DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fz and Fzd1

DIOPT Version :10

Sequence 1:NP_001261836.1 Gene:fz / 45307 FlyBaseID:FBgn0001085 Length:612 Species:Drosophila melanogaster
Sequence 2:NP_067089.2 Gene:Fzd1 / 58868 RGDID:61916 Length:642 Species:Rattus norvegicus


Alignment Length:610 Identity:282/610 - (46%)
Similarity:367/610 - (60%) Gaps:60/610 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 WRQILFILPTLIQ-----GVQRY---------DQSPLDASPYYRSGGGLMASSGTELDGLPHHNR 52
            |.:.|.:|..|::     ||:..         .|:|....|  :.||  ...:|.....:|.|..
  Rat    50 WARGLLLLLWLLEAPLLLGVRAQAAGQVSGPGQQAPPPPQP--QQGG--QQYNGERGISIPDHGY 110

  Fly    53 CEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTIL 117
            |:||:|.:|.:|.||.||||||:|||.||:||||||||.||||:.||.:|:.||||:|.||||:|
  Rat   111 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVL 175

  Fly   118 ERPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPVHGGEDLCVAENTTSSASTAATPTRS 181
            |:.:||||||||.||. ||.||..:.|.||:.|:|.||||||..:|||.:||    |...|||.|
  Rat   176 EQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNT----SDKGTPTPS 236

  Fly   182 VAK---VTTRKH--------QTGVESPHRNIGFVCPVQLKTPLGMGYELKVGGKDLHDCGAPCH- 234
            :..   .:..:|        ..|...|.....|.||..|:.|..:.|.. :|.|   ||||||. 
  Rat   237 LLPEFWTSNPQHGGGGYRGGYPGGAGPVERGKFSCPRALRVPSYLNYHF-LGEK---DCGAPCEP 297

  Fly   235 -----AMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGC 294
                 .|:|...|....|.|:|.|:.:|.||.||||||:|:|..||.||||.|:||:.||..|..
  Rat   298 TKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAV 362

  Fly   295 AYVAGLGAGDSVSCREPFPPPVKLGRLQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLA 359
            ||:||....|.|.|.:.|..       ....|:.||.:: ..||:|||.|||..||:..||..|:
  Rat   363 AYIAGFLLEDRVVCNDKFAE-------DGARTVAQGTKK-EGCTILFMMLYFFSMASSIWWVILS 419

  Fly   360 FAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGA 424
            ..||||||:||||||||..|..|||.||||||::||::|||.:|:||:||||||||..:..:|..
  Rat   420 LTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRG 484

  Fly   425 FLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLLGC 489
            |::.||.:||.||..||||||:|||||||:||.||.:|:|||:||:|||.||.|:.:||..::.|
  Rat   485 FVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIAC 549

  Fly   490 LFYEYYNFDEWMIQWHRDICKPFSIPCP----AARAPGSPEARPIFQIFMVKYLCSMLVGVTSSV 550
            .|||....|:|...|....||.::||||    ....|..|...|.|.:||:|||.:::||:||..
  Rat   550 YFYEQAFRDQWERSWVAQSCKSYAIPCPHLQGGGGVPPHPPMSPDFTVFMIKYLMTLIVGITSGF 614

  Fly   551 WLYSSKTMVSWRNFVERL----QGK 571
            |::|.||:.|||.|..||    ||:
  Rat   615 WIWSGKTLNSWRKFYTRLTNSKQGE 639

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fzNP_001261836.1 CRD_FZ1_like 51..167 CDD:143567 73/116 (63%)
7tmF_FZD1_insect 236..568 CDD:320376 167/335 (50%)
TM helix 1 245..270 CDD:320376 13/24 (54%)
TM helix 2 279..300 CDD:320376 11/20 (55%)
TM helix 3 338..364 CDD:320376 13/25 (52%)
TM helix 4 381..397 CDD:320376 11/15 (73%)
TM helix 5 419..448 CDD:320376 14/28 (50%)
TM helix 6 468..495 CDD:320376 14/26 (54%)
TM helix 7 527..552 CDD:320376 11/24 (46%)
Fzd1NP_067089.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 74..99 5/28 (18%)
CRD_FZ1 107..233 CDD:143574 77/129 (60%)
7tmF_FZD1 294..641 CDD:320375 173/354 (49%)
TM helix 1 313..338 CDD:320375 13/24 (54%)
TM helix 2 347..368 CDD:320375 11/20 (55%)
TM helix 3 398..424 CDD:320375 13/25 (52%)
TM helix 4 441..457 CDD:320375 11/15 (73%)
TM helix 5 479..508 CDD:320375 14/28 (50%)
TM helix 6 528..555 CDD:320375 14/26 (54%)
TM helix 7 591..616 CDD:320375 11/24 (46%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 620..625 2/4 (50%)
PDZ-binding 640..642 282/610 (46%)

Return to query results.
Submit another query.