Protein Alignment kn and Ebf3

DIOPT Version :10

• Sequence 1: NP_001097317.1
• Gene: kn / 45318
• FlyBaseID: FBgn0001319
• Length: 689
• Species: Drosophila melanogaster
• Sequence 2: XP_030097945.1
• Gene: Ebf3 / 13593
• MGIID: 894289
• Length: 629
• Species: Mus musculus
• Alignment Length: 585
• Identity: 365/585 - (62%)
• Similarity: 417/585 - (71%)
• Gaps: 99/585 - (16%)

  Fly   154 MFGLPPTAAVDMNQPRGPMTSLKEEPLGSRWAMQP---------VVD-----QSNLGIGRAHFEK 204
            |||      :..|.|||. |::|||||||  .|.|         |||     ||.:|:.||||||
Mouse     1 MFG------IQENIPRGG-TTMKEEPLGS--GMNPVRSWMHTAGVVDANTAAQSGVGLARAHFEK 56

  Fly   205 QPPSNLRKSNFFHFVIALYDRAGQPIEIERTAFIGFIEKDSESDATKTNNGIQYRLQLLYANGAR 269
            |||||||||||||||:|||||.|||:|||||||:.|:||:.|.:..||||||.|:|||||:||.|
Mouse    57 QPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVEKEKEPNNEKTNNGIHYKLQLLYSNGVR 121

  Fly   270 QEQDIFVRLIDSVTKQAIIYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVIIDRF 334
            .|||::||||||:|||||:||||||||||||||||||:|||||||||||||||||||||||||||
Mouse   122 TEQDLYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRF 186

  Fly   335 FLKFFLKCNQNCLKNAGNPRDMRRFQVVISTQVAVDGPLLAISDNMFVHNNSKHGRRAKRLDTTE 399
            ||||||||||||||||||||||||||||:||.|.|||.:||:||||||||||||||||:|||.:|
Mouse   187 FLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSE 251

  Fly   400 GTGNTSLSISGHPLAPDSTYDGLYPPLPVATPCIKAISPSEGWTTGGATVIIVGDNFFDGLQVVF 464
            ||            ||  :|      |..|||||||||||||||||||||||:||||||||||||
Mouse   252 GT------------AP--SY------LENATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVF 296

  Fly   465 GTMLVWSELITSHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGSPGRFVYVSALNEPTIDYGFQRL 529
            |||||||||||.||||||||||||||||||||||||||||||:|||||| :||||||||||||||
Mouse   297 GTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFVY-TALNEPTIDYGFQRL 360

  Fly   530 QKLIPRHPGDPEKLQKEIILKRAADLVEALYSMP------------------------------- 563
            ||:|||||||||:|.||::||||||||||||.||
Mouse   361 QKVIPRHPGDPERLPKEVLLKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQIPTL 425

  Fly   564 -RSPG--GSTGFNSYAGQLAVSVQDGSGQWTEDDYQRAQSSSVSPRGGYCSSASTPHSSGGSYGA 625
             .:|.  |..|.||::.||||:|.:.|....:..|.| .:|||||| ||..| |||..|  :|.
Mouse   426 GNTPAHTGMMGVNSFSSQLAVNVSETSQANDQVGYSR-NTSSVSPR-GYVPS-STPQQS--NYN- 484

  Fly   626 TAASAAVAATANGYAPA--PNMGTLSSSPGSVFNSTSRVSSLSFNPFAL-PTCNTQGYSTQLVTS 687
                 .|:.:.|||...  .|:| :..|||.:..|::.      :|:.: |:..|...|:..:.|
Mouse   485 -----TVSTSMNGYGSGAMANLG-VPGSPGFLNGSSAN------SPYGIVPSSPTMAASSVTLPS 537

  Fly   688  687
            Mouse   538  537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kn	NP_001097317.1	COE_DBD	184..395	CDD:212156	174/224 (78%)
		IPT_COE	431..515	CDD:238580	80/83 (96%)
		COE1_HLH	517..560	CDD:406751	37/42 (88%)
Ebf3	XP_030097945.1	COE1_DBD	21..247	CDD:435333	176/227 (78%)
		IPT_COE	263..347	CDD:238580	80/84 (95%)
		COE1_HLH	348..391	CDD:406751	37/42 (88%)