Protein Alignment kn and EBF4

DIOPT Version :9

• Sequence 1: NP_001097317.1
• Gene: kn / 45318
• FlyBaseID: FBgn0001319
• Length: 689
• Species: Drosophila melanogaster
• Sequence 2: XP_016883473.1
• Gene: EBF4 / 57593
• HGNCID: 29278
• Length: 646
• Species: Homo sapiens
• Alignment Length: 636
• Identity: 350/636 - (55%)
• Similarity: 414/636 - (65%)
• Gaps: 102/636 - (16%)

  Fly   108 GFKLRSEEPVP-GFSSASPWPTLELGMEWGRKLYPSAVSGPRSAGGLMFGLPPTAAVDMNQPRGP 171
            |..|:.|..:| |..|...|      |: |..:..::.:..| .||.....|        :.|..
Human     8 GLNLKEEPLLPAGLGSVRSW------MQ-GAGILDASTAAQR-VGGWGCAEP--------EKRLG 56

  Fly   172 MTSLKEEPLGSR---------WAMQ---PVVDQSNLGIGRAHFEKQPPSNLRKSNFFHFVIALYD 224
            ....:.:.:|||         ||..   |.|....:|:.|||||||||||||||||||||:|:||
Human    57 AGRWRRDEVGSRPGWTDWPGNWAGPLPFPRVFFCGVGLARAHFEKQPPSNLRKSNFFHFVLAMYD 121

  Fly   225 RAGQPIEIERTAFIGFIEKDSESDATKTNNGIQYRLQLLYANGARQEQDIFVRLIDSVTKQAIIY 289
            |.|||:|:||||||.|:|||.|..|.||||||.|||:|:|.||.|.|||::||||||::||||||
Human   122 RQGQPVEVERTAFIDFVEKDREPGAEKTNNGIHYRLRLVYNNGLRTEQDLYVRLIDSMSKQAIIY 186

  Fly   290 EGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPR 354
            |||||||||||||||||:|||||||:|||||||||||||||||||||||||||||||||||||||
Human   187 EGQDKNPEMCRVLLTHEIMCSRCCDRKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPR 251

  Fly   355 DMRRFQVVISTQVAVDGPLLAISDNMFVHNNSKHGRRAKRLDTTEGTGNTSLSISGHPLAPDSTY 419
            ||||||||:||.|:|||.:||:||||||||||||||||:|||.:|
Human   252 DMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRLDPSE-------------------- 296

  Fly   420 DGLYPPLPVATPCIKAISPSEGWTTGGATVIIVGDNFFDGLQVVFGTMLVWSELITSHAIRVQTP 484
                    .||||||||||.|||||||||||::|||||||||||||.:||||||||.||||||||
Human   297 --------AATPCIKAISPGEGWTTGGATVIVIGDNFFDGLQVVFGNVLVWSELITPHAIRVQTP 353

  Fly   485 PRHIPGVVEVTLSYKSKQFCKGSPGRFVYVSALNEPTIDYGFQRLQKLIPRHPGDPEKLQKEIIL 549
            ||||||||||||||||||||||.|||||| :||||||||||||||||:|||||||||:|.||::|
Human   354 PRHIPGVVEVTLSYKSKQFCKGCPGRFVY-TALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLL 417

  Fly   550 KRAADL----------------------VEALYSMPRSPG------------GSTGFNSYAGQLA 580
            ||||||                      .|||||.||:||            ...|.|:::..||
Human   418 KRAADLAEALYGVPGSNQELLLKRAADVAEALYSTPRAPGPLAPLAPSHPHPAVVGINAFSSPLA 482

  Fly   581 VSVQDGSGQWTEDDYQRAQSSSVSPRGGYCSSASTPHSSGGSYGATAASAAVAATAN-GYAPAPN 644
            ::|.|.: ...|..|.|: .||.||||...|..|.....||..||..........|. |...:|:
Human   483 IAVGDAT-PGPEPGYARS-CSSASPRGFAPSPGSQQSGYGGGLGAGLGGYGAPGVAGLGVPGSPS 545

  Fly   645 M--GTLSSSPGSVFNST---SRVSSLSFNPFALPTCNTQGYS-TQLVTSTK 689
            .  |:.::||.::..|:   :..||:|. |.|.||.:...:| ..::::.|
Human   546 FLNGSTATSPFAIMPSSPPLAAASSMSL-PAAAPTTSVFSFSPVNMISAVK 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kn	NP_001097317.1	COE_DBD	184..395	CDD:212156	170/213 (80%)
		IPT_COE	431..515	CDD:238580	76/83 (92%)
		COE1_HLH	517..560	CDD:293032	36/64 (56%)
EBF4	XP_016883473.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159112
Domainoid	1	1.000	374	1.000	Domainoid score	I884
eggNOG	1	0.900	-	-		E1_KOG3836
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	649	1.000	Inparanoid score	I795
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352969at33208
OrthoFinder	1	1.000	-	-		FOG0000764
OrthoInspector	1	1.000	-	-		otm41320
orthoMCL	1	0.900	-	-		OOG6_102533
Panther	1	1.100	-	-	O	PTHR10747
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X577
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760