DRSC/TRiP Functional Genomics Resources

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Protein Alignment trol and igsf10

DIOPT Version :10

Sequence 1:NP_001401049.1 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4489 Species:Drosophila melanogaster
Sequence 2:XP_009289666.2 Gene:igsf10 / 100329456 ZFINID:ZDB-GENE-130530-827 Length:2497 Species:Danio rerio


Alignment Length:2519 Identity:476/2519 - (18%)
Similarity:792/2519 - (31%) Gaps:876/2519 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1533 HCIPKSFQCDNVPDCTDGTDEVGCMAPLPIRPPPQSVSLLEYEV------------LELTCVATG 1585
            |||..|:...:|               |..|.....:.:.|.|:            |.|.|.:..
Zfish   553 HCIATSYLDADV---------------LAFRVTVMPLDIEEEEINGIRVSHHLGQNLRLDCTSLS 602

  Fly  1586 TPTPTIVWRLNWGHVPDKCE-SKSYG-----GTGTLRCPDMRPQDSGAYSCEIINTRGTHFVNPD 1644
            :|..:|.|.|     ||... .||||     ..|||....:..:|.|.|.|...|     |:..|
Zfish   603 SPQASIQWIL-----PDHTVLDKSYGKRTLHRNGTLVIHGLTYRDIGFYRCLAGN-----FLGAD 657

  Fly  1645 TIVTVRPVRTDVCEAGFFNMLARKAEECVQCFCFGVAKACDSANLFTYAIHPPILSHRVVSVELS 1709
            .:.:...:..|:..:                               |...|....:||||     
Zfish   658 LLASQVTIYDDLLNS-------------------------------TMPTHVKESNHRVV----- 686

  Fly  1710 PLRQIVINEAAPGQDLLTLLHGVQFRATNVHFSGRETPYLALPADYMGNQLKSYGGNLRYEVNYR 1774
               ||:.|....|...|:.....:.|:..     .:.||..|.:.:.           :..:..|
Zfish   687 ---QIIDNSQTLGSRYLSQRTSEESRSIT-----SDRPYTWLQSRFH-----------KVPIGRR 732

  Fly  1775 GSGRPVNGPDVIITGNRFTLTYRVRTQPGQNNRVSIPFVPGGWQKPDGRKASREEIMMILANVDN 1839
            |:||  |...|:   |:       |.|......:|         ||..::.::|.:     |:..
Zfish   733 GNGR--NSRRVV---NK-------RFQKEGKTLIS---------KPQIKEINKEAV-----NLSK 771

  Fly  1840 ILIRLGYLDSTAREVDLIN----IALDSAGTADKGLGSASLVEKCQCPPGYVGDSCESCASGYVR 1900
            .|.:....|:.|...|.||    |.:.:..|.:|...|:...|   .|..|     ::..|.:::
Zfish   772 TLFKEQSDDNNAASGDGINEDEFIVMTTTKTLEKKQVSSINTE---IPRTY-----KTVNSAFIQ 828

  Fly  1901 QPGGPWLGHCVPFIPDSCPSGTYGDPRR-----GVPCKECPC-PLTGSNNFAS-GCQQSPDGDVV 1958
                         :.....|......::     |:...:.|. |:|.|...:: |.|::      
Zfish   829 -------------VTSDDTSHVLRTKKKSNLVTGITDSQTPTPPITPSYTLSNYGTQRN------ 874

  Fly  1959 CRCNEGYTGRRCEQCAAGYQGNPLAAGGICRRIPDTSCNVDGTYSVHSNGTCQCKDSVIGEQCDT 2023
                  |  ::..:..:.|:.|                ..||..|::...|.:..::::     |
Zfish   875 ------Y--KKQSKTKSDYKLN----------------QTDGETSLYDTATSRPSETLV-----T 910

  Fly  2024 CKSKSFHLNSFTYTGCIECFCSGVGLDCDSSTWYRDQVTSTFGRSRVDHGFVLVTNYMQPTPDTV 2088
            .|.....:...|::|..|...:|       :|.|..|..:             ||| ::|...|:
Zfish   911 HKPSLIEVTELTFSGDSEDVATG-------TTQYNFQGPN-------------VTN-VEPKSQTI 954

