DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz and MFRP

DIOPT Version :9

Sequence 1:	NP_001261836.1	Gene:	fz / 45307	FlyBaseID:	FBgn0001085	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_113621.1	Gene:	MFRP / 83552	HGNCID:	18121	Length:	579	Species:	Homo sapiens

Alignment Length:	118	Identity:	38/118 - (32%)
Similarity:	56/118 - (47%)	Gaps:	4/118 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 PHHNRCEPITISICKNIPYNMTIMPNL-IGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYV 111
            |....|||:.:.:|..:.||.|..||: :|...|||....:..:..|..:.|....:..||.|.|
Human   461 PPELACEPVQVEMCLGLSYNTTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCGLLV 525

  Fly   112 PVCTILERPIPPCRSLCESA-RVCEKLMKTYNFNWPENLECSKFPVHGGEDLC 163
            |.||.|...:|||||:|:.| ..|:..:......||.|  |::.|.....:.|
Human   526 PRCTPLGSVLPPCRSVCQEAEHQCQSGLALLGTPWPFN--CNRLPEAADLEAC 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	37/115 (32%)
fz	NP_001261836.1	Frizzled	237..564	CDD:279827
MFRP	NP_113621.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..143
		CUB	144..252	CDD:238001
		LDLa	260..294	CDD:238060
		CUB	301..411	CDD:238001
		LDLa	421..454	CDD:238060
		Fz	466..569	CDD:279700	35/104 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810