DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kn and SPT23

DIOPT Version :9

Sequence 1:	NP_001097317.1	Gene:	kn / 45318	FlyBaseID:	FBgn0001319	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_012905.1	Gene:	SPT23 / 853848	SGDID:	S000001503	Length:	1082	Species:	Saccharomyces cerevisiae

Alignment Length:	747	Identity:	137/747 - (18%)
Similarity:	227/747 - (30%)	Gaps:	300/747 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 NHPSPDPSPSPSGGQAALQLVDI----------------LEWKKLLRAG-----------LGGDV 78
            |..|||.....|      :|:||                |..:|::.||           |..|:
Yeast    22 NDGSPDLDLLES------ELLDIALLNSGSSLQDPGLLSLNQEKMITAGTTTPGKEDEGELRDDI 80

  Fly    79 AAYAD-LHQHSHSHHPNPHPHPHPHPFATDGFKLRSEEPVPGFSSASPWPTLELGMEWGRKLYPS 142
            |:... |.:|.......|...|:.:|.              .|.:.:| .:|.|.:|
Yeast    81 ASLQGLLDRHVQFGRKLPLRTPYANPL--------------DFININP-QSLPLSLE-------- 122

  Fly   143 AVSGPRSAGGLMFGLPPTAAVDMNQPRGPMTSLKEEPLGSRWAMQPVVDQSNLGIGRAHFEKQ-- 205
                       :.|||..:.|:        |.:|   |..|             |..||..|.
Yeast   123 -----------IIGLPKVSRVE--------TQMK---LSFR-------------IRNAHARKNFF 152

  Fly   206 ---PPSNLRKSNFFHFVIALYDRAGQPIEI--------ERTAFIGFIEKDSESDATKTNNGIQYR 259
               |...:.|..||       ..:..|..:        |||.|:     |:.......||...::
Yeast   153 IHLPSDCIAKDKFF-------TSSDDPTNLTIPNRDINERTLFL-----DAFLLCASNNNSNNFK 205

  Fly   260 LQLLYAN---------GARQEQDIFVRLI--DSVTKQAIIYEG---------------------- 291
             |....|         .:|::..:....|  ::..|:|||:..
Yeast   206 -QTYVCNRCINREKRRASRRKSGLNDNSIWQNNENKRAIIFNSKQLFIISNNGLSGNSNCINFDL 269

  Fly   292 -----------------------QDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPS------- 326
                                   :|.|.::....:|..:|   ..|||:..| ..||:
Yeast   270 PTRIVCYCRHHKATNGFVVLFLLRDHNGDILAKTITDPIM---IMDKKNASN-TTTPTSTSNAQV 330

  Fly   327 DPVIID-----------RFFLKFFLKCNQ-------NCL-----KNAGNPRDMRRFQVVISTQVA 368
            .|:..|           .|..:|.|..|.       ||:     .|..|..|.:.   .|.|..|
Yeast   331 SPMTNDTRSFSSPQSDLNFPSEFPLPSNSKNFVISTNCMLDSNCNNNNNDNDNKN---NIKTNTA 392

  Fly   369 V--------------DGPLLAISDNMFVHNNSKHGRRAKRLDTTEGTG-----NTSL-------- 406
            :              :....:.||..|.:||..:..|:  ||:...||     |.:|
Yeast   393 MMNNNRHFPSPNSSSEDSNHSFSDIHFSNNNDNNLHRS--LDSWSSTGFNSSSNPALTTLTSDFS 455

  Fly   407 ------------SISGHPLAPDSTYDGL-------------YPPLPVA---TPCIKAISPSEGWT 443
                        |::...::..:|:..|             :..:|||   .|.|:.:.|::|..
Yeast   456 AASARHTGKRQRSVNEPFMSTPNTFSRLPQKFIDSSKDISNHNSVPVALNNKPSIQRVIPAQGSI 520

  Fly   444 TGGATVIIVGDNFFDGLQVVFGTMLV-----WSE--LITSHAIRVQTPPRHIPGVVEVTLSYKSK 501
            .||..|.::|..|..||.:.||..:.     |:|  ::|      ..||...||.|.||:...|:
Yeast   521 NGGIEVTLLGSKFKQGLIIKFGENIALSSQCWNESTMVT------YLPPSSKPGPVLVTIVDPSE 579

  Fly   502 QFCKGSPGRFVYVSALNEPTIDYGFQRLQKLIPRHPGDPEK----LQKEII-------LKRAADL 555
            ...:.:....|..|......:.......:|.|..:..|.::    |..:|:       |:.|.::
Yeast   580 TSMRNNSNSSVSTSNSTNDILHLNKYTGEKAIFTYVDDTDRQLIELALQIVGLKMNGKLEDARNI 644

  Fly   556 VEALYSMPRSPGG--------STGFNSYAGQL 579
            .:.:.....||..        ::..|||...:
Yeast   645 AKRIVGSDSSPSNNNAGLHSQNSSLNSYTNMM 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kn	NP_001097317.1	COE_DBD	184..395	CDD:212156	54/323 (17%)
		IPT_COE	431..515	CDD:238580	25/90 (28%)
		COE1_HLH	517..560	CDD:293032	7/53 (13%)
SPT23	NP_012905.1	ANKYR	79..>209	CDD:223738	37/200 (19%)
		IPT	508..578	CDD:238050	23/75 (31%)
		PLN03192	<612..>765	CDD:215625	10/65 (15%)
		Ank_2	694..772	CDD:403870
		ANK repeat	709..740	CDD:293786
		ANK repeat	742..767	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3836
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900