  Fly  2089 PVSMAAEPNALSFIGSADQSGNTLYWSLPAAFLGNKLSSYGGKLTYTLSYSPLPNGIMSRNSAPD 2153
            ..::..         :.||.                      |:|:..:..      :.....|.
Zfish   955 FTAVTT---------TEDQE----------------------KITFQTTQR------IKSELLPG 982

  Fly  2154 VVIKSGEDLRLIHYRKSQVVPSVANTYSVEIKESAWQRGDEVVANREHVL--MALSDITAIYIKA 2216
            ..|.|...::::..||.|  |.....::                .|..::  ..:|||.:|..|.
Zfish   983 STIISKHQIQIVPSRKLQ--PGKKRKFN----------------GRRRIIRPSKISDIQSILDKF 1029

  Fly  2217 TYTTSTKEASLRQVTLDVATPTNLGTPRAVEVEQCRCPEGYLGLSCEQCAPGYARDP-------- 2273
            ...::.||.:|         |.:..|.:..|..:.:..:.  |:|.::|.....:.|        
Zfish  1030 KLHSTNKEDNL---------PISETTDKFAECVKMKSDKS--GVSRDKCRTSVDQSPINSTDMYH 1083

  Fly  2274 ---------EGGIYLGLCRPC---------------ECNGHSKYCNSDTGDCEECSDNTEGPSCE 2314
                     |..:..|.....               |..|:.||.||.                 
Zfish  1084 ITISSLSVTEKPVRAGSRTTVTDSQMSTTLVHSISEESGGYKKYFNSK----------------- 1131

  Fly  2315 RCAAGYVGDATRGTIYDCQPDEGYPIPSPPAPGNQTLECTAYCQIEGIYDCRGNECLCKRNVIGD 2379
              ...:....|..|....|..:|..:                  .:|.::..|......:|.|  
Zfish  1132 --EKAFTAPTTSTTTMSSQFTQGKIL------------------WQGSFENNGETPRKHQNSI-- 1174

  Fly  2380 QCDQCRPGTYGLSAQNQDGCKECYCSGLASQCRSAALYRQLIP-------VDFILNAPLIT---- 2433
                      .||...:.          .:...:|..|:...|       :..:..:|..|    
Zfish  1175 ----------TLSTNKEQ----------MTSTSTAEPYKSTTPLPTTELHLTHVNVSPTKTKENN 1219

  Fly  2434 --------DESGAVQDTENLIPDISRNMYTYTHTSYLPKYWSLRGSVLGNQLFSYGGRLSYSLIV 2490
                    |.||:...||.   |.|.|:.|.:..|  ..:.|.....|.......|  :||||:.
Zfish  1220 NTPDASSDDSSGSSSLTET---DFSDNIITPSKPS--RSFTSPTLHELSTTTEPTG--VSYSLVA 1277

  Fly  2491 ESYGNYERGHDIVLIGNGLKLIWSRPDGNENQEEYNVRLHEDEQWTRQDRESARPASRSDFMTVL 2555
            ..               .:|.:       :.|:....:......|.:|.....|...|.      
Zfish  1278 PP---------------TMKTV-------QKQDTSQSKFSRTGLWRKQKPGYHRRGFRG------ 1314

  Fly  2556 SDLQHILIRATPRVPTQSTSIGNVILESAVT--TRTPGAT-HASDIELCQCPSGYVGTSCESCAP 2617
               :..:.:.|.:.|.  :::..:.:|||.|  |.||..| |..                   |.
Zfish  1315 ---RRPIKKTTTKSPV--STMTKIAVESAATQSTNTPTQTKHRG-------------------AG 1355

  Fly  2618 LHYRDASGSCSLCPCDVSNTESCDLVSGGYVECRCKARWKGD---RCREIDTNDPTDIGTEDPVL 2679
            :|:...:...|..|....||:|   .|.|         |...   :...:|.| ||.......|.
Zfish  1356 IHHLHPTLKESERPVSTGNTDS---GSKG---------WSDSLTTKTTIVDIN-PTVTRPHTTVQ 1407

  Fly  2680 TQIIVSIQKPEITIVPVGGSMTLSCSGRMRWSNSPVIVNWYKENSRLPENVEVQGGNLYLYDLQV 2744
            :||....:.|::.....|   ||....|:. :.||||              ::|...   ::..|
Zfish  1408 SQIQRKTKNPKVNTNMRG---TLERFWRLT-TQSPVI--------------KIQPTT---HEHTV 1451

