DRSC/TRiP Functional Genomics Resources

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Protein Alignment trol and lrp12

DIOPT Version :10

Sequence 1:NP_001401049.1 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4489 Species:Drosophila melanogaster
Sequence 2:XP_002931586.3 Gene:lrp12 / 100491530 XenbaseID:XB-GENE-980112 Length:844 Species:Xenopus tropicalis


Alignment Length:535 Identity:138/535 - (25%)
Similarity:200/535 - (37%) Gaps:152/535 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   820 ACHNRDCISIESV---CDGIPDCGRNED----------EDDALCKCS-------GDK-------Y 857
            |..:.|.:.:..:   |.|||:..|::.          :..|...||       |:|       :
 Frog    27 ALESADNVHVSELPVACGGIPEQIRDKSGIITSPGWPADYPARINCSWYIRASPGEKITIRFQEF 91

  Fly   858 KCQRGGGC------IPKSQVCDGKPQCHDR--------SDESACHLHGRLNKTRLGV-------- 900
            ..|....|      |..||..||...|...        .|......|...:.:|.|.        
 Frog    92 DLQGSSTCSFDWVTIGPSQNYDGARACGSTIPAPYTSLQDHVWIKFHSDEHVSRKGFCLSYLAEK 156

  Fly   901 -KCLESQYQCGDGSCISGYKRCNGIHDCADASDEYNCIYDYEDTYDTDPNNNPLNECDILEFEC- 963
             ||...:::|.:|.||....|||.:.||.|.|||..|      .....|..:....|.:.:|:| 
 Frog   157 KKCESDRFRCDNGKCIPEILRCNRMDDCGDGSDEKLC------AKANRPTLSSFQPCTVSQFQCL 215

  Fly   964 -----DYSQCLPLEKKCDGYADCEDMSDELECQSYTDHCLES-EFECDSYCLPRDQLCNGIPNCQ 1022
                 .|: |||...||||..||.|:.|||:|.  ...|.:| ::...::         ..||..
 Frog   216 SRFTKAYT-CLPNSLKCDGNIDCLDLGDELDCD--VPSCGQSLKYFYGAF---------SSPNYP 268

  Fly  1023 D----GSDERNCTFCREDAYLCNTGECVADNQRCNGIADCADGSDERHCARIYCPPNKLACNGTC 1083
            |    ||   |||      :|.:||                   |.|   ::.........:|| 
 Frog   269 DFYPPGS---NCT------WLIDTG-------------------DRR---KVILRFTDFKLDGT- 301

  Fly  1084 VSRRIKCDGIRDCLDGYDEMYCPETNNHYPTQNVNVIRPKLGPNPIPKSCRPHEWQCANLECIDS 1148
                    |..|.:..||.:   |.|..      |::|       :..:...|    |.|..:.|
 Frog   302 --------GYGDYVKIYDGL---EENPR------NLLR-------VLTAFDSH----APLTVVSS 338

  Fly  1149 SLQCNEIKDCSDGSDEELSVCFGTATTRLKPSDCSPEQFYC--DESCYNRSVRCNGHVDCSDGSD 1211
            |.|. .:..|:|    :::...|...|......|.|.:..|  :..||....||:|:..|.:|.|
 Frog   339 SGQI-RVHFCAD----KVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRD 398

  Fly  1212 EVGCSLPCPQHQCP---SGRCYTESERCDRHRHCEDGSDEANC--CYANQFRCNNGDCVSGSAPC 1271
            |:.|:: |.:.:.|   :|.||..|:||:...||.:||||.||  |....|.|.|..||..|..|
 Frog   399 ELNCTM-CQKDEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCYFCQPGNFHCKNNRCVFESWVC 462

