DRSC/TRiP Functional Genomics Resources

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Protein Alignment trol and cntn4

DIOPT Version :10

Sequence 1:NP_001401049.1 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4489 Species:Drosophila melanogaster
Sequence 2:NP_001135636.1 Gene:cntn4 / 100216195 XenbaseID:XB-GENE-492899 Length:1028 Species:Xenopus tropicalis


Alignment Length:1115 Identity:253/1115 - (22%)
Similarity:384/1115 - (34%) Gaps:341/1115 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  2796 PSHVTF---EEYVNNEIICEVLGNPAPRVTWARVDG----HADAQSTRTYDNRLIFDSP-RKSDE 2852
            |.::.|   .|.....::|||.|:|.|.|.| ||:|    .|.....|..|..||..|| |..|.
 Frog    31 PPNINFPLDSEDRTLRLVCEVQGHPKPVVRW-RVNGTLMDEAQDYRYRVLDRSLIIASPDRNRDV 94

  Fly  2853 GRYRCQAENDQN---RDEKYV-IVYVQSNPPQPPPQQDRLYITPEEINGLAGESFQLNC-QFTSV 2912
            |.::|:|.|...   ..|.|| ..|:.|       .|.|   |...::...|:...|.| .....
 Frog    95 GTFQCEATNSLGTILSREAYVQFSYLDS-------FQTR---TRSTVSVREGQGMVLLCGPPAHS 149

  Fly  2913 ASLRYDW----------SHNGRSLSSSPARNVEIRGNTLEVRDASESDSGVYTCVAYD-VRTRRN 2966
            ..|.|.|          ..|.|.:|       ::.|| |.:.....||:|.||||..: |...|.
 Frog   150 GELVYAWIFNEYPPFVQQDNRRFVS-------QVTGN-LYIAKVEPSDAGNYTCVVTNTVTNTRE 206

  Fly  2967 FTESARVNIDRREEQPFGN-KPIIE-SLEQNILIIQGEDYSITCEASGSPYPSIKWAKVHDFMP- 3028
            ...|..:.:  |.:...|. :|.|| ...:::...:|....:.|.|.|:|.|:|.|.:. |..| 
 Frog   207 LGPSTPLTL--RTDGVMGEYEPKIEVHFPESVPSAKGSTVKLECFALGNPVPTITWRRA-DGKPI 268

  Fly  3029 ---ENVHISGNVLTIYGARFENRGVYSCVAENDHGSDLSSTSIDIEPRERPSVKIVSAPLQTFSV 3090
               ...|.|..||.|...:.|:.|.|.|||||..|.::....:..........||..|.:   ::
 Frog   269 SRKVRRHRSSGVLEIPNFQQEDAGPYECVAENTRGKNMVRGQLTYFAPPTWVQKINDAHI---AI 330

  Fly  3091 GAPASLYCTVEGIPDPTVEWVRVDGQPLSPRHKIQ-SPGYMVIDDIQLEDSGDYECRAKNIVGEA 3154
            .......|...|.|..:..|:: :||.|..:.::| ..|.:.|..:.:.|||.|:|.|:|..|..
 Frog   331 EENILWECKASGRPKASYTWLK-NGQRLQSKGRLQIDHGSLTITSVNISDSGMYQCLAENKHGTI 394

  Fly  3155 TGVATITVQEPTLVQIIPDNRD---LRLT---EGDELSLTCVGSGVPNPEVEWVNEMALKRDLYS 3213
            ...|.:.|     :.:.||...   .|:|   .|..:.:.|.....|.|.:.|.....|:|:   
 Frog   395 YSSAELRV-----IAVGPDFSKGFVKRVTLGKVGGSVLIECKPKASPKPSITWKKGKELQRE--- 451

  Fly  3214 PPSNTAI-----LKIYRVTKADAGIYTCHGKNEAGSDEAHVRVEVQERRGDIGGVDDDSDRDPIN 3273
             .|..:|     |||..:||||||.|||...|..|:..:...:.|               :||..
 Frog   452 -SSRISILDDGTLKISNLTKADAGSYTCTASNHFGTASSTGTLVV---------------KDPTQ 500

