Protein Alignment kn and unc-3

DIOPT Version :10

• Sequence 1: NP_001097317.1
• Gene: kn / 45318
• FlyBaseID: FBgn0001319
• Length: 689
• Species: Drosophila melanogaster
• Sequence 2: NP_510453.1
• Gene: unc-3 / 181573
• WormBaseID: WBGene00006743
• Length: 491
• Species: Caenorhabditis elegans
• Alignment Length: 544
• Identity: 287/544 - (52%)
• Similarity: 355/544 - (65%)
• Gaps: 79/544 - (14%)

  Fly   143 AVSGPRSAGGLMFGLPPTAAVDMNQPRGPM------TSLKEEPLGSRWAMQPVVDQSNLG--IGR 199
            :::.|..||.:.|         .::|..|:      .|:|:|...|.|   |::|.||..  |.|
 Worm     2 SLTAPLRAGQMNF---------YDEPYNPVLNLHIQPSVKDENQRSTW---PIIDTSNTSTQIAR 54

  Fly   200 AHFEKQPPSNLRKSNFFHFVIALYDRAGQPIEIERTAFIGFIEKDSESDATKTNNGIQYRLQLLY 264
            |||||.||:|||||||||||||||||..||||:|||.|.||:||:.|.|...|.|||.|||.|::
 Worm    55 AHFEKHPPNNLRKSNFFHFVIALYDRNSQPIEVERTQFAGFVEKEKEVDGQDTRNGIHYRLSLMF 119

  Fly   265 ANGARQEQDIFVRLIDSVTKQAIIYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPV 329
            .||.|.|.|:|||||||.|||||.|||||||||||||||||||||||||:|||||||||||||||
 Worm   120 QNGIRSEHDLFVRLIDSSTKQAITYEGQDKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDPV 184

  Fly   330 IIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVISTQVAVDGPLLAISDNMFVHNNSKHGRRAKR 394
            |||||||||||||||||||||||||||||||||:.:...:||||||:|||||||||||||||.||
 Worm   185 IIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVLCSSARIDGPLLAVSDNMFVHNNSKHGRRTKR 249

  Fly   395 LDTTEGTGNTSLSISGHPLAPDSTYDGLYPPLPVATPCIKAISPSEGWTTGGATVIIVGDNFFDG 459
            .|.::                ||.|.. ...||.:.|.|||:.|||||..||..|:::|:|||:|
 Worm   250 TDASD----------------DSEYSE-SAELPSSVPVIKALFPSEGWIQGGTQVVLIGENFFEG 297

  Fly   460 LQVVFGTMLV-WSE---LITSHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGSPGRFVYVSALNEP 520
            |||.|||... |.|   ||:.|||||.|||:|..|.|:|||.||||.:.:|:|.||.|:: |.||
 Worm   298 LQVAFGTASPNWGESVQLISPHAIRVTTPPKHSAGPVDVTLQYKSKTYSRGTPLRFSYIT-LAEP 361

  Fly   521 TIDYGFQRLQKLIPRHPGDPEKLQKEIILKRAADLVEALYSMPRSPGGSTGFNSYAGQLAVSVQD 585
            .|:|||||||||:|::|||||:|.|:.||||||:|.||||:...:...|:.:::...
 Worm   362 GIEYGFQRLQKLLPKYPGDPERLPKDQILKRAAELAEALYNRTSTESLSSYYHTQFD-------- 418

  Fly   586 GSGQWTEDDYQRAQSSSVSPRGGYCSSASTPHSSGGSYGATAASAAVAATANGYAPAPNMGTLSS 650
                 ...||  |..:..|||      ::.|:.:    |..|.|:||..|        :..|:::
 Worm   419 -----ATSDY--AARTHTSPR------STLPYGA----GPPALSSAVYQT--------SYPTVNA 458

  Fly   651 SPGSVFNSTSRVSSLSF---NPFA 671
            :|.:.|.:| :....:|   ||||
 Worm   459 TPAANFLNT-QTGFATFGAVNPFA 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kn	NP_001097317.1	COE_DBD	184..395	CDD:212156	165/212 (78%)
		IPT_COE	431..515	CDD:238580	50/87 (57%)
		COE1_HLH	517..560	CDD:406751	30/42 (71%)
unc-3	NP_510453.1	COE_DBD	45..249	CDD:212156	161/203 (79%)
		IPT_COE	269..357	CDD:238580	50/87 (57%)
		COE1_HLH	358..401	CDD:406751	30/42 (71%)