Protein Alignment fz and fzd8b

DIOPT Version :9

• Sequence 1: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_571628.1
• Gene: fzd8b / 58072
• ZFINID: ZDB-GENE-000328-4
• Length: 576
• Species: Danio rerio
• Alignment Length: 567
• Identity: 227/567 - (40%)
• Similarity: 327/567 - (57%)
• Gaps: 51/567 - (8%)

  Fly    53 CEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTIL 117
            |:.|::.:|:.|.||.|.|||...|..|:|||||||||.|||:|.||.||:.||||:|.|:|  |
Zfish    31 CQEISVPLCRGIGYNYTYMPNQFNHDNQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPIC--L 93

  Fly   118 E---RPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPVHGGED-LCVAENTTSSASTAAT 177
            |   :|:|||||:||.|:. |..||:.|.|.||:.:.|...||.|..: ||:..|.|.:.|:.|.
Zfish    94 EDYKKPLPPCRSVCERAKAGCAPLMRQYGFPWPDRMRCDLLPVQGDPNTLCMDYNRTDATSSPAA 158

  Fly   178 P--TRSVAKVTTRKHQTGVESPHRNIGFVCPVQLKTPLGMGY-----ELKVGGKDLHDCGAPCHA 235
            |  |....|...||:::...|........|...: .|:...:     .:|.|  .:.:|..|||.
Zfish   159 PKTTSRPGKPFKRKNKSSPGSSSCEPECYCRAPM-VPVHSDHHPLYNRVKTG--QIPNCAMPCHN 220

  Fly   236 MFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGL 300
            .:..:.|||...:|:|.|:.:|..|...||.|||||..||:||||.|:||:.||:.|...|:..|
Zfish   221 PYLSQEERTFATFWIGIWSVLCFLSTFATVATFLIDIERFKYPERPIIFLSACYMFVSLGYIIRL 285

  Fly   301 GAG-DSVSCREPFPPPVKLGRLQMMSTITQGHRQTTS---CTVLFMALYFCCMAAFAWWSCLAFA 361
            .|| :.|:|.:             ...:...|.:||.   ||::|:.:||..||:..||..|:|.
Zfish   286 IAGHERVACNQ-------------NHEVDHIHYETTGPALCTLVFLLIYFFGMASAIWWVILSFT 337

  Fly   362 WFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFL 426
            ||||||||||:|||...|..||:.||.:|::::|:||||:.|:||.::|:|:||..:..:|..|:
Zfish   338 WFLAAGLKWGNEAIARYSQYFHMAAWLIPSVKSITVLALSSVDGDSIAGICYVGNQNLDNLRGFV 402

  Fly   427 ILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLLGCLF 491
            :.||.|||.||.:||.|||:|:||||:|:|..|.:||||||||:|||.|:.|:.:.|:.::.|..
Zfish   403 LAPLVIYLFIGTIFLFAGFVSMFRIRSVIKQGGTKTDKLERLMVRIGVFTVLYTVVAIMIVACYV 467

  Fly   492 YEYYNFDEWMIQWHRDICKPFSIPCPAARAPGSPEARPIFQIFMVKYLCSMLVGVTSSVWLYSSK 556
            ||::|.:.|.|. |...|.      ...:||     :|.:.:||:||...:|:|:||..|.:|||
Zfish   468 YEHHNREAWEIA-HACNCS------SDKKAP-----KPDYAVFMLKYFMCLLIGITSGAWTWSSK 520

  Fly   557 TMVSWRNFVERLQGKEPRTRAQAYVXYETGPAG-----GAKSTPLTP 598
            |:.|||....|.......|:..:...|....:|     |..|:.|.|
Zfish   521 TLDSWRALCTRCCCCRWATKGTSGSVYSDASSGLTWRSGTASSVLCP 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	60/118 (51%)
		Frizzled	237..564	CDD:279827	141/330 (43%)
fzd8b	NP_571628.1	CRD_FZ8	27..151	CDD:143570	61/121 (50%)
		7tmF_FZD8	221..530	CDD:320378	141/333 (42%)
		TM helix 1	230..255	CDD:320378	9/24 (38%)
		TM helix 2	264..285	CDD:320378	9/20 (45%)
		TM helix 3	314..336	CDD:320378	9/21 (43%)
		TM helix 4	357..373	CDD:320378	6/15 (40%)
		TM helix 5	395..418	CDD:320378	10/22 (45%)
		TM helix 6	446..471	CDD:320378	9/24 (38%)
		TM helix 7	491..516	CDD:320378	10/29 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810