back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trol and XB5969698

DIOPT Version :10

Sequence 1:	NP_001401049.1	Gene:	trol / 45320	FlyBaseID:	FBgn0284408	Length:	4489	Species:	Drosophila melanogaster
Sequence 2:	NP_001123798.1	Gene:	XB5969698 / 100170549	XenbaseID:	XB-GENE-5969699	Length:	1853	Species:	Xenopus tropicalis

Alignment Length:	2012	Identity:	383/2012 - (19%)
Similarity:	612/2012 - (30%)	Gaps:	687/2012 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1616 RCPDMRPQDSG---------------AYSCEI----------INTRGTHFVNPDTIVTVRPVRTD 1655
            |..|:.|...|               .||.||          ||....|.:. |.::..||   :
Frog   207 RYSDIEPSSEGEVIYKVLDPAITVEDPYSAEIQELLQITNLRINFTKLHTLG-DNLLDQRP---E 267

  Fly  1656 VCEAGFFNMLARKAEECV---QCFCFGVAKACDSANLFTYAIHPPILSHRVVSVELSPLRQIVIN 1717
            |.:..::::.     |.|   .|||:|.|..|.........:...|....|.......|
Frog   268 VLQKYYYSVY-----ELVVRGSCFCYGHASECSPVEGIEAGVEGMIHGRCVCKHHTKGL------ 321

  Fly  1718 EAAPGQDLLTLLHGVQFRATNVHFSGRETPYLALPADYMGNQLKSYGGNLRYEVN-YRGSGRPVN 1781
            .....||   ..|.:.:|....:     .|:.....:...:..|.:     :::. |..:|:...
Frog   322 NCEQCQD---FYHDLPWRPAEAN-----DPHTCKRCNCNNHSRKCH-----FDMAVYLATGKESG 373

  Fly  1782 GPDVIITGNRFTLTYRVRTQPGQNNRVSIPFVPGGWQKPDGRKASREEIMMILANVDNILIRLGY 1846
            |  |.......|:        |:|..:..||.   :|.|  |...|.:...|..:.|.:    |.
Frog   374 G--VCDDCQHNTM--------GRNCELCKPFY---YQDP--RADIRADNACISCDCDPV----GS 419

  Fly  1847 LDSTAREVDLINIALDSAGTADKGLGSASLVEKCQCPPGYVGDSCESCASGYVRQPGGPWLGHCV 1911
            ||..         ..||....:.|:    :..:|:|.....|:.|:||...:
Frog   420 LDGG---------VCDSHTNVNLGM----IAGQCRCKGNVKGERCDSCKESF------------- 458

  Fly  1912 PFIPDSCPSGTYG----DPRRGVPCKECPCPLTGSNNFASGCQQSPDGDVVCRCNEGYTGRRCEQ 1972
                       ||    ||   |.|:.|.|...|.....:.|.|. .||  |.|....|||.|.|
Frog   459 -----------YGLSMNDP---VGCQPCSCDPRGIITGNTPCDQI-SGD--CYCKRFVTGRYCNQ 506

  Fly  1973 CAAGYQG--NPLAAGGICRRIPDTSCNVDGTYSVH---SNGTCQCKDSVIGEQCDTCKSKSF--H 2030
            |...|.|  |.:..   ||   ...|:..|.|:..   .:|.|.|:.::||.||...:...|  .
Frog   507 CLPEYWGLSNDITG---CR---PCDCDFGGAYNNKCSLGDGQCDCRSNIIGRQCGDVQLGYFCMP 565

  Fly  2031 LNSFTY------------------------TGCIECFCSGVGLDCDSSTWYRDQ----------- 2060
            |:.:||                        |.|:|.|   .|:........|.|
Frog   566 LDYYTYEAENAKGLSPTDPQLPGSPKPEAQTDCLEYF---NGIQNGKKVRLRRQRRTARVLQQRA 627

  Fly  2061 --------------------------VTST---FGRSRVDHGFVLVTNYMQPTPDTVPVSMAAEP 2096
                                      ||.|   |.|.|...|.:...:.: |.|....:.:..||
Frog   628 SQRRARQLQQKPDTEVIRREHNSGHMVTWTGQGFVRVRDGAGLLFQIDNV-PYPMDYDIMIRYEP 691

