DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz and Fzd1

DIOPT Version :9

Sequence 1:NP_001261836.1 Gene:fz / 45307 FlyBaseID:FBgn0001085 Length:612 Species:Drosophila melanogaster
Sequence 2:NP_067089.2 Gene:Fzd1 / 58868 RGDID:61916 Length:642 Species:Rattus norvegicus


Alignment Length:610 Identity:282/610 - (46%)
Similarity:367/610 - (60%) Gaps:60/610 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 WRQILFILPTLIQ-----GVQRY---------DQSPLDASPYYRSGGGLMASSGTELDGLPHHNR 52
            |.:.|.:|..|::     ||:..         .|:|....|  :.||  ...:|.....:|.|..
  Rat    50 WARGLLLLLWLLEAPLLLGVRAQAAGQVSGPGQQAPPPPQP--QQGG--QQYNGERGISIPDHGY 110

  Fly    53 CEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTIL 117
            |:||:|.:|.:|.||.||||||:|||.||:||||||||.||||:.||.:|:.||||:|.||||:|
  Rat   111 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVL 175

  Fly   118 ERPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPVHGGEDLCVAENTTSSASTAATPTRS 181
            |:.:||||||||.||. ||.||..:.|.||:.|:|.||||||..:|||.:||    |...|||.|
  Rat   176 EQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNT----SDKGTPTPS 236

  Fly   182 VAK---VTTRKH--------QTGVESPHRNIGFVCPVQLKTPLGMGYELKVGGKDLHDCGAPCH- 234
            :..   .:..:|        ..|...|.....|.||..|:.|..:.|.. :|.|   ||||||. 
  Rat   237 LLPEFWTSNPQHGGGGYRGGYPGGAGPVERGKFSCPRALRVPSYLNYHF-LGEK---DCGAPCEP 297

  Fly   235 -----AMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGC 294
                 .|:|...|....|.|:|.|:.:|.||.||||||:|:|..||.||||.|:||:.||..|..
  Rat   298 TKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAV 362

  Fly   295 AYVAGLGAGDSVSCREPFPPPVKLGRLQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLA 359
            ||:||....|.|.|.:.|..       ....|:.||.:: ..||:|||.|||..||:..||..|:
  Rat   363 AYIAGFLLEDRVVCNDKFAE-------DGARTVAQGTKK-EGCTILFMMLYFFSMASSIWWVILS 419

  Fly   360 FAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGA 424
            ..||||||:||||||||..|..|||.||||||::||::|||.:|:||:||||||||..:..:|..
  Rat   420 LTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRG 484

  Fly   425 FLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLLGC 489
            |::.||.:||.||..||||||:|||||||:||.||.:|:|||:||:|||.||.|:.:||..::.|
  Rat   485 FVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIAC 549

  Fly   490 LFYEYYNFDEWMIQWHRDICKPFSIPCP----AARAPGSPEARPIFQIFMVKYLCSMLVGVTSSV 550
            .|||....|:|...|....||.::||||    ....|..|...|.|.:||:|||.:::||:||..
  Rat   550 YFYEQAFRDQWERSWVAQSCKSYAIPCPHLQGGGGVPPHPPMSPDFTVFMIKYLMTLIVGITSGF 614

  Fly   551 WLYSSKTMVSWRNFVERL----QGK 571
            |::|.||:.|||.|..||    ||:
  Rat   615 WIWSGKTLNSWRKFYTRLTNSKQGE 639

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fzNP_001261836.1 CRD_FZ1_like 51..167 CDD:143567 73/116 (63%)
Frizzled 237..564 CDD:279827 165/330 (50%)
Fzd1NP_067089.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 74..99 5/28 (18%)
CRD_FZ1 107..233 CDD:143574 77/129 (60%)
Frizzled 305..629 CDD:279827 165/331 (50%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 620..625 2/4 (50%)
PDZ-binding 640..642 282/610 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 160 1.000 Domainoid score I3954
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20750
Inparanoid 1 1.050 533 1.000 Inparanoid score I1169
OMA 1 1.010 - - QHG48699
OrthoDB 1 1.010 - - D167933at33208
OrthoFinder 1 1.000 - - FOG0001848
OrthoInspector 1 1.000 - - otm45657
orthoMCL 1 0.900 - - OOG6_104642
Panther 1 1.100 - - O PTHR11309
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X126
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.840

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