  Fly  3274 YNPPQQQNPGIHQPGSNQLLATDIGDNVTLTCDM--------------------FQPLNTRWERV 3318
            ...|         |.|   :...:|:::.|.|.:                    ||.....:|||
 Frog   501 VLVP---------PSS---MDVTVGESIVLPCQVSHDHSLDISFSWVFNGQLIDFQKDGEHFERV 553

  Fly  3319 DGAPLPRNAYTIKNRLEIVRVEQQNLGQYRCNGIGRDGNVKTYFVK-----ELVLMPLPRIRFYP 3378
            .|.....:       |.|..::.::.|:|.|       .|.|...|     :|:      :|..|
 Frog   554 GGQDSAGD-------LMIRSIQLKHAGKYIC-------LVHTSVDKLSAGADLI------VRGPP 598

  Fly  3379 NIP--LTVEAGQNLDVHCQVENVRPEDVHW--STDNNRPL---------PSSV--RIVGSVLRFV 3428
            ..|  ||||  :..|...|:.        |  ..||:.|:         |.||  :.|.:|...|
 Frog   599 GPPDALTVE--EITDTTAQLS--------WMPGVDNHSPIIMYSVQARTPFSVGWQAVSTVPEVV 653

  Fly  3429 ---SITQAAAG-------EYRCSAFNQYGNRSQIARVAVKKPADFHQVPQSQLQRHREGENIQLQ 3483
               |.|....|       |:|..|.|:.|         :.:|:     |.|..:|..|.......
 Frog   654 DGRSFTATVVGLSPWVEYEFRVIAINEIG---------IGEPS-----PPSDKRRTEEALPEVTP 704

  Fly  3484 CTVTDQYGVRAQDNVEFNWFRDDRRPLPNNARTDSQILVLTNLRP-------------EDAGRYI 3535
            ..|:...|.:.:  :...|     .|:|...:.......:...||             .|:.|| 
 Frog   705 ANVSGGGGSKGE--LVITW-----EPVPEELQNGGGFGYVVAFRPFGTISWMQTVVASADSSRY- 761

  Fly  3536 CNSYDVDRGQQLPEVSIDLQVLRAPQYPY--------NRFKGGVSLKDTPCMVLYICAAATPPPN 3592
                 |.|.:.||           |..||        ||.:|..|    |..|:|  :|...|..
 Frog   762 -----VYRNESLP-----------PFSPYEVKVGVYNNRGEGPFS----PLTVVY--SAEEEPGR 804

  Fly  3593 SP-----------------IYLPPQLPAKSR--DYSL---KLDDQSSNLR----AGEST------ 3625
            :|                 |.:|..| :|.|  .|.:   |.:::..|.|    .|..|      
 Frog   805 APAGVFSRSLTAWDIEVSWIAVPGSL-SKGRIQGYEVRYWKQNEKEQNARKLRTLGNQTSTKLSH 868

  Fly  3626 ---------DVECYSSDDTYTDVVWERSDGAPLSNNVRQVGNRLVISNVS-----PSD-AGNYVC 3675
                     :|..|:|..|           .|.|..|          ||:     ||. .||.: 
 Frog   869 LQGHTLYHLNVRAYNSAGT-----------GPASTTV----------NVTTRKPPPSQPPGNII- 911

  Fly  3676 KCKTDEGDLYTTSYKLEVEDQPHELKSSKIVYAKVGANADLQCGADESRQPTYRWSRQYGQLQAG 3740
             ..:....:.....::..::...|:|..:::                     |||:|..|.....
 Frog   912 -WNSSNSKIILNWDQVTAQEDESEVKGYRVL---------------------YRWNRPGGASVIE 954