  Fly  2097 NALSFIGSADQSGNTLYWSLPAAFL------GNKLSS---YGGKLTYTLSYSPLPN--------- 2143
            .      ||:....|:  |:.:..|      ||.|.|   |..||.:|..|..||.
Frog   692 E------SAEDWEATV--SVTSRILPMSPRCGNVLPSEQMYKEKLPHTERYLVLPKPFCFESNNQ 748

  Fly  2144 ----------GIMSRNSAPDVVIKS--------------GEDLRLIHYR------------KSQV 2172
                      |..:|:.|..::|.|              |.|...:|:|            |...
Frog   749 YEISIRFQRWGAANRHPAAFILIDSLVLLPKIYELPGFHGNDPVSVHHREEMERYMCLDSFKMAT 813

  Fly  2173 VPSVAN-------TYSVEIKESAWQRGDEVVANREHVLMALSD----ITAIYIKATYTTSTKEAS 2226
            :|.:|.       :.|..|.:.|              |..|.|    ::|:..|.......|...
Frog   814 MPDLAEMCIKLLCSISAIIHDGA--------------LPCLCDLQGSLSAVCDKIGGQCKCKPNV 864

  Fly  2227 LRQVTLDVATPTNLG----------------TPRAVE--VEQCRCPEGYLGLSCEQCAPGYARDP 2273
            :.| ..|...|...|                |.|...  ..||.|.....|..|:||.||....|
Frog   865 IGQ-RCDQCAPGTYGFGPYGCSKCDCHPQGSTSRLCNPFTGQCPCQSNVAGRQCDQCLPGQWGYP 928

  Fly  2274 EGGIYLGLCRPCECNGHSKYCNSDTGDCEECSDNTEGPSCERCAAGYVGDATRGTIYDCQPDEGY 2338
            .       ||||.|||||..|:|.||.|..|.|:|.|..||:|..||.||...|:...|:
Frog   929 H-------CRPCVCNGHSDECDSKTGACIRCRDSTTGRHCEKCLDGYYGDPILGSGQQCR----- 981

  Fly  2339 PIPSPPAPGNQTLECTAYCQIEGIYDCRGNECLCKRNVIGDQCDQCRPGTYGLSAQNQDGCKECY 2403
            |.|.|..||::....:: |..:  .|.....|||.....|.:||:|.||.:|...|....|:.|.
Frog   982 PCPCPGYPGSRNYHGSS-CYAD--KDSHQIVCLCAPGYTGTRCDRCSPGYFGNPEQEGGECRPCQ 1043

  Fly  2404 C---------------SGLASQCR-----------SAALYRQLIPVDFILNAPLIT-DESGAVQD 2441
            |               ||:..:|.           .|..|...:.    .|....| :|.|.:|
Frog  1044 CNNNIDPTDPESCDSHSGMCMKCLYNTDGAHCEECKAGFYGSAMQ----RNCRRCTCNEQGTLQ- 1103

  Fly  2442 TENLIPDISRNMYTYTHTSYLPKYWSLRGSVLG-------NQLFSYGGRLSYSLIVESYGNYERG 2499
             .:...|:   .|....|.:.|    .|.:|||       :..:::||.|
Frog  1104 -SHCTRDV---CYCDRVTGHCP----CRANVLGKSCDQCASNFWNFGGDL--------------- 1145

  Fly  2500 HDIVLIGNGLKLIWSRPDGNENQEEYNVRLHEDEQWTRQDRESARPASRSDFMTVLSDLQHILIR 2564
                    |.:.....| .:..:::.||       :|.|
Frog  1146 --------GCEPCTCDP-AHSLRQDCNV-------FTGQ-------------------------- 1168

  Fly  2565 ATPRVPTQSTSIGNVILESAVTTRTPGATHASDIELCQCPSGYVGTSCESCAPLHYRDASGSCSL 2629
                                                |.|..|:.|..|..|...::.|....|.:
Frog  1169 ------------------------------------CHCQPGFGGRVCSHCQENYWGDPQIKCEV 1197

  Fly  2630 CPCDV--SNTESCDLVSGGYVECRCKARWKGDRC----REIDTNDPTDIGTE------DPVLTQI 2682
            |.||.  |.|..||.::|   :|.|:..:.|.||    |....|.|..:...      |.:::|:
Frog  1198 CDCDAYGSETAQCDPLTG---KCFCRKGFTGQRCDQCARGFQNNYPRCLPCHECFAQWDMIISQL 1259