  Fly  2745 SD---------SGVYICQAVNNETASVFKDTVS------ITITRYAQEMLARYEKDQLSPAEIVN 2794
            .|         ||       .::..:|..||::      ||...|.............|..:...
Zfish  1452 KDCFGCLHPKASG-------KSQRRTVTSDTMTTSTAFPITPFPYTSSTTGNLNAYDHSTWDATT 1509

  Fly  2795 LPSHVT------------FEEYVNNE--IICEVLGNPAPRVTWARVDGHADAQST---------R 2836
            ...|:|            |....|::  :.|:..|||...::|.|.........|         .
Zfish  1510 SLKHITSKPVIDGGKAASFTVLSNSDAFLPCKATGNPEAIISWNRFTSTTGVMLTIKGKMGKFEV 1574

  Fly  2837 TYDNRLIFDSPRKSDEGRYRCQAENDQNRDEKYVIVYVQSNPPQPPPQQDRLYITP-EEINGLAG 2900
            ..:..|:.......|.|:|.|.||||...|:..|.:.|.:.|.       |:..|. .|:..|||
Zfish  1575 LKNGTLLIHRANIKDHGQYICIAENDYGSDKLVVTLSVVAYPA-------RILETKMRELKILAG 1632

  Fly  2901 ESFQLNCQFTSVASLRYDWSHNGRS---LSSSPARNVEIRG-------------NTLEVRDASES 2949
            ::..:.|:            ..||.   :|.....:.|::|             .||.:::.|.|
Zfish  1633 KTVHMACR------------TEGRPVPIVSWILPNHTEVKGPNGEHGRVKVSPMGTLTIQEVSVS 1685

  Fly  2950 DSGVYTCVAYDVRTRRNFTESARVNIDRREEQPFGNKPII-ESLEQNILIIQGEDYSITCEASGS 3013
            |.|.|.|||    :....|::|.|::     |.....|:| |..:|.:....|::..:.|...|.
Zfish  1686 DHGHYKCVA----SNPGGTDTATVHL-----QVVATPPVILEEKQQLVEADAGQNLFLPCTTHGD 1741

  Fly  3014 PYPSIKWAKVHD--------FMPENVHISGN-VLTIYGARFENRGVYSCVAENDHGSDLSSTSID 3069
            |.|:..|. :|:        :....:.:..| .|.:........|.|.|:|.:..||:....::.
Zfish  1742 PEPTTHWV-LHNGVIVLPLTYSHTKISVFANGTLYLRNLDVSESGKYECIATSSTGSERRVVTLS 1805

  Fly  3070 IEPRER-PSVKIVSAPLQTFSVGAPASLYCTVEGIPDPTVEW-----VRVD-GQPLSPRHKIQSP 3127
            ::..|. |.:.:.|........|....|.|:..|.|.|.:.|     |.|| ...:..|.|:...
Zfish  1806 VKRTETIPRIVVTSRHHTDVEYGGQLHLNCSAVGNPTPEIMWRLPSKVLVDKTHRMGSRIKVLEN 1870

  Fly  3128 GYMVIDDIQLEDSGDYECRAKNIVGEATGVATITV-QEPTLVQIIPDNRDLRLTEGDELSLTCVG 3191
            |.::|:.:..:||||:.|.|:|.||:.|.:..::| .:|..::....:|. ::..|::|.:.||.
Zfish  1871 GTLIIESLNEKDSGDFLCVARNKVGDDTQLMKVSVSMKPARIKPSVFSRK-QVPYGNDLKVDCVA 1934

  Fly  3192 SGVPNPEVEW------VNEMALKRD-----------LYSPPSNTAILKIYRVTKADAGIYTCHGK 3239
            :|||.||:.|      :...||:.|           |:    |...|.:..|...:.|.|||:.:
Zfish  1935 AGVPMPEISWGLPDGTLLNSALQADETEGDQLKRYILF----NNGTLYLNTVGTDEEGDYTCYAE 1995

  Fly  3240 NEAGSDEAHVRVEVQERRGDIGGVDDDSDRDPINYNPPQQQNPGIHQPGSNQLLATDIGDNVTLT 3304
            |:.|.|:.||.:.|...                   .|..|:|.:.....|.      |.||...
Zfish  1996 NKLGKDKMHVHISVLTA-------------------APYIQHPKLSDARVNP------GGNVRFD 2035

