DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kn and Ebf1

DIOPT Version :10

Sequence 1:NP_001097317.1 Gene:kn / 45318 FlyBaseID:FBgn0001319 Length:689 Species:Drosophila melanogaster
Sequence 2:NP_001277638.1 Gene:Ebf1 / 13591 MGIID:95275 Length:592 Species:Mus musculus


Alignment Length:617 Identity:370/617 - (59%)
Similarity:421/617 - (68%) Gaps:116/617 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   154 MFGLPPTAAVDMNQPRGPMTSLKEEPLGS-----RWAMQ--PVVD-----QSNLGIGRAHFEKQP 206
            |||:..:.     |..|  :|:|||||||     |..||  .|:|     ||.:|:.||||||||
Mouse     1 MFGIQESI-----QRSG--SSMKEEPLGSGMNAVRTWMQGAGVLDANTAAQSGVGLARAHFEKQP 58

  Fly   207 PSNLRKSNFFHFVIALYDRAGQPIEIERTAFIGFIEKDSESDATKTNNGIQYRLQLLYANGARQE 271
            |||||||||||||:|||||.|||:|||||||:||:||:.|:::.||||||.|||||||:||.|.|
Mouse    59 PSNLRKSNFFHFVLALYDRQGQPVEIERTAFVGFVEKEKEANSEKTNNGIHYRLQLLYSNGIRTE 123

  Fly   272 QDIFVRLIDSVTKQAIIYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVIIDRFFL 336
            ||.:||||||:|||||:||||||||||||||||||:|||||||||||||||||||||||||||||
Mouse   124 QDFYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFL 188

  Fly   337 KFFLKCNQNCLKNAGNPRDMRRFQVVISTQVAVDGPLLAISDNMFVHNNSKHGRRAKRLDTTEGT 401
            ||||||||||||||||||||||||||:||.|.|||.:||:||||||||||||||||:|||.:|||
Mouse   189 KFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGT 253

  Fly   402 GNTSLSISGHPLAPDSTYDGLYPPLPVATPCIKAISPSEGWTTGGATVIIVGDNFFDGLQVVFGT 466
            .    |...|                .|||||||||||||||||||||||:||||||||||:|||
Mouse   254 P----SYLEH----------------AATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGT 298

  Fly   467 MLVWSELITSHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGSPGRFVYVSALNEPTIDYGFQRLQK 531
            |||||||||.||||||||||||||||||||||||||||||:||||:| :||||||||||||||||
Mouse   299 MLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGRFIY-TALNEPTIDYGFQRLQK 362

  Fly   532 LIPRHPGDPEKLQKEIILKRAADLVEALYSMPRS------------------------------- 565
            :|||||||||:|.||:|||||||||||||.||.:                               
Mouse   363 VIPRHPGDPERLPKEVILKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQLPALAN 427

  Fly   566 ---PGGSTGFNSYAGQLAVSVQDGSGQWTEDDYQRAQSSSVSPRGGYCSSASTPH--------SS 619
               ..|..|.||::|||||:|.:.| |.|...:.| .||||||. ||..| :||.        :|
Mouse   428 TSVHAGMMGVNSFSGQLAVNVSEAS-QATNQGFTR-NSSSVSPH-GYVPS-TTPQQTNYNSVTTS 488

  Fly   620 GGSYGATAAS--AAVAATANG------YAPAPNMGTLSSSPGSVFNSTSRVSSLSFNPFAL---- 672
            ...||:.|.|  .......||      ||..|:..|::||.....|.:|.....||:|..:    
Mouse   489 MNGYGSAAMSNLGGSPTFLNGSAANSPYAIVPSSPTMASSTSLPSNCSSSSGIFSFSPANMVSAV 553

  Fly   673 -----------------PTC-NTQGYSTQLVT 686
                             ||| :|.|.|.|.::
Mouse   554 KQKSAFAPVVRPQTSPPPTCTSTNGNSLQAIS 585

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
knNP_001097317.1 COE_DBD 184..395 CDD:212156 175/217 (81%)
IPT_COE 431..515 CDD:238580 78/83 (94%)
COE1_HLH 517..560 CDD:406751 38/42 (90%)
Ebf1NP_001277638.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 10/26 (38%)
COE1_DBD 21..247 CDD:435333 178/225 (79%)
Interaction with DNA. /evidence=ECO:0000269|PubMed:20876732, ECO:0007744|PDB:3MLN, ECO:0007744|PDB:3MLO, ECO:0007744|PDB:3MLP 63..66 2/2 (100%)
Interaction with DNA. /evidence=ECO:0000269|PubMed:20876732, ECO:0007744|PDB:3MLN, ECO:0007744|PDB:3MLO, ECO:0007744|PDB:3MLP 197..204 6/6 (100%)
Interaction with DNA. /evidence=ECO:0000269|PubMed:20876732, ECO:0007744|PDB:3MLN, ECO:0007744|PDB:3MLO, ECO:0007744|PDB:3MLP 236..239 2/2 (100%)
IPT_COE 263..347 CDD:238580 78/84 (93%)
COE1_HLH 348..391 CDD:406751 38/42 (90%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 458..481 12/25 (48%)

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