DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz and FZD6

DIOPT Version :9

Sequence 1:NP_001261836.1 Gene:fz / 45307 FlyBaseID:FBgn0001085 Length:612 Species:Drosophila melanogaster
Sequence 2:NP_001158087.1 Gene:FZD6 / 8323 HGNCID:4044 Length:706 Species:Homo sapiens


Alignment Length:529 Identity:219/529 - (41%)
Similarity:297/529 - (56%) Gaps:45/529 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 CEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTIL 117
            |||||:..|..:.||||..|||:||..|..|.:|:..|.||..:.||.:::.|||..:||.|...
Human    24 CEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVPTCIEQ 88

  Fly   118 ERPIPPCRSLCESA-RVCEKLMKTYNFNWPENLECSKFPVHGGEDLCVAENTTSSASTAATPTRS 181
            ...:||||.|||.. ..|:||:.|:...|||.|||.:        |...:.|             
Human    89 IHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDR--------LQYCDET------------- 132

  Fly   182 VAKVTTRKH------QTGVESPHRNIGFVCPVQLKTPLGMGYELKVGGKDLHDCGAPCHAMFFPE 240
             ..||...|      |...|...|:|||.||..|||..|.||:. :|   :..|..||..|:|..
Human   133 -VPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSGGQGYKF-LG---IDQCAPPCPNMYFKS 192

  Fly   241 RERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAGDS 305
            .|....:.::|:.:..|:.:.|||.||||||..|||||||.|::.:|||.:|...|..|...|||
Human   193 DELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFIGFLLGDS 257

  Fly   306 VSCREPFPPPVKLGRLQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKW 370
            .:|.:...      :|::..|:..| .|..:||||||.|||..||...||..|...||||||.||
Human   258 TACNKADE------KLELGDTVVLG-SQNKACTVLFMLLYFFTMAGTVWWVILTITWFLAAGRKW 315

  Fly   371 GHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLS 435
            ..||||.|:..||.|||..|...|:.:||:.|||||.:|||||||..|..:...|::||||:.:.
Human   316 SCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVF 380

  Fly   436 IGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLLGCLFYEYYNFDEW 500
            :|...||||.|||..:|.|::.||:..:||::.|:|||.||||:::|.|.||||..||..|...|
Human   381 VGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITW 445

  Fly   501 MIQWHRDICKPFSIPCP-AARAPGSPEARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNF 564
            .|.|..|.|:.:.|||| .|:|    :|||...:||:|||.:::||:::..|:.|.||...|..|
Human   446 EITWVSDHCRQYHIPCPYQAKA----KARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGF 506

  Fly   565 VERLQGKEP 573
            .:|.:.::|
Human   507 FKRNRKRDP 515

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fzNP_001261836.1 CRD_FZ1_like 51..167 CDD:143567 47/114 (41%)
Frizzled 237..564 CDD:279827 146/327 (45%)
FZD6NP_001158087.1 CRD_FZ6 20..146 CDD:143559 51/143 (36%)
Frizzled 189..507 CDD:279827 146/328 (45%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 498..503 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 588..706
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D167933at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11309
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X126
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.920

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