Protein Alignment fz and SMO

DIOPT Version :10

• Sequence 1: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_005622.1
• Gene: SMO / 6608
• HGNCID: 11119
• Length: 787
• Species: Homo sapiens
• Alignment Length: 598
• Identity: 166/598 - (27%)
• Similarity: 262/598 - (43%)
• Gaps: 126/598 - (21%)

  Fly    28 PYYRSGGGLMASSGTELDGLP----HHNR---CEPITISICKN--IPYNMTIMPNLIGHT-KQEE 82
            |..||.|| .|.....:.|.|    |..|   |||:..::|..  :||..| ...|.|.: .|||
Human    39 PGPRSAGG-SARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGAT-STLLAGDSDSQEE 101

  Fly    83 A--------GLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTILERPIPPCRSLCESAR----VCE 135
            |        ||   :.||    .|...:|..||::|:|.|. .:|...|.|:||::.|    :.|
Human   102 AHGKLVLWSGL---RNAP----RCWAVIQPLLCAVYMPKCE-NDRVELPSRTLCQATRGPCAIVE 158

  Fly   136 KLMKTYNFNWPENLECS--KFPVHGGEDLCVAENTTSSASTAATPTRSVAKVTTRKHQTGVESPH 198
            :     ...||:.|.|:  :||          |..|:..
Human   159 R-----ERGWPDFLRCTPDRFP----------EGCTNEV-------------------------- 182

  Fly   199 RNIGFVCPVQLKTPLGMGYELKVGGKDLHDCGAPCHAMFFPERERTVLRYWVGSWAAVCVASCLF 263
            :||.|....|.:.||......|...:|:..||..|....|.|.|...:..::.::.||.....||
Human   183 QNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLF 247

  Fly   264 TVLTFLID-SSRFRYPERAIVFLAVCYLVVGCAYVAGL--GAGDSVSCREPFPPPVKLGRLQMMS 325
            |:.||:.| .:..|||...:.::..|:.|....::|..  ||...:.||.  ...::||.
Human   248 TLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRA--DGTMRLGE----- 305

  Fly   326 TITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAW---FLAAGLKWGHEAIENKSHLFHLVAW 387
               ....:|.||.::|:.:|:..||...|:..|.:||   |.|.|..  ::.:..|:..|||:.|
Human   306 ---PTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTT--YQPLSGKTSYFHLLTW 365

  Fly   388 AVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIR 452
            ::|.:.|:::||:|:|:||.:||:||||..:......|::.|:.:.|.:|..||:.|.::||.|:
Human   366 SLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIK 430

  Fly   453 TVMKTDG----KRTDKLERLMLRIGFFSGL---FILPAVGLLGCLFYEYYNFDEWMIQWHRDICK 510
            :  ...|    |...|:...|||:|.|..|   |:|..   ..|.||:::|..||...: ||.
Human   431 S--NHPGLLSEKAASKINETMLRLGIFGFLAFGFVLIT---FSCHFYDFFNQAEWERSF-RDY-- 487

  Fly   511 PFSIPCPAARAPGSPEARPIFQIFMVKYLCSMLV-----------GVTSSVWLYSSKTMVSWRNF 564
               :.|.|....|.|..:||... .:|...|:||           |:..|.|:::..|::.||..
Human   488 ---VLCQANVTIGLPTKQPIPDC-EIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRT 548

  Fly   565 VERLQGK---EPR 574
            ..||.|:   ||:
Human   549 WCRLTGQSDDEPK 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	38/135 (28%)
		7tmF_FZD1_insect	236..568	CDD:320376	101/355 (28%)
		TM helix 1	245..270	CDD:320376	7/24 (29%)
		TM helix 2	279..300	CDD:320376	3/20 (15%)
		TM helix 3	338..364	CDD:320376	8/28 (29%)
		TM helix 4	381..397	CDD:320376	6/15 (40%)
		TM helix 5	419..448	CDD:320376	7/28 (25%)
		TM helix 6	468..495	CDD:320376	11/29 (38%)
		TM helix 7	527..552	CDD:320376	8/35 (23%)
SMO	NP_005622.1	CRD_SMO	66..196	CDD:143560	44/179 (25%)
		7tmF_SMO_homolog	220..550	CDD:320158	101/353 (29%)
		TM helix 1	229..254	CDD:320158	7/24 (29%)
		TM helix 2	264..285	CDD:320158	3/20 (15%)
		TM helix 3	315..341	CDD:320158	8/25 (32%)
		TM helix 4	359..375	CDD:320158	6/15 (40%)
		TM helix 5	397..426	CDD:320158	7/28 (25%)
		TM helix 6	448..475	CDD:320158	11/29 (38%)
		TM helix 7	511..536	CDD:320158	5/24 (21%)