  Fly  3305 CDMFQPLNTRWERVDGAPLPRNAYTIKNR-----------------LEIVRVEQQNLGQYRC--- 3349
            |           :..|.|.|:..:.:.::                 |:|..|:..:.|:|.|   
Zfish  2036 C-----------KAIGEPKPKVFWMLPSKDIIAASNERYFVHANGSLDIRNVKLSDAGEYVCMAR 2089

  Fly  3350 NGIGR---------DGN---VKTYFVKELVLM------------------PLPRIRFY--PNIPL 3382
            |..|.         |||   :..:.....||.                  |:|:|.:.  .||.|
Zfish  2090 NAAGEENKVYKLDIDGNPPIINGFKQNRTVLKDTAIKYTRKLIDCNAEGDPVPKITWIMPDNIFL 2154

  Fly  3383 TVE-AGQNLDVH----CQVENVRPEDVHWSTDNNRPLPSSVRIVGSVLRFVSITQAAAGEYRCSA 3442
            |.. .|..::||    .::.||||.|                               ..|:.|.|
Zfish  2155 TAPYYGSRINVHVNGTLEIRNVRPSD-------------------------------TAEFICIA 2188

  Fly  3443 FNQYGNRSQIARVAV--KKPADFHQVPQSQLQRHREGENIQLQCTVTDQYGVRAQDNVEFNWFRD 3505
            .|..|....:.::.|  |......:.|.::....|.|....|.|:..      .|...:..|   
Zfish  2189 QNDGGEAVMLVQLEVTDKLMRPIFKNPFNERVVTRFGRTALLNCSAD------GQPTPDIIW--- 2244

  Fly  3506 DRRPLPNNAR-TDSQIL-------------VLTNLRPEDAGRYICNSYD-VDRGQQLPEVSIDLQ 3555
               .|||..| |.:|.|             |:.|...||:|:|.|.:.: |...::|    :.|:
Zfish  2245 ---TLPNKTRFTRAQGLEGSRYHLGRDGTFVIYNSSIEDSGKYRCAAKNKVGYIEKL----VVLE 2302

  Fly  3556 VLRAPQYPYNRFKG---GVSLKDTPCMVLYICAAATPPPNSPIYLPPQLPAKSRDYSLKLDDQSS 3617
            |::.| |...|.||   |:|                                             
Zfish  2303 VIQKP-YILTRPKGIIRGIS--------------------------------------------- 2321

  Fly  3618 NLRAGESTDVECYSSDDTYTDVVWERSDGAPLSNNVRQVGNR--------LVISNVSPSDAGNYV 3674
                |:|..:.|. :|:..:.:.|....|..|::  .||..|        ||:...:..|.||||
Zfish  2322 ----GQSLFLHCL-TDEIKSTISWTMPGGFVLAS--PQVSGRYQLMENGTLVVHETTMQDRGNYV 2379

  Fly  3675 CKCKTDEGDLYTT------SYKLEVED-QPHELKSSKIVYAKVGANADLQCGADESRQPTYRW-- 3730
            ||...|.|:...|      :|...:.: .|..||      ...|....|||.|:....|...|  
Zfish  2380 CKATNDAGEAVLTVSVIILAYPARITNGPPPALK------GVTGVPVHLQCVANGIPTPDIVWEL 2438

  Fly  3731 -------SRQYGQ------LQA-GRSLMNEKLSLDSVQANDAGTYICTA 3765
                   :...||      ||| |..|:.....:.|      |.|.|.|
Zfish  2439 PDRSILATNGKGQPVGSELLQAQGTLLIRNPTRMHS------GNYKCIA 2481

