DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fz and Fzd2

DIOPT Version :9

Sequence 1:NP_001261836.1 Gene:fz / 45307 FlyBaseID:FBgn0001085 Length:612 Species:Drosophila melanogaster
Sequence 2:NP_065256.1 Gene:Fzd2 / 57265 MGIID:1888513 Length:570 Species:Mus musculus


Alignment Length:538 Identity:260/538 - (48%)
Similarity:339/538 - (63%) Gaps:31/538 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 LPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYV 111
            :|.|..|:||:|.:|.:|.||.||||||:|||.||:||||||||.||||:.||.:|:.||||:|.
Mouse    38 IPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYA 102

  Fly   112 PVCTILERPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPVHGGEDLCVAENTTSSASTA 175
            ||||:||:.||||||:||.||. ||.||..:.|.|||.|.|..||.||.|.:||.:|.:...:.|
Mouse   103 PVCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPA 167

  Fly   176 ATPTRSVAKVTTRKHQT-----GVESPHR----NIGFVCPVQLKTPLGMGYELKVGGKDLHDCGA 231
            ...|...:.:......|     |..||.|    ...|.||..||.|..:.|:. :|.:   ||.|
Mouse   168 LLTTAPPSGLQPGAGGTPGGPGGGGSPPRYATLEHPFHCPRVLKVPSYLSYKF-LGER---DCAA 228

  Fly   232 PCH------AMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYL 290
            ||.      :|||.:.|....|.|:.:|:.:|.||..|||.|:|:|..|||||||.|:||:.||.
Mouse   229 PCEPARPDGSMFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYT 293

  Fly   291 VVGCAYVAGLGAGDSVSCREPFPPPVKLGRLQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWW 355
            :|..||:||....:.|.|.|.|..       ....|:.||.:: ..||:|||.|||..||:..||
Mouse   294 MVSVAYIAGFVLQERVVCNERFSE-------DGYRTVVQGTKK-EGCTILFMMLYFFSMASSIWW 350

  Fly   356 SCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTH 420
            ..|:..||||||:||||||||..|..|||.||||||::||::||:.:::||:||||||||.....
Mouse   351 VILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLD 415

  Fly   421 SLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVG 485
            .|..|::.||.:||.||..||||||:|||||||:||.||.:|:||||||:|||.||.|:.:||..
Mouse   416 PLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATI 480

  Fly   486 LLGCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARAPGSPEARPIFQIFMVKYLCSMLVGVTSSV 550
            ::.|.|||....:.|...|....||..:|||||..   :|...|.|.::|:|||.:::||:||..
Mouse   481 VIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHY---TPRMSPDFTVYMIKYLMTLIVGITSGF 542

  Fly   551 WLYSSKTMVSWRNFVERL 568
            |::|.||:.|||.|..||
Mouse   543 WIWSGKTLHSWRKFYTRL 560

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fzNP_001261836.1 CRD_FZ1_like 51..167 CDD:143567 72/116 (62%)
Frizzled 237..564 CDD:279827 161/326 (49%)
Fzd2NP_065256.1 CRD_FZ2 40..166 CDD:143573 74/125 (59%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 166..194 4/27 (15%)
Frizzled 240..557 CDD:279827 161/327 (49%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 548..553 2/4 (50%)
PDZ-binding 568..570
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 158 1.000 Domainoid score I4103
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 528 1.000 Inparanoid score I1213
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48699
OrthoDB 1 1.010 - - D167933at33208
OrthoFinder 1 1.000 - - FOG0001848
OrthoInspector 1 1.000 - - otm43585
orthoMCL 1 0.900 - - OOG6_104642
Panther 1 1.100 - - O PTHR11309
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X126
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.840

Return to query results.
Submit another query.