  Fly  3741 RSLMNEKLSL 3750
            .:..:.:|||
 Frog   955 TNQTSVELSL 964

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trolNP_001401049.1 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060
LDLa 813..847 CDD:238060
LDLa 852..887 CDD:238060
LDLa 902..936 CDD:238060
LDLa 956..990 CDD:238060
LDLa 997..1030 CDD:238060
LDLa 1033..1067 CDD:238060
LDLa 1072..1105 CDD:238060
LDLa 1133..1165 CDD:238060
LDLa 1182..1215 CDD:238060
LDLa 1221..1251 CDD:238060
LDLa 1252..1286 CDD:238060
LDLa 1292..1326 CDD:238060
Ig 1344..1405 CDD:472250
Ig strand B 1355..1359 CDD:409353
Ig strand C 1369..1372 CDD:409353
Ig strand E 1388..1392 CDD:409353
LDLa 1439..1473 CDD:238060
LDLa 1479..1513 CDD:238060
LDLa 1522..1556 CDD:238060
Ig_Perlecan_like 1574..1649 CDD:143220
Ig strand B 1577..1583 CDD:143220
Ig strand C 1590..1595 CDD:143220
Ig strand E 1613..1617 CDD:143220
Ig strand F 1626..1632 CDD:143220
Ig strand G 1641..1647 CDD:143220
Laminin_B 1748..1878 CDD:459652
EGF_Lam 1935..1989 CDD:238012
Laminin_B 2113..2249 CDD:459652
EGF_Lam <2250..2276 CDD:238012
EGF_Lam 2284..2333 CDD:238012
Laminin_EGF <2369..2399 CDD:395007
Laminin_B 2465..2599 CDD:459652
Ig_3 2688..2756 CDD:464046
Ig_3 2791..2861 CDD:464046 26/72 (36%)
Ig_3 2890..2958 CDD:464046 19/78 (24%)
Ig 2987..3071 CDD:472250 27/88 (31%)
Ig strand B 3004..3008 CDD:409353 0/3 (0%)
Ig strand C 3017..3021 CDD:409353 1/3 (33%)
Ig strand E 3036..3040 CDD:409353 2/3 (67%)
Ig strand F 3050..3055 CDD:409353 2/4 (50%)
Ig strand G 3063..3066 CDD:409353 0/2 (0%)
I-set 3089..3162 CDD:400151 19/73 (26%)
Ig strand B 3094..3098 CDD:409353 0/3 (0%)
Ig strand C 3107..3111 CDD:409353 0/3 (0%)
Ig strand E 3128..3132 CDD:409353 1/3 (33%)
Ig strand F 3142..3147 CDD:409353 2/4 (50%)
Ig strand G 3155..3158 CDD:409353 0/2 (0%)
Ig 3165..3253 CDD:472250 27/98 (28%)
Ig strand B 3185..3189 CDD:409353 0/3 (0%)
Ig strand C 3198..3202 CDD:409353 0/3 (0%)
Ig strand E 3219..3223 CDD:409353 2/8 (25%)
Ig strand F 3233..3238 CDD:409353 3/4 (75%)
Ig strand G 3246..3249 CDD:409353 0/2 (0%)
Ig 3298..3355 CDD:472250 14/76 (18%)
Ig strand B 3301..3305 CDD:409353 1/3 (33%)
Ig strand C 3313..3316 CDD:409353 0/2 (0%)
Ig strand E 3333..3336 CDD:409353 1/2 (50%)
IG_like 3381..3457 CDD:214653 25/100 (25%)
Ig strand B 3390..3394 CDD:409353 1/3 (33%)
Ig strand C 3403..3407 CDD:409353 1/5 (20%)
Ig strand F 3437..3442 CDD:409353 2/4 (50%)
IG_like 3475..>3536 CDD:214653 11/73 (15%)
Ig strand B 3480..3484 CDD:409353 0/3 (0%)
Ig strand C 3491..3503 CDD:409353 1/11 (9%)
Ig strand E 3519..3523 CDD:409353 0/3 (0%)
Ig 3613..3675 CDD:472250 17/86 (20%)
Ig strand B 3625..3629 CDD:409353 2/18 (11%)