  Fly  2683 IVSIQKPEITIVPVGGSMTLSCSGRMRWSNSPVIVNWYKENSRLPE----NVEVQGGNLYLYDLQ 2743
            ...:|..:..::.                        ::|.:..||    .::.....|...:..
Frog  1260 RDRLQGVQQKLLD------------------------FQEGAVAPEISHSQIKELDNKLRTIEEL 1300

  Fly  2744 VSDSGV-------YICQAVNNETASVFKDTVSITITRYAQEMLARYEKDQLSPAEIVNLPSHVT- 2800
            :.|.|.       .:.:.||..::.|.:  :|..:....::|.....||:....::..|...:|
Frog  1301 IKDGGADGMRMLEQMTKLVNKISSEVAQ--LSFQLHTQEKQMNGTEAKDRWQRGKLDQLTLDITV 1363

  Fly  2801 -------------------FEEYVNNEIICEVLGNPAPRVTWARVDGHA----DAQSTRTYDNRL 2842
                               |.|..|:.:...:....|.::....|.|..    .:|.||....||
Frog  1364 VNETVYDLKVQIEAIVAAGFNESYNSIVKSYLESTEAEKIANGSVYGPGSPVFQSQQTREETERL 1428

  Fly  2843 IFDSPRKSDEGRYRCQAENDQNRD-EKYVIVYVQSNPPQPPPQQDRLYITPEEINGLAGESFQLN 2906
            :   ..|.|..:....|:....:: :|.|             |...:....|:|.|..|:.   .
Frog  1429 L---KEKLDTYKRNMTAQKSSLKELQKKV-------------QGLNVSKINEKICGAPGDQ---E 1474

  Fly  2907 CQFTSVASLRYDWSHNGRSLSSSPARNVEIRGNTLEVRDASESDSGVYTCVAYDVRTRRNFTESA 2971
            |:                   .||......|....:.:...:..:|.....|..:.|.:|.|
Frog  1475 CE-------------------DSPCGGANCRDEDGKRKCGGDDCNGALPVSAKALSTAQNIT--- 1517

  Fly  2972 RVNIDRREEQPFGNKPIIESLEQNILIIQG--EDYSITCEASGSPYPSIK-------------WA 3021
                  .|.:...|:  ::.:.|.|..|||  :|..:..||:.:.....|             ..
Frog  1518 ------LELENMANR--LKDIAQKIQDIQGIAQDAKVQTEATLANAKESKRRIEDSTEKLREFIK 1574

  Fly  3022 KVHDFM------PENVHI-------------SGNVLTIYGARFENRGVYSCVAENDHGSDLSSTS 3067
            |:.||:      ||::.:             .|::..:.....|:.|..||..|     .|::||
Frog  1575 KIKDFLTEEGADPESIELVARQVLNISLPASPGDIEALVNKIKESIGNLSCTDE-----ILTNTS 1634

  Fly  3068 IDIEPRERPSVKIVSAPLQTFSVGAPASLYCTVEGIPDPTVEWVRVDGQPLSPRHKIQSPGYMVI 3132
                     .:...:..|...:|.|.|........|.|........:.:..|....::.....:
Frog  1635 ---------EILATAKNLHKEAVEAQAKAEAVSANISDAQALLQEAEAKAKSAEKALKKAKQSI- 1689

  Fly  3133 DDIQLEDSGDYECRAKNIVGEATGV-----------ATITVQEPTLVQIIPDNRDLRLTEGDELS 3186
                    .|.:.:.:..:...|||           ..::.:...|:.....||.:.....:..:
Frog  1690 --------KDVKSKVEQTMQTLTGVEQKEMDIMERIGNLSEKVDDLLDKTESNRQIASDAKERAN 1746

  Fly  3187 LTCVGSGVPNPEVEWV----NEMALKRDLYSPPSNTAILKIYRVTKADAGIY--TCHGKNEAGSD 3245
            |....:|....|::.|    :::..|...|:..|.||:.:|.::.:....:|  ....|.|....
Frog  1747 LVLNSTGELRKEMDDVQRKYDDLKEKVGGYNSSSGTALDRIEKIKEEAKALYDKANTAKKELAKL 1811

  Fly  3246 EAHVRVEVQERRGDIGGVDDDSDRDPINYNPPQQQNPGIHQPGSNQLLATDIGD--NVTLTC 3305
            ||..|.........|..::             |.:|.      :.||| .||.:  |:..||
Frog  1812 EAQFRANEANMTAKILTIE-------------QLENQ------TTQLL-NDIREKSNIYSTC 1853

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.