  Fly  1272 NGYSECSDHSDELNC 1286
            :...:|.|.|||.||
 Frog   463 DSQDDCGDGSDEENC 477

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trolNP_001401049.1 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060
LDLa 813..847 CDD:238060 7/39 (18%)
LDLa 852..887 CDD:238060 13/62 (21%)
LDLa 902..936 CDD:238060 14/33 (42%)
LDLa 956..990 CDD:238060 17/39 (44%)
LDLa 997..1030 CDD:238060 7/37 (19%)
LDLa 1033..1067 CDD:238060 5/33 (15%)
LDLa 1072..1105 CDD:238060 6/32 (19%)
LDLa 1133..1165 CDD:238060 8/31 (26%)
LDLa 1182..1215 CDD:238060 12/34 (35%)
LDLa 1221..1251 CDD:238060 13/32 (41%)
LDLa 1252..1286 CDD:238060 13/33 (39%)
LDLa 1292..1326 CDD:238060
Ig 1344..1405 CDD:472250
Ig strand B 1355..1359 CDD:409353
Ig strand C 1369..1372 CDD:409353
Ig strand E 1388..1392 CDD:409353
LDLa 1439..1473 CDD:238060
LDLa 1479..1513 CDD:238060
LDLa 1522..1556 CDD:238060
Ig_Perlecan_like 1574..1649 CDD:143220
Ig strand B 1577..1583 CDD:143220
Ig strand C 1590..1595 CDD:143220
Ig strand E 1613..1617 CDD:143220
Ig strand F 1626..1632 CDD:143220
Ig strand G 1641..1647 CDD:143220
Laminin_B 1748..1878 CDD:459652
EGF_Lam 1935..1989 CDD:238012
Laminin_B 2113..2249 CDD:459652
EGF_Lam <2250..2276 CDD:238012
EGF_Lam 2284..2333 CDD:238012
Laminin_EGF <2369..2399 CDD:395007
Laminin_B 2465..2599 CDD:459652
Ig_3 2688..2756 CDD:464046
Ig_3 2791..2861 CDD:464046
Ig_3 2890..2958 CDD:464046
Ig 2987..3071 CDD:472250
Ig strand B 3004..3008 CDD:409353
Ig strand C 3017..3021 CDD:409353
Ig strand E 3036..3040 CDD:409353
Ig strand F 3050..3055 CDD:409353
Ig strand G 3063..3066 CDD:409353
I-set 3089..3162 CDD:400151
Ig strand B 3094..3098 CDD:409353
Ig strand C 3107..3111 CDD:409353
Ig strand E 3128..3132 CDD:409353
Ig strand F 3142..3147 CDD:409353
Ig strand G 3155..3158 CDD:409353
Ig 3165..3253 CDD:472250
Ig strand B 3185..3189 CDD:409353
Ig strand C 3198..3202 CDD:409353
Ig strand E 3219..3223 CDD:409353
Ig strand F 3233..3238 CDD:409353
Ig strand G 3246..3249 CDD:409353
Ig 3298..3355 CDD:472250
Ig strand B 3301..3305 CDD:409353
Ig strand C 3313..3316 CDD:409353
Ig strand E 3333..3336 CDD:409353
IG_like 3381..3457 CDD:214653
Ig strand B 3390..3394 CDD:409353
Ig strand C 3403..3407 CDD:409353
Ig strand F 3437..3442 CDD:409353
IG_like 3475..>3536 CDD:214653
Ig strand B 3480..3484 CDD:409353
Ig strand C 3491..3503 CDD:409353
Ig strand E 3519..3523 CDD:409353
Ig 3613..3675 CDD:472250
Ig strand B 3625..3629 CDD:409353
Ig strand C 3637..3642 CDD:409353
Ig strand E 3658..3662 CDD:409353
IG_like 3706..3772 CDD:214653
Ig strand B 3714..3718 CDD:409353
Ig strand C 3727..3731 CDD:409353
Ig strand E 3746..3750 CDD:409353
Ig strand F 3760..3765 CDD:409353
Ig strand G 3774..3777 CDD:409353
LamG 3794..3939 CDD:238058
EGF 3962..3994 CDD:394967
LamG 4042..4195 CDD:238058
EGF_CA 4254..4286 CDD:238011
LamG 4295..4448 CDD:238058
lrp12XP_002931586.3 CUB 43..152 CDD:238001 22/108 (20%)
LDLa 159..193 CDD:238060 14/33 (42%)
LDLa 207..246 CDD:238060 17/39 (44%)
CUB 251..363 CDD:238001 35/185 (19%)
LDLa 405..440 CDD:238060 14/34 (41%)
LDLa 443..477 CDD:238060 13/33 (39%)
Blue background indicates that the domain is not in the aligned region.

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