DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz and SFRP4

DIOPT Version :9

Sequence 1:	NP_001261836.1	Gene:	fz / 45307	FlyBaseID:	FBgn0001085	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_003005.2	Gene:	SFRP4 / 6424	HGNCID:	10778	Length:	346	Species:	Homo sapiens

Alignment Length:	123	Identity:	54/123 - (43%)
Similarity:	81/123 - (65%)	Gaps:	8/123 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 GLPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLY 110
            |.|    ||.:.|.:|:::|:|:|.|||.:.|:.||.|.|.:.|:..||.:.||..|:.|||::|
Human    21 GAP----CEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMY 81

  Fly   111 VPVCTI--LERPIPPCRSLCESAR-VCEKLMKTYNFNWPENLECSKFPVHGGEDLCVA 165
            .|:||:  |..||.||:|:|:.|| .||.|||.||.:|||:|.|.:.||: ...:|::
Human    82 APICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVY-DRGVCIS 138

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	52/118 (44%)
fz	NP_001261836.1	Frizzled	237..564	CDD:279827
SFRP4	NP_003005.2	CRD_FZ	20..146	CDD:321937	54/123 (44%)
		NTR_like	188..296	CDD:321963
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..346
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810