Protein Alignment fz and fzd3b

DIOPT Version :9

• Sequence 1: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_001074070.1
• Gene: fzd3b / 567746
• ZFINID: ZDB-GENE-070122-1
• Length: 667
• Species: Danio rerio
• Alignment Length: 579
• Identity: 225/579 - (38%)
• Similarity: 314/579 - (54%)
• Gaps: 63/579 - (10%)

  Fly    36 LMASSGTELDGLPHHN--RCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGC 98
            |..|....:|.:..|:  .||.|.:.:|:::|||.|.||||:.|..|:.|.|.:..|.|:|.:.|
Zfish    21 LSGSMAIHMDSVGSHSLFTCESIGLRMCQDLPYNNTFMPNLLNHYDQQTAALAMEPFHPMVNLQC 85

  Fly    99 SDDLQLFLCSLYVPVCTILERPIPPCRSLCESA-RVCEKLMKTYNFNWPENLECSKFP-----VH 157
            |.||:.|||:||.|||....|...||||||..| |.|:|||..:...|||.:||::||     ..
Zfish    86 SPDLRPFLCALYAPVCMEYGRVSLPCRSLCHHAKRDCQKLMDMFGVTWPEEMECTRFPDCDESYP 150

  Fly   158 GGEDLCVAENTTSSASTAATPTRSVAKVTTRKHQTGVESPHRNIGFVCPVQLKTPLGMGYELKVG 222
            ..|||.|.::.|..:..                     |..|:.||.||.:||....:||.. :|
Zfish   151 RAEDLLVIDDPTDQSPM---------------------SVQRDYGFWCPRELKMEPDLGYTF-LG 193

  Fly   223 GKDLHDCGAPCHAMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAV 287
               :.||..||..|:|...|.|..||::|..:.||:::.|||.||||||.:|||||||.|:|.||
Zfish   194 ---VRDCSPPCPNMYFRREELTFARYFIGVVSIVCLSATLFTFLTFLIDVTRFRYPERPIIFYAV 255

  Fly   288 CYLVVGCAYVAGLGAGDSVSCREPFPPPVKLGRLQMMSTITQG-HRQTTSCTVLFMALYFCCMAA 351
            ||::|...:..|....|.|:|....|...|      .||:||| |.:  :||:|||.|||..||.
Zfish   256 CYMMVSLVFFLGFLLEDRVACNSANPGQYK------TSTVTQGSHNK--ACTLLFMVLYFFTMAG 312

  Fly   352 FAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQ 416
            ..||..|...|||||..|||.||||.|:.|||..||.:|.:.||::|||.|:|||.:|||||||.
Zfish   313 SVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGMLTIALLALNKIEGDNISGVCFVGV 377

  Fly   417 LDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFIL 481
            .|..:|..|::.|||:.:.:|...||||.::|.|:|..:..:.:..:||.:.|:|||.||.|:::
Zfish   378 YDVQTLRWFVLAPLCLDVLVGVSLLLAGIVALNRVRMEIPLEKENQEKLVKFMIRIGVFSVLYLV 442

  Fly   482 PAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARAPGSPEARPIFQIFMVKYLCSMLVGV 546
            |.:.::||..||......|...|.::.|:.:.||||......|   ||...:|::|||..::||:
Zfish   443 PLLTVVGCYLYEQTYRSVWETTWVQERCREYHIPCPFKVEQTS---RPDLVLFLIKYLMVLVVGI 504

  Fly   547 TSSVWLYSSKTMVSWRNFVERLQGKEPRTRAQAYVXYETGPAGGA--KSTPLTPDPEAA 603
            .|..|:.|.||...|..|....:.|:                .||  :|..:..||:.|
Zfish   505 PSVFWVGSKKTCFEWAGFFHGRRRKD----------------SGAVHESRQVLQDPDFA 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	55/123 (45%)
		Frizzled	237..564	CDD:279827	141/327 (43%)
fzd3b	NP_001074070.1	CRD_FZ	36..162	CDD:382974	55/125 (44%)
		7tmF_FZD3	204..524	CDD:320161	143/330 (43%)
		TM helix 1	213..238	CDD:320161	11/24 (46%)
		TM helix 2	247..268	CDD:320161	9/20 (45%)
		TM helix 3	299..325	CDD:320161	13/25 (52%)
		TM helix 4	342..364	CDD:320161	11/21 (52%)
		TM helix 5	378..403	CDD:320161	7/24 (29%)
		TM helix 6	431..456	CDD:320161	11/24 (46%)
		TM helix 7	485..510	CDD:320161	10/27 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11309
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920