Protein Alignment kn and EBF2

DIOPT Version :10

• Sequence 1: NP_001097317.1
• Gene: kn / 45318
• FlyBaseID: FBgn0001319
• Length: 689
• Species: Drosophila melanogaster
• Sequence 2: NP_073150.2
• Gene: EBF2 / 64641
• HGNCID: 19090
• Length: 575
• Species: Homo sapiens
• Alignment Length: 600
• Identity: 354/600 - (59%)
• Similarity: 399/600 - (66%)
• Gaps: 124/600 - (20%)

  Fly   154 MFGLPPTAAVDMNQPRGPMTSLKEEPLGSR------WAMQ-PVVD-----QSNLGIGRAHFEKQP 206
            |||:..|..      |||  :|||:.||:.      |... .|||     ||.:.:.||||||||
Human     1 MFGIQDTLG------RGP--TLKEKSLGAEMDSVRSWVRNVGVVDANVAAQSGVALSRAHFEKQP 57

  Fly   207 PSNLRKSNFFHFVIALYDRAGQPIEIERTAFIGFIEKDSESDATKTNNGIQYRLQLLYANGARQE 271
            |||||||||||||:|||||.|||:|||||||:.|:|.|.|....|||||..|:|||||:||.|.|
Human    58 PSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVENDKEQGNEKTNNGTHYKLQLLYSNGVRTE 122

  Fly   272 QDIFVRLIDSVTKQAIIYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVIIDRFFL 336
            ||::||||||||||.|.||||:||||||||||||||||||||:||||||||||||||||||||||
Human   123 QDLYVRLIDSVTKQPIAYEGQNKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDPVIIDRFFL 187

  Fly   337 KFFLKCNQNCLKNAGNPRDMRRFQVVISTQVAVDGPLLAISDNMFVHNNSKHGRRAKRLDTTEGT 401
            ||||||||||||.|||||||||||||:||.|.|||.:||:||||||||||||||||:|||.:|
Human   188 KFFLKCNQNCLKTAGNPRDMRRFQVVLSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSE-- 250

  Fly   402 GNTSLSISGHPLAPDSTYDGLYPPLPVATPCIKAISPSEGWTTGGATVIIVGDNFFDGLQVVFGT 466
                                       |||||||||||||||||||.|||:||||||||||||||
Human   251 ---------------------------ATPCIKAISPSEGWTTGGAMVIIIGDNFFDGLQVVFGT 288

  Fly   467 MLVWSELITSHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGSPGRFVYVSALNEPTIDYGFQRLQK 531
            |||||||||.||||||||||||||||||||||||||||||:||||:| :||||||||||||||||
Human   289 MLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFIY-TALNEPTIDYGFQRLQK 352

  Fly   532 LIPRHPGDPEKLQKEIILKRAADLV----------------------EALYSMPRSP-------- 566
            :|||||||||:|.||::||||||||                      |||||:||:|
Human   353 VIPRHPGDPERLAKEMLLKRAADLVEALYGTPHNNQDIILKRAADIAEALYSVPRNPSQLPALSS 417

  Fly   567 ----GGSTGFNSYAGQLAVSVQDGSGQWTEDDYQRAQSSSVSPRGGYCSSASTPHSSGGSYGATA 627
                .|..|.|||..||.||:.: |.|.....|.| .:||:||||  .||:|||..|  :|..::
Human   418 SPAHSGMMGINSYGSQLGVSISE-STQGNNQGYIR-NTSSISPRG--YSSSSTPQQS--NYSTSS 476

  Fly   628 ASAAVAATANGYA--PAPNMGT------------------LSSSPGSVFNSTSRVSSLSFNPFA- 671
            .|      .|||:  |..|:|.                  :||||....:|||.:...|.:.|.
Human   477 NS------MNGYSNVPMANLGVPGSPGFLNGSPTGSPYGIMSSSPTVGSSSTSSILPFSSSVFPA 535

  Fly   672 -------LPTCNTQG 679
                   .|....||
Human   536 VKQKSAFAPVIRPQG 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kn	NP_001097317.1	COE_DBD	184..395	CDD:212156	169/216 (78%)
		IPT_COE	431..515	CDD:238580	78/83 (94%)
		COE1_HLH	517..560	CDD:406751	37/64 (58%)
EBF2	NP_073150.2	COE1_DBD	20..246	CDD:435333	170/225 (76%)
		Interaction with DNA. /evidence=ECO:0000250	62..65		2/2 (100%)
		Interaction with DNA. /evidence=ECO:0000250	196..203		5/6 (83%)
		Interaction with DNA. /evidence=ECO:0000250	235..238		2/2 (100%)
		IPT_COE	253..337	CDD:238580	78/84 (93%)
		COE1_HLH	338..381	CDD:406751	35/42 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..479		18/48 (38%)