Protein Alignment fz and FZD9

DIOPT Version :10

• Sequence 1: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_003499.1
• Gene: FZD9 / 8326
• HGNCID: 4047
• Length: 591
• Species: Homo sapiens
• Alignment Length: 624
• Identity: 234/624 - (37%)
• Similarity: 330/624 - (52%)
• Gaps: 98/624 - (15%)

  Fly    36 LMASSGTELD-GL--PHHNR----CEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPL 93
            |:|:.|..|: |.  |...|    |:.:.|.:|:.|.||:|.||||:|||.|.||..|:.:||||
Human    15 LLAAGGAALEIGRFDPERGRGAAPCQAVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAELAEFAPL 79

  Fly    94 VKIGCSDDLQLFLCSLYVPVCT-ILERPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPV 156
            |:.||...|:.||||||.|:|| .:..|||.||.:||.||: |..:|:.:||.||::|:|::.|.
Human    80 VQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPT 144

  Fly   157 HGG-EDLCV--AENTTSSASTAATPTRSVAKVTTRKHQTGVESPHRNIGF--VCPVQLKTP--LG 214
            ... ..||:  .||.|:                      |...||:.:|.  |.|...:.|  ||
Human   145 RNDPHALCMEAPENATA----------------------GPAEPHKGLGMLPVAPRPARPPGDLG 187

  Fly   215 MGYELKVGGKDLHD-----------------CGAPCHAMFFPERERTVLRYWVGSWAAVCVASCL 262
            .|    .||....:                 || |...:|:..|::.....|:..|:|:|..|..
Human   188 PG----AGGSGTCENPEKFQYVEKSRSCAPRCG-PGVEVFWSRRDKDFALVWMAVWSALCFFSTA 247

  Fly   263 FTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAG-DSVSCREPFPPPVKLGRLQMMST 326
            |||||||::..||:||||.|:||::||.|...|::....|| .||:|.:      :.|.|.
Human   248 FTVLTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACDQ------EAGALY---- 302

  Fly   327 ITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPA 391
            :.|...:.|.||::|:.||:..||:..||..|...||||||.||||||||.....||:.||.:||
Human   303 VIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLPA 367

  Fly   392 LQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMK 456
            |:||.:|.|.||.||.|:|:|:|...|..:|..|:::||..||.:|:.|||.||::||.||.:||
Human   368 LKTIVILTLRKVAGDELTGLCYVASTDAAALTGFVLVPLSGYLVLGSSFLLTGFVALFHIRKIMK 432

  Fly   457 TDGKRTDKLERLMLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARA 521
            |.|..|:|||:||::||.||.|:.:||..::.|..||..|.|.|.:       :....||.||..
Human   433 TGGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRL-------RATEQPCAAAAG 490

  Fly   522 PGSPE-------ARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVERLQGKEPRTRAQA 579
            ||...       :.|...:||:|...|::||:||.||::||||..:|::...|   |....||:|
Human   491 PGGRRDCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQSLCYR---KIAAGRARA 552

  Fly   580 YVXYETGPAG-GAKSTPLTP---------DPEAANESYL 608
            .. ...|..| |.......|         ||...|.::|
Human   553 KACRAPGSYGRGTHCHYKAPTVVLHMTKTDPSLENPTHL 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	56/124 (45%)
		7tmF_FZD1_insect	236..568	CDD:320376	141/339 (42%)
		TM helix 1	245..270	CDD:320376	11/24 (46%)
		TM helix 2	279..300	CDD:320376	9/20 (45%)
		TM helix 3	338..364	CDD:320376	10/25 (40%)
		TM helix 4	381..397	CDD:320376	9/15 (60%)
		TM helix 5	419..448	CDD:320376	12/28 (43%)
		TM helix 6	468..495	CDD:320376	12/26 (46%)
		TM helix 7	527..552	CDD:320376	10/24 (42%)
FZD9	NP_003499.1	CRD_FZ	35..161	CDD:470581	57/125 (46%)
		Required for Wnt-activated receptor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8	58..172		53/135 (39%)
		7tmF_FZD9	221..542	CDD:320164	141/337 (42%)
		TM helix 1	230..255	CDD:320164	11/24 (46%)
		TM helix 2	264..285	CDD:320164	9/20 (45%)
		TM helix 3	314..340	CDD:320164	10/25 (40%)
		TM helix 4	357..373	CDD:320164	9/15 (60%)
		TM helix 5	395..425	CDD:320164	12/29 (41%)
		TM helix 6	444..471	CDD:320164	12/26 (46%)
		TM helix 7	503..528	CDD:320164	10/24 (42%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	532..537		2/4 (50%)
		Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8	554..591		7/36 (19%)