Protein Alignment fz and fzd8a

DIOPT Version :9

• Sequence 1: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_570993.2
• Gene: fzd8a / 58073
• ZFINID: ZDB-GENE-000328-3
• Length: 579
• Species: Danio rerio
• Alignment Length: 580
• Identity: 236/580 - (40%)
• Similarity: 329/580 - (56%)
• Gaps: 68/580 - (11%)

  Fly    36 LMASSGTELDGLPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSD 100
            |..||||....:    .|:.|.:.:||.|.||.|.|||...|..|:|||||||||.|||:|.||.
Zfish    17 LPRSSGTTAKEI----TCQEIAVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSP 77

  Fly   101 DLQLFLCSLYVPVCTILE---RPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPVHGGED 161
            ||:.||||:|.|:|  ||   :|:|||||:||.|:. |..||:.|.|.||:.:.|...||.|..|
Zfish    78 DLKFFLCSMYTPIC--LEDYKKPLPPCRSVCERAKAGCAPLMRQYGFPWPDRMRCDLLPVQGAPD 140

  Fly   162 -LCVAENTTSSASTA---ATPTRSVAK-VTTRKHQTGVE--SPHRNIGFVCPVQLKTPL------ 213
             ||:..|.|.|.:.:   :.||...:| :...|.::|..  .|::|.......|.:.|:
Zfish   141 TLCMDYNRTDSTTVSPVLSKPTNYPSKAINPHKKKSGRPGVGPNKNKPCEPGCQCRAPMVPVNSD 205

  Fly   214 --GMGYELKVGGKDLHDCGAPCHAMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFR 276
              .:...:|.|  .:.:|..|||..:|.:.|||...:|:|.|:.:|..|...||.|||||..||:
Zfish   206 RHPLYNRVKTG--QIPNCAMPCHNPYFTQDERTFTAFWIGLWSVLCFISTFATVATFLIDMERFK 268

  Fly   277 YPERAIVFLAVCYLVVGCAYVAGLGAG-DSVSCREPFPPPVKLGRLQMMSTITQGHRQTTS---C 337
            ||||.|:||:.||:.|...|:..|.|| :.|:|...:             .:...|.:||.   |
Zfish   269 YPERPIIFLSACYMFVSIGYIVRLIAGHEKVACNREY-------------DVEHIHYETTGPALC 320

  Fly   338 TVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAK 402
            ||:|:.:||..||:..||..|:..||||||:|||:|||...|..|||.||.:|::::|:||||:.
Zfish   321 TVVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLIPSMKSIAVLALSS 385

  Fly   403 VEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLER 467
            |:||.::|:|:||..:..:|..|::.||.|||.||.:||||||:||||||:|:|..|.:|||||:
Zfish   386 VDGDPVAGICYVGNQNLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQGGTKTDKLEK 450

  Fly   468 LMLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQWHRDIC------KPFSIPCPAARAPGSPE 526
            ||:|||.|:.|:.:||..::.|.|||.:|...|.|. |...|      |
Zfish   451 LMIRIGIFTVLYTVPATIIVACYFYEQHNRQSWEIT-HNCSCLLEQEIK---------------- 498

  Fly   527 ARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVERLQGKEPRTRAQAYVXYETG 586
             ||.:.:||:||...:|||:||.||.:|.||:.|||:|..|.......:....|. ..||
Zfish   499 -RPDYAVFMLKYFMCLLVGITSGVWTWSGKTLESWRSFCTRCCWGSKGSGGSMYSDVSTG 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	62/120 (52%)
		Frizzled	237..564	CDD:279827	146/336 (43%)
fzd8a	NP_570993.2	CRD_FZ8	26..150	CDD:143570	63/129 (49%)
		7tmF_FZD8	228..537	CDD:320378	147/339 (43%)
		TM helix 1	237..262	CDD:320378	9/24 (38%)
		TM helix 2	271..292	CDD:320378	9/20 (45%)
		TM helix 3	321..343	CDD:320378	10/21 (48%)
		TM helix 4	364..380	CDD:320378	7/15 (47%)
		TM helix 5	402..425	CDD:320378	10/22 (45%)
		TM helix 6	453..478	CDD:320378	11/24 (46%)
		TM helix 7	498..523	CDD:320378	13/41 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810