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trolNP_001401049.1 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060
LDLa 813..847 CDD:238060
LDLa 852..887 CDD:238060
LDLa 902..936 CDD:238060
LDLa 956..990 CDD:238060
LDLa 997..1030 CDD:238060
LDLa 1033..1067 CDD:238060
LDLa 1072..1105 CDD:238060
LDLa 1133..1165 CDD:238060
LDLa 1182..1215 CDD:238060
LDLa 1221..1251 CDD:238060
LDLa 1252..1286 CDD:238060
LDLa 1292..1326 CDD:238060
Ig 1344..1405 CDD:472250
Ig strand B 1355..1359 CDD:409353
Ig strand C 1369..1372 CDD:409353
Ig strand E 1388..1392 CDD:409353
LDLa 1439..1473 CDD:238060
LDLa 1479..1513 CDD:238060
LDLa 1522..1556 CDD:238060 5/22 (23%)
Ig_Perlecan_like 1574..1649 CDD:143220 24/92 (26%)
Ig strand B 1577..1583 CDD:143220 3/5 (60%)
Ig strand C 1590..1595 CDD:143220 2/4 (50%)
Ig strand E 1613..1617 CDD:143220 3/3 (100%)
Ig strand F 1626..1632 CDD:143220 3/5 (60%)
Ig strand G 1641..1647 CDD:143220 1/5 (20%)
Laminin_B 1748..1878 CDD:459652 26/133 (20%)
EGF_Lam 1935..1989 CDD:238012 9/55 (16%)
Laminin_B 2113..2249 CDD:459652 21/137 (15%)
EGF_Lam <2250..2276 CDD:238012 5/42 (12%)
EGF_Lam 2284..2333 CDD:238012 8/63 (13%)
Laminin_EGF <2369..2399 CDD:395007 4/29 (14%)
Laminin_B 2465..2599 CDD:459652 24/136 (18%)
Ig_3 2688..2756 CDD:464046 14/76 (18%)
Ig_3 2791..2861 CDD:464046 17/92 (18%)
Ig_3 2890..2958 CDD:464046 19/84 (23%)
Ig 2987..3071 CDD:472250 19/93 (20%)
Ig strand B 3004..3008 CDD:409353 0/3 (0%)
Ig strand C 3017..3021 CDD:409353 0/3 (0%)
Ig strand E 3036..3040 CDD:409353 2/4 (50%)
Ig strand F 3050..3055 CDD:409353 2/4 (50%)
Ig strand G 3063..3066 CDD:409353 0/2 (0%)
I-set 3089..3162 CDD:400151 24/78 (31%)
Ig strand B 3094..3098 CDD:409353 1/3 (33%)
Ig strand C 3107..3111 CDD:409353 1/8 (13%)
Ig strand E 3128..3132 CDD:409353 1/3 (33%)
Ig strand F 3142..3147 CDD:409353 2/4 (50%)
Ig strand G 3155..3158 CDD:409353 1/2 (50%)
Ig 3165..3253 CDD:472250 28/104 (27%)
Ig strand B 3185..3189 CDD:409353 1/3 (33%)
Ig strand C 3198..3202 CDD:409353 2/9 (22%)
Ig strand E 3219..3223 CDD:409353 1/3 (33%)
Ig strand F 3233..3238 CDD:409353 3/4 (75%)
Ig strand G 3246..3249 CDD:409353 0/2 (0%)
Ig 3298..3355 CDD:472250 15/85 (18%)
Ig strand B 3301..3305 CDD:409353 1/3 (33%)
Ig strand C 3313..3316 CDD:409353 0/2 (0%)
Ig strand E 3333..3336 CDD:409353 1/19 (5%)
IG_like 3381..3457 CDD:214653 15/80 (19%)
Ig strand B 3390..3394 CDD:409353 2/7 (29%)
Ig strand C 3403..3407 CDD:409353 1/3 (33%)
Ig strand F 3437..3442 CDD:409353 2/4 (50%)
IG_like 3475..>3536 CDD:214653 19/74 (26%)
Ig strand B 3480..3484 CDD:409353 1/3 (33%)
Ig strand C 3491..3503 CDD:409353 1/11 (9%)
Ig strand E 3519..3523 CDD:409353 2/16 (13%)
Ig 3613..3675 CDD:472250 16/69 (23%)
Ig strand B 3625..3629 CDD:409353 0/3 (0%)
Ig strand C 3637..3642 CDD:409353 0/4 (0%)
Ig strand E 3658..3662 CDD:409353 2/11 (18%)
IG_like 3706..3772 CDD:214653 19/76 (25%)
Ig strand B 3714..3718 CDD:409353 1/3 (33%)
Ig strand C 3727..3731 CDD:409353 1/12 (8%)
Ig strand E 3746..3750 CDD:409353 0/3 (0%)
Ig strand F 3760..3765 CDD:409353 2/4 (50%)
Ig strand G 3774..3777 CDD:409353
LamG 3794..3939 CDD:238058
EGF 3962..3994 CDD:394967
LamG 4042..4195 CDD:238058
EGF_CA 4254..4286 CDD:238011
LamG 4295..4448 CDD:238058
igsf10XP_009289666.2 None
Blue background indicates that the domain is not in the aligned region.

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