DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kn and Ebf3

DIOPT Version :9

Sequence 1:	NP_001097317.1	Gene:	kn / 45318	FlyBaseID:	FBgn0001319	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	XP_006230524.1	Gene:	Ebf3 / 361668	RGDID:	1304956	Length:	629	Species:	Rattus norvegicus

Alignment Length:	585	Identity:	365/585 - (62%)
Similarity:	417/585 - (71%)	Gaps:	99/585 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 MFGLPPTAAVDMNQPRGPMTSLKEEPLGSRWAMQP---------VVD-----QSNLGIGRAHFEK 204
            |||      :..|.|||. |::|||||||  .|.|         |||     ||.:|:.||||||
  Rat     1 MFG------IQENIPRGG-TTMKEEPLGS--GMNPVRSWMHTAGVVDANTAAQSGVGLARAHFEK 56

  Fly   205 QPPSNLRKSNFFHFVIALYDRAGQPIEIERTAFIGFIEKDSESDATKTNNGIQYRLQLLYANGAR 269
            |||||||||||||||:|||||.|||:|||||||:.|:||:.|.:..||||||.|:|||||:||.|
  Rat    57 QPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVEKEKEPNNEKTNNGIHYKLQLLYSNGVR 121

  Fly   270 QEQDIFVRLIDSVTKQAIIYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVIIDRF 334
            .|||::||||||:|||||:||||||||||||||||||:|||||||||||||||||||||||||||
  Rat   122 TEQDLYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRF 186

  Fly   335 FLKFFLKCNQNCLKNAGNPRDMRRFQVVISTQVAVDGPLLAISDNMFVHNNSKHGRRAKRLDTTE 399
            ||||||||||||||||||||||||||||:||.|.|||.:||:||||||||||||||||:|||.:|
  Rat   187 FLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSE 251

  Fly   400 GTGNTSLSISGHPLAPDSTYDGLYPPLPVATPCIKAISPSEGWTTGGATVIIVGDNFFDGLQVVF 464
            ||            ||  :|      |..|||||||||||||||||||||||:||||||||||||
  Rat   252 GT------------AP--SY------LENATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVF 296

  Fly   465 GTMLVWSELITSHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGSPGRFVYVSALNEPTIDYGFQRL 529
            |||||||||||.||||||||||||||||||||||||||||||:|||||| :||||||||||||||
  Rat   297 GTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFVY-TALNEPTIDYGFQRL 360

  Fly   530 QKLIPRHPGDPEKLQKEIILKRAADLVEALYSMP------------------------------- 563
            ||:|||||||||:|.||::||||||||||||.||
  Rat   361 QKVIPRHPGDPERLPKEVLLKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQIPTL 425

  Fly   564 -RSPG--GSTGFNSYAGQLAVSVQDGSGQWTEDDYQRAQSSSVSPRGGYCSSASTPHSSGGSYGA 625
             .:|.  |..|.||::.||||:|.:.|....:..|.| .:|||||| ||..| |||..|  :|.
  Rat   426 GNTPAHTGMMGVNSFSSQLAVNVSETSQANDQVGYSR-NTSSVSPR-GYVPS-STPQQS--NYN- 484

  Fly   626 TAASAAVAATANGYAPA--PNMGTLSSSPGSVFNSTSRVSSLSFNPFAL-PTCNTQGYSTQLVTS 687
                 .|:.:.|||...  .|:| :..|||.:..|::.      :|:.: |:..|...|:..:.|
  Rat   485 -----TVSTSMNGYGSGAMANLG-VPGSPGFLNGSSAN------SPYGIVPSSPTMAASSVTLPS 537

Fly 688 687
Rat 538 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kn	NP_001097317.1	COE_DBD	184..395	CDD:212156	174/224 (78%)
		IPT_COE	431..515	CDD:238580	80/83 (96%)
		COE1_HLH	517..560	CDD:293032	37/42 (88%)
Ebf3	XP_006230524.1	COE1_DBD	21..247	CDD:406750	176/227 (78%)
		IPT_COE	263..347	CDD:238580	80/84 (95%)
		COE1_HLH	348..391	CDD:406751	37/42 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353124
Domainoid	1	1.000	374	1.000	Domainoid score	I843
eggNOG	1	0.900	-	-		E1_KOG3836
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56472
Inparanoid	1	1.050	648	1.000	Inparanoid score	I768
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352969at33208
OrthoFinder	1	1.000	-	-		FOG0000764
OrthoInspector	1	1.000	-	-		otm45447
orthoMCL	1	0.900	-	-		OOG6_102533
Panther	1	1.100	-	-	LDO	PTHR10747
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X577
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760