DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz and col18a1a

DIOPT Version :9

Sequence 1:	NP_001261836.1	Gene:	fz / 45307	FlyBaseID:	FBgn0001085	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_021334395.1	Gene:	col18a1a / 564123	ZFINID:	ZDB-GENE-030516-3	Length:	1645	Species:	Danio rerio

Alignment Length:	200	Identity:	49/200 - (24%)
Similarity:	75/200 - (37%)	Gaps:	29/200 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LMASSGTELDGLPHHNRCEPIT--ISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGC 98
            |:||.....:.|    ||.|:.  :..|.........:||.:..:..||..:.:.::|.|::.||
Zfish   194 LIASMPASFEPL----RCLPVDSGLPFCTRRGVESFSVPNFLNQSSVEEVRMVLTEWAWLLRSGC 254

  Fly    99 SDDLQLFLCSLYVPVC----TILERPIPPCRSLCESAR-VCEKLMKTYNFNWPENLECSKFP--V 156
            ...|:.|.|.|..|.|    ::|     ||||.||..: .|..|:.....    .:||...|  .
Zfish   255 HHSLEWFFCLLLTPRCGHSGSLL-----PCRSSCEVLQDSCWTLLDEGRL----PVECKSLPEEK 310

  Fly   157 HGGEDLCVAENTTSSASTAA------TPTRSVAKVTTRKHQTG-VESPHRNIGFVCPVQLKTPLG 214
            |.|.......|....:..:.      .|...|:||..:.:..| |..|..|:|......|..|..
Zfish   311 HDGYRCLSVSNLKEESGVSLLQLIGDPPPNGVSKVFDQANSPGYVFGPSSNVGQSAAAHLPNPFY 375

  Fly   215 MGYEL 219
            ..:.|
Zfish   376 RDFSL 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	32/124 (26%)
fz	NP_001261836.1	Frizzled	237..564	CDD:279827
col18a1a	XP_021334395.1	CRD_Collagen_XVIII	203..340	CDD:143564	35/149 (23%)
		LamG	327..516	CDD:328935	11/53 (21%)
		Collagen	816..860	CDD:189968
		Collagen	<937..980	CDD:189968
		Collagen	959..1055	CDD:189968
		Endostatin	1471..1639	CDD:310825
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810