Ig strand C 3637..3642 CDD:409353 0/4 (0%)
Ig strand E 3658..3662 CDD:409353 0/3 (0%)
IG_like 3706..3772 CDD:214653 8/45 (18%)
Ig strand B 3714..3718 CDD:409353 0/3 (0%)
Ig strand C 3727..3731 CDD:409353 2/3 (67%)
Ig strand E 3746..3750 CDD:409353 1/3 (33%)
Ig strand F 3760..3765 CDD:409353
Ig strand G 3774..3777 CDD:409353
LamG 3794..3939 CDD:238058
EGF 3962..3994 CDD:394967
LamG 4042..4195 CDD:238058
EGF_CA 4254..4286 CDD:238011
LamG 4295..4448 CDD:238058
cntn4NP_001135636.1 Ig 24..119 CDD:472250 30/88 (34%)
Ig strand B 45..49 CDD:409353 0/3 (0%)
Ig strand C 58..62 CDD:409353 2/4 (50%)
Ig strand E 81..85 CDD:409353 1/3 (33%)
Ig strand F 96..101 CDD:409353 1/4 (25%)
Ig strand G 110..113 CDD:409353 0/2 (0%)
Ig 128..213 CDD:472250 22/92 (24%)
Ig strand B 139..143 CDD:409353 1/3 (33%)
Ig strand C 153..157 CDD:409353 1/3 (33%)
Ig strand E 178..182 CDD:409353 3/4 (75%)
Ig strand F 192..197 CDD:409353 3/4 (75%)
Ig strand G 208..211 CDD:409353 0/2 (0%)
IgI_3_Contactin 226..314 CDD:409357 27/88 (31%)
Ig strand A 226..231 CDD:409357 3/4 (75%)
Ig strand A' 234..239 CDD:409357 0/4 (0%)
Ig strand B 242..251 CDD:409357 1/8 (13%)
Ig strand C 257..261 CDD:409357 1/3 (33%)
Ig strand C' 264..266 CDD:409357 1/1 (100%)
Ig strand D 275..278 CDD:409357 1/2 (50%)
Ig strand E 279..284 CDD:409357 2/4 (50%)
Ig strand F 292..300 CDD:409357 5/7 (71%)
Ig strand G 303..314 CDD:409357 1/10 (10%)
Ig 319..402 CDD:472250 22/86 (26%)
Ig strand B 334..338 CDD:409353 0/3 (0%)
Ig strand C 347..351 CDD:409353 0/3 (0%)
Ig strand E 368..372 CDD:409353 1/3 (33%)
Ig strand F 382..387 CDD:409353 2/4 (50%)
Ig strand G 395..398 CDD:409353 0/2 (0%)
Ig5_Contactin 407..495 CDD:409358 27/91 (30%)
Ig strand A 407..412 CDD:409358 2/4 (50%)
Ig strand A' 415..420 CDD:409358 2/4 (50%)
Ig strand B 424..431 CDD:409358 0/6 (0%)
Ig strand C 439..443 CDD:409358 0/3 (0%)
Ig strand D 457..460 CDD:409358 1/2 (50%)
Ig strand E 461..466 CDD:409358 2/4 (50%)
Ig strand F 474..482 CDD:409358 4/7 (57%)
Ig strand G 488..495 CDD:409358 0/6 (0%)
Ig6_Contactin-4 497..598 CDD:409439 24/132 (18%)
Ig strand A 497..503 CDD:409439 2/5 (40%)
Ig strand A' 506..511 CDD:409439 1/7 (14%)
Ig strand B 514..522 CDD:409439 2/7 (29%)
Ig strand C 531..535 CDD:409439 0/3 (0%)
Ig strand D 556..559 CDD:409439 0/2 (0%)
Ig strand E 560..564 CDD:409439 1/10 (10%)
FN3 572..>949 CDD:442628 96/488 (20%)
Ig strand F 573..580 CDD:409439 3/13 (23%)
Ig strand G 587..591 CDD:409439 0/3 (0%)
FN3 598..690 CDD:238020 28/115 (24%)
Blue background indicates that the domain is not in the aligned region.

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