DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz and FZD3

DIOPT Version :10

Sequence 1:NP_001261836.1 Gene:fz / 45307 FlyBaseID:FBgn0001085 Length:612 Species:Drosophila melanogaster
Sequence 2:NP_001399834.1 Gene:FZD3 / 7976 HGNCID:4041 Length:689 Species:Homo sapiens


Alignment Length:556 Identity:221/556 - (39%)
Similarity:301/556 - (54%) Gaps:78/556 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 CEPITISICKNIPYNMTIMPNLIGHTKQEEAGL--------EVHQ---------------FAPLV 94
            |||||:.:|:::|||.|.||||:.|..|:.|.|        .:||               |.|:|
Human    28 CEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEEALENNIHQCRNKLIHPHLKGLVPFHPMV 92

  Fly    95 KIGCSDDLQLFLCSLYVPVCTILERPIPPCRSLCESA-RVCEKLMKTYNFNWPENLECSKFP--- 155
            .:.||.|.:.|||:||.|:|....|...|||.||:.| ..|.|||:.:...|||::|||:||   
Human    93 NLDCSRDFRPFLCALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCD 157

  Fly   156 ------VHGGEDLCVAENTTSSASTAATPTRSVAKVTTRKHQTGVESPHRNIGFVCPVQLKTPLG 214
                  |    ||.:|...|..|..|.                     .|:.||.||.:||....
Human   158 EPYPRLV----DLNLAGEPTEGAPVAV---------------------QRDYGFWCPRELKIDPD 197

  Fly   215 MGYELKVGGKDLH--DCGAPCHAMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRY 277
            :||..      ||  ||..||..|:|...|.:..||::|..:.:|:::.|||.||||||.:||||
Human   198 LGYSF------LHVRDCSPPCPNMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRY 256

  Fly   278 PERAIVFLAVCYLVVGCAYVAGLGAGDSVSCREPFPPPVKLGRLQMMSTITQG-HRQTTSCTVLF 341
            |||.|:|.||||::|...:..|....|.|:|....|...|      .||:||| |.:  :||:||
Human   257 PERPIIFYAVCYMMVSLIFFIGFLLEDRVACNASIPAQYK------ASTVTQGSHNK--ACTMLF 313

  Fly   342 MALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGD 406
            |.|||..||...||..|...|||||..|||.||||.|:.|||..||.:|...||.:||:.|:|||
Human   314 MILYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGD 378

  Fly   407 ILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLR 471
            .:|||||||..|..:|..|::.|||:|:.:|...||||.|||.|:|..:..:.:..|||.:.|:|
Human   379 NISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIR 443

  Fly   472 IGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARAPGSPEARPIFQIFMV 536
            ||.||.|:::|.:.::||.|||......|...|.::.|:.:.||||......|   ||...:|::
Human   444 IGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMS---RPDLILFLM 505

  Fly   537 KYLCSMLVGVTSSVWLYSSKTMVSWRNFVERLQGKE 572
            |||.:::||:.|..|:.|.||...|.:|....:.||
Human   506 KYLMALIVGIPSVFWVGSKKTCFEWASFFHGRRKKE 541

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fzNP_001261836.1 CRD_FZ1_like 51..167 CDD:143567 56/146 (38%)
7tmF_FZD1_insect 236..568 CDD:320376 145/332 (44%)
TM helix 1 245..270 CDD:320376 10/24 (42%)
TM helix 2 279..300 CDD:320376 9/20 (45%)
TM helix 3 338..364 CDD:320376 13/25 (52%)
TM helix 4 381..397 CDD:320376 8/15 (53%)
TM helix 5 419..448 CDD:320376 12/28 (43%)
TM helix 6 468..495 CDD:320376 13/26 (50%)
TM helix 7 527..552 CDD:320376 9/24 (38%)
FZD3NP_001399834.1 CRD_FZ3 24..173 CDD:143558 56/148 (38%)
7tmF_FZD3 215..535 CDD:320161 145/330 (44%)
TM helix 1 224..249 CDD:320161 10/24 (42%)
TM helix 2 258..279 CDD:320161 9/20 (45%)
TM helix 3 310..336 CDD:320161 13/25 (52%)
TM helix 4 353..375 CDD:320161 10/21 (48%)
TM helix 5 389..414 CDD:320161 8/24 (33%)
TM helix 6 442..467 CDD:320161 12/24 (50%)
TM helix 7 496..521 CDD:320161 10/27 (37%)

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