Protein Alignment kn and ebf2

DIOPT Version :10

• Sequence 1: NP_001097317.1
• Gene: kn / 45318
• FlyBaseID: FBgn0001319
• Length: 689
• Species: Drosophila melanogaster
• Sequence 2: XP_005165675.1
• Gene: ebf2 / 30692
• ZFINID: ZDB-GENE-990715-11
• Length: 580
• Species: Danio rerio
• Alignment Length: 581
• Identity: 345/581 - (59%)
• Similarity: 397/581 - (68%)
• Gaps: 100/581 - (17%)

  Fly   172 MTSLK-----EE--PLGSRWAMQ-PVVD-----QSNLGIGRAHFEKQPPSNLRKSNFFHFVIALY 223
            :|.||     ||  |:.| |... .|:|     ||.:.:.|||||||||||||||||||||:|||
Zfish    12 ITELKVRTFEEEMDPVRS-WVRNVGVIDANIAAQSGVALSRAHFEKQPPSNLRKSNFFHFVLALY 75

  Fly   224 DRAGQPIEIERTAFIGFIEKDSESDATKTNNGIQYRLQLLYANGARQEQDIFVRLIDSVTKQAII 288
            ||.|||:|:|||:|:.|:|:|.|....|||||..|:|||||:||.|.|||::.|||||||||.|.
Zfish    76 DRNGQPVEVERTSFVDFVEQDKEQTGEKTNNGTHYKLQLLYSNGVRTEQDLYARLIDSVTKQPIS 140

  Fly   289 YEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNP 353
            ||||:||||||||||||||||||||:||||||||||||||||||||||||||||||||||.||||
Zfish   141 YEGQNKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKTAGNP 205

  Fly   354 RDMRRFQVVISTQVAVDGPLLAISDNMFVHNNSKHGRRAKRLDTTEGTGNTSLSISGHPLAPDST 418
            |||||||||:||.|.||||:||||||||||||||||||::|:|..|...|.
Zfish   206 RDMRRFQVVLSTTVCVDGPVLAISDNMFVHNNSKHGRRSRRMDPNETVENN-------------- 256

  Fly   419 YDGLYPPLPVATPCIKAISPSEGWTTGGATVIIVGDNFFDGLQVVFGTMLVWSELITSHAIRVQT 483
                   :..|||||||||||||||||||.||::|:|||||||||||:|||||||||.|||||||
Zfish   257 -------MEYATPCIKAISPSEGWTTGGAMVIVIGENFFDGLQVVFGSMLVWSELITPHAIRVQT 314

  Fly   484 PPRHIPGVVEVTLSYKSKQFCKGSPGRFVYVSALNEPTIDYGFQRLQKLIPRHPGDPEKLQKEII 548
            |||||||||||||||||||||||:||||:| :|||||||||||||||||||||||||:||.||::
Zfish   315 PPRHIPGVVEVTLSYKSKQFCKGAPGRFIY-TALNEPTIDYGFQRLQKLIPRHPGDPDKLAKEML 378

  Fly   549 LKRAADLVEALY--------------------------------SMPRSP--GGSTGFNSYAGQL 579
            ||||||:||:||                                :||.||  |...|.:||..||
Zfish   379 LKRAADVVESLYGNTTSNQDMLLKRAADIAEALYSVPRPHSQLQAMPSSPVHGSVMGLSSYPTQL 443

  Fly   580 AVSVQDGSGQWTEDDYQRAQSSSVSPRGGYCSSASTPH-----SSGG-SYGATAASAAVAATANG 638
            .||:.: .||.:...|.| .|||:||| ||.|| |||.     |:|| ||||...|:...:.:.|
Zfish   444 GVSIGE-PGQTSGQGYTR-NSSSLSPR-GYPSS-STPQQSAYGSNGGMSYGAVPMSSLGVSGSPG 504

  Fly   639 Y-APAPNMGTLSSSPGSVFNSTSRVSSLSFNPF-------------------ALPTCNTQG 679
            : :.:||....:..|.|...|:|..|.|.|:.|                   ..|.|.|.|
Zfish   505 FNSASPNSSPYAIMPSSPPGSSSSSSLLPFSSFPSSTKQKSAFAPVLRPQGSPSPVCQTSG 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kn	NP_001097317.1	COE_DBD	184..395	CDD:212156	166/216 (77%)
		IPT_COE	431..515	CDD:238580	75/83 (90%)
		COE1_HLH	517..560	CDD:406751	36/42 (86%)
ebf2	XP_005165675.1	COE1_DBD	21..247	CDD:435333	170/226 (75%)
		IPT_COE	262..346	CDD:238580	75/84 (89%)
		COE1_HLH	347..390	CDD:406751	36/42 (86%)