DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz and FZD5

DIOPT Version :10

Sequence 1:NP_001261836.1 Gene:fz / 45307 FlyBaseID:FBgn0001085 Length:612 Species:Drosophila melanogaster
Sequence 2:NP_003459.2 Gene:FZD5 / 7855 HGNCID:4043 Length:585 Species:Homo sapiens


Alignment Length:574 Identity:235/574 - (40%)
Similarity:325/574 - (56%) Gaps:68/574 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 CEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVC-TI 116
            |:.||:.:|:.|.||:|.|||...|..|:|||||||||.|||:|.||.||:.||||:|.|:| ..
Human    33 CQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPD 97

  Fly   117 LERPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPVHG--GEDLCVAENTTSSASTAATP 178
            ..:|:|||||:||.|:. |..||:.|.|.|||.:.|.:.||.|  .|.||:..|  .|.:|.|.|
Human    98 YHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYN--RSEATTAPP 160

  Fly   179 TRSVAKVT----TRKHQTGVESPHRNIGFVC-------PVQLKTPLGMGYELKVGGKDLHDCGAP 232
            ....||.|    .....:|.|.|... .|||       |: ||....:..:::.|  .:.:|..|
Human   161 RPFPAKPTLPGPPGAPASGGECPAGG-PFVCKCREPFVPI-LKESHPLYNKVRTG--QVPNCAVP 221

  Fly   233 CHAMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYV 297
            |:...|...|||...:|:|.|:.:|..|...||.|||||..|||||||.|:||:.|||.|...::
Human   222 CYQPSFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFL 286

  Fly   298 AGLGAGD-SVSC-REPFPPPVKLGRLQMMSTITQGHRQTTS---CTVLFMALYFCCMAAFAWWSC 357
            ..|..|. ||:| ||.                ...|.:||.   ||::|:.:||..||:..||..
Human   287 VRLVVGHASVACSREH----------------NHIHYETTGPALCTIVFLLVYFFGMASSIWWVI 335

  Fly   358 LAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSL 422
            |:..||||||:|||:|||...:..|||.||.:|::::|:.|||:.|:||.::|:|:||..:.:||
Human   336 LSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSL 400

  Fly   423 GAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLL 487
            ..|::.||.:||.:|.|||||||:||||||:|:|..|.:|||||:||:|||.|:.|:.:||..::
Human   401 RGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVV 465

  Fly   488 GCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARAPGSPEARPIFQIFMVKYLCSMLVGVTSSVWL 552
            .|..||.:..:.|.        ...:..|| ....|.|.|:|.:.:.|:||...::||:||.||:
Human   466 ACYLYEQHYRESWE--------AALTCACP-GHDTGQPRAKPEYWVLMLKYFMCLVVGITSGVWI 521

  Fly   553 YSSKTMVSWRNFVER---------------LQGKEPRTRAQAYVXYETGPAGGA 591
            :|.||:.|||.|..|               ..|..|  .|.|.: ..|||.|.|
Human   522 WSGKTVESWRRFTSRCCCRPRRGHKSGGAMAAGDYP--EASAALTGRTGPPGPA 573

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fzNP_001261836.1 CRD_FZ1_like 51..167 CDD:143567 61/117 (52%)
7tmF_FZD1_insect 236..568 CDD:320376 144/351 (41%)
TM helix 1 245..270 CDD:320376 9/24 (38%)
TM helix 2 279..300 CDD:320376 9/20 (45%)
TM helix 3 338..364 CDD:320376 10/25 (40%)
TM helix 4 381..397 CDD:320376 7/15 (47%)
TM helix 5 419..448 CDD:320376 15/28 (54%)
TM helix 6 468..495 CDD:320376 12/26 (46%)
TM helix 7 527..552 CDD:320376 10/24 (42%)
FZD5NP_003459.2 CRD_FZ5 29..156 CDD:143569 63/124 (51%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 156..179 6/22 (27%)
7tmF_FZD5 225..535 CDD:320377 143/334 (43%)
TM helix 1 234..259 CDD:320377 9/24 (38%)
TM helix 2 268..289 CDD:320377 9/20 (45%)
TM helix 3 316..342 CDD:320377 10/25 (40%)
TM helix 4 359..375 CDD:320377 7/15 (47%)
TM helix 5 397..426 CDD:320377 15/28 (54%)
TM helix 6 446..473 CDD:320377 12/26 (46%)
TM helix 7 496..521 CDD:320377 10/24 (42%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 525..530 2/4 (50%)
PDZ-binding 583..585
Blue background indicates that the domain is not in the aligned region.

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