DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz and FZD1

DIOPT Version :9

Sequence 1:NP_001261836.1 Gene:fz / 45307 FlyBaseID:FBgn0001085 Length:612 Species:Drosophila melanogaster
Sequence 2:NP_003496.1 Gene:FZD1 / 8321 HGNCID:4038 Length:647 Species:Homo sapiens


Alignment Length:616 Identity:290/616 - (47%)
Similarity:370/616 - (60%) Gaps:71/616 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 RQILFIL----PTLIQGV--QRYDQSPLDASPYYRSGGG---------LMASSGTELDG-----L 47
            ||:|.:|    ..|:.||  |...|.|       ..|.|         ....||.:.:|     :
Human    53 RQLLLLLWLLEAPLLLGVRAQAAGQGP-------GQGPGPGQQPPPPPQQQQSGQQYNGERGISV 110

  Fly    48 PHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVP 112
            |.|..|:||:|.:|.:|.||.||||||:|||.||:||||||||.||||:.||.:|:.||||:|.|
Human   111 PDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAP 175

  Fly   113 VCTILERPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPVHGGEDLCVAENTTSSASTAA 176
            |||:||:.:||||||||.||. ||.||..:.|.||:.|:|.||||||..:|||.:||    |...
Human   176 VCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNT----SDKG 236

  Fly   177 TPTRS-VAKVTTRKHQTGVESPHR-----NIG------FVCPVQLKTPLGMGYELKVGGKDLHDC 229
            |||.| :.:..|...|.| ...||     ..|      |.||..||.|..:.|.. :|.|   ||
Human   237 TPTPSLLPEFWTSNPQHG-GGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHF-LGEK---DC 296

  Fly   230 GAPCH------AMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVC 288
            ||||.      .|:|...|....|.|:|.|:.:|.||.||||||:|:|..||.||||.|:||:.|
Human   297 GAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGC 361

  Fly   289 YLVVGCAYVAGLGAGDSVSCREPFPPPVKLGRLQMMSTITQGHRQTTSCTVLFMALYFCCMAAFA 353
            |..|..||:||....|.|.|.:.|..       ....|:.||.:: ..||:|||.|||..||:..
Human   362 YTAVAVAYIAGFLLEDRVVCNDKFAE-------DGARTVAQGTKK-EGCTILFMMLYFFSMASSI 418

  Fly   354 WWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLD 418
            ||..|:..||||||:||||||||..|..|||.||||||::||::|||.:|:||:||||||||..:
Human   419 WWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNN 483

  Fly   419 THSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPA 483
            ..:|..|::.||.:||.||..||||||:|||||||:||.||.:|:|||:||:|||.||.|:.:||
Human   484 VDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPA 548

  Fly   484 VGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPCP----AARAPGSPEARPIFQIFMVKYLCSMLV 544
            ..::.|.|||....|:|...|....||.::||||    ...||..|...|.|.:||:|||.:::|
Human   549 TIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQAGGGAPPHPPMSPDFTVFMIKYLMTLIV 613

  Fly   545 GVTSSVWLYSSKTMVSWRNFVERL----QGK 571
            |:||..|::|.||:.|||.|..||    ||:
Human   614 GITSGFWIWSGKTLNSWRKFYTRLTNSKQGE 644

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fzNP_001261836.1 CRD_FZ1_like 51..167 CDD:143567 73/116 (63%)
Frizzled 237..564 CDD:279827 166/330 (50%)
FZD1NP_003496.1 CRD_FZ1 112..238 CDD:143574 77/129 (60%)
Frizzled 310..634 CDD:279827 166/331 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 158 1.000 Domainoid score I4112
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20750
Inparanoid 1 1.050 531 1.000 Inparanoid score I1219
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48699
OrthoDB 1 1.010 - - D167933at33208
OrthoFinder 1 1.000 - - FOG0001848
OrthoInspector 1 1.000 - - otm41535
orthoMCL 1 0.900 - - OOG6_104642
Panther 1 1.100 - - O PTHR11309
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3233
SonicParanoid 1 1.000 - - X126
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.870

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