DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz and Fzd4

DIOPT Version :9

Sequence 1:	NP_001261836.1	Gene:	fz / 45307	FlyBaseID:	FBgn0001085	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_072145.1	Gene:	Fzd4 / 64558	RGDID:	71017	Length:	538	Species:	Rattus norvegicus

Alignment Length:	557	Identity:	210/557 - (37%)
Similarity:	296/557 - (53%)	Gaps:	99/557 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 GLPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLY 110
            |.....||:||.|::|:|:.||:|.||||:||..|.:|.|::..|.||::.|||..||.||||:|
  Rat    39 GDEEERRCDPIRIAMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVY 103

  Fly   111 VPVCT-ILERPIPPCRSLCESA-RVCEKLMKTYNFNWPENLECSKFPVHGGEDLCVAENTTSSAS 173
            ||:|| .:..||.||..:|.|. |.||.::|.:.|.||::|.|||||
  Rat   104 VPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPDSLNCSKFP------------------ 150

  Fly   174 TAATPTRSVAKVTTRKHQTGVESPHRNIGFVC---------PVQLKTPLGMGYELKVGG------ 223
                                   |..:...:|         |:..|||:..|.|....|
  Rat   151 -----------------------PQNDHNHMCMEGPGDEEVPLPHKTPIQPGEECHSVGTNSDQY 192

  Fly   224 ---KDLHDCGAPC--HAMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIV 283
               |...:|...|  .|..:....:.....|:..||::|..|..|||||||||||||.||||.|:
  Rat   193 IWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTTFTVLTFLIDSSRFSYPERPII 257

  Fly   284 FLAVCYLVVGCAYVAGLGAG-DSVSCR-EPFPPPVKLGRLQMMSTITQGHRQTTSCTVLFMALYF 346
            ||::||.:...||:..|..| :.:||. |....||          :.|...:.|.|.::|:.:||
  Rat   258 FLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPV----------LIQEGLKNTGCAIIFLLMYF 312

  Fly   347 CCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGV 411
            ..||:..||..|...|||||||||||||||..|..||:.|||:||::||.:|.:..|:.|.|:|:
  Rat   313 FGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGL 377

  Fly   412 CFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFS 476
            |:||.....:|..|::.||..||.||.||:.||.::||:||:.::.||.:||||||||::||.||
  Rat   378 CYVGNQSLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFS 442

  Fly   477 GLFILPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARAPGSPEARPIFQIFMVKYLCS 541
            .|:.:||..::.|.|||..|   |.:..:              .|..|..|..:.:|||     |
  Rat   443 VLYTVPATCVIACYFYEISN---WALFRY--------------SADDSNMAVEMLKIFM-----S 485

  Fly   542 MLVGVTSSVWLYSSKTMVSWRNFVERL--QGKEPRTR 576
            :|||:||.:|::|:||:.:|:....||  .||..|.:
  Rat   486 LLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREK 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	55/117 (47%)
fz	NP_001261836.1	Frizzled	237..564	CDD:279827	136/328 (41%)
Fzd4	NP_072145.1	CRD_FZ4	43..168	CDD:143557	57/165 (35%)
		Frizzled	211..510	CDD:279827	136/330 (41%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	500..505		2/4 (50%)
		PDZ-binding	536..538
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810