Protein Alignment fz and fzd1

DIOPT Version :9

• Sequence 1: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_001124086.1
• Gene: fzd1 / 557384
• ZFINID: ZDB-GENE-990415-219
• Length: 538
• Species: Danio rerio
• Alignment Length: 551
• Identity: 273/551 - (49%)
• Similarity: 352/551 - (63%)
• Gaps: 40/551 - (7%)

  Fly    34 GGLMASS--GTELDGLPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKI 96
            |.|.|.:  |.....:|.|..|:||:|.:|.:|.||.||||||:|||.||:||||||||.||||:
Zfish    12 GALSARAQYGDRGMSVPEHGFCQPISIPLCTDIAYNETIMPNLLGHTNQEDAGLEVHQFYPLVKV 76

  Fly    97 GCSDDLQLFLCSLYVPVCTILERPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPVHGGE 160
            .||.||:.||||:|.||||:||:.:||||||||.||. ||.||..:.|.|||:|.|..|||||||
Zfish    77 QCSPDLKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPESLACESFPVHGGE 141

  Fly   161 DLCVAENTTSSASTAATPTRSVAKVTTRKHQTGVESPHRNIGFVCPVQLKTPLGMGYELKVGGKD 225
             |||.:||| ..|...:||....:......|.|        .|.||..|:.|..:.|...  |:|
Zfish   142 -LCVGQNTT-GPSPPVSPTPDATQAPPEPSQRG--------RFQCPPSLRVPPYLNYRFM--GED 194

  Fly   226 LHDCGAPCH------AMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVF 284
              :|||||.      .|:|.|.|:...|.|:|.|:.:|.||.||||||:|:|..||.||||.|:|
Zfish   195 --NCGAPCEPRKLHGMMYFSEDEQKFARIWIGIWSVLCCASTLFTVLTYLVDMKRFSYPERPIIF 257

  Fly   285 LAVCYLVVGCAYVAGLGAGDSVSCREPFPPPVKLGRLQMMSTITQGHRQTTSCTVLFMALYFCCM 349
            |:.||.:|..||:||....|.|.|.|.|....:        |:.||.:: ..||:|||.|||..|
Zfish   258 LSGCYTMVSIAYIAGFLLEDKVVCNEQFENEFR--------TVVQGTKK-EGCTILFMMLYFFSM 313

  Fly   350 AAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFV 414
            ::..||..||..||||||:||||||||..|..|||.||||||::||::||:.:|:||:|||||||
Zfish   314 SSSIWWVILALTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILAVGQVDGDVLSGVCFV 378

  Fly   415 GQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLF 479
            |.....:|..|::.||.:||.||..||||||:|||||||:||.||.:|:|||:||:|||.||.|:
Zfish   379 GINSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGIFSVLY 443

  Fly   480 ILPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARAPGSPEARPIFQIFMVKYLCSMLV 544
            .:||..::.|.|||......|...|....||.:::||||    .:|:..|.|.:||:|||.:::|
Zfish   444 TVPATIVIACYFYEQAFRAHWEQTWSAHSCKTYAVPCPA----HNPQMNPDFTVFMIKYLMTLIV 504

  Fly   545 GVTSSVWLYSSKTMVSWRNFVERL----QGK 571
            |:||..|::|.||:.|||.|..||    ||:
Zfish   505 GITSGFWIWSGKTLNSWRKFYTRLANSKQGE 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	76/116 (66%)
		Frizzled	237..564	CDD:279827	164/326 (50%)
fzd1	NP_001124086.1	CRD_FZ1_like	31..148	CDD:143567	76/117 (65%)
		7tm_GPCRs	199..537	CDD:391938	172/350 (49%)
		TM helix 1	219..243	CDD:341315	13/23 (57%)
		TM helix 2	252..273	CDD:341315	11/20 (55%)
		TM helix 3	302..324	CDD:341315	11/21 (52%)
		TM helix 4	345..361	CDD:341315	11/15 (73%)
		TM helix 5	383..406	CDD:341315	9/22 (41%)
		TM helix 6	434..459	CDD:341315	12/24 (50%)
		TM helix 7	487..512	CDD:341315	11/24 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4077
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	548	1.000	Inparanoid score	I1115
OMA	1	1.010	-	-		QHG48699
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	1	1.000	-	-		FOG0001848
OrthoInspector	1	1.000	-	-		otm24936
orthoMCL	1	0.900	-	-		OOG6_104642
Panther	1	1.100	-	-	O	PTHR11309
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980