)
Ig 3086..3153 CDD:299845 16/75 (21%)
I-set 3155..3243 CDD:254352 11/87 (13%)
IGc2 3171..3233 CDD:197706 7/61 (11%)
IG 3371..3447 CDD:214652 12/75 (16%)
IGc2 3377..3437 CDD:197706 11/59 (19%)
Ig 3456..3534 CDD:299845 10/77 (13%)
IG 3465..>3526 CDD:214652 8/60 (13%)
Ig 3603..3665 CDD:299845 3/61 (5%)
IG 3610..3683 CDD:214652 4/72 (6%)
IG 3696..3762 CDD:214652 5/65 (8%)
Ig 3704..3771 CDD:299845 5/66 (8%)
LamG 3784..3929 CDD:238058 45/145 (31%)
EGF 3952..3984 CDD:278437 11/31 (35%)
LamG 4032..4185 CDD:238058 49/171 (29%)
Laminin_G_2 4315..4444 CDD:280389 41/159 (26%)
agrnXP_017951501.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D17288at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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